Made available in DSpace on 2014-12-17T15:31:02Z (GMT). No. of bitstreams: 1 CandiceFRB.pdf: 345545 bytes, checksum: a87f0c9c7b61e16a29dfad599e006ac3 (MD5) Previous issue date: 2007-10-29 / INTRODUCTION: The high sensitivity C-reactive protein (hsCRP) constitutes an inflammatory mediator used as predictor of cardiovascular risk that comes being researched as indicative relation factor between cardiovascular and periodontal diseases. PROPOSITION: To compare serumals levels of C-reactive protein between patients with and without generalized severe chronic periodontitis. METHODOLOGY: A seccional study was realized using a sample with 62 patients, being 31 participants carriers of periodontal diseases (Group I) and 31 without periodontal diseases (Group II), grouped to the pairs by age and sex. As inclusion criterio were selected patients with diagnosis of generalized severe chronic periodontitis, being preculeds, individuals which presented systemic disease, recent infection history, historical of CVA or stroke, smokers, pregnants and lactants. The research consisted of two stages, a clinc and other biochemist. The clinical stage is constituted of periodontal examination and the biochemist stage, of the peripheral blood collection for determination hsCRP levels and a hemogram to inquire any panel which could suggest infectious and/or inflammatory process. RESULTS: Periodontal disease group presented a average of 0,36mg/dL, while the group without disease presented 0,17 mg/dL, do not existing significant difference statistically between the averages (p = 0,061). The cardiovascular risk for the group I was classified high for 27,6% of participants and low for 72,4% of them. In the group II, 6,45% presented high risk e 93,5% low risk, being this significant relation statistically gotten for Fisher s Test (p = 0,042) presenting OR = 5,33; IC = 95% (1,02 27,4). The independets variables reseacred do not presented significant association statistically with the levels of hsCRP. CONCLUSION: The study indicated that despite of carriers patients of periodontal diseases do not present differents serumals levels of hsCRP from the other group, the periodontal disease was considered as risk factor for hsCRP plasmatic levels elevation / INTRODU??O: A prote?na C-reativa ultra-sens?vel (PCR-US) constitui um mediador inflamat?rio utilizada como preditor do risco cardiovascular que vem sendo pesquisado como fator indicativo da rela??o entre doen?as cardiovasculares e periodontais. PROPOSI??O: Comparar os n?veis s?ricos de prote?na C-reativa entre pacientes com e sem periodontite cr?nica severa generalizada. METODOLOGIA: Foi realizado um estudo seccional, utilizando uma amostra de 62 pacientes, sendo 31 participantes com doen?a periodontal (Grupo I) e 31 sem doen?a periodontal (Grupo II), selecionados segundo idade e sexo. Como crit?rios de inclus?o foram selecionados pacientes com diagn?stico de periodontite cr?nica severa generalizada, sendo exclu?dos, indiv?duos que apresentassem doen?a sist?mica, hist?ria de infec??o recente, hist?rico de AVC ou infarto, fumantes, gestantes e lactantes. A pesquisa constou de duas etapas, sendo uma cl?nica e outra bioqu?mica. A etapa cl?nica consistiu no exame periodontal e a bioqu?mica na coleta de sangue perif?rico para determina??o dos n?veis de PCR-US e um hemograma para averiguar algum quadro que pudesse sugerir processo infeccioso e/ou inflamat?rio. RESULTADOS: O grupo com doen?a periodontal apresentou uma m?dia de 0,36 mg/dL, enquanto o sem doen?a de 0,17 mg/dL, n?o existindo diferen?a estatisticamente significativa entre as m?dias (p=0,061). O risco cardiovascular para o grupo I foi classificado como alto para 27,6% dos participantes e baixo para 72,4%. No grupo II, 6,45% apresentavam alto risco e 93,5% baixo risco, sendo essa rela??o estatisticamente significativa obtida pelo teste de Fisher (p=0,042), apresentando um OR=5,33; IC95%(1,02-27,4). As vari?veis intervenientes pesquisadas n?o apresentaram associa??o estatisticamente significativa com os n?veis de PCR-US. CONCLUS?O: O estudo indicou que apesar dos pacientes portadores de periodontite severa cr?nica generalizada n?o apresentarem n?veis s?ricos de PCR-US diferentes dos sem doen?a, a doen?a periodontal atuou como fator de risco para eleva??o dos n?veis plasm?ticos de PCR-US

Made available in DSpace on 2014-12-17T14:13:57Z (GMT). No. of bitstreams: 1 CarlosEATC_DISSERT.pdf: 535957 bytes, checksum: 4a4cb0797470f9dc7e83436d9bfc8330 (MD5) Previous issue date: 2012-03-16 / This study aimed to determine the influence of strength training (ST), in three weekly sessions over ten weeks, on cardiovascular parameters and anthropometric measurements. It is a before and after intervention trial, with a sample composed of 30 individuals. Participants were adults aged between 18 and 40 years, from both sexes and sedentary for at least three months previously. Tests were computed ergospirometry, CRP, PWV and body composition (dependent variables) before and after the experiment. Independent variables, age and sex, were considered in order to determine their influence on the dependent variablesevaluatedend. By comparing the initial cardiovascular parameters with those obtained after intervention in patients undergoing the ST proposed (a Student s t-test was conducted within each group for samples matched to parameters with normal distribution, while the Wilcoxin was applied for those without), there was no significant difference in PWV(p =0469) or PCR(p =0.247), but there was an increase in anaerobic threshold(AT) (p=0.004) and Maximal Oxygen Uptake(VO2max) (p =0.052). In regard to anthropometric measures, individuals significantly reduced their body fat percentage (p<0.001) and fat mass (p<0,001), as well as increasing lean mass (p<0.001). However, no changes were recorded in the waist-to-hip ratio (WHR) (p= 0.777), body mass (p=0.226) or body mass index (BMI) (p =0.212). Findings of this study lead us to believe that the proposed ST, and did not increase the VOP or PCR improves cardiorespiratory capacity and body composition. Devotees of this training can therefore safely enjoy all its benefits without risk to the cardiovascular system / O objetivo desse estudo foi verificar a influ?ncia do TF, com frequ?ncia de tr?s sess?es semanais e dura??o de dez semanas, sobre par?metros cardiovasculares e antropom?tricos. Trata-se de um estudo de interven??o do tipo antes-depois, cuja amostra foi composta por 30 indiv?duos. Os mesmos eram adultos com idade compreendida entre 18 e 40 anos, de ambos os sexos e sedent?rios h? pelo menos tr?s meses. Foram realizados os testes da ergoespirometria computadorizada, PCR, VOP e composi??o corporal (vari?veis dependentes), antes e logo ap?s o experimento. As vari?veis independentes, idade e sexo, foram aferidas no sentido de verificar seus efeitos sobre as vari?veis dependentes avaliadas. Ao comparar os par?metros cardiovasculares iniciais com os obtidos ap?s a interven??o nos indiv?duos submetidos ao TF proposto(atrav?s dos testes t de Student para amostras emparelhadas para os par?metros que tiveram distribui??o normal e para os que n?o a possu?ram, o Wilcoxon), n?o houve diferen?a significativa nem na VOP (p =0.469) nem na PCR (p=0,247), por?m houve aumento no Limiar Anaer?bio (LA) (p=0,004) e no consumo m?ximo de oxig?nio (VO2m?x) (p=0,052). Em rela??o ?s medidas antropom?tricas, os indiv?duos diminu?ram significativamente o percentual de gordura (p<0,001) e a massa de gordura (p<0,001), aumentaram a massa livre de gordura (p<0,001), por?m n?o alteraram a rela??o cintura-quadril (RCQ) (p= 0,777), massa corporal (p=0,226) nem o ?ndice de massa corporal (IMC) (p =0,212). Os achados do presente estudo nos levam a crer que o TF proposto, al?m de n?o aumentar a VOP nem a PCR, melhora a capacidade cardiorrespirat?ria e a composi??o corporal. Portanto, os adeptos de tal treinamento podem usufruir, com seguran?a, de todos os seus benef?cios sem risco ao sistema cardiovascular

Made available in DSpace on 2014-12-17T15:32:30Z (GMT). No. of bitstreams: 1 AdrianaGA_TESE.pdf: 950866 bytes, checksum: c8ffb7409c37936ff546c9f7cffeb2d8 (MD5) Previous issue date: 2012-02-29 / The present study evaluated the influence of non-surgical periodontal treatment on the levels of C- reactive protein (hsCRP) in patients with chronic renal failure (CRF) in pretransplant. We conducted a controlled and randomized trial to evaluate the periodontal condition and plasma concentrations of hsCRP, albumin and transferrin in 56 dialysis patients divided into two groups: experimental and control. The study was conducted at the dental clinic of Family and Community Health s Unit (USFC), located in Onofre Lopes University Hospital (HUOL), Federal University of Rio Grande do Norte (UFRN), from December 2010 to November 2011. Severe periodontitis was the type of periodontal disease more common, affecting 78.6% of patients. Periodontal conditions, evaluated through the means of probing depth, clinical attachment level, bleeding index and plaque index, proved to be uniform for both groups at the initial examination. There were no differences in levels of inflammatory markers between the two groups. The analysis of the concentrations of hsCRP allowed classifying study participants as at high risk of developing cardiovascular disease. After completion of periodontal treatment in the experimental group, there was a statistically significant reduction of the mean of all periodontal parameters assessed; however this improvement of periodontal health was not accompanied by changes in the levels of hsCRP, albumin and transferrin in the evaluation time. Given this, the periodontal treatment did not promote the reduction of systemic inflammatory burden and risk of cardiovascular complications in patients with CRF / O presente estudo se prop?s a avaliar a influ?ncia do tratamento periodontal n?o cir?rgico sobre os n?veis da prote?na C reativa (PCR-US) em indiv?duos com Insufici?ncia Renal Cr?nica (IRC) em fase de pr?-transplante. Realizou-se um ensaio cl?nico, controlado e randomizado para avaliar as condi??es periodontais e as concentra??es plasm?ticas de PCRUS, albumina e transferrina em 56 pacientes dial?ticos com doen?a periodontal divididos em dois grupos: Experimental e Controle. O estudo foi realizado no ambulat?rio odontol?gico da Unidade de Sa?de Familiar e Comunit?ria (USFC), localizada no Hospital Universit?rio Onofre Lopes (HUOL), Universidade Federal do Rio Grande do Norte (UFRN), no per?odo de dezembro de 2010 a novembro de 2011. A periodontite severa foi o tipo de doen?a periodontal mais frequente, acometendo 78,6% dos pacientes. As condi??es periodontais, avaliadas atrav?s das m?dias da profundidade de sondagem, n?vel de inser??o cl?nica, ?ndice de sangramento e ?ndice de biofilme se mostraram uniformes para os dois grupos no exame inicial. Tamb?m n?o foram encontradas diferen?as nos n?veis dos marcadores inflamat?rios entre os grupos. A an?lise inicial das concentra??es da PCR-US permitiu classificar os participantes do estudo como de alto risco para o desenvolvimento de doen?as cardiovasculares. Ap?s a realiza??o do tratamento periodontal no grupo Experimental, houve redu??o estatisticamente significante das m?dias de todos os par?metros periodontais avaliados, entretanto esta melhora das condi??es de sa?de periodontal n?o foi acompanhada pela altera??o dos n?veis da PCR-US, albumina e transferrina no tempo de avalia??o da pesquisa. Diante disto, o tratamento periodontal n?o promoveu a redu??o da carga inflamat?ria sist?mica e o risco de desenvolvimento de complica??es cardiovasculares nos indiv?duos com IRC