Thesis (M.Ed.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 152-155). Also available in print.

京都大学 / 0048 / 新制・課程博士 / 博士(農学) / 甲第17987号 / 農博第2034号 / 新制||農||1019(附属図書館) / 学位論文||H26||N4812(農学部図書室) / 80831 / 京都大学大学院農学研究科食品生物科学専攻 / (主査)教授 河田 照雄, 教授 谷 史人, 教授 保川 清 / 学位規則第4条第1項該当 / Doctor of Agricultural Science / Kyoto University / DFAM

Human immunodeficiency virus infection is a chronic condition causing significant changes in the immune system, which are reflected in the altered gene expression patterns of the immune cells. By studying these patterns through gene expression profiling it is possible to describe not only the current states the cells are in, but also to extrapolate the proximal signals that resulted in the observed patterns. In the studies described herein, we have applied this approach to better understand the alterations in the immune function that occur in HIV infection. First, we have obtained transcriptional profiles of CD4+ and CD8+ T cells from patients in early infection, in chronic infection, and in non-progressive infection, and we compared these profiles to each other and to the profiles from uninfected donors. The analyses of the profiles revealed no discernable changes in the T cells of the non-progressive patients when compared to the uninfected individuals. On the other hand, T cells from patients with progressive infection, both early and late, showed patterns characteristic of type I interferon (IFN) exposure. We next examined experimentally the possible proximal causes of the observed transcriptional profiles. We analyzed the gene expression patterns induced by TGFβ, 13 type I interferons, as well as recombinant HIV Tat protein, in T cells and peripheral blood mononuclear cells. The TGFβ responses were inconsistent with the transcriptional profiles seen in HIV-infected patients, whereas both type I IFNs and HIV Tat induced genes in patterns consistent with those seen in patients. In fact, the thirteen IFN-induced patterns were indistinguishable from each other. Tat treatments induced interferon-stimulated genes (ISGs) as well as other genes and the response was not dependent on the presence of plasmacytoid dendritic cells (pDCs), suggesting monocytes as the possible source of the interferon response. In the last study, we examined the responses of plasmacytoid dendritic cells (pDCs) to HIV and other stimuli in healthy and HIV-infected subjects. We observed induction of IFN genes in pDCs of all subjects in response to influenza virus and TLR7 agonist imiquimod, but not to HIV virus. In summary, HIV infection results in chronic induction of type I IFN response in cells of the immune system. The source of this response is likely to be type I IFNs produced by monocytes/macrophages rather than plasmacytoid cells. The monocytic production of type I IFN may be a Tat-dependent response.

Title: Comparison of participation in physical activities of secondary school students and primary school pupils in Prague Objectives: The aim of the thesis was to find and compare the participation in extracurricular physical and sport activities of Prague's secondary school students and Prague's primary school pupils based on questionnaire survey and following evaluation of the obtained data. Methods: The research was realized using the questionnaire survey. The questionnaire was designed specifically for this research. Results: The research results suggest that the physical activities are comparatively expanded among secondary school students and primary school pupils in Prague. It has been statistically proven that primary school pupils are interested in physical activities in organized form more than secondary school students. There are not significant statistical differences between primary school pupils and secondary school students in the frequency of doing physical activities. Keywords: physical activities, secondary school, primary school

A Reforma Psiquiátrica brasileira defende o tratamento não asilar para indivíduos diagnosticados com transtornos mentais severos e/ou persistentes, principalmente através dos Centros de Atenção Psicossocial (CAPS). Esta pesquisa propõe mostrar como se dá a dinâmica dos ajustamentos primários e secundários em uma unidade CAPS, levando em consideração as interações sociais e os discursos produzidos na instituição. Para isso, é utilizada a técnica de observação participante e a análise de documentos formais e informais. O diálogo teórico principal é com a produção de Erving Goffman e é tomado como contraponto o trabalho de Michel Foucault. Existem dois fatos que chamam a atenção na unidade pesquisada: o ativismo da equipe técnica e a obrigação de aprovação da pesquisa por um Comitê de Ética relacionado ao Ministério da Saúde. Verifica-se que a participação dos usuários modificou a forma como se dão as relações sociais na instituição. Em instituições não totais que buscam respeitar os direitos humanos, como o CAPS, há controle social e, consequentemente, resistência. O controle social imposto pela instituição gera, por parte dos pacientes, a necessidade de defender seus self dessas violações mesmo que esses possam ser consideradas mais sutis, em comparação com a realidade de um hospital psiquiátrico. Acredita-se que a fronteira entre os ajustamentos primários e secundários se tornou mais conflitiva e que essas questões foram reformuladas devido à participação dos usuários na instituição, o que leva a instituição a constantemente fazer acordos com os pacientes para manter o controle da instituição. Ao verificar na instituição os ajustamentos e as relações de poder através das interações e dos discursos dos atores sociais, pode-se dizer que uma característica nova na instituição CAPS, em relação ao hospital psiquiátrico, é a participação dos usuários na instituição e essa mudança produz acordos e conflitos entre usuários e membros da equipe multiprofissional. / The Brazilian Psychiatric Reform advocates non-asylum treatment for individuals diagnosed as suffering from severe and/or persistent mental disorders, mainly through the Psychosocial Care Centers (CAPS). This research proposes to show how the dynamics of primary and secondary adjustments occurs in a CAPS unit, taking on account the social interactions and the discourses produced in the institution. For that, it is used the participant observation technique and the analysis of formal and informal documents. The main theoretical dialogue is with the production of Erving Goffman and it is taken as counterpoint the work of Michel Foucault. There are two facts that draw attention in the unit researched: the activism of the psy staff and the obligation to have the research approved by an Ethics Committee related to the Ministry of Health. It is verified that the participation of the users modified the way in which the social relations in the institution take place. In non-total institutions that seek to respect human rights, as the CAPS, there are social control and, consequently, resistance. The social control imposed by the institution generates on the part of the patients the need to defend their self from these violations even if they can be considered subtler, when compared to the reality of a psychiatric hospital. It is believed that the boundary between primary and secondary adjustments has become more conflicting and that these issues have been reformulated due to the participation of the users in the institution, which leads the institution to constantly make agreements with the patients to maintain the control of the institution. When verifying in the institution the adjustments and the power relations through the interactions and the discourses of the social actors, it can be said that a new feature at the CAPS institution, in relation to the psychiatric hospital, is the participation of the users in the institution and this change produces agreements and conflicts between users and members of the multiprofessional staff.

This research focuses on the language environment of children with Down syndrome (DS) in primary and secondary classrooms. In contrast to much of the previous work in this area, the study takes both qualitative and quantitative approaches to data collection. In particular, it highlights teachers’ speech rates and speech strategies in relation to children’s individual listening comprehension. Previous research shows that the listening comprehension of children with DS may be limited by deficits in phonological loop capacity and hearing loss. However, most of this previous research has used quantitative measures to compare the memory performances of children with DS with their typically developing or mental agematched peers. This has tended to result in conclusions that regard children with DS as a homogeneous group. This study, however, aims to consider each child with DS as an individual and to explore in depth the relationship between their listening comprehension and teachers’ speech rates and speech strategies in classroom settings. The study was conducted in 2 stages, both using case-study approach to investigate individual children’s interactions with their class teachers (CTs) and teaching assistants (TAs). The Stage 1 research was conducted with three case-study children in four distinct phases and used an inductive approach to collect data. Phase one observed each child in their classroom environment, involving the interactions between teaching staff and the case-study child. Phase two identified the child’s language ability by using standardised language assessments. Phase three then assessed the impact of speech rates on children’s understandings and, finally, Phase four tested the research validity by representing the stories with a counter-balanced design. The results of the Stage 1 research suggested that the use of the slow speech rate improves the children’s listening comprehension although there were clear indications that there would be more significant benefit if they could be given more time to process information. The Stage 2 research focused on speech strategies, with an emphasis on clustered speech and a deductive approach was adopted. Six additional children with DS were assessed by the BPVS and WISC-IV to investigate further speech rate but also in the context of speech strategies. This further examined whether clustered speech could be beneficial to improving the children’s listening comprehension. The findings show that the clustered speech strategy can improve the listening comprehension of all of the children in this phase, particularly at the slow normal speech rate. The key benefit of this strategy is that it can be used to offset problems in processing information that the children experience because of their limited memory capacity. The outcome of my research can provide teaching staff with knowledge that will enable them to enhance the listening comprehension of children with DS.

This thesis examines inequality of educational opportunities (IEO) in the transition to higher education. IEO measures the difference in higher education entry rates across social groups. The theoretical framework lays on Boudon's decomposition of IEO into primary and secondary effects of stratification. Furthermore, the theoretical propositions of Maximally Maintained Inequality (MMI) and Effectively Maintained Inequality (EMI) were also assessed to gain further understanding of IEO. The longitudinal data for the empirical analysis was created for a student cohort by linking administrative records of Chile's national student register, standardised tests and higher education enrolment. The student cohort was followed through the 12-years of compulsory education up to the transition to higher education, a year after completing secondary education. The results from the empirical analysis showed that secondary effects were consistently predominant over primary effects, driving the overall IEO. On the other hand, controlling for school characteristics increased the relative importance of secondary effects. However, primary effects explained a large extent of IEO in the transition to traditional (most prestigious) universities, by the same token, in the transition to undergraduate programmes. Differences in parental education levels between secondary education completion and higher education transitions proved to be consistent with MMI. Likewise, the higher likelihood of less advantaged students to enrol in vocational colleges or vocational programmes, and the higher likelihood of advantaged students to enrol in traditional universities or undergraduate programmes, evidenced support for EMI. The modelling setting was based on non-linear mediation modelling, accounting for sample-selection in the student cohort, two-level cross-classification between primary and secondary schools, and multinomial outcomes for type of institution and programme. This thesis contributes to the educational attainment literature by finding evidence that, in emerging economies like Chile, educational inequality persists despite the sustained expansion of the educational system.

Abstract : Information and communication technologies (ICTs, henceforth) have become ubiquitous in our society. The plethora of devices competing with the computer, from iPads to the Interactive whiteboard, just to name a few, has provided teachers and students alike with the ability to communicate and access information with unprecedented accessibility and speed. It is only logical that schools reflect these changes given that their purpose is to prepare students for the future. Surprisingly enough, research indicates that ICT integration into teaching activities is still marginal. Many elementary and secondary schoolteachers are not making effective use of ICTs in their teaching activities as well as in their assessment practices. The purpose of the current study is a) to describe Quebec ESL teachers’ profiles of using ICTs in their daily teaching activities; b) to describe teachers’ ICT integration and assessment practices; and c) to describe teachers’ social representations regarding the utility and relevance of ICT use in their daily teaching activities and assessment practices. In order to attain our objectives, we based our theoretical framework, principally, on the social representations (SR, henceforth) theory and we defined most related constructs which were deemed fundamental to the current thesis. We also collected data from 28 ESL elementary and secondary school teachers working in public and private sectors. The interview guide used to that end included a range of items to elicit teachers’ SR in terms of ICT daily use in teaching activities as well as in assessment practices. In addition, we carried out our data analyses from a textual statistics perspective, a particular mode of content analysis, in order to extract the indicators underlying teachers’ representations of the teachers. The findings suggest that although almost all participants use a wide range of ICT tools in their practices, ICT implementation is seemingly not exploited to its fullest potential and, correspondingly, is likely to produce limited effects on students’ learning. Moreover, none of the interviewees claim that they use ICTs in their assessment practices and they still hold to the traditional paper-based assessment (PBA, henceforth) approach of assessing students’ learning. Teachers’ common discourse reveals a gap between the positive standpoint with regards to ICT integration, on the one hand, and the actual uses of instructional technology, on the other. These results are useful for better understanding the way ESL teachers in Quebec currently view their use of ICTs, particularly for evaluation purposes. In fact, they provide a starting place for reconsidering the implementation of ICTs in elementary and secondary schools. They may also be useful to open up avenues for the development of a future research program in this regard. / Résumé : Les technologies d’information et de communication (TIC) sont devenues omniprésentes dans notre société. L’abondante panoplie de dispositifs rivalisant avec l’ordinateur, allant de l’iPad au Tableau blanc interactif, pour n’en nommer que quelques-uns, a permis aux enseignantes et enseignants ainsi qu’aux élèves de communiquer et d’obtenir de l’information avec une vitesse et une accessibilité jamais égalées jusqu’à aujourd’hui. De ce fait, il serait attendu que les pratiques éducatives traditionnelles, qui ne semblent plus compatibles avec les attentes des élèves et les besoins de main-d’œuvre d’aujourd’hui soient modifiées (Ahmed et Nasser, 2015). Malheureusement, la recherche indique que les réalités d’intégration des TIC sont toujours loin de la rhétorique. Plusieurs enseignantes et enseignants d’écoles primaires et secondaires n’utilisent pas les TIC d’une façon efficace et ce, autant dans leurs activités d’enseignement que dans leurs pratiques évaluatives. La présente étude, de type exploratoire-descriptif, vise à 1) décrire les profils des enseignantes et enseignants d’anglais langue seconde (ALS) utilisant les TIC dans leurs activités quotidiennes d’enseignement et leurs pratiques évaluatives; 2) décrire les pratiques d'intégration des TIC dans les activités d’enseignement et les pratiques d'évaluation de ces enseignantes et enseignants; et 3) décrire les représentations sociales (RS) des enseignantes et enseignants concernant l'utilité et la pertinence de l'utilisation des TIC dans leurs activités quotidiennes d'enseignement et leurs pratiques d'évaluation. Pour atteindre nos objectifs, nous basons principalement notre cadre théorique sur la théorie de la RS et nous définissons les concepts et les construits les plus étroitement associés qui sont considérés comme fondamentaux pour la thèse actuelle. Nous avons recueilli nos données auprès d’un échantillon de 28 enseignantes et enseignants d’ALS du primaire et du secondaire qui travaillent dans les secteurs publics et privés. Le guide d'entretien utilisé à cette fin comprend un nombre d’items visant à favoriser l’élucidation des RS des enseignants en matière de l’usage quotidien des TIC dans les activités d'enseignement ainsi que des pratiques d'évaluation. De plus, nous avons réalisé nos analyses dans une perspective de statistique textuelle, un mode particulier d’analyse de contenu, afin d’extraire les indicateurs sous-jacents aux représentations des enseignants. Les résultats suggèrent que, bien que presque tous les participants utilisent un large éventail d'outils de TIC dans leurs pratiques, il s’avère que la mise en œuvre des TIC n’est pas exploitée à son plein potentiel et, en conséquence, est susceptible de produire des effets limités sur l'apprentissage des élèves. En outre, aucun des interviewés affirment qu'ils utilisent les TIC dans leurs pratiques d'évaluation et ils tiennent encore à l'approche traditionnelle du papier-crayon dans l'évaluation de l'apprentissage des élèves. Le discours commun des enseignantes et enseignants révèle un écart entre le point de vue positif en ce qui concerne l'intégration des TIC, d'une part, et les utilisations réelles de la technologie pédagogique, de l'autre part. Ces résultats sont utiles pour mieux comprendre la façon dont les enseignantes et les enseignants d'anglais langue seconde au Québec perçoivent leur utilisation des TIC, en particulier à des fins d'évaluation. En effet, ils fournissent un point de départ pour reconsidérer la mise en œuvre des TIC dans les écoles primaires et secondaires. Ils pourraient également être utiles pour élaborer des pistes pour le développement d’un futur programme de recherche à cet égard.

Nesta última década (2005-2015), a educação brasileira passou por transformações intensas relativas ao ingresso das crianças na Educação Básica. A entrada aos seis anos de idade no Ensino Fundamental, período que compreende agora nove anos, desafiou os educadores a definir mais claramente o que se espera da escola nos anos iniciais da educação. Assim, o objetivo deste trabalho foi caracterizar determinadas competências para a leitura e a escrita em crianças iniciantes no processo de alfabetização e relacionar essas competências com o nível da escrita. Realizamos, então, pesquisa de campo, com abordagem quanti-qualitativa dos dados, de cujos resultados extraímos inferências, a partir do quadro teórico de referências sistematizado. Foram selecionadas 70 crianças de ambos os gêneros, que cursaram o 1o semestre do 1o ano do ensino fundamental I. Todos os escolares tinham formação em educação infantil. As crianças foram submetidas à bateria de Avaliação de Competências iniciais para a leitura e escrita BACLE que caracteriza-se por um conjunto de atividades para aferir pré-competências para início de leitura e escrita. As crianças foram avaliadas também pela análise de nível de escrita, nível pré-silábico, silábico sem valor sonoro, silábico com valor sonoro, silábico alfabético e alfabético. O desempenho das crianças foi comparado com as tabelas de valores de estágio qualitativo da BACLE e para a correlação entre o desempenho na bateria e o nível de escrita foi utilizado o coeficiente de correlação de Pearson (nível de significância de 5 % - p<0,05). Os resultados indicam que a média de desempenho obtida pelo grupo de escolares em maturidade perceptiva foi de 76,95%. No conjunto de provas que implicaram em esquema corporal e orientação espaço temporal, subdivididos em três grupos, identificação em si, no outro e posição no espaço gráfico, foram, respectivamente, 85,36%, 75,26% e 89,57%. No bloco desenvolvimento motor, a média foi de 84,9%. No bloco linguagem, a maior média se deu em expressão oral, 85,82% e a menor média se deu em consciência fonológica 75,17%. Quanto à psicogênese de construção da escrita verificou-se que a maior parte da amostra 51,4% encontra-se em hipótese de escrita no nível silábico com valor sonoro e apresentam um resultado em consciência fonológica condizente ao esperado, devido ao nível de escrita em que se encontram. O estudo apontou relação significante entre a hipótese de escrita e duas áreas da BACLE, esquema corporal/orientação espaço-temporal e linguagem. Concluímos que as crianças com melhores níveis de escrita tiveram uma pontuação elevada na área de Linguagem e Esquema corporal/ Orientação espaço temporal, sugerindo que dentre os campos avaliados pela bateria, a linguagem e esquema corporal/ orientação espaço temporal pode ser aquele que melhor se relaciona com o nível de escrita. Espera-se respeitados os limites deste estudo contribuir para a formação continuada de docentes, almejando alterações em sua prática pedagógica, principalmente na avaliação diagnóstica do escolar. / In the last decade (2005-2015), the Brazilian education passed through intense transformations about the entry of children in basic education. The entrance to six years old children in elementary school, a period which now comprises nine years, challenged educators to define more clearly what is expected of the school in the early years of education. Then, the objective of this study was to characterize certain skills for reading and writing in children beginners in the literacy process and relate these skills to the level of writing. We performed then field research with quantitative and qualitative approach, the results of which draw inferences from the theoretical framework of systematic references. We selected 70 children of both genders, who attended the 1st half of the 1st year of elementary school. All students had training in Early Childhood Education. Children were subjected to a battery of initial skills assessment for reading and writing (BACLE), which is characterized by a set of activities to measure for early reading and writing pre-skills. The children were also evaluated by the writing level of analysis, pre-syllabic level, syllabic without sound value, with syllabic sound value, syllabic-alphabetic and alphabetic. Children\'s performance was compared to the qualitative stage of tables of values of BACLE and the correlation between performance on battery and the writing level we used the Pearson correlation coefficient (5% significance level - p<0,05). The results indicate that the average performance achieved by the school group in perceptual maturity was 76.95%. In the group of tests that implicated in corporal scheme and time-space orientation, divided into three groups, identifying itself, identifying itself in relation of other person and in relation of the graphic space, were, respectively, 85.36%, 75.26% and 89.57%. In the motor development block, the average was 84.9%. In the language pack, the highest average was in speaking, 85.82% and the lowest average was in phonological awareness 75.17%. Regarding the construction of the writing Psychogenesis it was found that most of the sample is 51.4% which is in hypothesis of writing with the syllabic sound value and exhibit a result in phonological awareness that was expected, due to the write level which they are. The study shows a significant relationship between the hypothesis of writing and two areas of BACLE, corporal scheme / time-space orientation and language. We conclude that children with higher levels of writing had a high score in the area of language and corporal scheme / time-space orientation, suggesting that among the fields evaluated by battery, language and corporal scheme / time-space orientation may be those that best relate to the writing level. We expect the limits of this study respected contribute to the continuing education of teachers, targeting changes in their teaching, especially in the diagnostic evaluation of the student.

A Reforma Psiquiátrica brasileira defende o tratamento não asilar para indivíduos diagnosticados com transtornos mentais severos e/ou persistentes, principalmente através dos Centros de Atenção Psicossocial (CAPS). Esta pesquisa propõe mostrar como se dá a dinâmica dos ajustamentos primários e secundários em uma unidade CAPS, levando em consideração as interações sociais e os discursos produzidos na instituição. Para isso, é utilizada a técnica de observação participante e a análise de documentos formais e informais. O diálogo teórico principal é com a produção de Erving Goffman e é tomado como contraponto o trabalho de Michel Foucault. Existem dois fatos que chamam a atenção na unidade pesquisada: o ativismo da equipe técnica e a obrigação de aprovação da pesquisa por um Comitê de Ética relacionado ao Ministério da Saúde. Verifica-se que a participação dos usuários modificou a forma como se dão as relações sociais na instituição. Em instituições não totais que buscam respeitar os direitos humanos, como o CAPS, há controle social e, consequentemente, resistência. O controle social imposto pela instituição gera, por parte dos pacientes, a necessidade de defender seus self dessas violações mesmo que esses possam ser consideradas mais sutis, em comparação com a realidade de um hospital psiquiátrico. Acredita-se que a fronteira entre os ajustamentos primários e secundários se tornou mais conflitiva e que essas questões foram reformuladas devido à participação dos usuários na instituição, o que leva a instituição a constantemente fazer acordos com os pacientes para manter o controle da instituição. Ao verificar na instituição os ajustamentos e as relações de poder através das interações e dos discursos dos atores sociais, pode-se dizer que uma característica nova na instituição CAPS, em relação ao hospital psiquiátrico, é a participação dos usuários na instituição e essa mudança produz acordos e conflitos entre usuários e membros da equipe multiprofissional. / The Brazilian Psychiatric Reform advocates non-asylum treatment for individuals diagnosed as suffering from severe and/or persistent mental disorders, mainly through the Psychosocial Care Centers (CAPS). This research proposes to show how the dynamics of primary and secondary adjustments occurs in a CAPS unit, taking on account the social interactions and the discourses produced in the institution. For that, it is used the participant observation technique and the analysis of formal and informal documents. The main theoretical dialogue is with the production of Erving Goffman and it is taken as counterpoint the work of Michel Foucault. There are two facts that draw attention in the unit researched: the activism of the psy staff and the obligation to have the research approved by an Ethics Committee related to the Ministry of Health. It is verified that the participation of the users modified the way in which the social relations in the institution take place. In non-total institutions that seek to respect human rights, as the CAPS, there are social control and, consequently, resistance. The social control imposed by the institution generates on the part of the patients the need to defend their self from these violations even if they can be considered subtler, when compared to the reality of a psychiatric hospital. It is believed that the boundary between primary and secondary adjustments has become more conflicting and that these issues have been reformulated due to the participation of the users in the institution, which leads the institution to constantly make agreements with the patients to maintain the control of the institution. When verifying in the institution the adjustments and the power relations through the interactions and the discourses of the social actors, it can be said that a new feature at the CAPS institution, in relation to the psychiatric hospital, is the participation of the users in the institution and this change produces agreements and conflicts between users and members of the multiprofessional staff.