Multicast traffic is common in today's networks. We need to simulate multicast architecture to be familiarized with its functionality in all situations. This thesis describes modelling and simulation of multicast routing using OMNeT++ tool. The text introduces protocol PIM and its particular modes (DM, SM, SSM, and BiDir) with emphasis on PIM-DM. The thesis focuses especially on design and implementation of OMNeT++ extension by multicast routing protocol PIM-DM. Correctness of implementation is verified by comparison of simulation and real network on example.

New approaches are needed for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) who fail to achieve remission with chemotherapy. Analysis of the effects of pan-PIM protein kinase inhibitors on human T-ALL cell lines demonstrated that the sensitive cell lines expressed higher PIM1 protein kinase levels, whereas T-ALL cell lines with NOTCH mutations tended to have lower levels of PIM1 kinase and were insensitive to these inhibitors. NOTCH-mutant cells selected for resistance to gamma secretase inhibitors developed elevated PIM1 kinase levels and increased sensitivity to PIM inhibitors. Gene profiling using a publically available T-ALL dataset demonstrated overexpression of PIM1 in the majority of early T-cell precursor (ETP)-ALLs and a small subset of non-ETP ALL. While the PIM inhibitors blocked growth, they also stimulated ERK and STAT5 phosphorylation, demonstrating that activation of additional signaling pathways occurs with PIM inhibitor treatment. To block these pathways, Ponatinib, a broadly active tyrosine kinase inhibitor (TKI) used to treat chronic myelogenous leukemia, was added to this PIM-inhibitor regimen. The combination of Ponatinib with a PIM inhibitor resulted in synergistic T-ALL growth inhibition and marked apoptotic cell death. Treatment of mice engrafted with human T-ALL with these two agents significantly decreased the tumor burden and improved the survival of treated mice. This dual therapy has the potential to be developed as a novel approach to treat T-ALL with high PIM expression.

BakgrundBakgrunden till idén till denna studie uppkom då vi under våra praktikperioder märkt av vissa negativa attityder kring arbetet med digitala verktyg samt PIM. Vi ville undersöka över användandet och de attityder som finns i förskolans verksamheter kring digitala verktyg ur ett kommunperspektiv.SyfteSyftet med studien är att belysa förskolors tillgång till digitala verktyg och om kompetensutvecklingen inom IKT inverkar på attityderna kring det digitala lärande i förskolan.MetodEn kvantitativ studie med enkät som redskap besvarad av pedagoger verksamma i Borås stads förskoleverksamhet.ResultatResultatet av studien visade att pedagogerna har en positiv attityd kring arbetet med digitala verktyg. Pedagogerna ansåg att PIM-utbildningen varit en bra kompetensutveckling, dock visade det sig att de bara till en viss del använde sig utav den nyförvärvade kunskapen. Pedagogerna lyfte att det i många fall beror på ålderdomliga datorer och brist på internetuppkoppling till iPad/lärplatta. Utifrån resultat kan vi utläsa att användningen av IKT i verksamheten till viss del är en generationsfråga. / Program: Lärarutbildningen

This thesis was concerned with investigating a visual-illusionary phenomenon that co-occurs with post-traumatic anxiety symptoms. More specifically, individuals who report recurring specific memories of a fearful event (RSM) also tend to report a persistent illusion of movement (PIM) upon prolonged visual fixation (Tym, Dyck & McGrath, 2000). The development of a visual test (i-Test) designed to reliably elicit PIM has enabled research to be conducted on the nature and correlates of this type of visual disturbance. The present research aimed: 1) To develop a standard protocol for assessment of PIM and RSM; 2) to test the reliability of the i-Test in eliciting PIM in a student sample 3) to test the predictive relationship between dissociation and anxiety symptoms with PIM and RSM 4) to formulate and test a hypothesis regarding a mechanism underlying PIM. The first study screened 142 participants for RSM and PIM using self-administered questionnaires designed by Tym (personal communication, 2001). There was an unexpectedly high rate (54.2%) of PIM and RSM (37.3%) in the sample, which appeared to be the product of questionnaire design limitations. Two semi-structured interviews were developed and subsequently tested on a new sample of 50 participants in Study 2. Study 2 documented intra-rater and inter-rater reliability co-efficient of sufficient strength to indicate good reliability for the semi-structured interviews. The results of Study 2 indicate that PIM is a relatively stable symptom over a 30-minute and one-week test-retest time frame. / The onset time for PIM was relatively consistent between participants, with a mean latency of approximately 7 seconds. The oscillation rate of PIM was relatively consistent between individuals, with a mean average oscillation of approximately 0.8Hz. The third study tested a sample of 148 participants using the revised assessment protocols. The base rate for PIM (16.2%) and RSM (18.9%), and the concordance rates (46% to 54%) were slightly stronger than the Tym et al. (2000) community based study (33%). In addition to this, 11 other illusionary phenomena were documented, however none of these visual symptoms significantly correlated with RSM. The average oscillation rate is comparable to the rate documented in Study 2, further establishing the consistency of the reported rate of PIM oscillations between individuals. In Study 3, each participant was assessed for levels of dissociation (Dissociative Experiences Scale), somatic arousal (Mood and Anxiety Symptoms Questionnaire – Anxious Arousal Scale) and anxiety sensitivity (Anxiety Sensitivity Index). The results indicate that gender and dissociation significantly predict RSM status, and self-reported levels of anxious-arousal significantly predict PIM status. A multiway frequency analysis between the sub-components of RSM and PIM revealed that the physiological arousal inducing properties of the recurring memory is the only significant predictor of PIM. / The observed relationship between RSM and PIM may reflect the broader relationship between anxiety and dissociation. A pulsatile hypothesis was proposed as a feasible mechanism underlying PIM, due to the rhythmical nature of the visual disturbance, the range of the documented oscillations, and its specificity to psychological disorders characterised by cardiovascular sensitivities. All participants were administered the i-Test prior to and following aerobic exercise aimed at increasing pulse rate to 80% of maximum load. An increase in physical exertion significantly increased the latency of PIM onset, but did not impact on the rate of PIM. PIM rate appeared relatively consistent between individuals at 0.6Hz to 0.8Hz at the pre-exercise condition. Several participants who reported PIM also displayed obvious nystagmoid-like movements during the i-Test perceptual task. The role of eye-movements in PIM requires further investigation by future ophthalmological research. The final aim of Study 3 was to investigate the relationship between RSM/PIM and flicker sensitivity. Through the use of a Critical Flicker Frequency/Fusion task (CFF), each participant’s sensitivity to flicker was determined. In addition to detecting sensitivity thresholds, CFF is also considered to be a reliable indicator of the level of cortical arousal. / The results of this study suggest that individuals with RSM have a higher sensitivity to flicker than other participants, however there was a non-significant relationship between CFF and PIM. The lack of relationship between PIM and CFF may be due to issues concerning statistical power and effect-size. Future research is required to investigate this link in more detail. The overall results of this thesis suggest that i-Test elicited PIM is a reliable phenomenon that is associated with higher rates of traumatic memories when compared with persons who do not report this visual symptom. The strength of the association between RSM and PIM, however, does not support the use of the i-Test as a marker for the presence of RSM outside a clinical sample. The reliability of PIM as a phenomenon and its association with anxiety symptoms may be of theoretical importance in enabling future research to investigate the relationship between visual symptoms and anxiety-related pathology.

Currently, a viable solution to provide multicast provision over a multiprotocol label switch with traffic engineering (MPLS-TE) domain is unavailable because of the missing link able to couple multicast traffic distribution with an MPLS-TE enabled network. This is due to the limited or less research investigation that was done in this area. Most of the investigation methods tackle the problem individually such as deploying internet protocol (IP) multicast in a plain network or MPLS domain but without considering a combination of both technologies that is aware of differentiated services requirements. This thesis presents an alternative solution for the multicast differentiated services provision problem over a MPLS-TE enabled network. The approach is exposed and analyzed through a practical solution that was developed within a network simulation environment. The research presented in this thesis orchestrates the already available technologies offered by the multicast protocols suite and differentiated services (DiffServ) aware MPLS-TE that allows applying separately the constraint-based routing and admission control to different classes of services. The novelty and solution of this thesis relies on using MPLS constraint-based routing concepts (e.g.traffic trunks) in order to solve TE issues revealed during multicast traffic distribution.

People today use the computer for many simultaneous work projects and activities. The traditional file system was developed for storing and retrieving files and it and the desktop have not evolved with users' practices. The first part of the dissertation presents a user study that generates a better understanding of the issues and practices regarding the organization of documents in support of activities. The second part provides the design of an environment to organize information based on an activity paradigm as opposed to an archiving paradigm and delivers the instantiation and the evaluation of a system based on such a design. The system, called Docksy, provides an environment structured in workspaces. Each workspace is segmented in areas or panels. Users can use documents as elements to structure their workflow or to manage their activities by separating files in the different panels, and by adding comments, tags, and flags. The Docksy design aims to create a flexible, lightweight environment that is easy to use and can be incorporated into users' daily practice, old or new. Such a system could be used to learn about users' practices and their evolution. Docksy was therefore developed for a double purpose; the short term purpose of testing new features (panels, comments, flags, and tags) and the long term purpose of facilitating learning about user practices. A study of Docksy use was conducted in which twenty participants used Docksy for at least two weeks and they were then interviewed. The study showed that participants valued the panels and the comment features. The results of the study showed the potential for changing users' practice and the potential for the system to be adopted by users.

Currently, a viable solution to provide multicast provision over a multiprotocol label switch with traffic engineering (MPLS-TE) domain is unavailable because of the missing link able to couple multicast traffic distribution with an MPLS-TE enabled network. This is due to the limited or less research investigation that was done in this area. Most of the investigation methods tackle the problem individually such as deploying internet protocol (IP) multicast in a plain network or MPLS domain but without considering a combination of both technologies that is aware of differentiated services requirements. This thesis presents an alternative solution for the multicast differentiated services provision problem over a MPLS-TE enabled network. The approach is exposed and analyzed through a practical solution that was developed within a network simulation environment. The research presented in this thesis orchestrates the already available technologies offered by the multicast protocols suite and differentiated services (DiffServ) aware MPLS-TE that allows applying separately the constraint-based routing and admission control to different classes of services. The novelty and solution of this thesis relies on using MPLS constraint-based routing concepts (e.g.traffic trunks) in order to solve TE issues revealed during multicast traffic distribution.

Teniendo en cuenta que actualmente el debate sobre el papel de las infraestructuras no se encuentra cerrado, y atendiendo a la especial relevancia que ha cobrado el conocimiento de los "stocks" de capital público de los países y regiones, en este trabajo se explora la posibilidad de identificar una solución metodológica que haga factible la provisión de estimaciones con un grado de detalle inédito hasta ahora en los datos referidos a Cataluña. Así pues, en esta Tesis se plantea tratar a las carreteras como una función específica, cuando el agente es la Comunidad Autónoma de Cataluña y el nivel de territorialización de los datos es comarcal.

Today there are many studies that have shown positive results in the treatment of ICT at an early age. The focus of the studies vary, and they target everything from the actual implementation of teaching resources in ICT, to student performance with ICT support. Regardless of the amount of studies on the subject, there is no precise strategy for how to implement, working with ICT, integrate ICT in different subjects, utilizing the hardware and software that is or how it will eventually respond to new technologies. This work will there by focusing on trying to develop a basis for further research and hopefully in the future to develop an ICT strategy at a national level.In order to provide a basis, a comparison was made of ten different schools. The schools were entered into a table showing the similarities and differences . To put a framework to this strategy, the teachers' own education "PIM" was included to set the limitations for the school education. It was revealed early in the work that a large divergence between schools and after te processing of the data collected, the recommendation was to try to get schools to start from a common basis. The hope is that the results between the schools in the future will be measurable, when one sees how students assimilate and learn on the same basis instead of having to have a lenient when students learn differently to all schools. The study will also get some key pillars to build a functioning ICT strategy.

In this master thesis the advanced design methodology is presented by which information systems requirements represented with precise UML models are transformed to project. The first section describes a research of five existing MDA tools comparison according to evaluation criteria. This criteria covers model to model and model to code transformations approach, platform of generated code and integration with UML CASE tools abilities. For requirements model transformation to design, plug-in for CASE tool MagicDraw is created according MDA standards. Model transformation plug-in takes system requirement model as input and generates design model. In this way it is possible to implement design methods that have explicit design rules. Created plug-in requirements, functional specification and architecture described in Project section. The investigation section describes investigation of the developed plug-in. In this section were investigate the working efficiency of designer increasing and the quality of design models ensuring with create MagicDraw plug-in.