Submitted in partial compliance with the requirements of the Master’s Degree in Technology: Homoeopathy, Durban University of Technology, Durban, South Africa, 2017. / Background Seborrheic dermatitis (SD) also known as pityriasis capitis is a common skin condition that affects mainly the scalp, causing scaly patches, red skin and stubborn dandruff (Preedy 2012). It has been reported that dandruff occurs in at least 50% of the world’s adult population and approximately 15% to 20% of the world’s total population (Mia 2016). Recent studies suggest that a scalp specific yeast called Malasseiza globosa appears to be responsible for SD (Zhang, Ran, Xie and Zhang 2013). Seborrheic dermatitis does not affect overall health but it can be uncomfortable and may cause embarrassment and low self-esteem (Del Rosso 2011; Preedy 2012). Anecdotal evidence at Ukuba Nesibindi Homoeopathic Community Clinic (UNHCC) indicated that patients with SD responded positively to Calendula officinalis Ø in combination with Olea europaea (olive oil). Notwithstanding this, there is a dearth of clinical data available to validate the aforesaid patient’s positive response. Hence this study aims to provide clinical evidence to prove or disprove patient’s response to Calendula officinalis Ø in combination with Olea europaea (olive oil). Objective The aim of this double blind randomized controlled study was to determine the efficacy of a topical application comprising Calendula officinalis Ø with Olea europaea in the management of SD of the scalp (dandruff). Material and methods The sample was selected by means of non-probability convenience sampling and consisted of 64 consenting participants between the ages of 18 to 50 years who had read the information letter and met the inclusion criteria. Participants were evenly distributed between the treatment and control groups according to the randomization list (32 participants in each group). The treatment group received Calendula officinalis Ø with Olea europaea and the control group received Olea europaea only. Three participants withdrew from the study resulting in only 61 completing the study, 30 from the control group and 31 from the treatment group. The study was conducted at the Durban University of Technology Homoeopathic Day Clinic (DUTHDC) under the supervision of a qualified and registered homoeopathic clinician. The duration of the study was six weeks with three consultations in total. Consultations took place on day 1, day 22 and day 43. At each consultation the participants were assessed by three individuals – the participant themselves, the researcher, and an independent party (the homoeopathic clinician on duty that day). The assessment tools included the Visual Analogue Scale (VAS) for the researcher and clinician consisting of the following categories: irritation, flaking, greasiness, percentage of the scalp involved and overall impression; and the Patient Perception Questionnaire (PPQ) for the patient consisting of the following categories: irritation, flaking, greasiness, itching and overall impression. This was accompanied by a detailed case history and physical examination performed by the researcher. Results Both the control and treatment groups displayed overall improvement in terms of Patient Perception Questionnaire and Visual Analogue Scale which means that a combination of Olea europeae with Calendula officinalis Ø (treatment group) and Olea europeae only (control group) were effective in the management of SD. There was no statistically significant difference between the effect of a combination of Olea europaea with Calendula officinalis Ø and Olea europaea only. In terms of the VAS and PPQ categories, there was a statistical significance between the groups, with the exception of irritation. Significant differences found were as follows: Flaking (clinician and patient rated p = 0.019) on visit 3 for the control group. Greasiness (clinician and patient rated p = 0.027) on visit 3 for the control group. Greasiness (researcher and patient rated p = 0.012) on visit 2 for the treatment group. Percentage of the scalp involved (researcher and clinician rated p = 0.013) on visit 2 for the treatment group. Overall impression (researcher and patient rated p = 0.026) on visit 2 for the control group. Overall impression (researcher and clinician rated p = 0.026) on visit 3 for the treatment group. Conclusion Both the combination of Olea europaea with Calendula officinalis Ø and Olea europaea only improve SD. Therefore, a topical application comprising Calendula officinalis Ø and Olea europaea is effective in the management of SD of the scalp (dandruff) and therefore permits further investigation. / M

virgen en spray para cocinar y para consumo directo. Utilizará una novedosa tecnología que evita el contacto entre el gas y el aceite y se orienta a un segmento de la sociedad que busque un producto saludable y de propiedades organolépticas agradables. Con relación al mercado para este producto el consumo interno va en aumento gracias a una tendencia creciente a consumir productos de estas características, proyectando al 2021 una demanda potencial de 807 toneladas de este producto. Sin embargo, considerando la competencia en el sector al que se dirige este producto y su intención e intensidad de compra, estimamos que la demanda del proyecto para el 2017 será de 21.46 toneladas del producto y para el 2021, 53 toneladas. Respecto a la localización de la planta, la provincia más adecuada luego de realizar un ranking de factores es Arequipa. Esto se debe a que, junto con Tacna, su producción de aceitunas es la más alta del Perú y la cercanía a la materia prima es vital. Su mayor proximidad a Lima a comparación a Tacna es lo que la define como el lugar más adecuado. La planta se localizará en el distrito Arequipa. / Trabajo de investigación

Background: The differential effects of using topical oils for the prevention or treatment of baby dry skin on skin barrier function may contribute to the development of childhood atopic eczema. Prevalence of atopic eczema has increased from 5% of children aged 2 to 15 years in the 1940s, to approaching 30% more recently. This increase cannot be attributed to genetic changes. It is likely that increases stem from environmental factors, including the increased use of some inappropriately formulated commercial and natural baby skincare products. Midwives, health visitors and other maternity service health professionals, in the UK, routinely recommend the use of olive oil and sunflower oil for baby dry skin or massage, but the effect of these oils on newborn baby skin has not been studied. Aim: The aim of this research was to assess the feasibility and acceptability of testing the hypothesis that the regular application of sunflower oil, when compared to no oil or olive oil, had an effect on skin barrier function of newborn term babies. Study Design: A pilot, assessor-blinded, single centre, three-arm, randomised controlled trial, with nested qualitative component, underpinned by post-positivism. Methods: Quantitative methods were used to establish proof of concept that the use of topical oils had some effect on newborn baby skin barrier function, and to assess the feasibility of trial processes and parameters. Qualitative methods were used to explore the acceptability to parents of having a newborn baby participating in a randomised controlled trial, and trial design and procedures. The study was conducted in St. Mary’s hospital, a large teaching hospital in North West England. Data were collected between September 2013 and August 2014.The randomised controlled trial included 115 babies who were randomised to three groups: sunflower oil, olive oil and no oil, using a computer-generated varied size block randomisation with concealed allocation. Parents of babies randomised to the oil groups were blinded to which oil they were allocated. Data were collected using standardised case report forms for demographic and clinical observation data, weekly telephone questionnaires and a follow-up questionnaire, informed by previous baby skincare trials. The qualitative study encompassed semi-structured interviews, conducted within six months of birth. The sample was a subset of the trial participants, purposively sampled to incorporate a mix of treatment groups and positive and negative experiences derived from the follow-up questionnaire. Data also included two open-text questions from the follow-up questionnaire. Quantitative data were managed using IBM SPSS Statistics versions 20 and 22 and analysed descriptively. Qualitative data were managed in NVivo 10 and analysed using Framework Analysis. Results: The pilot study found that a definitive randomised controlled trial is not the optimal next step. A longitudinal observational study and further mechanistic work is recommended. Recruitment was challenging and loss to follow-up was higher than anticipated. Protocol adherence was reasonable and the study was acceptable to parents. Some statistically significant results were obtained, which must be interpreted with caution as the study was not powered to detect such a difference. These results showed that both oils may impede the development of the skin barrier function from birth; clinical importance of the results is not known. Conclusion: A longitudinal observational study is required, which maps the diagnosis of atopic eczema with environmental factors such as the use of baby skincare products from birth. Mechanistic work is also required to consider the optimal skincare formulation. As any intervention should do more good than harm, it would be wrong to support the recommendation of topical olive oil or sunflower oil for newborn baby dry skin or massage, based on the study data.

Orientador: Juliana Alves Macedo / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos / Made available in DSpace on 2018-08-27T12:01:55Z (GMT). No. of bitstreams: 1 Baroni_NaiaraAparecidaFranco_M.pdf: 1466937 bytes, checksum: 5a517dbdb43e197ac98d726b669f3c2d (MD5) Previous issue date: 2015 / Resumo: O azeite de oliva virgem extra é considerado um alimento funcional com importantes propriedades biológicas relacionadas à elevada concentração de ácido graxo monoinsaturado. Estudos recentes indicam que os componentes minoritários na composição do azeite têm sido muito associados com benefícios à saúde, muito além do conteúdo de ácido oleico, destacando-se os compostos fenólicos, principalmente hidroxitirosol e tirosol. A região na qual as oliveiras são cultivadas pode ter influência direta na composição do azeite, principalmente no que se refere aos compostos minoritários. O objetivo deste trabalho foi avaliar se o potencial antioxidante dos azeites de oliva produzidos no Brasil (ArbequinaRS, ArbequinaMG e Maria da Fé) se assemelha ao dos azeites europeus (ArbequinaMed e Gallo®) tradicionais no mercado brasileiro. O perfil de ácidos graxos mostrou que a amostra Maria da Fé assemelha-se à amostra referência Gallo®, apresentando as maiores concentrações de ácido oleico. O teor de tocoferóis foi maior nas amostras ArbequinaRS e Maria da Fé. Quanto à determinação de fenólicos totais, pelo método de Folin-Ciocalteu, destacaram-se a ArbequinaRS e ArbequinaMed. Esta também apresentou maior concentração de hidroxitirosol, enquanto que, a referência Gallo® apresentou maior teor de tirosol. A capacidade antioxidante foi avaliada por métodos de sequestro de radicais, ORAC e DPPH, este permitiu identificar diferença estatística entre as amostras testadas. Dentre as amostras de variedade Arbequina, destaca-se o azeite produzido na região Sul do Brasil, equiparando-se estatisticamente ao comercial de origem mediterrânea; foi observada uma correlação positiva entre conteúdo de fenólicos totais e a capacidade antioxidante pelo método de sequestro de radical DPPH. O método ORAC não mostrou diferença estatística significativa entre as amostras. A atividade biológica foi avaliada através da mensuração da atividade de enzimas endógenas, catalase e superóxido dismutase, do arsenal antioxidante de hepatócitos humanos. Após o ensaio MTT de viabilidade celular foram definidas duas concentrações de estudo para os testes enzimáticos: 0,5 e 2mg/mL. De forma geral, nos ensaios de ativação do sistema celular endógeno antioxidante de hepatócitos, dentre os azeites testados os de maior potencial biológico foram os brasileiros, com importante destaque para a variedade Arbequina produzida no Rio Grande do Sul, ArbequinaRS / Abstract: The extra virgin olive oil is considered a functional food with important biological properties related to the high concentration of monounsaturated fatty acid. Recent studies indicate that minor components in olive oil composition have been very associated with health benefits, far beyond the content of oleic acid, highlighting the phenolic compounds, especially hydroxytyrosol and tyrosol. The region where the olive trees are grown may have direct influence on oil composition, especially with regard to minority compounds. The objective of this study was to evaluate the antioxidant potential of olive oils produced in Brazil (ArbequinaRS, ArbequinaMG and Maria da Fé) is similar to European oil (ArbequinaMed and Gallo®) traditional in the Brazilian market. The fatty acid profile showed that the sample Maria da Fé resembles the reference sample Gallo®, with the highest concentrations of oleic acid. The tocopherols content was higher in ArbequinaRS and Maria da Fé samples. The determination of total phenolic by the Folin-Ciocalteu method, the highlights were the ArbequinaRS and ArbequinaMed. This also showed a higher concentration of hydroxytyrosol, while the Gallo® reference showed greater tyrosol content. The antioxidant capacity was evaluated by sequestration methods of radicals, ORAC and DPPH, this allowed us to identify significant differences between the samples tested. Among the samples of Arbequina variety, stand out from the oil produced in southern Brazil, equating statistically the trade of Mediterranean origin; was observed a positive correlation between total phenolic content and antioxidant activity by DPPH radical sequestration method. The ORAC method was not significantly different between the samples. The biological activity was evaluated by measuring the activity of endogenous enzymes of the antioxidant arsenal of human hepatocytes: superoxide dismutase and catalase. After the MTT assay cell viability was defined two concentrations to study enzyme tests 0,5 and 2 mg/mL. In general, the antioxidant endogenous cellular system hepatocyte activation assays, among the oils tested the highest biological potential were Brazilians, with major emphasis on the Arbequina variety produced in Rio Grande do Sul, ArbequinaRS / Mestrado / Nutrição Experimental e Aplicada à Tecnologia de Alimentos / Mestra em Alimentos e Nutrição

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Dès la fin du Ier s. ap. J.-C., la population de Rome avoisine le million d’habitants. À cette époque, Auguste planifie la conquête des contrées septentrionales. L’approvisionnement du peuple de l’Vrbs et des armées est une préoccupation de premier ordre et le ravitaillement en huile d’olive, produit indispensable au quotidien romain, devient un enjeu de taille. La province de Bétique réunit toutes les conditions nécessaires pour accueillir une production d’huile à grande échelle, grâce à son climat optimal et aux conditions d’exportation idéales que lui offrent ses cours d’eau navigables. C’est ainsi que l’huile produite dans le Bassin du Guadalquivir et transportée dans les amphores globulaires Dressel 20 alimentera tout l’Occident romain entre le Ier et le IIIe s. ap. J.-C. Si ce phénomène économique majeur est relativement bien appréhendé du point de vue des sites de consommation, la question de la production de l’huile et des amphores en Bétique a été longtemps délaissée.Les ateliers de potiers d’amphores à huile (Dressel 20 et Dressel 23), installés sur les berges du Guadalquivir et du Genil, sont indéniablement les meilleurs témoins de l’intensité de l’oléiculture dans la région, en raison de l’ampleur des vestiges occasionnés par cette industrie potière. En tant qu’activité subsidiaire de l’oléiculture spéculative, l’évolution de la fabrication d’amphores est donc le reflet fidèle de celle de ce secteur économique. Cette étude microrégionale, consacrée aux ateliers de la vallée du Genil, constitue une approche détournée pour parvenir à appréhender le développement de l’oléiculture à caractère spéculatif. Elle vise à analyser la dynamique économique des ateliers d’amphores à huile de ce territoire, à comprendre les interactions existantes entre la production industrielle d’huile, le développement de l’industrie potière et les conséquences de ces activités sur l’environnement.Cette thèse qui s’inscrit dans une perspective archéo-historique, repose à la fois sur un travail documentaire et sur une analyse globale des faits matériels mis en évidence lors d’enquêtes de terrain. Les campagnes de prospections conduites dans la zone étudiée et la fouille de l’atelier de potiers de Las Delicias ont permis un renouvellement considérable des connaissances grâce à la collecte de nombreuses données inédites. La caractérisation des ateliers qui découle du classement et de l’analyse de ces données a permis d’aborder un certain nombre de problématiques relatives à l’organisation du travail, aux procédés de fabrication et aux différentes activités connexes à la production des amphores à huile.De plus, la richesse épigraphique qui caractérise l’amphore Dressel 20, a permis de corréler les observations archéologiques d’ordre structurel et topographique avec les marques de fabrique à caractère onomastique et toponomastique. L’étude épigraphique poussée des estampilles des différents centres de production a ainsi permis de retracer l’histoire de chaque atelier, en identifiant les acteurs de la production, les stratégies et les modes de gestion mis en place par ces derniers.Cette approche multiscalaire, partant de l’analyse de chaque atelier, pour ensuite passer à la mise en corrélation des résultats obtenus à l’échelle de la vallée, et rejoindre enfin la sphère de l’oléiculture, a permis de mettre en regard l’histoire sociale avec l’histoire des techniques, et ainsi retracer tout un pan de l’histoire socio-économique de la Bétique romaine. / From the end of the 1st century BC, the population of Rome is close to one million inhabitants. At this time, Augustus plans the conquest of the northern regions. The supply of the people of the Vrbs and the armies is a prime concern and the refuelling of olive oil, essential product of the Roman daily, becomes a major challenge. The province of Betica combines all the conditions necessary to accommodate large-scale oil production, thanks to its optimal climate and the ideal export conditions offered by its navigable waterways. Thus the oil produced in the Guadalquivir Basin, transported in the Dressel 20 globular amphorae, will feed the entire Roman West between the 1st and the 3rd centuries. Although this major economic phenomenon is relatively well understood from the point of view of consumption sites, the question of the production of oil and amphorae in Betica has long been neglected.The oil amphorae potters' workshops (Dressel 20 and Dressel 23), located on the banks of the Guadalquivir and Genil, are undeniably the best witnesses to the intensity of olive growing in the region, due to the magnitude vestiges caused by this pottery industry. As a subsidiary activity of speculative olive growing, the evolution of amphora production is therefore a faithful reflection of this economic sector. This microregional study, devoted to the workshops of the Genil valley, is an indirect approach to apprehend the development of speculative olive growing. It aims to analyse the economic dynamics of oil amphorae workshops in this region, to understand the existing interactions between industrial oil production, the development of the pottery industry and the consequences of these activities on the environment.This thesis, which is part of an archaeo-historical perspective, is based at the same time on a documentary work and on a global analysis of the material facts highlighted during field investigations. The archaeological surveys conducted in the study area and the excavation of the Las Delicias potters' workshop have allowed a considerable renewal of knowledge thanks to the collection of many brand-new data. The characterization of the workshops resulting from the classification and analysis of these data made it possible to address a number of issues relating to the organization of work, the manufacturing processes and the various activities related to the production of oil amphorae.In addition, the epigraphic richness that characterizes the Dressel 20 amphora has made it possible to correlate archaeological observations of structural and topographical order with onomastic and toponomastic stamps. The in depth epigraphic study of the stamps of the different production centres thus made it possible to trace the history of each workshop, identifying the actors of the production, the strategies and the management methods put in place by the latter.This multiscalar approach, starting from the analysis of each workshop, then moving on to the correlation of the results obtained at the valley scale, and finally joining the sphere of olive growing, made it possible to confront the social history with the history of techniques, and thus trace a whole section of the socio-economic history of the Roman Betica.

L'huile d'olive est la principale source d’apports lipidique dans le régime méditerranéen. Elle est reconnue comme une source de nutriments et est à l’origine de plusieurs effets biologiques bénéfiques pour la santé. Plusieurs études montrent notamment que la consommation d'huile d'olive peut être efficace dans le traitement de maladies cardiovasculaires. Cependant, peu d'études mettent en évidence un effet antiinflammatoire, antiallergique et anti-Alzheimer de l’huile d’olive. De même, aucune étude n’a déterminé un lien entre ces effets et les variétés d’olives dont sont issues les huiles ainsi que les composés présents responsables de ces effets. Le but de ce travail est donc d'évaluer l'effet biologique, et plus particulièrement le potentiel antiinflammatoire et antiallergique des composés hydrophiles obtenus après extraction en phase solide (SPE-Diol), à partir de plusieurs variétés d’huiles d'olive extra vierge (EVOO) issues de trois années de récolte différentes. L'effet neuroprotecteur de la variété Picholine, contre la maladie d'Alzheimer a également été évalué. Les résultats montrent que l'effet anti-inflammatoire et l’effet anti-allergique varies de façon concentration dépendante et en fonction de la variété d’EVOO. De plus, nous avons mis en évidence que la variété de Picholine a un effet neuroprotecteur. L’ensemble de ce travail a établi une corrélation entre des activités anti-inflammatoire, anti-allergique et anti-Alzheimer des huiles d’olives issues de plusieurs variétés et les différents composés présents, ce qui a permis de mettre en avant la variété Picholine. / Olive oil is the primary source of fat in the Mediterranean diet. It is not only known as a distinctive source of nutrients but also as an origin of several biological effects that represent a very important factor for the health. Several studies demonstrate that olive oil consumption has to be effective against heart and cardiovascular diseases. Few studies show up the anti-inflammatory, the anti-allergic and the anti-Alzheimer effects of olive oil but there is no study about the cultivar effect and the interference that could occur between the different olive oil compounds. The aim of this work is to evaluate the biological effect and more particularly the potential anti-inflammatory and anti-allergic of hydrophilic components obtained by solid phase extraction (SPE-Diol) of different extra virgin olive oil (EVOO) cultivars and from three different harvest years. Moreover the neuroprotective effect of Picholine cultivar against Alzheimer’s disease was also studied. The results show that the anti-inflammatory and the anti-allergic activities differ depending on the EVOO cultivar and they are concentration-dependent. The results show also that Picholine cultivar has an anti-Alzheimer activity. All of these studies have established a correlation between the anti-inflammatory, the anti-allergic and the anti-Alzheimer effects of different EVOO cultivars and different compounds present, which enabled us to highlight the Picholine cultivar.

<p>Design of products permits to yield goods and services to produce satisfaction on customers, which is measured as value. However, it is at this stage in which most of the environmental impact, from a lifecycle perspective, is added to the product. Eco-design aims at increasing value of products while reducing the burdens on the environment by means conscious design towards efficient use of resources. That efficiency, referred to as eco-efficiency, can be increased in a number of manners within environmental engineering. Traditionally, different fields have tackled materials, energy flows and products from different angles or approaches. In this thesis we describe Functional Sales (FS) and Industrial Ecology (IE) as examples of these. Within this latter, we put emphasis on Industrial Symbiosis (IS) and Eco-effectiveness. We consider these approaches are suitable to work in the framework of eco-design to increase ecoefficiency. By adding services to material products, and managing material and energy flows with a more ecological consciousness, we expect to increase value of products while reducing the impact on the environment.</p><p>To analyse this potential improvement, we developed a method involving a new eco-efficiency index (VERI), that recursively intends to ease decisions on possible eco-efficient alternatives. This index and its method are applied to a case study on management of olive oil supply in region of Murcia, Spain. Here, we propose three scenarios that will involve the implementation of FS and IE to compare the outcomes in value and environmental performance against an idealised current supply chain. The results obtained, although not accurate, suggest that FS and EI should be more taken into account in eco-design and, this latter, to also consider holistic viewpoints to find more eco-efficient alternatives for a product development.</p>

Design of products permits to yield goods and services to produce satisfaction on customers, which is measured as value. However, it is at this stage in which most of the environmental impact, from a lifecycle perspective, is added to the product. Eco-design aims at increasing value of products while reducing the burdens on the environment by means conscious design towards efficient use of resources. That efficiency, referred to as eco-efficiency, can be increased in a number of manners within environmental engineering. Traditionally, different fields have tackled materials, energy flows and products from different angles or approaches. In this thesis we describe Functional Sales (FS) and Industrial Ecology (IE) as examples of these. Within this latter, we put emphasis on Industrial Symbiosis (IS) and Eco-effectiveness. We consider these approaches are suitable to work in the framework of eco-design to increase ecoefficiency. By adding services to material products, and managing material and energy flows with a more ecological consciousness, we expect to increase value of products while reducing the impact on the environment. To analyse this potential improvement, we developed a method involving a new eco-efficiency index (VERI), that recursively intends to ease decisions on possible eco-efficient alternatives. This index and its method are applied to a case study on management of olive oil supply in region of Murcia, Spain. Here, we propose three scenarios that will involve the implementation of FS and IE to compare the outcomes in value and environmental performance against an idealised current supply chain. The results obtained, although not accurate, suggest that FS and EI should be more taken into account in eco-design and, this latter, to also consider holistic viewpoints to find more eco-efficient alternatives for a product development.