This project is a Web portal. It is dedicated for better communication between students and teachers, achieve better studies quality. It will help students more efficiently choose and develop their graduation works. It will help students and lecturers to decrease time and affords to share common documents, information, participate in discussions. The main advantage of this portal is ability to use it at any time anywhere (with internet access) interactively.

Presented work describe about new public e-services implementation, they presentation in internet, e-services between companies and public office development. Government intention to establish conditions to implement e-government and new enterprise services creation at eenvironment. There are suggested implement enterprise information portal with e-services: new companies name registration, business license receiving, new companies registration and enterprise dissolution.

Web analysis is important task in web portals development. Web measurement can answer to many questions related to user activity. Web analytics is the study of whether the web site is meeting its diverse goals. Just as important, it is the presentation of the results to the various divisions of the company in a comprehensible format. The core of the web analytical system is built on traditional decision support technologies that are focused specifically on capturing, analyzing and reporting on web visitor data. In this work analyzed methods ant technologies required for web portal analysis system design. This paper compares possible data gathering sources and methods for reports creation. There is offered conceptual design of analysis system using hybrid data collection sources. System realization is used in KTU Computer Cathedral activity.

The aim of this study was to determine growth responses and apparent total tract nutrient digestibility in growing pigs fed diets containing graded levels of distillers dried grains with solubles (DDGS) and to determine the effect of a multicarbohydrase enzyme (MC) supplementation on visceral organ mass and fasting whole-body oxygen consumption (FWBOC). In Experiment 1, 48 pigs (25.5 ± 0.14 kg BW) were assigned on the basis of sex and BW (2 pigs per pen) to 4 diets (6 pens per diet) based on corn-barley-soybean meal with 0, 10, 20 and 30% DDGS in a 42-d trial. Apparent total tract digestibilities (ATTD) of energy and other nutrients were determined using acid insoluble ash (AIA) as the indigestible marker. Inclusion of DDGS in the diets decreased (linear, P < 0.05) average daily gain (ADG) and tended to decrease gain to feed ratio (G:F) (linear, P = 0.067) but not average daily feed intake (ADFI) (P > 0.10); however, pigs fed the 20% DDGS diet had similar ADG as pigs fed the 0% DDGS diet. Increasing DDGS content in the diet linearly decreased (P < 0.01) the ATTD of DM, energy and CP (cubic, P < 0.05) but not (P > 0.10) P and Ca; however, ATTD of neutral detergent fiber (NDF) increased (linear, P < 0.01) when DDGS was included in the diet. In Experiment 2, 24 pigs (19.9 ± 0.46 kg BW) were randomly assigned to 3 corn-soybean meal-basal diets (8 pigs per diet): Control (C, 0% DDGS); basal diet with 30% DDGS (C+30% DDGS) or C+30% DDGS supplemented with MC (C+30% DDGS+MC). On d 15, WBOC during the 24- to 30-h postprandial period was determined using an open-circuit indirect calorimeter on 4 pigs per diet. On d 28, pigs were killed to determine visceral organ mass and intestinal morphology. There was no diet effect (P > 0.10) on final BW, FWBOC, and liver, spleen, pancreas, heart, stomach and caecum weights relative to empty BW. However, pigs fed the C and C+30% DDGS+MC had heavier (P = 0.05) empty BW compared with those fed unsupplemented 30% DDGS-containing diet. Small intestine, colon plus rectum and the portal-drained viscera (PDV) were heavier (P < 0.05) in DDGS-fed pigs compared with C; supplementing with MC substantially decreased the effect of DDGS on the weight of these visceral organs. Feeding pigs DDGS tended to decrease (P < 0.10) villous height (VH) and VH:CD in the ileum. Results show that including DDGS in grower pig diets up to 20% has no effect on performance although ATTD of energy, DM, and N may be reduced. Inclusion of DDGS at 30% increased PDV mass and reduced dressing percentage but these effects were overcome by a multicarbohydrase enzyme supplementation.

The research area of this master work is problems of information processing in County State Tax Inspectorate and their resolution approaches. The aim of this work is to find the best approach, to create appropriate software to resolve theses problems and to fulfill user’s needs. The main problems of information processing were determined during County State Tax Inspectorate business analysis: • usable legacy information systems imperfect integration and functionality; • some information not computerized processing. After analyzing many approaches three tiers client-server software architecture, internet technologies and relational databases integration was chosen for new information system implementation. Internet browser is used for user interface on client side. All business logic was placed in middle tier. Server side scripts are used for interaction with system new database and legacy database which is working in Oracle DBMS environment. Microsoft ASP technology is used for server-side scripting. Legacy database reverse engineering was accomplished for this database documentation. County State Tax Inspectorate intranet portal users can do data operative registration and processing, quick report formation. The modern CASE tool Rational Rose 2002 Enterprise Edition was used from business analysis to new information system project creation that will help for system maintenance and future development.

The main purpose of this work is to create information system which would deliver relevant information about flights from airports website to mobile phone. The most important task here is to collect data from Vilnius airport website, organize and put it into our database then deliver it to interested individuals.

The aim of this study was to determine growth responses and apparent total tract nutrient digestibility in growing pigs fed diets containing graded levels of distillers dried grains with solubles (DDGS) and to determine the effect of a multicarbohydrase enzyme (MC) supplementation on visceral organ mass and fasting whole-body oxygen consumption (FWBOC). In Experiment 1, 48 pigs (25.5 ± 0.14 kg BW) were assigned on the basis of sex and BW (2 pigs per pen) to 4 diets (6 pens per diet) based on corn-barley-soybean meal with 0, 10, 20 and 30% DDGS in a 42-d trial. Apparent total tract digestibilities (ATTD) of energy and other nutrients were determined using acid insoluble ash (AIA) as the indigestible marker. Inclusion of DDGS in the diets decreased (linear, P < 0.05) average daily gain (ADG) and tended to decrease gain to feed ratio (G:F) (linear, P = 0.067) but not average daily feed intake (ADFI) (P > 0.10); however, pigs fed the 20% DDGS diet had similar ADG as pigs fed the 0% DDGS diet. Increasing DDGS content in the diet linearly decreased (P < 0.01) the ATTD of DM, energy and CP (cubic, P < 0.05) but not (P > 0.10) P and Ca; however, ATTD of neutral detergent fiber (NDF) increased (linear, P < 0.01) when DDGS was included in the diet. In Experiment 2, 24 pigs (19.9 ± 0.46 kg BW) were randomly assigned to 3 corn-soybean meal-basal diets (8 pigs per diet): Control (C, 0% DDGS); basal diet with 30% DDGS (C+30% DDGS) or C+30% DDGS supplemented with MC (C+30% DDGS+MC). On d 15, WBOC during the 24- to 30-h postprandial period was determined using an open-circuit indirect calorimeter on 4 pigs per diet. On d 28, pigs were killed to determine visceral organ mass and intestinal morphology. There was no diet effect (P > 0.10) on final BW, FWBOC, and liver, spleen, pancreas, heart, stomach and caecum weights relative to empty BW. However, pigs fed the C and C+30% DDGS+MC had heavier (P = 0.05) empty BW compared with those fed unsupplemented 30% DDGS-containing diet. Small intestine, colon plus rectum and the portal-drained viscera (PDV) were heavier (P < 0.05) in DDGS-fed pigs compared with C; supplementing with MC substantially decreased the effect of DDGS on the weight of these visceral organs. Feeding pigs DDGS tended to decrease (P < 0.10) villous height (VH) and VH:CD in the ileum. Results show that including DDGS in grower pig diets up to 20% has no effect on performance although ATTD of energy, DM, and N may be reduced. Inclusion of DDGS at 30% increased PDV mass and reduced dressing percentage but these effects were overcome by a multicarbohydrase enzyme supplementation.

En los países occidentales, la gran mayoría de los pacientes con hipertensión portal están afectos de una cirrosis hepática, de etiología alcohólica o vírica; en España la cirrosis hepática constituye la octava causa de muerte en varones y la decimotercera en mujeres. Sentado este hecho, cabe remarcar que el síndrome de hipertensión portal puede aparecer durante el curso clínico de muchas otras enfermedades; de entre ellas, merece destacarse el síndrome de Budd-Chiari (SBC), un proceso plurietiológico, que afecta a pacientes sin hepatopatía previa y que está gravado con una alta morbimortalidad. En los últimos años se han producido notables avances en el diagnóstico y en el tratamiento del síndrome de hipertensión portal, que van a aumentar la supervivencia y la calidad de vida de los pacientes. En el ámbito del diagnóstico merece destacarse la implementación de las técnicas hemodinámicas que, mediante la cateterización de las venas suprahepáticas permiten evaluar el gradiente de presión portal (GPP). Estas técnicas se utiliza cada vez con mayor frecuencia en el manejo clínico del paciente afecto de una hepatopatía inductora de hipertensión portal. Está establecido que estos procedimientos proporcionan una información única en cuanto al grado de hipertensión portal y de la respuesta a tratamiento farmacológico. En el ámbito de la terapéutica, el advenimiento de la derivación portosistémica percutánea intrahepática (DPPI o TIPS) ha marcado un hito. Esta técnica ha desplazado la cirugía derivativa en muchos casos. Objetivos:Parece demostrado que en la hepatopatía alcohólica, el gradiente de presión en las venas suprahepáticas (GPVH) medida mediante cateterismo de las venas suprahepáticas equivale al GPP medido obtenido por punción directa de la vena porta. En los pacientes afectos de hepatopatía crónica por VHC, se desconoce si pueden considerarse equivalentes estas dos medidas. Por otra parte, no se conoce si los cambios observados en el GPVH durante el tratamiento con propranolol reflejan adecuadamente los cambios en la presión venosa portal. Por tanto el primer objetivo fue analizar la concordancia entre el valor de la presión portal medida directamente mediante punción y la presión suprahepática enclavada (PSE), obtenida por cateterismo de venas suprahepáticas; en tres grupos de pacientes: pacientes con hepatopatía crónica por VHC, pacientes con hepatopatía alcohólica y pacientes con ambas causas de hepatopatía. El segundo objetivo fue analizar, en un subgrupo de pacientes con hipertensión portal sinusoidal, la concordancia entre los cambios del GPP y el GPVH durante el tratamiento agudo con propranolol.En un segundo estudio, en el ámbito terapéutico de las técnicas hemodinámicas los objetivos fueron: analizar los resultados, a largo plazo, del los pacientes afectos de SBC tratados con DPPI como primera alternativa terapéutica derivativa; analizar los resultados, a largo plazo, de los pacientes afectos de SBC que no han precisado tratamiento derivativo; establecer cuál es la prevalencia de SBC idiopático, si se aplican los nuevos conceptos diagnósticos en el ámbito de la patología trombofílica, tanto en las enfermedades mieloproliferativas como en los trastornos de coagulación.Conclusiones: 1. En pacientes con hepatopatía crónica por VHC la medición del GPVH es equivalente a la medición del GPP ya que la PSE refleja adecuadamente la presión portal. En esta patología se puede, pues, utilizar el GPVH como equivalente de la presión portal de la misma forma que se realiza en la cirrosis de origen enólico. 2. En cambio, con independencia de la etiología de la hepatopatía crónica, cuando la perfusión portal se encuentra comprometida por la presencia de flujo hepatofugal o de una trombosis, existe una elevada probabilidad de que el GPVH sobreestime el GPP real. 3. Los cambios de la hemodinámica esplácnica en respuesta a la administración de propranolol son evaluables mediante el cateterismo de venas suprahepáticas, ya que existe una buena concordancia entre la modificación del GPP y la del GPVH. 4. Parte de los pacientes con SBC, con índices clínico-analíticos correspondientes a formas leves de SBC, pueden manejarse de forma satisfactoria sólo con tratamiento médico y anticoagulación.5. Un elevado índice de sospecha, incluyendo exámenes ultrasonográficos detallados, permiten efectuar un cateterismo diagnóstico en fases precoces de la enfermedad, antes de que sea necesario el tratamiento derivativo. 6. En los pacientes con SBC más avanzado, que no responden al tratamiento médico, la DPPI constituye un tratamiento seguro y eficaz; ya que la supervivencia que se alcanza es similar a la que presentan los pacientes con formas leves de Budd-Chiari que no requieren tratamiento derivativo, y en un seguimiento a largo plazo la mayoría de pacientes no requieren ningún otro tratamiento invasivo. 7. Con la aplicación de protocolos diagnósticos encaminados a demostrar la existencia de una hemopatía o de un trastorno de la coagulación, puede establecerse un diagnóstico etiológico del SBC en la gran mayoría de los casos. En nuestro medio las causas más frecuentes de SBC son los síndromes mieloproliferativos, la hemoglobinuria paroxística nocturna y el síndrome antifosfolípido primario. En la serie que se ha presentado un 10 % de los casos tenían más de una enfermedad que podía ocasionar un síndrome de hipercoagulabilidad. El conocimiento de la enfermedad de base posibilitará la instauración de un tratamiento más individualizado. / Nowadays the hemodinamic techniques for the study of liver diseases are of great applicability. This work is structured in two studies: one in the diagnostic field and the second one in the therapeutic field. FIRST STUDY: Measurements of portal venous pressure (PVP) are increasingly used in the evaluation of patients with chronic liver diseases since they provide useful prognostic information regarding the risk of variceal bleeding, the outcome of patients with acute variceal hemorrhage and long-term survival. Wedged hepatic venous pressure (WHVP) is equivalent to portal venous pressure (PVP) in patients with alcoholic liver diseases. However, it may underestimate PVP in non-alcoholics, which is important since hepatitis C virus infection is a frequent cause of chronic liver disease. Aim: To investigate the agreement between directly measured portal pressure and WHVP in alcoholic and HCV-related liver diseases. Methods: Seventy-one patients with liver disease due to either HCV-infection (n=32), alcohol (n=25), or both (n=14) underwent simultaneous measurements of WHVP (hepatic vein catheterization) and PVP (direct puncture). In 9 patients, measurements were repeated 20 min after propranolol administration. Results: WHVP showed an excellent agreement with PVP in patients with cirrhosis due to either HCV, alcohol or both (intraclass correlation coefficient: 0.94, 0.93 and 0.97, respectively; p<0.001). A discrepancy ³5 mmHg was observed in 7 cases: WHVP underestimated PVP in one case and overestimated PVP in six. The WHVP response to propranolol closely correlated with changes in PVP (intraclass correlation coefficient: 0.87, p<0.004). CONCLUSIONS: The simple and safe measurement of WHVP accurately reflects PVP in alcoholic and HCV-related liver disease. This technique allows to accurately assess the portal pressure response to propranolol in alcoholic and HCV-related cirrhosis. SECOND STUDY: BACKGROUND/AIMS: Patients with Budd-Chiari syndrome (BCS) may require treatment with portal decompressive surgery or liver transplantation. Transjugular intrahepatic portosystemic shunt (TIPS) represents a new treatment alternative, but its long-term effect on BCS outcome has not been evaluated. METHODS / RESULTS: 21 patients with BCS consecutively admitted to our unit were evaluated. The mean follow-up was 4 ± 3 years. Seven patients had non-progressive forms and were successfully controlled with medical therapy; one case, with a short length hepatic vein stenosis was successfully treated by angioplasty. All 8 patients are alive and asymptomatic. The remaining 13 patients, had a TIPS because of clinical deterioration followed by an improvement in clinical condition. However, a patient with fulminant liver failure before TIPS insertion, died 4 months later and another patient with liver cirrhosis at diagnosis had liver transplantation two years later. The remaining 11 patients are alive and free of ascites. In 3 of these patients TIPS is patent after 3, 6 and 12 months. The remaining 8 patients developed late TIPS dysfunction. Two of these cases, after angioplasty and re-stenting, TIPS is patent after a follow-up of 9 and 80 months. In 5 other patients, recurring TIPS occlusion was not further corrected because no signs of portal hypertension were present. CONCLUSION. In patients with BCS uncontrolled with medical therapy, TIPS is a highly effective technique that is associated with long-term survival.

Zugl.: Kassel, Univ., Diss., 2005

Hildesheim, Universiẗat, Diss., 2007.