Orientador: Marcelo Moreira Ganzarolli / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica / Made available in DSpace on 2018-07-22T20:18:14Z (GMT). No. of bitstreams: 1 Avelar_AnaCristina_M.pdf: 5757345 bytes, checksum: ab66436b252ec7b8b48d4756dd9e7f42 (MD5) Previous issue date: 1997 / Resumo: Os constantes avanços tecnológicos em eletrônica e informática tem tornado os sistemas eletrônicos cada vez mais compactos, aumentando-se a quantidade de calor a ser removida dos componentes e placas de circuito impresso. Por este motivo, atualmente são exigidos sistemas de dissipação de calor altamente eficientes. Este estudo analisa teórica e experimentalmente a transferência de calor em canais verticais formados por placas de circuito impresso dispostas paralelamente, resfriadas por convecção natural e propõe uma modelagem, baseada em relações existentes na literatura, que busca prever a distribuição de temperaturas em pontos significativos nos canais e placas em função da potência dissipada e da distância entre as placas. Este estudo visa também analisar os efeitos do aquecimento não-uniforme das placas que formam o canal. Na simulação teórica, devido à pequena espessura da placa o gradiente de temperatura ao longo da espessura da mesma foi desprezado e resolveu-se numericamente a equação de transferência de calor em coordenadas cartesianas bidimensionais e em regime permanente. Equacionou-se balanços de energia para os componentes e para o ar no canal e o problema foi resolvido numericamente através de um programa computacional. As placas de circuito impresso utilizadas nos testes experimentais, concebidas exclusivamente para fins de estudos térmicos, possuem uma base de epóxi com 25 resistores discretamente distribuídos sobre sua superfície de 200x164mm. Realizou-se testes com aquecimento uniforme e não-uniforme, variando-se a potência por componentes nas placas. Variou-se também as potências por placas e as distâncias entre as mesmas. Testou-se as potências de 2, 4,6 e 8 W e as distâncias entre placas de 12,24, e 48mm. Verificou-se boa concordância entre os resultados numéricos e experimentais, principalmente para a menor distância entre placas, 12 mm, onde a diferença entre os resultados teóricos e experimentais foi muito pequena / Abstract: The constant technological advances in electronics and computations have made the electronic system increasingly more compact, thus increasing the amount of heat to be removed ITomthe components and printed circuit boards. For this reason, highly efficient system of heat removal are presently required. This study analyses both theoretically and experimentallyheat transfer in an array of vertical parallel printed circuit boards, cooled off by natural convection and proposes a modeling, based on correlation found in literature which tries to predict temperature distribution in significant places in the channels and boards as regards dissipated power and distance among boards. This study also aims at analyzing nonuniform heating effets of the channel made boards. In the theoritical simulation, due to the board' s small thickness, the temperature gradient across the board has been neglected, and the equation of heat transfer in two-dimensional Cartesian was numericallysolved, and on a steady state. Energy balances for the componentes were formulated, and the problem was numerically solved by a computer programo The printed circuit boards used in the experimental tests, manufactured speciallyfor heat trasnfer studies have an epoxy basis with 25 resistors discretely distributed on 200 x 164 mm. Uniform and non-uniform heating tests were performed, thus a variation of power and distance among them had a variation. The 2, 4, 6 and 8 W power and distance among 12, 24 and 48 mm boards were tested. Good agreements between numerical and experimentalresults were observed, mainlyfor the smaller distance among boards, 12 mm, the differencesbetween the theoretical and experimentalresults were small / Mestrado / Termica e Fluidos / Mestre em Engenharia Mecânica

FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico / A presente pesquisa teve como objetivo avaliar os efeitos do uso de raÃÃes de muda contendo diferentes nÃveis de torta de mamona nÃo destoxificada (TM) na induÃÃo da muda forÃada em poedeiras comerciais. Foram utilizadas 120 poedeiras da linhagem Lohman LSL, com 81 semanas de idade, distribuÃdas em delineamento inteiramente casualizado com quatro tratamentos e cinco repetiÃÃes de seis aves cada. Os tratamentos consistiram na induÃÃo da muda forÃada pelo mÃtodo do jejum e, os demais, utilizando raÃÃes de muda, composta pela mistura de raÃÃo postura com torta de mamona nos nÃveis de 20, 30 e 40%. O mÃtodo do jejum foi aplicado por 11 dias e, para os demais tratamentos, estabeleceu-se a suspensÃo da raÃÃo de muda quando as aves atingiram 23% de perda do peso inicial ou atà 21 dias de alimentaÃÃo. DiferenÃas significativas foram observadas entre os mÃtodos de induÃÃo da muda forÃada para os parÃmetros medidos durante a induÃÃo da muda e no desempenho das aves apÃs a muda. Entretanto, a qualidade dos ovos nÃo variou significativamente entre os mÃtodos avaliados. No geral, o uso de raÃÃo de muda contendo 40% de TM possibilitou a obtenÃÃo de resultados semelhante na produÃÃo e qualidade dos ovos aos obtidos com o mÃtodo do jejum, mas com menor alteraÃÃo dos parÃmetros sanguÃneos. O uso de raÃÃo contendo 20% ou 30% de TM promoveu, no perÃodo apÃs a muda, desempenho significativamente menor que os demais mÃtodos. O uso de raÃÃo de muda composta por raÃÃo de postura contendo torta de mamona nÃo destoxificada no nÃvel de 40% se mostrou uma alternativa viÃvel ao uso do mÃtodo do jejum. / This study aimed to evaluate the effects of changing diets containing different levels of non-detoxified castor bean meal (TM) in the induction of molt and compare them with the method of fasting. Used 120 Lohman LSL strain hens at 81 weeks of age were assigned to completely randomized design with four treatments and five replicates of six birds each. Treatments were the induction of molt by the method of fasting as a treatment, and others using diets change, being composed of approach ration containing castor bean at levels of 20, 30 and 40% (T2, T3 and T4 ). The method was applied to fast for 11 days and the other treatments, was established to suspend the declaration of change when the birds reached 23% loss of initial weight or up to 21 days supply. Blood samples were collected, one bird per replicate / treatment at the end of induction of changes were analyzed. Significant differences were observed between the methods of molt induction to the parameters measured during the induction of changes in performance of birds after molting. However, the quality of the eggs did not vary significantly among the evaluated methods. In general, the use of feed containing 40% of changes of TM enabled to obtain similar results in the production and egg quality to those obtained with the method of fasting, but with less alteration of blood parameters. The use of feed containing 20% or 30% of TM promoted in the period after the changes, performed significantly lower than other methods. The ration of changes made by laying diet containing not detoxified castor bean meal in the level of 40% proved to be a viable alternative to using the method of fasting.

Recentemente suspeitas de que mecanismos epigenéticos poderiam estar relacionados à fisiopatologia da depressão foram levantadas. Estudos recentes indicam que as alterações na transcrição gênica, induzidas por estresse ou por drogas antidepressivas, parecem envolver mecanismos epigenéticos. Nesse sentido, resultados preliminares de nosso grupo de pesquisa indicaram pioneiramente inibição global da metilação de DNA através da administração sistêmica do agente inibidor da DNA metiltransferase (DNMTs), 5-aza-2-deoxicitidina (5-azaD), induz efeito tipo-antidepressivo, dose-dependente, no modelo animal do nado forçado em ratos(Sales et al., 2011). O córtex pré-frontal medial ventral (CPFMv) é uma estrutura límbica intimamente relacionada com a neurobiologia da depressão. Evidências recentes indicam que o efeito tipo-antidepressivo aparece associado a aumento dos níveis da neurotrofina BDNF (brain derived neurotrophic factor) e de seu receptor TrkB no CPFMv, sendo a sinalização intracelular mediada pela ativação da proteína m-TOR. Contudo, não há evidências de que esses mecanismos moleculares estariam envolvidos nos efeitos induzidos pelos inibidores da metilação do DNA. Sabe-se, no entanto, que tanto o BDNF quanto TrkB têm sua expressão regulada por metilação do DNA. Diante disso, o objetivo presente trabalho será investigar a participação da via BDNF-TrkB-mTOR do CPFMv no efeito antidepressivo induzido por inibidores da metilação de DNA. Para tanto, ratos tratados com inibidores da metilação de DNA (5-azaD ou RG-108), em dois momentos diferentes (imediatamente após o PT e 23horas após o PT) foram submetidos ao teste do nado forçado (FST). Outro grupo de animais recebeu uma injeção intra-CPMv de k252a ou Rapamicina, 40 minutos antes do teste e uma injeção de BDNF intra-CPFMv, 30 minutos antes do teste. Em outro experimento, grupos independentes de animais submetidos ao nado forçado foram tratados sistemicamente com RG-108 e receberam injeção intra-CPFMv de K252a (antagonista de Trk) ou de rapamicina (inibidor da m-Tor), a fim de investigar se o efeito dessas drogas depende da via BDNF-TrkB-mTOR no CPFMv. Um grupo independente foi tratado com RG108 e CPFM desses animais foi dissecado para posterior análise da expressão de BDNF, TrkB e m-TOR, bem como da metilação de DNA. O tratamento com RG108 e 5azaD sistêmico reduziu o tempo de imobilidade dos animais submetidos ao nado forçado nos dois tempo de administração. A administração intra-CPFMv de BDNF promoveu efeito antidepressivo no FST, e esse efeito foi bloqueado pela administração de k252a ou Rapamicina no CPFMv. No mesmo sentido, o efeito antidepressivo do RG108 sistêmico foi bloqueado pela administração intra-CPFMv de k252a ou Rapamicina. Entretanto, a medida dos níveis de metilação global no CPFMv não apresentou alteração como tratamento com RG108, e também não mostrou alteração nos níveis de BDNF presente no CPF. O tratamento com RG108 não alterou a expressão, bem como a ativação de TRkB e mTOR. Concluímos que os inibidores da metilação do DNA apresentam agudamente efeito tipo antidepressivo rápido, que necessita da funcionalidade integral da via BDNF-TRkB-mTOR. Entretanto, esse efeito parece não alterar a síntese e expressão das proteínas envolvidas nessa via no que diz respeito ao CPFmv. / Recent studies indicate that changes in gene transcription induced by stress or antidepressant drugs appear to involve epigenetic mechanisms. Accordingly, results of our research group pioneered indicated global inhibition of DNA methylation through systemic administration of an inhibitor of DNA methyltransferase (DNMTs), 5-aza-2-deoxycytidine (5-AzaD), induces antidepressant-like effect dose-dependent in the animal model of forced swimming in rats (Sales et al., 2011). The ventral medial prefrontal (vmPFC) cortex is a limbic structure closely related to the neurobiology of depression. Recent evidence indicates that the antidepressant-like effect appears associated with increased levels BDNF (Brain derived neurotrophic factor) and its receptor TrkB in vmPFC, and intracellular signaling mediated by activation of protein mTOR. However, there is no evidence that these molecular mechanisms are involved in the effects induced by inhibitors of DNA methylation. It is known, however, both as BDNF and TrkB expression is regulated by DNA methylation. Thus, the goal of this work is to investigate the role of BDNF-TRkB pathway mTOR-vmPFC in the antidepressant effect induced by inhibitors of DNA methylation. To this end, rats treated with inhibitors of DNA methylation (5-Azad or RG-108), at two different times (immediately after 23hours after the PT and PT) were subjected to the forced swim test (FST). Another group received an intra-vmPFC injection of K252a or Rapamycin 40 minutes before the test, and an injection intra-vmPFC of BDNF 30 minutes before the test. In another experiment, separate groups undergoing the forced swim were treated systemically with RG-108 and received intra-vmPFC of K252a (Trk antagonist) or injection of rapamycin (m-Tor inhibitors) in order to investigate the effect these drugs depends on BDNF-TrkB-mTOR pathway in vmPFC. A separate group was treated with RG108 and mPFC these animals were dissected for analysis of the expression of BDNF and TrkB m-TOR, as well as DNA methylation. The systemic treatment whit 5azaD and RG108 reduced the immobility time of rats subjected to FST administration in both time. The intra-vmPFC BDNF administration promoted antidepressant effect in the FST, and this effect was blocked by the administration of K252a or Rapamycin in vmPFC. Similarly, the antidepressant effect of systemic RG108 was blocked by intra-vmPFC of K252a or Rapamycin administration. However, the measurement of the levels of global methylation in CPFMv did not change as treatment with RG108, and also showed no change in the levels of BDNF present in the CPF. Treatment with RG108 did not alter the expression and activation of TrkB and mTOR. We conclude that inhibitors of DNA methylation present acutely antidepressant-like effect, it needs the full functionality of the BDNF-TrkB-mTOR pathway. However, this effect seems not to alter the synthesis and expression of proteins involved in this pathway at vmPFC.

Além do comprometimento motor, os pacientes com Distrofia Muscular de Duchenne cursam com queda da função respiratória que está associada à fraqueza muscular. O objetivo do estudo foi avaliar a evolução da função pulmonar e a força dos músculos respiratórios em diferentes estágios da doença, comparando-os com o tempo e idade de início da corticoterapia e com o quadro motor. A função pulmonar e as pressões respiratórias de 87 pacientes com idade entre sete e 23 anos foram avaliadas durante dois anos, totalizando cinco visitas para função pulmonar e três para as pressões respiratórias. Além disto, parte da amostra (n: 21) completou três avaliações de função pulmonar com aproximadamente um ano de intervalo. Para a comparação, considerouse: idade cronológica; idade de início e tempo de duração da corticoterapia, e se o paciente deambulava ou não. Na avaliação transversal, observou-se que em valores absolutos a CVF, o VEF1 e a PImáx, mantiveram-se até a faixa etária de 13 a 14 anos e a PEmáx até nove a 10 anos; em valores relativos (aos valores de pacientes saudáveis) notou-se queda constante da função pulmonar e das pressões respiratórias. No acompanhamento longitudinal, a função pulmonar e a força muscular respiratória mostraram aumento em valores absolutos, principalmente nos pacientes deambuladores, sendo este aumento influenciado pelo crescimento; em valores relativos houve manutenção pelo período de dois anos. Em conclusão, durante o tempo de estudo, a corticoterapia pode ter contribuído para o retardo da progressão da doença, através da intervenção na musculatura respiratória da mesma forma que atua na musculatura proximal dos membros. O tempo e a idade de início do medicamento não mostraram relação clara com a manutenção da função respiratória, porém o início da corticoterapia abaixo de sete anos de idade parece ser mais efetivo para a preservação da força dos músculos respiratórios e da função pulmonar / Besides motor impairment, patients with DMD show loss of respiratory function which one is associated to muscle weakness. The aim of the study was to evaluate the pulmonary function evolution and the respiratory muscle strength in different stages and then to compare them to duration and initial age of corticostheroids treatment age as well as the function motor. The pulmonary function and the maximal respiratory pressure of the 87 patients aged 7-23 years were evaluated over the course of two years. The patients\' pulmonary function was assessed over five visits and their maximum respiratory pressure was assessed during three visits. Moreover, the sample (n = 21) completed three assessments of lung function with approximately one year apart. For comparison, we considered: chronological age, age of onset and duration of corticosteroid therapy, and if patient were ambulant or not. In the transversal evaluation we noticed that CVF, VEF1and PImax in absoluts values showed no changes until age of 13-14 years and no changes for the PEmax until age of 9-10 years. In predicted for their actual height values we noticed a constant decline for loss of pulmonary function and maximal respiratory pressure. In the longitudinal follow, the pulmonary function and the respiratory muscle strength raised in absolutes values, mainly in ambulatory patients due to the growth. In relatives values the pulmonary function and maximal respiratory pressure showed stability for 2 years. In conclusion, during the study, corticosteroid treatment may have contributed to the delay of disease progression, through intervention in the respiratory muscles in the same way that acts in the proximal muscles of limbs. Both time and the initial age of corticosteroids treatment didn´t show relationship with respiratory function. But the beginning of corticosteroids bellow seven years old seems to be more effective for preserving respiratory muscle strength and pulmonary function

No description available.

La présente étude vise à comprendre les écoulements ainsi que les transferts de chaleur par convection dans une configuration représentative d’un moteur de traction automobile. La zone d’étude est constituée d’un stator extérieur lisse et fixe et d’un rotor intérieur tournant. Deux géométries de rotor ont été étudiées : un rotor cylindrique et un rotor encoché. Un écoulement axial est superposé à l’écoulement produit par la rotation. Pour le rotor lisse, des mesures ont été réalisées pour des valeurs du nombre de Reynolds axial de 2500 à 13900 et de rotation de 1250 à 4000. Pour le rotor encoché, le nombre de Reynolds axial varie également de 2500 à 13900 et le nombre de Reynolds de rotation de 5000 à 26000. Les mesures de vitesse réalisées par PIV au sein des encoches montrent un écoulement tourbillonnaire contrarotatif complexe. Dans la zone d’entrée, on peut noter une forte interaction entre l’écoulement des encoches et celui provenant des zones polaires. Les résultats thermiques obtenues par thermographie infrarouge sur le rotor encoché montrent que les transferts thermiques augmentent avec l’augmentation du nombre de Reynolds axial mais l’influence de la vitesse de rotation est plus complexe. Enfin, la comparaison des résultats thermiques entre rotors lisse et encoché, a permis de mieux comprendre l’effet des encoches sur le refroidissement global. / The present work aimed to experimentally study the flow and heat transfer in a configuration corresponding to the gap of an automotive electrical motor (a thin airlayer between the rotating (rotor) and stationary (stator) parts.) Two rotor geometries are studied: one cylindrical and the other one with four slots which reproduce a synchronous motor used in automotive traction. An axial flow is superimposed to the rotation flow thanks to a ventilation system. The two most important parameters are axial Reynolds number and rotational Reynolds number. Velocity measurements are performed by PIV and heat transfer by infrared thermography coupled with heated thin foils. A complex counter rotational vortex flow has been recorded in the slots. Moreover, this slot flow seems to interact with the pole flow in the inlet region. This interaction seems to disappear rapidly after entrance area. Heat transfer rate is 3D, with great differences between the two slots faces and the pole. Classically, heat transfer rate grows with increasing axial Reynolds number. The relation between heat transfer rate and rotation Reynolds number is more complex

1 Abstract Slavery and its modern aspects This diploma thesis deals with the current and controversial topic. Aim of this thesis is to put attention to the speeches, forms and incredible frequency of modern slavery - phenomenon that would be at first glance wrongly seen as just historical issue. First chapter of the thesis speaks about historical excursion of slavery. Because of the limited scope is history focused on the main areas of ancient Greece and Rome, the area of the American continent with its huge business of African slaves, the period of Second World War and finally on the brief history at Czech territory. After the historical chapter is focus stressed on theoretical presentation of the problem - the nature of this phenomenon. Slavery is especially considered as part of International Guardianship of Human Rights. Theoretical part is followed by examples of most frequent real forms of modern slavery. These forms include sexual slavery and human trafficking, forced labor, forced marriage and child slavery as probably the most serious form of modern slavery. Chapter about international regulation of slavery is divided into few parts. After a brief history of the international perception of the slavery is attention paid to the general international law, then the law concerning the protection of...

The overall aim was to evaluate the effectiveness of forced use on arm and hand recovery after stroke by applying a restraining sling on the non-affected arm and to investigate psychometric properties of selected upper limb measures. Papers I and II reported a randomised trial with 1- and 3-month follow-ups. Thirty patients 1 to 6 months after stroke were included and received regular training for 2 weeks of intervention. The forced-use group had in addition a restraining sling on the non-paretic arm. Outcome measures were the Fugl-Meyer Assessment, the Modified Ashworth scale, the 16-hole peg test, grip force, the Action Research Arm test, and the Motor Assessment Scale (Paper I), and the Motor Activity Log (MAL) (Paper II). Results in Papers I and II showed no statistical difference in change between groups. Both groups improved over time. Paper III assessed the responsiveness of the MAL and its cross-sectional and longitudinal validity. The MAL was responsive to change, with Standardised Response Means and Responsiveness Ratios larger than 1.0. Correlations between the MAL and the other measures were mostly close to 0.50. Paper IV investigated test–retest intra-rater reliability of measuring grip force with Grippit, and assessed relationships between grip forces of both hands, and between sustained and peak grip force. The paretic hand needs to score a change of 10% or 50 N to exceed the measurement error. The mean ratio between sides was 0.66, and between sustained and peak grip force, 0.80–0.84. In conclusion, this thesis provides preliminary evidence that forced use does not generate greater improvement on upper limb motor impairment, capacity, and performance of activity than regular rehabilitation. The findings indicate that the MAL is a responsive measure of daily hand use in patients with stroke. Correlations of construct validity indicated that daily hand use might need to be measured separately from body function and activity capacity. The coefficients calculated for repeatability and reproducibility were acceptable, and the Grippit instrument can be recommended.

To control various response biases and rater errors in noncognitive assessment, multidimensional forced choice (MFC) measures have been proposed as an alternative to single-statement Likert-type scales. Historically, MFC measures have been criticized because conventional scoring methods can lead to ipsativity problems that render scores unsuitable for inter-individual comparisons. However, with the recent advent of classical test theory and item response theory scoring methods that yield normative information, MFC measures are surging in popularity and becoming important components of personnel and educational assessment systems. This dissertation presents developments concerning a GGUM-based MFC model henceforth referred to as the GGUM-RANK. Markov Chain Monte Carlo (MCMC) algorithms were developed to estimate GGUM-RANK statement and person parameters directly from MFC rank responses, and the efficacy of the new estimation algorithm was examined through computer simulations and an empirical construct validity investigation. Recently derived GGUM-RANK item information functions and information indices were also used to evaluate overall item and test quality for the empirical study and to give insights into differences in scoring accuracy between two-alternative (pairwise preference) and three-alternative (triplet) MFC measures for future work. This presentation concludes with a discussion of the research findings and potential applications in workforce and educational setting.

租買選擇對於家戶來說是一件十分重要的家庭決策。當家戶決定購屋時，由於購屋支出是一筆極大的支出，勢必會影響到家戶各方面的支出，如食衣住行育樂等。。另一方面家戶需要多儲蓄以因應未來房屋的支出。 本文根據中國家庭金融調查(CHFS)的資料，將中國的家戶分為三種租買選擇分別為租屋、買屋有貸款、買屋無貸款。首先，我們先估計中國家戶的租買選擇，接著我們利用Heckman二階段模型估計租買選擇對於中國家戶儲蓄的影響。我們發現inverse Mill’s ratio的結果為顯著說明了在估計儲蓄函數是該考慮家戶的租買選擇。另外其他家戶特性的變數也有所變化，這些結果說明了如果不將租買選擇考慮進去 儲蓄行為的估計結果會有偏誤。 / Tenure choice is a very important decision for households. When the household decide to buy a house, it will have a heavily effect on the household’s spending, including food, clothes, transportation, education, and leisure, and so on. On the other hand, household have to save more money to meet housing expenses. Applying a data set from “China Household finance Survey” (CHFS) and separating Chinese households with three types of tenure choice, namely, renters, owner-occupied with loan payment, and owner-occupied without loan payment. First, we estimate the tenure choice of Chinese households. And then we use Heckman two-stage model to estimate how tenure choice affect household saving behavior. We find that the coefficient of inverse Mill’s ratio are significant. And the coefficient of household characters have some different from traditional model. The result show that if we don’t consider the tenure choice of household, the household’s saving behavior we estimate will be biased.