The involvement of end users in the design process is gaining popularity, particularly through human-centred design (HCD). This case study addresses two practical issues: the lack of engagement of Swedish public sector office workers in designing their workspaces and the need to prioritize user needs in new meeting places. The research examines engagement at the leadership/ownership level using participatory speculative design (PSD), which goes beyond HCD. Through participatory action research (PAR), users are empowered to question their needs and lead the design process. The study employs PSD in two workshops to explore its contribution to the process and outcome. It focuses on identifying ownership-level engagement indicators and assessing how PSD influences reflecting user needs in the initial prototype of future meeting spaces. The central research question revolves around identifying indicators of ownership-level engagement in PSD and assessing how the PSD methodology influences the reflection of user needs in the initial prototype of future meeting spaces. Data collection involves secondary data, literature review, and design workshops, analysing workshop design and participant behaviour’s impact on engagement levels and organizations. The study aims to provide practical solutions and bridge knowledge gaps in participant engagement. Findings demonstrate the practical implications of involving end users at the highest level, including fresh insights, broader perspectives, and the democratization of the design process. PSD at the ownership level proves feasible, offering novel insights within the realm of PSD.

A non-contact angular measurement system for Pitch Static Attitude (PSA) and Roll Static Attitude (RSA) of hard disk drive sliders is designed and built. Real-time sampling at over 15 KHz is achieved with accuracy of +/- 0.05 degrees over a range of approximately 2-3 degrees. Measuring the PSA and RSA is critical for hard drive manufacturers to control and improve the quality and reliability of hard drives. Although the hard drive industry is able to measure the PSA and RSA at the subassembly level at this time, there is no system available that is able to measure PSA/RSA at the final assembly level. This project has successfully demonstrated a methodology that the PSA/RSA can be reliably measured in-situ using a laser and position sensitive detector (PSD) technology. A prototype of the measurement system has been built using simple and inexpensive equipment. This device will allow a continuous measurement between the parked position on the ramp and the loading position just off of the disk surface. The measured data can be used to verify manufacturing processes and reliability data.

A holy grail in neuroscience is being able to control plasticity to facilitate recovery from insult in the adult brain. Despite success in animal models, few therapies have translated from bench to bedside. This thesis is aimed at addressing 2 major stumbling blocks in translation. The first gap is in our understanding of the mechanisms of plasticity-enhancing therapies, and the second is in our understanding the relevance of those mechanisms for human development. In chapters 2 and 3, I address the first gap by asking whether fluoxetine, a selective serotonin reuptake inhibitor, which reinstates juvenile-like plasticity in adult animals, reinstates a juvenile-like synaptic environment. We found evidence to suggest that fluoxetine is neuroprotective, as it rescued all of the MD-driven changes, but surprisingly we found no evidence that fluoxetine recreated a juvenile-like synaptic environment, with the exception of Ube3A. Ube3A is necessary for critical period plasticity, indicating that Ube3A may play a crucial in enhancing plasticity in the adult cortex. In chapter 4, I address whether D-serine, an amino acid that has similar effects to fluoxetine in terms of both plasticity and anti-depression, shares a common neurobiological signature with fluoxetine. I found that D-serine’s effects were strikingly similar to fluoxetine, with respect to markers of the E/I balance, indicating that it may be an effective alternative to fluoxetine. In chapter 5, I address the second gap by studying the development of 5 glutamatergic proteins in human V1. Some changes occurred early, as would be predicted from animals studies, while other changes were protracted, lasting into the 4th decade. These results will help guide the use of treatments, like fluoxetine, which effect glutamatergic proteins. iv Together the findings in this thesis significantly advances our understanding of the mechanisms involved in restating plasticity in the adult cortex, and their relevance to humans. / Dissertation / Doctor of Philosophy (PhD) / Neurons change to rewire, adapt, and recover. This plasticity is greatest early in development, so much research has focused on bringing it back in adults. There has been amazing progress in animal models, but this has not translated to humans. Two reasons for this are that we do not fully understand the mechanisms of these treatments in animals or whether those mechanisms are relevant for humans. My thesis addresses this by studying how 2 treatments, fluoxetine and D-serine, affect proteins that are important for plasticity, and how those proteins develop in the humans. I found that these treatments are neuroprotective, but do not recreate a younger state. One interesting standout is an increase in Ube3A, which is essential for juvenile plasticity. I also found that much of human development is similar to animals, but the time course for some proteins is uniquely prolonged in humans. These findings have implications for the use of plasticity-enhancing treatments at different ages.

No description available.

Ultra wide band (UWB) is an extremely promising wireless technology for researchers and industrials. One of the most interesting is its high data rate and fading robustness due to selective frequency fading. However, beside such advantages, UWB system performance is highly affected by existing narrowband interference (NBI), undesired UWB signals and tone/multi-tone noises. For this reason, research about NBI cancellation is still a challenge to improve the system performance vs. receiver complexity, power consumption, linearity, etc. In this work, the two major receiver sections, i.e., analog (radiofrequency or RF) and digital (digital signal processing or DSP), were considered and new techniques proposed to reduce circuit complexity and power consumption, while improving signal parameters. In the RF section, different multiband UWB low-noise amplifier key design parameters were investigated like circuit configuration, input matching and desired/undesired frequency band filtering, highlighting the most suitable filtering package for efficient UWB NBI cancellation. In the DSP section, due to pulse transmitter signals, different issues like modulation type and level, pulse variety, shape and color noise/tone noise assumptions, were addressed for efficient NBI cancelation. A comparison was performed in terms of bit-error rate, signal-to-interference ratio, signal-to-noise ratio, and channel capacity to highlight the most suitable parameters for efficient DSP design. The optimum number of filters that allows the filter bandwidth to be reduced by following the required low sampling rate and thus improving the system bit error rate was also investigated.

The aim of this thesis is to clearly describe all payment services which can be found in current Act on Payments of 2009 and also new payment services under new Act on Payments. New Act on Payments will come into effect on 13 January 2018. The reason for its adoption was the need of transposition of the revised Payment Services Directive known as PSD II. This directive brings significant number of changes into the area of the regulation of payments. Moreover, this thesis devotes to introduction and analysis of all subject authorized to provide payment services in the Czech Republic. The development of the regulation of payments in the Czech Republic is briefly described in the first part of the thesis. Regarding the extensiveness of this topic, it is only outlined which acts have regulated payments in the Czech Republic. The second part of the thesis deals with positive and negative definition of payment services. When describing a single payment service, the difficult situations which can occur due to this payment service are mentioned. The section on negative definition of payment services explains the exceptions which cause that some activities are not consider to payment services pursuant to current and new Act on Payments. For the provider it is essential to determine whether some activity is...

O presente trabalho otimizou os parâmetros concentrados do sistema de suspensão de um modelo de veículo completo, representando um automóvel de passeio que trafega a uma velocidade constante por um determinado perfil de pista previsto na norma ISO 8608, 1995, através da utilização de um algoritmo meta-heurístico de otimização multiobjetivo. Duas rotinas numérico-computacionais foram desenvolvidas, visando realizar tal otimização tanto no domínio do tempo quanto no domínio da frequência. A utilização de algoritmos meta-heurísticos vem ganhando espaço na otimização de sistemas mecânicos, proporcionando rapidez e precisão na obtenção de resultados ótimos. Ao se combinar um algoritmo de otimização a um modelo que represente satisfatoriamente um sistema mecânico, obtém-se uma ferramenta indicadora dos parâmetros de máxima eficiência do sistema, que pode ser utilizada em inúmeras aplicações. Pretendeu-se, com a integração de rotinas de análise dinâmica nos domínios do tempo e da frequência ao algoritmo genético de otimização multiobjetivo NSGA-II, desenvolvido por Deb et al., 2002, a obtenção de duas fronteiras ótimas de Pareto. Estas fronteiras consistem no conjunto de soluções não dominadas que minimizam as seguintes funções objetivo: o valor RMS ponderado da aceleração vertical do assento do motorista, o valor RMS da média do fator de amplificação dinâmica das quatro rodas do modelo e o máximo deslocamento relativo entre cada roda e a carroceria. O método proposto por Shinozuka e Jan, 1972, é utilizado para a obtenção do perfil de irregularidades da pista no domínio do tempo a partir das equações de densidade espectral de potência (PSD) que representam as diferentes classes de pavimentos. O método de Newmark, 1959, é utilizado para resolver a equação diferencial de movimento no domínio do tempo e obter a resposta dinâmica do modelo a tais irregularidades. O comportamento dinâmico do modelo de veículo no domínio da frequência foi obtido através da utilização da função de resposta em frequência (FRF) do modelo de veículo analisado. Os resultados demonstraram a capacidade de ambas as rotinas de análise dinâmica desenvolvidas de produzir resultados consistentes com os encontrados na literatura, bem como a capacidade dos algoritmos de otimização implementados de fornecer fronteiras ótimas de Pareto para os problemas propostos. / The proposed work optimized the concentrated parameters of a full-vehicle model’s suspension system, being that model representative of a passenger car which travels at a constant speed on a certain road profile provided by the ISO 8608, 1995, standard, using a multi-objective meta-heuristic optimization algorithm. Two numerical-computational routines were developed, seeking to perform said optimization for both the time and frequency domains. The use of meta-heuristic algorithms has been increasing in mechanical systems optimization, providing speed and accuracy in obtaining an optimal result. Combining an optimization algorithm with a model that satisfactorily represents a mechanical system yields a tool that indicates the system’s maximum efficiency parameters, which can be used in numerous applications. It was intended, with the integration of the dynamic analysis routines to the multi-objective genetic optimization algorithm NSGA-II, developed by Deb et al., 2002, the obtainment of two Pareto-optimal fronts. These fronts consist in the set of non-dominated solutions that minimize the following objective functions: the weighted RMS value of the driver’s seat vertical acceleration, the mean RMS value of the model wheel’s dynamic amplification factor, and the maximum relative displacement between each wheel and the body of the vehicle model. The method proposed by Shinozuka and Jan, 1972, is used to obtain the road irregularity profile in the time domain from the power spectral density (PSD) equations that represent the different pavement classes. The Newmark’s method (1959) is used to solve the differential motion equation in the time domain, in order to obtain the vehicle model’s responses to these irregularities. The dynamic behavior of the vehicle model in the frequency domain was obtained through the use of the frequency response function (FRF) of the analyzed model. The results showed the capacity of both the dynamic analysis routines developed in generating results that are consistent with those found in literature, as well as the capacity of the optimization algorithms implemented in providing Pareto optimal fronts to the proposed problems.

O Ruído de Baixa Frequência (LFN), tais como o ruído flicker e o Random Telegraph Noise (RTN), são limitadores de performance em muitos circuitos analógicos e digitais. Para transistores diminutos, a densidade espectral de potência do ruído pode variar muitas ordens de grandeza, impondo uma séria limitação na performance do circuito e também em sua confiabilidade. Nesta tese, nós propomos um novo modelo de RTN estatístico para descrever o ruído de baixa frequência em MOSFETs. Utilizando o modelo proposto, pode-se explicar e calcular o valor esperado e a variabilidade do ruído em função das polarizações, geometrias e dos parâmetros físicos do transistor. O modelo é validado através de inúmeros resultados experimentais para dispositivos com canais tipo n e p, e para diferentes tecnologias CMOS. É demonstrado que a estatística do ruído LFN dos dispositivos de canal tipo n e p podem ser descritos através do mesmo mecanismo. Através dos nossos resultados e do nosso modelo, nós mostramos que a densidade de armadilhas dos transistores de canal tipo p é fortemente dependente do nível de Fermi, enquanto para o transistor de tipo n a densidade de armadilhas pode ser considerada constante na energia. Também é mostrado e explicado, através do nosso modelo, o impacto do implante de halo nas estatísticas do ruído. Utilizando o modelo demonstra-se porque a variabilidade, denotado por σ[log(SId)], do RTN/LFN não segue uma dependência 1/√área; e fica demonstrado que o ruído, e sua variabilidade, encontrado em nossas medidas pode ser modelado utilizando parâmetros físicos. Além disso, o modelo proposto pode ser utilizado para calcular o percentil do ruído, o qual pode ser utilizado para prever ou alcançar certo rendimento do circuito. / Low Frequency Noise (LFN) and Random Telegraph Noise (RTN) are performance limiters in many analog and digital circuits. For small area devices, the noise power spectral density can easily vary by many orders of magnitude, imposing serious threat on circuit performance and possibly reliability. In this thesis, we propose a new RTN model to describe the statistics of the low frequency noise in MOSFETs. Using the proposed model, we can explain and calculate the Expected value and Variability of the noise as function of devices’ biases, geometry and physical parameters. The model is validated through numerous experimental results for n-channel and p-channel devices from different CMOS technology nodes. We show that the LFN statistics of n-channel and p-channel MOSFETs can be described by the same mechanism. From our results and model, we show that the trap density of the p-channel device is a strongly varying function of the Fermi level, whereas for the n-channel the trap density can be considered constant. We also show and explain, using the proposed model, the impact of the halo-implanted regions on the statistics of the noise. Using this model, we clarify why the variability, denoted by σ[log(SId)], of RTN/LFN doesn't follow a 1/√area dependence; and we demonstrate that the noise, and its variability, found in our measurements can be modeled using reasonable physical quantities. Moreover, the proposed model can be used to calculate the percentile quantity of the noise, which can be used to predict or to achieve certain circuit yield.

No description available.

This thesis describes research carried out to investigate techniques for (i) rapidly assessing the reactivity of fly ash; and (ii) evaluating its interaction with air-entraining admixtures (AEAs), both with regard to use in concrete. The materials considered for the project included, 54 fly ashes from 8 UK sources, and an additional three materials from Bangladesh, covering a range of fineness, loss-on-ignition (LOI) and production conditions (run-of-station, carbon removed, air-classified, co-combustion, oxy-fuel technology); Portland Cements (PCs) from five UK sources with various properties (strength classes 32.5 R, 42.5 N and 52.5 N); laboratory grade hydrated and quick limes; and three commercial AEAs and a standard laboratory grade reagent (surfactant). The research examining fly ash reactivity considered activity index tests to BS EN 450 (BSI, 2005c) as the reference and investigated tests covering fly ash properties/providing measures of fly ash behaviour to rapidly assess this. These included (i) fly ash fineness (45 µm sieve residue, or LASER particle size distribution (PSD) parameters), LOI and flow properties; (ii) accelerated curing of PC and lime-based mortars (iii) lime consumption by fly ash when combined with PC in paste or suspension (Frattini) or from a saturated lime solution; (iv) various measures of fly ash chemical composition (based on oxide/mineralogical analysis); and (v) a quicklime slaking test. The test results were validated by strength tests with 100 mm concrete cube. Results of the above indicated good correlations between fly ash fineness, mortar flow/water requirement and (pozzolanic) activity index (standard or accelerated curing). However, fly ash reactivity and fresh properties appeared to be influenced by the properties of the test PC (e.g. chemical composition and fineness) and there is a need to take this into account during assessment. Generally, finer fly ashes gave better flow; however, there is an optimum fineness (d90 ~40 µm) for best performance, and which is similar to the fineness of the test PC. Strong correlations between the accelerated and standard cured PC-based mortar indicate the latter can be used to estimate the former taking account of the fly ash properties. In view of eliminating the effect of PC properties on reactivity, mortar tests with laboratory grade hydrated lime suggested potential for this. However, for better assessment, this approach requires further work to address issues relating to slower rates of strength gain and increased time requirements, although high temperature conditions were used for curing. Measuring Ca(OH)2 consumption from fly ash/PC paste or suspension agreed with the behaviour in mortar, but needs special instruments (e.g. TGA or XRF). A similar approach with saturated lime did not work well, despite several measures being taken to try and improve this. The oxide and mineralogical analysis results of fly ash did not give good correlations with activity index, but improved when a factor combining them with fineness was considered. The test results were validated in concrete and with air-classified fly ashes from single sources which gave clear trend/behaviour. The lime slaking test was found to be ineffective for identifying fly ash reactivity. The reactivity assessment results were validated by carrying out concrete strength tests. In general, more consistent trends were obtained for fly ash from single source as noted with mortar earlier. Methods adopted/developed to assess the interaction of fly ash with AEA included (i) the foam index test; (ii) acid blue 80 (AB80) dye adsorption test (spectroscopic method); and (iii) methylene blue test. High variability in foam index test results between different operators were noted, which reflected differences in the degree of shaking applied and difficulties in identification of the test end point. Adoption of an automatic shaker and determination of suitable test conditions reduced this by more than 50%. Reliable test procedures were also established for the AB80 dye adsorption method. The results obtained from these tests gave very good correlations with fly ash specific surface area and the AEA dose required (both with commercial AEAs and standard reagent) for achieving target air contents in mortar and concrete. The methylene blue dye test also gave good correlations with these parameters, but was less effective for low LOI fly ashes. Between laboratory tests were carried out at three UKQAA members and considered, LOI, fineness (45 µm sieve and LASER PSD), and activity index. The results gave good agreement with those obtained at the Concrete Technology Unit for this work and again emphasized the role of fly ash fineness on its reactivity. Overall, fly ash fineness was found to be the best means of rapidly assessing its reactivity. Some of the other methods considered gave promising behaviour but require further refinements. Therefore, it is suggested that in addition to 45 µm sieve residue, other types of fineness measurement (e.g. sub 10 µm quantities, d50 and d90) can be considered suitable alternatives to activity index. Similarly, foam index tests with the automatic shaker or the AB80 test method could both be used as fly ash physical requirement tests, or in production control for air-entrained concrete.