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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
41

The Perry Street Edge: Developing A New Pedestrian Portal To Virginia Tech

West, Aaron William 19 June 2009 (has links)
At the crossing of a strong architectural edge and an axis line, it is necessary to articulate the intersection and acknowledge the moment. But what if, at the point of this intersection, other contextual factors work against the articulation? What if there is an opportunity to not only mark the intersection, but in doing so strengthen the edge condition, elevate the importance of the axis line and provide a celebrated threshold experience? This project looks at this very condition as it exists within the context of the Virginia Tech campus in Blacksburg, Virginia. At the intersection of the axis of symmetry for the campus and the building edge along Perry Street, there is no acknowledgment of this crossing. In fact, in its present condition, the intersection is beset by a breakdown in the edge condition and only a trace of the powerful axis line. In addressing the challenges that plague this existing condition, this project will seek to achieve four things with respect to the Virginia Tech campus, at large: 1. Articulate the termination point of the axis of symmetry for the campus by strengthening the pedestrian path that runs along the axis providing a clearly defined route to the Drill Field. 2. A redefinition of the edge along Perry Street, repairing the breech in the building wall and connecting the components that make up the edge. 3. Strengthen intersection of the edge and the axis/path line by developing a new pedestrian portal into the heart of campus thereby providing a formal entry point along an edge that currently does not articulate the entry points into campus. 4. Develop the architectural context within the site, bridging the divide between the architectural traditions of the campus core with the modernist vernacular of the Perry Street Edge. / Master of Architecture
42

Portale und Ontologien

Zimmermann, Kerstin 24 June 2005 (has links) (PDF)
Kerstin Zimmermann, DERI Innsbruck, stellte herkömmliche Portale vor sowie sog. „Ontologien“. Diese erwachsen aus den elementaren Fragen nach „What“ (topic), „Who“ (person), „When“ (time/event), „Where“ (location) und „How“ (meta). Entscheidend bei den Ontologien: Zur Erstellung ist einiger Aufwand notwendig, der aber sich in Mehrwert auszahlt. Mehr dazu unter http://sw-portal.deri.org/ontologies/swportal.html
43

Portale und Ontologien

Zimmermann, Kerstin 21 August 2007 (has links) (PDF)
Das Original-Dokument wurde in das Format pdf umgewandelt. Kerstin Zimmermann, DERI Innsbruck, stellte herkömmliche Portale vor sowie sog. „Ontologien“. Diese erwachsen aus den elementaren Fragen nach „What“ (topic), „Who“ (person), „When“ (time/event), „Where“ (location) und „How“ (meta). Entscheidend bei den Ontologien: Zur Erstellung ist einiger Aufwand notwendig, der aber sich in Mehrwert auszahlt. Mehr dazu unter http://sw-portal.deri.org/ontologies/swportal.html
44

Papel del factor de transcripción Kruppel-like factor 2 en la disfunción endotelial hepática asociada a la hipertensión portal y al daño por isquemia y reperfusión

Russo, Lucia 19 December 2011 (has links)
El endotelio disfuncional presenta, entre otras caracteristicas, alteración en los mecanismos de vasodilatación, complicaciones trombóticas, disminución de la resistencia al estrés oxidativo, aumento de la expresión de moléculas de adhesión y de la secreción de moléculas proinflamatorias. El factor de transcripción endotelial KLF2 juega un importante papel en la regulación del fenotipo protector endotelial y su expresión depende de las fuerza hemodinámicas generadas por el flujo sanguíneo y de la administración exógena de estatinas. La hipertensión portal y el daño hepático por I/R son dos condiciones patológicas asociadas a disfunción endotelial. Los trastornos estructurales característicos de la cirrosis hepática, la mayor causa prevalente de hipertensión portal en nuestro entorno, se acompañan de variaciones en las fuerzas hemodinámicas que pueden modificar la expresión de KLF2 y su programa transcripcional vasoprotector. Asímismo, durante la isquemia asociada a la preservación de injertos hepáticos para transplante, la interrupción de las fuerzas hemodinámicas generadas por el flujo sanguíneo podría resultar en la reducción de los programas endoteliales vasoprotectores, que se debería en parte a la pérdida de expresión de KLF2. Los trabajos de investigación de la presente tesis doctoral amplian el conocimiento de los mecanismos moleculares responsables de la disfunción endotelial hepática, demostrando: 1. Que KLF2 está muy expresado en los hígados cirróticos y que su expresión se induce en las fases tempranas de la progresión de la enfermedad, representando un mecanismo compensador para mejorar los desórdenes vasculares característicos de los hígados cirróticos. 2. Que los hígados preservados en condiciones de transplante muestran un descenso tiempo-dependiente de KLF2, acompañado de daño hepático y aumentada resistencia vascular. Además, demostran que la modulación farmacologica de la expresión de KLF2 puede ser beneficiosa tanto en el tratamiento de la hipertensión portal como en la preservación de los injertos hepáticos para transplante.
45

The effect of enhancing portal venous inflow on hepatic haemodynamics and function

Jiao, Long Richard January 2001 (has links)
No description available.
46

Plan de Negocio para un Portal de Selección de Subcontratistas para el Rubro de la Construcción

García Paskvan, Claudia Patricia January 2007 (has links)
Memoria para optar al título de Ingeniera Civil Industrial / La entrada en vigencia de la ley de subcontrataciones, en la cual se le entrega mayor responsabilidad al contratista sobre el subcontratado acrecentó la necesidad de contar con un medio en el cual se pueda hacer una rápida y objetiva selección de subcontratistas. A su vez existen necesidades específicas dentro del mercado, tales como contar con evaluaciones de desempeño de subcontratistas o tener oportunidad de competir con igualdad de condiciones y diferenciarse de sus competidores, que tampoco nadie ha sabido cómo satisfacer. El presente informe detalla un plan de negocio en el cual gran parte de estas necesidades se podrán satisfacer. Un negocio que cuenta con el apoyo de una empresa emergente que ofrece servicios de digitalización de documentos y que le permitirá tener ventajas competitivas claves. Para el desarrollo del plan de negocio se realizó una investigación de mercado que permitió identificar con mayor claridad todas las necesidades que tienen los principales actores en el sector de la construcción, los contratistas y subcontratistas. También se diseñó una encuesta que entregó datos de primera fuente sobre la intención de participar en un negocio como éste y la disposición de las partes a entregar información. Esta información permitirá tener metas atractivas del punto de vista económico y permitirá desarrollar un procedimiento pionero para lo que es actualización de información, características. Lo anterior determina que el producto final será la entrega de una ficha personalizada referente a cada subcontratista, en la que se entregan datos objetivos y una evaluación de su desempeño que permitirá al contratista hacer una rápida selección de ellos. Los usuarios tendrán acceso a esta ficha, que se actualizará permanentemente, a través de un instrumento electrónico como lo es un portal web. Este procedimiento permite a su vez que cada subcontratista tenga un medio a través del cual podrá dar a conocer sus cualidades y potencialidades a sus futuros demandantes. Esta propuesta tecnológica, respaldada por una política de precios y una profundización en la investigación de los temas operacionales internos, permiten obtener alentadores resultados económicos y financieros, los cuales bajo cualquier escenario de evaluación generan tasas internas de retorno atractivas.
47

Caracterização farmacologica dos receptores de endotelina na circulação portal de figado isolado de cão

Stella, Heryck Jose 24 November 1997 (has links)
Orientador: Gilberto de Nucci / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-07-23T06:38:03Z (GMT). No. of bitstreams: 1 Stella_HeryckJose_M.pdf: 3166466 bytes, checksum: 82c9dc79250bed0f2b40a6de27f31a67 (MD5) Previous issue date: 1997 / Resumo: Endotelinas constituem família de mediadores vasoativos, capazes de produzir respostas pressoras potentes e de longa duração em vários territórios vasculares. Por exemplo a endotelina-1 participa no controle da resistência ao fluxo sangüíneo portal, principalmente na presença de cirrose hepática e hipertensão portal. Entretanto, os receptores envolvidos nesse fenômeno não são completamente conhecidos. O objetivo do presente estudo foi caracterizar a população de receptores de endotelina na circulação portal de fígado canino. Respostas vasculares portais à administração de endotelina-1 (agonista misto de receptores ETA/ETB), IRL 1620 (agonista seletivo ETB) e noradrenalina foram avaliadas utilizando preparação de perfusão hepática in vitro. Estas respostas foram investigadas na presença/ausência de antagonistas seletivos de ETA (FR 139317) e ETB (BQ-788). O papel do óxido nítrico e prostaglandinas nesse fenômeno foi avaliado através do uso de inibidores da óxido nítrico sintase e ciclooxigenase (L-NAME e indometacina respectivamente). Administração intraportal de endotelina-1 e IRL1620 resultou em aumento dependente da dose na resistência do fluxo portal, efeito atenuado pelo tratamento com FR 139317 e BQ-788, respectivamente. Inibição da síntese de óxido nítrico e prostaglandinas potencializou a resposta vascular portal induzida pela endotelina-1, sem afetar as respostas ao IRL 1620. Os resultados sugerem a existência de uma população mista de receptores de endotelina na circulação portal de fígado canino. O aumento na resistência ao fluxo portal induzido pela administração de endotelina-1 é mediado por receptores ETA e ETB, sendo o efeito mediado pelos receptores ETA modulado por óxido nítrico e prostaglandinas. A ativação de receptores ETB pode ter papel importante no controle da resistência ao fluxo sangüíneo portal na presença de cirrose hepática e hipertensão portal, condição associada a elevados níveis circulantes de endotelina-1 e de endotelina-3 / Abstract: Endothelins constitute a family of vasoactive mediators, capable of producing potent and long-lasting pressor responses in several vascular territories. Endothelin-1 has been implicated in the regulation of resistance to portal blood flow, particularly in the presence of cirrhosis and portal hypertension. However, the receptor subtypes mediating this phenomenon have not been clearly elucidated. In this study we attempted to characterize the endothelin receptor population in the portal circulation. Portal vascular responses to endothelin-1 (ETA/ETB agonist), IRL 1620 (ETB agonist) and noradrenaline were investigated using the isolated, perfused canine liver. The effects of a selective ETA receptor antagonist, FR 139317, and the selective ETB receptor antagonist, BQ -788, on portal vascular responses to the agonists were investigated, in addition, the modulation of these responses by prostaglandins and nitric oxide were also assessed. Endothelin-1 and IRL 1620 produced a dose-dependent increase in portal inflow resistance. This effect was significantly attenuated by treatment with FR 139317 and BQ-788. Blockade of prostaglandin and nitric oxide synthesis with indomethacin and L-NAME, respectively, potentiated the endothelin-1-, but not IRL 1620-induced portal vascular responses. We conclude that there is a mixed population of endothelin receptors in the portal circulation of the canine liver. Endothelin-1-induced portal vasoconstriction is mediated by ETA and ETB receptors. The effects induced via ETA receptors is modulated by prostaglandins and nitric oxide. ETB receptor activation might play an important role in resistance to portal blood flow in disease states such as portal hypertension, a condition associated with increased circulating levels of endothelin-1 and endothelin-3 / Mestrado / Mestre em Ciências Médicas
48

The role of endoscopic ultrasonography in the management of portal hypertension and vericeal hemorrage. / CUHK electronic theses & dissertations collection

January 2001 (has links)
by Yuk-Tong Lee. / "September 2001." / Thesis (M.D.)--Chinese University of Hong Kong, 2001. / Includes bibliographical references (p. 255-288). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web.
49

Relaxin as a therapeutic haemodynamic modulator in liver disease

Snowdon, Victoria Katherine January 2016 (has links)
Introduction: Hepatorenal syndrome (HRS) is a common complication of advanced cirrhosis with a high mortality rate and limited treatment options. Central to its pathogenesis is severe, but potentially reversible, renal vasoconstriction leading to functional renal failure. Current pharmacological treatment using splanchnic vasoconstrictors is suboptimal and prognosis without liver transplantation is dismal. The peptide hormone relaxin (RLN) mediates haemodynamic adaptations to pregnancy including increased renal blood flow (RBF) and glomerular filtration rate (GFR). I hypothesised that exogenous RLN could be used therapeutically to improve RBF and renal function in the context of experimental cirrhosis and HRS. Methods: To address this I generated pathologically distinct rat models of liver cirrhosis with features of human HRS including renal vasoconstriction and renal failure. Compensated cirrhosis was induced in male rats by 16 weeks of i.p. carbon tetrachloride (CCl4) and decompensated cirrhosis by bile duct ligation (BDL). I studied the effects of acute i.v. or sustained (72 hr) s.c. infusion of RLN compared with vehicle on systemic haemodynamics, RBF, GFR and kidney histology. I used blood oxygen dependent-magnetic resonance imaging (BOLD-MRI) to detect changes in kidney parenchymal oxygenation and Doppler ultrasound to monitor changes in RBF (velocity time integral, VTI) and renal arterial resistance (resistive index, RI). Hepatic and renal expression of the relaxin receptor RXFP1 was determined by quantitative polymerase chain reaction (qPCR) and immunohistochemistry (IHC). Vascular functional responses in isolated renal arteries were assessed by wire myography. Relaxin mediated changes in key vaso-regulatory signalling pathways in the kidney and renal vessels were analysed by qPCR, IHC and ELISA. Results: I showed using in vitro myography that the pathophysiological mechanism that underlies renal vasoconstriction in experimental cirrhosis models is an impairment of endothelium-dependent vasodilatation. Selective targeting of renal vasoconstriction using relaxin improved renal blood flow, tissue oxygenation, and normalized glomerular filtration rate in both compensated and decompensated rat cirrhosis. Furthermore, relaxin treatment restored endothelium-dependent vasodilation in isolated renal vessels from CCl4 cirrhotic rats. Relaxin-induced effects on renal blood flow and glomerular filtration rate were mediated though activation of the AKT/eNOS/nitric oxide signalling pathway in kidney, though systemic nitric oxide levels were unaffected. Crucially for human translation, relaxin did not reduce mean arterial blood pressure even in advanced cirrhosis. Conclusion: My findings identify relaxin as the first potential targeted treatment reversing the vascular dysfunction which causes HRS and directly improving renal function in HRS. Clinical translation in carefully selected populations is warranted.
50

A web 2.0 na dinamização de um portal educativo

Guimarães, Helena Bárbara Araújo January 2009 (has links)
Tese de mestrado. Tecnologia Multimédia. Faculdade de Engenharia. Universidade do Porto. 2009

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