No description available.

This thesis studies certain aspects of the global properties, including geometric and arithmetic, of the moduli spaces of complex structures of some special Calabi-Yau threefolds (B-model), and of the corresponding topological string partition functions defined from them which are closely related to the generating functions of Gromov-Witten invariants of their mirror Calabi-Yau threefolds (A-model) by the mirror symmetry conjecture. / Mathematics

This dissertation examines the roles of popular sports baseball and Gaelic Games in Taiwanese and Irish society respectively between the years 1884 and 1968. During this period, the spread of each sport in popularity and the subsequent increased profile in the public realm highlighted similar challenges faced by the societies of each territory as inhabitants of minor players in a global political system dominated by major powers. The development of Taiwanese baseball and its spread in popularity during the colonial period reveals the extent to which divisions between colonial Japanese and local Taiwanese blurred beyond the parameters of governmental efforts at coexistence and assimilation. Two teams in particular, the Nenggao team of 1924-25 and the KANO team of 1931, give evidence of a colonial Taiwanese sporting culture that featured strengthening connections with sporting culture in Japan. In both cases, baseball displayed potential as an integrating force in colonial Taiwanese society between social groups resident on the island rather than as a source for opposition to colonial rule. This is in direct contrast to Irish society, where the resurgence in popularity of Gaelic Games occurred within the political context of exclusivist nationalism. Gaelic Games existed as cultural markers of an Irish culture defined by a Gaelic ethnic identity and political commitment to an Irish nation state, choosing to ignore the realities of partition and the existence of a sizable Loyalist community in the north of the country. This viewpoint persisted until the late 1960s, when the eruption of paramilitary violence in Northern Ireland irrevocably changed the terms of Irish political participation. At the same time, Taiwanese baseball transitioned from a shared cultural form between Taiwan and Japan to a potent avenue for emerging Taiwanese political voices in 1968 with the widely celebrated success of the Hongye schoolboy baseball team. Baseball’s popularity had persisted in the face of ambivalent attitudes among ruling Guomindang officials following retrocession, but the Hongye victory marked the introduction of specific political overtones to Taiwanese baseball, bringing an end to decades of the sport’s primary role as an act of public participation with limited political connotations. / text

Percutaneous delivery of drugs promises many advantages over oral or intravenous administration, such as a better control of blood levels, a reduced incidence of systemic toxicity, an absence of hepatic first-pass metabolism, better patient compliance, etc. However, the dermal drug transport is limited by the unsuitable physicochemical properties of most drugs and the efficient barrier function of the skin. Thus, numerous attempts have been reported to improve topical absorption of drugs, concentrating mainly on the barrier function of the stratum corneum by use of penetration enhancers and/or skin warming. An alternative and interesting possibility for improved dermal permeability is the synthesis of derivatives or analogues with the aim of changing the physicochemical properties in favour of skin permeation, efficacy and therapeutic value. Cyclizine (I) is an anti-emetic drug primarily indicated for the prophylaxis and treatment of nausea and vomiting associated with motion sickness, post operation and Meniere's disease. It acts both on the emetic trigger zone and by damping the labyrinthine sensitivity. Pharmacologically it has anti-histaminic, antiserotonergic, local anaesthetic and vagolytic actions. It is widely used and also suitable for children from six year of age. Percutaneous absorption of (I) can, among others, avoid the "first-pass" effect and the discomfort of injection. The main objective of this study was to explore the feasibility of percutaneous absorption of (I) and its alkyl analogues via physicochemical characterization and assessment of their permeation parameters. The intent was also to establish a correlation between the physicochemical properties of these compounds and their percutaneous rate of absorption. To achieve these objectives, the study was undertaken by synthesizing the alkyl analogues and determining the physicochemical parameters relevant to skin transport. Identification and level of purity for the prepared analogues were confirmed by mass spectrometry (MS), nuclear magnetic resonance (NMR) spectrometry and infrared (IR) spectrometry. Experimental aqueous solubility (25 °c & 32 °C) and partition coefficient for each compound were determined. In vitro permeation studies were performed at pH 7.4, using Franz diffusion cells with human epidermal membranes. Diffusion experiments were conducted over a period of 24 hours maintaining a constant temperature (37 DC) by means of water bath. All samples were analysed by high pressure liquid chromatography (HPLC). Cyclizine (I) has a methyl group at N-4. Increasing the alkyl chain length on N-4 of the piperazine ring resulted' in compounds with lower melting points and higher water solubility than (I). (II) exhibited 3-fold increase in water solubility, followed by (IV) with about 2.5 fold increase. The water solubility of (III) was almost the same as that of (I). Log partition coefficients increased linearly with increasing alkyl chain length. The analogues therefore, possessed more favourable physicochemical properties to be delivered percutaneously. Indeed, the in vitro skin permeation data proved that these analogues could be delivered more easily than (I) itself. The flux of (I) was 0.132 ug/cm2/h in a saturated aqueous solution. Compound (II) resulted in a 53-fold (6.952 ug/cm2/h) increase in permeation compared to (I). (III) and (IV) resulted in a 2- and 5fold enhancement of permeation respectively. Based on the results of the study, it seems that increased aqueous solubility and low level of crystallinity play a vital role in optimizing percutaneous absorption of (I) and its alkyl analogues. But the importance of the effect of increased lipophilicity cannot be ignored. The low percutaneous• absorption of (I) might be attributed to its low aqueous solubility and increased crystallinity, as is evident from the higher melting point than the analogues. From all the permeability data using aqueous solutions, it is clear that compound (II) is the best permeant of this series and in addition it is known that this compound antagonizes the effects of histamine. / Thesis (M.Sc. (Pharm.))--North-West University, Potchefstroom Campus, 2004.

Cette thèse est consacrée à l'étude de quelques propriétés mathématiques de deux modèles de population : le processus Fleming-Viot généralisé d'une part et le processus de branchement d'autre part. Dans les deux cas, la population est composée d'une infinité d'individus, chacun étant caractérisé par un type génétique. Au cours du temps les fréquences asymptotiques de ces types évoluent de façon aléatoire au travers d'événements de reproduction où un individu tiré aléatoirement donne naissance à une descendance portant le même type génétique. Mathématiquement ces deux modèles sont décrits par des processus aléatoires à valeurs mesures. Afin de donner un sens à la généalogie de la population sous-jacente, plusieurs approches ont été proposées au cours des quinze dernières années. La contribution principale de cette thèse consiste en l'unification de deux constructions : la représentation lookdown définie par Peter Donnelly et Thomas Kurtz en 1999 et les flots stochastiques de ponts (ou de subordinateurs) introduits au début des années 2000 par Jean Bertoin et Jean-François Le Gall. Cette unification nécessite l'introduction d'objets nouveaux (les Eves, les flots stochastiques de partitions) et repose sur une étude fine des comportements asymptotiques des deux modèles mentionnés précédemment. En particulier, nous définissons la propriété d'Eve comme suit : si la fréquence asymptotique d'un type génétique tend vers $1$ lorsque $t$ devient grand alors la population descend asymptotiquement d'un seul individu au temps initial, appelé l'Eve de la population. Dans le cas des processus de branchement nous obtenons une condition nécessaire et suffisante sur le paramètre du modèle (aussi appelé mécanisme de branchement) qui assure que cette propriété d'Eve est vérifiée. Nous obtenons également une classification complète de tous les autres comportements possibles. Dans le cas des processus Fleming-Viot généralisés, nous obtenons une classification partielle des comportements possibles en fonction du paramètre du modèle. Enfin, lorsque la propriété d'Eve est vérifiée, nous construisons de façon trajectorielle la représentation lookdown à partir d'un flot stochastique de ponts (ou de subordinateurs). Nous présentons également une étude complète du processus de branchement explosif conditionné à la non-explosion et faisons apparaître une famille infinie de mesures quasi-stationnaires pour ce processus. Finalement nous nous intéressons au processus des longueurs du coalescent de Kingman dynamique et présentons une construction alternative à celle de Pfaffelhuber, Wakolbinger et Weisshaupt.

No description available.

Percutaneous delivery of drugs promises many advantages over oral or intravenous administration, such as a better control of blood levels, a reduced incidence of systemic toxicity, an absence of hepatic first-pass metabolism, better patient compliance, etc. However, the dermal drug transport is limited by the unsuitable physicochemical properties of most drugs and the efficient barrier function of the skin. Thus, numerous attempts have been reported to improve topical absorption of drugs, concentrating mainly on the barrier function of the stratum corneum by use of penetration enhancers and/or skin warming. An alternative and interesting possibility for improved dermal permeability is the synthesis of derivatives or analogues with the aim of changing the physicochemical properties in favour of skin permeation, efficacy and therapeutic value. Cyclizine (I) is an anti-emetic drug primarily indicated for the prophylaxis and treatment of nausea and vomiting associated with motion sickness, post operation and Meniere's disease. It acts both on the emetic trigger zone and by damping the labyrinthine sensitivity. Pharmacologically it has anti-histaminic, antiserotonergic, local anaesthetic and vagolytic actions. It is widely used and also suitable for children from six year of age. Percutaneous absorption of (I) can, among others, avoid the "first-pass" effect and the discomfort of injection. The main objective of this study was to explore the feasibility of percutaneous absorption of (I) and its alkyl analogues via physicochemical characterization and assessment of their permeation parameters. The intent was also to establish a correlation between the physicochemical properties of these compounds and their percutaneous rate of absorption. To achieve these objectives, the study was undertaken by synthesizing the alkyl analogues and determining the physicochemical parameters relevant to skin transport. Identification and level of purity for the prepared analogues were confirmed by mass spectrometry (MS), nuclear magnetic resonance (NMR) spectrometry and infrared (IR) spectrometry. Experimental aqueous solubility (25 °c & 32 °C) and partition coefficient for each compound were determined. In vitro permeation studies were performed at pH 7.4, using Franz diffusion cells with human epidermal membranes. Diffusion experiments were conducted over a period of 24 hours maintaining a constant temperature (37 DC) by means of water bath. All samples were analysed by high pressure liquid chromatography (HPLC). Cyclizine (I) has a methyl group at N-4. Increasing the alkyl chain length on N-4 of the piperazine ring resulted' in compounds with lower melting points and higher water solubility than (I). (II) exhibited 3-fold increase in water solubility, followed by (IV) with about 2.5 fold increase. The water solubility of (III) was almost the same as that of (I). Log partition coefficients increased linearly with increasing alkyl chain length. The analogues therefore, possessed more favourable physicochemical properties to be delivered percutaneously. Indeed, the in vitro skin permeation data proved that these analogues could be delivered more easily than (I) itself. The flux of (I) was 0.132 ug/cm2/h in a saturated aqueous solution. Compound (II) resulted in a 53-fold (6.952 ug/cm2/h) increase in permeation compared to (I). (III) and (IV) resulted in a 2- and 5fold enhancement of permeation respectively. Based on the results of the study, it seems that increased aqueous solubility and low level of crystallinity play a vital role in optimizing percutaneous absorption of (I) and its alkyl analogues. But the importance of the effect of increased lipophilicity cannot be ignored. The low percutaneous• absorption of (I) might be attributed to its low aqueous solubility and increased crystallinity, as is evident from the higher melting point than the analogues. From all the permeability data using aqueous solutions, it is clear that compound (II) is the best permeant of this series and in addition it is known that this compound antagonizes the effects of histamine. / Thesis (M.Sc. (Pharm.))--North-West University, Potchefstroom Campus, 2004.

This thesis introduces normal factor graphs under a new semantics, namely, the exterior function semantics. Initially, this work was motivated by two distinct lines of research. One line is ``holographic algorithms,'' a powerful approach introduced by Valiant for solving various counting problems in computer science; the other is ``normal graphs,'' an elegant framework proposed by Forney for representing codes defined on graphs. The nonrestrictive normality constraint enables the notion of holographic transformations for normal factor graphs. We establish a theorem, called the generalized Holant theorem, which relates a normal factor graph to its holographic transformation. We show that the generalized Holant theorem on one hand underlies the principle of holographic algorithms, and on the other reduces to a general duality theorem for normal factor graphs, a special case of which was first proved by Forney. As an application beyond Forney's duality, we show that the normal factor graphs duality facilitates the approximation of the partition function for the two-dimensional nearest-neighbor Potts model. In the course of our development, we formalize a new semantics for normal factor graphs, which highlights various linear algebraic properties that enables the use of normal factor graphs as a linear algebraic tool. Indeed, we demonstrate the ability of normal factor graphs to encode several concepts from linear algebra and present normal factor graphs as a generalization of ``trace diagrams.'' We illustrate, with examples, the workings of this framework and how several identities from linear algebra may be obtained using a simple graphical manipulation procedure called ``vertex merging/splitting.'' We also discuss translation association schemes with the aid of normal factor graphs, which we believe provides a simple approach to understanding the subject. Further, under the new semantics, normal factor graphs provide a probabilistic model that unifies several graphical models such as factor graphs, convolutional factor graphs, and cumulative distribution networks.

Nowadays, Industrial Control Systems (ICSs) are becoming larger and implement more complex functions. Therefore, technologies that are currently used to implement these functions, like hardware platforms and communication protocols might soon become unusable due to the lack of resources. The industry is trying to adopt new technologies that will allow these functionalities to be developed without an increase in the size of the equipment, or of the development costs. To enumerate some of these technologies: virtualization, multi-core technologies are the ones that show the biggest potential. Because these technologies are not mature, research has to be done in order to fully maximize their potential. Another technology that is highly used by the industry is the Ethernet communication protocol. It presents some advantages, but due to the non-real-time nature of the applications that it was designed for, it has to be extended in order to be used in real-time applications. The objective of this thesis work is to model an Ethernet network comprised of software partitions so that it can provide timing guarantees for the traffic that traverses the network. A Response Time Analysis for real-time flows over such networks is proposed. The model and the RTA are evaluated by experiments.

P1 is a low copy number plasmid that uses a dedicated partition system that actively ensures each daughter cell inherits a copy of the plasmid. P1 plasmid partition is a positioning reaction, ensuring that each plasmid copy is correctly localized to the one-quarter and three-quarter position or midcell in an E. coli cell prior to partition. The factors involved in this positioning process are not well understood. I utilized cell biology techniques and E. coli mukB mutants that produce cells with chromosomal condensation defects to study the role of the bacterial chromosome and P1 ParA as possible localization signals. P1 plasmid prefers to localize to the bacterial nucleoid even when the chromosome is perturbed. ParA is necessary for plasmid localization to the chromosome. In this study, live cell microscopy analysis of ParA indicates that an interaction between P1 ParA and the E. coli nucleoid may underlie the localization mechanism of the plasmid partition system.