<p><b>Background: </b>Male<b> </b>contraceptive options are limited to condoms or vasectomy and have lacked significant developments for about a century, suggesting the value of exploring male hormonal contraceptives (MHC). In October 2018, a transdermal gel method entered Phase 2 clinical trials, indicating MHC may soon be available. However, eventual uptake of potentially contentious innovations, like MHC, requires informed marketing and promotional strategy. Consumer behavior research methodologies can aid in determining consumer perspectives, providing a framework for effective marketing to encourage MHC adoption upon market introduction.</p><p> </p><p><b>Methods: <i>Phases 1 & 2.</i> </b>Focus groups (n=29) and individual, in-depth interviews (n=20) among college-aged men and women aged 18-26 years were conducted using a semi-structured approach. Techniques from expanded grounded theory were used, allowing for a constant comparative approach to data contextualization and theme identification. Ads were created based on focus group results and tested in the interviews. Content analysis served as the data analysis strategy, allowing for a constant comparative approach to data contextualization and theme identification. <b><i>Phase 3.</i></b> College-aged men and women (n=1,997) aged 18-26 years participated in a web-based survey. Multiple linear regression was used to examine significant predictors of attitudes toward, interest in, and intention to use or encourage use of MHC. A conjoint analysis procedure was also used to assess the relative importance of attributes on ad effectiveness and preference.</p><p> </p><p><b>Results: <i>Phase 1.</i> </b>Three primary themes emerged from focus group discussions: 1) openness to MHC; 2) resistance to MHC; and 3) MHC gel innovation characteristics. Men and women were generally interested in the idea of an MHC method. Hesitance about MHC surrounded the social acceptance of a novel contraceptive product, resistance to changing current contraceptive routines, and fear of health consequences. Participants shared insights about promotional strategies which fell within the diffusion of innovations (DOI) characteristics of relative advantage, complexity, compatibility, and observability. <b><i>Phase 2.</i></b> In-depth interviews offered insight into perceptions of message development for MHC. Four themes emerged: 1) humor, 2) information, 3) relatability, and 4) credibility. Message testing in interviews yielded an understanding of elements participants responded most strongly to, including: 1) ad sentiment, 2) trustworthiness, and 3) visual appeal. <b><i>Phase 3.</i></b> Regression analyses revealed being sexually active (p=0.001) and having prior knowledge of potential MHC methods (p=0.031) aligned with positive MHC attitudes, interest, and intention. Conservative political views (p=0.002) and being satisfied with current male birth control offerings (p=0.000) were associated with negative MHC attitudes. Conjoint analysis identified informational messages as most important (56.62%). Informational (p=0.000) and aspirational messages (p=0.003) paired with relatable characters were the most highly preferred ads.</p><p><b> </b></p><p><a></a></p><p><b>Conclusions: </b>Findings revealed college-aged men and women express a general interest in the idea of MHC, with hesitance stemming from social acceptance of a novel contraceptive product, resistance to changing current contraceptive routines, and fear of potential side effects and long-term health consequences. Promotional strategy for MHC, or similar novel health products, must focus on stratifying consumers based on their readiness to accept a potential innovation and use tactics like aspirational marketing, social norms marketing, and informational marketing to confirm benefits and address concerns. Qualitative formative research also illuminated salient concepts for MHC advertising. Message testing revealed informational ads with elements of credibility may be most useful for promoting MHC, along with ad concepts audiences feel they can relate to or trust, and practical messaging or imagery meant to increase agency in use. The quantitative survey further supported these findings among a broader, university audience, indicating informational messages or aspirational messages paired with trustworthy, relatable characters are the most effective ad attributes to incorporate into marketing strategy when promoting a novel contraceptive product, like MHC.<b></b></p>

Indigenous research methodologies encourage indigenous scholars and allies to re-make research. Deliberately positioning academic inquiry as part of a research design, research can sustain and renew a community’s ability to engage their political priorities while fostering a transition back to community-based knowledge production. In this dissertation, I report on two research projects I was involved in that were led by Tla-o-qui-aht First Nations. Both projects examine Tla-o-qui-aht knowledge systems and values in relation to other lifeforms like salmon. I document how the Tla-o-qui-aht community and I, as a researcher, navigated a series of existing institutional and community-based ethical processes together and were able to create new ones to guide our research as well as research in the future. These processes included: creating a Tla-o-qui-aht Research Liaison position, establishing a Traditional Resource Committee for the review of all research involving Tla-o-qui-aht, and relocating the researcher to the community. The practices emerging from these processes reoriented Tla-o-qui-aht First Nations’ research accountabilities toward their ḥaw̓iiḥ (hereditary chiefs) and ḥatkm̓iiḥ (high-ranking women) as part of their regeneration of their relationships with the ḥaḥuułi (chiefly territories). This praxis of indigenous research in Tla-o-qui-aht ḥaḥuułi, that is, ensuring that practice is informed by community knowledge, demonstrates the importance of placing research leadership in the community. By situating leadership and researcher in community the ontologies of Tla-o-qui-aht knowledge systems emerged as a way to describe dissonance, recentre lived values and imagine possible futures of abundance. The use of filming as research method, centring Ciiqciqasa (speaking Nuučaan̓ułʔath), digitization of community records, and analysis of existing community records of ḥaaḥuupa (teaching, storytelling) were directed by Tla-o-qui-aht and reflect how academic research can serve community renewal. / Graduate / 2023-05-31

The   purpose   of   this   pilot   study   was   to   identify   and   evaluate   different   business   cases   for   Epiroc’s  Parts   &amp;   Services   Division   (PSD)   regarding   the   use   of   additive   manufacturing   (AM),   also   known   as  3D   printing,   for   their   spare   parts   within   the   mining   industry.    This   study   presents   an   approach   for  how   spare   parts   promising   for   AM   can   be   identified   and   shows   the   difficulties   with   AM.   The   study  follows   the   design   research   methodology   (DRM)   standard   for   research   within   product   and   process  development.   Through   interviews   and   literature   searches,   a   "top-down"   approach   was   applied.   A  developed   cost-benefit   model   accompanied   this   approach   and   was   used   to   identify   and   evaluate  potential   spare   parts   for   AM   from   Epiroc’s   current   spare   parts   portfolio.   The   results   were   evaluated  as   promising   for   several   of   the   spare   parts   in   terms   of   reduced   manufacturing,   procurement,   tool  cost,   and   lead   time   reduction,   which   results   in   increased   uptime   for   the   customer.   With   reduced   lead  times,   the   availability   increases   for   the   customer,   who   may   increase   Epiroc’s   sales   and   aftermarket  revenues   in   the   long   run.   There   is   also   great   potential   for   reducing   the   costs   for   warehousing,   where  spare   parts   of   low   demand   can   have   their   stocks   reduced   or   eliminated   by   securing   supply   through  on-demand   manufacturing.   Although   many   exciting   business   cases   have   been   identified   and  evaluated,   it   has   been   acknowledged   that   CNC-machining   in   many   cases   is   the   cheaper   alternative.  Despite   this,   it   is   worth   investing   in   AM   from   a   strategic   point   of   view   as   it   is   seen   as   a   tool   for   the  future.   Before   it   can   be   adopted   and   implemented,   Epiroc   should   do   test   trials   with   companies  offering   AM   services.   These   can   be   used   to   update   and   tune   the   cost-benefit   model   accordingly   to  increase   its   reliability   and   validity.   The   model   could   also   be   developed   further   to   incorporate   AM’s  additional   benefits,   such   as   weight   and   material   reduction   through   design   for   additive  manufacturing   (DfAM). / Syftet   med   denna   förstudie   var   att   identifiera   och   utvärdera   olika   affärsmöjligheter   för   Epirocs   Parts  &amp;   Services-division   (PSD)   gällande   användningen   av   additiv   tillverkning   (AM),   även   känd   som  3D-printning,   för   deras   reservdelar   inom   gruvindustrin.   Denna   studie   presenterar   ett  tillvägagångssätt   för   hur   reservdelar   passande   för   AM   kan   identifieras   och   visar   på   svårigheterna  med   AM.   Studien   följer   "design   research   methodology"   (DRM),   vilket   kan   översättas   till  designforsknings-metodologin,   som   är   vanligt   förekommande   vid   forskning   inom   produkt-   och  processutveckling.   Genom   intervjuer   och   litteratursökningar   tillämpades   en   "top-down"-metod.  Detta   åtföljdes   av   en   utvecklad   kostnadsnyttomodell   som   tillsammans   användes   för   att   identifiera  och   utvärdera   potentiella   reservdelar   för   AM   från   Epirocs   nuvarande   reservdelsportfölj.   Resultaten  utvärderades   som   lovande   för   flertalet   av   reservdelarna   vad   gäller   reducerad   kostnad   för  tillverkning,   inköp,   verktyg   och   minskad   ledtid,   vilket   resulterar   i   ökad   drifttid   för   kunden.   Med  minskade   ledtider   ökar   tillgängligheten   för   kunden,   som   kan   öka   Epirocs   försäljning   och  eftermarknadsintäkter   på   lång   sikt.   Det   finns   också   en   stor   potential   i   att   minska   kostnaderna   för  lagerhållning,   där   reservdelar   med   låg   efterfrågan   kan   få   sina   lager   att   reduceras   eller   elimineras  genom   att   säkra   utbudet   genom   tillverkning   vid   behov.   Även   om   många   intressanta  affärsmöjligheter   har   identifierats   och   utvärderats   har   det   uppmärksammats   att   CNC-bearbetning   i  många   fall   kan   vara   det   billigare   alternativet.   Trots   detta   är   det   värt   att   investera   i   AM   ur   en  strategisk   synvinkel   eftersom   det   ses   som   ett   verktyg   för   framtiden.   Innan   AM   kan   anammas   och  implementeras   bör   Epiroc   göra   testförsök   med   företag   som   erbjuder   AM-tjänster.   Dessa   kan  användas   för   att   uppdatera   och   justera   kostnadsnyttomodellen   i   enlighet   med   detta   för   att   öka   dess  validitet   och   reliabilitet.   Modellen   kan   också   utvecklas   vidare   för   att   införliva   AM:s   ytterligare  fördelar,   såsom   vikt-   och   materialreduktion   genom   design   för   additiv   tillverkning   (DfAM).

Previous research has identified student engagement as an important antecedent to student learning in higher education. Although student engagement is viewed as important for learning, a significant number of college students still report frequently feeling bored in their courses. The use of music as a pedagogical tool is believed to be beneficial for promoting student engagement and student learning in higher education sociology courses, yet it has been suggested that sociology faculty members do not commonly incorporate the technique into their courses. The purpose of this comparative interview study is to explore higher education sociology faculty members' understandings of the use of music as a pedagogical tool, and the perceived importance of student engagement to student learning among higher education sociology faculty members. In this study, it is found that higher education sociology faculty members believe student engagement can lead to increased student learning. It is also found that higher education sociology faculty members generally identify music as an effective pedagogical tool for promoting student engagement and learning in higher education sociology courses. Interestingly, participants believed the use of music as a pedagogical tool to be an uncommon practice in higher education sociology courses in the United States. As part of their efforts to explain their choices to use or not use music as a pedagogical tool, faculty participants described potential barriers that may impact faculty member choices to use music in their higher education sociology courses. Sociology faculty participants in this study agreed that a lack of discussion of pedagogical tools among colleagues and in teaching courses might serve as a potential barrier for the use of music as a pedagogical tool. Higher education sociology faculty participants also identified a lack of knowledge of how to use music as a pedagogical tool as a potential barrier for the use of music in sociology courses. This research suggests that the lack of faculty knowledge of music as a pedagogical tool may be due to the lack of discussion of pedagogical tools both among colleagues and in the teaching courses completed by higher education sociology faculty members. Past research has suggested that sociology faculty members need to create an environment that encourages students to be active and engaged participants in their own learning through building a community of learners. This study suggests that higher education sociology faculty members may successfully build a community of learners through using music as a pedagogical tool in their courses. This study recommends that changes at the departmental level need to occur in order to make it easier for sociology faculty members to gain the knowledge required to use music effectively in their courses. Suggestions for practice and future research are provided.

Indiana University-Purdue University Indianapolis (IUPUI) / Linking the new institutionalism to entrepreneurial orientation (EO), my dissertation investigates institutional forces and entrepreneurial forces—two contradicting types of forces—as main effects and moderating effects upon practices and performance of organizations embedded in the institutional duality. The case chosen observes unique hybrid funders that this study collectively calls social investment funders (SIF), which integrate philanthropy and venture capital investment to create and implement a venture philanthropy model for a pursuit of their mission. A theoretical framework is developed to propose regulative and normative pressures from two dominant institutions governing SIFs. Original data collected from 146 organizations are scrutinized by moderated multiple regressions for two empirical studies: Study 1 for effects on SIFs’ venture philanthropy practices, and Study 2 for effects on SIFs’ social and financial performance. Multiple imputations, diagnostic analyses, and several post hoc analyses are also conducted for robustness of data and results from multiple regression analyses. Results from these analyses find that EO and venture capital institutional forces both enhance SIFs’ venture philanthropy practices. A hypothesis postulated for a negative relationship between the nonprofit status and venture philanthropy practices is also supported. Results from moderated regression analyses, along with a subgroup and EO subdimension analyses, confirm a moderating effect between EO and the nonprofit status, i.e., a regulative institutional pressure. A positive relationship is found in EO- financial performance, but not in EO-social performance. While support is lent to hypotheses posited for a social/financial performance relationship with donors’/investors’ demand for social outcomes, and with the management team’s training in business, the overall results remain mixed for Study 2. Nonetheless, this dissertation appears to be the first study to theorize and test EO as a micro-level condition enabling organizations to strategically shape and resist institutional pressures, and it reinforces that organizations’ behavior is not merely a product of their passive conformity to environmental forces, but of the agency, also. As such, this study aims to contribute to scholarly efforts by the “agency camp” of the new institutionalism and EO, answering a call from the leading scholars of both EO (Miller) and the new institutionalism (Oliver).

Current chemotherapeutics pose many di sadvantages due to their lack of specificity and low therapeutic index. To overcome these challenges, research has focused its attention on the development of nano-based delivery systems that can penetrate the leaky vasculature of tumor endothelium, use site-directed ligands that can bind with high affinity and specific ity to tumor cells, physically entrap poorly soluble drugs, and deliver these cytotoxic agents directly to the tumor site. One approach to nanosystem drug delivery is with the use of peptide amphiphiles (PAs) that are conjugated with the Arginine-Glycine-Aspartic Acid (RGD) motif to actively target a αVβ3 integrin receptors on cancer cells or tumor endothelium. The current work is focused on mechanistic studies to evaluate the uptake of novel RGD amphiphi les with varying alkyl chain lengths (palmitic acid : Cl 6 and stearic acid: C 18) and hydrophilic linkers, 8-amino- 3,6-dioxaoctonoic acid (ADA) or glucose, as micellar delivery systems of hydrophobic anticancer agents. PAs were confirmed for their self-assembling properties and further evaluated for their RGD-mediated binding specificity to purified αVβ3 integrin through a competitive binding fluorescence polarization assay (with novel RGD micelles displacing an integrin-bound fluorescent RGD probe by as much as 63.03%). Ultimately, these nanocarriers were assessed for their ability to deliver phys ically entrapped fluorescein isoth iocyanate (FITC) to A2058 cells overexpressing αVβ3 integrin receptors. Results from confocal microscopy indicate that uptake of RGD micelles was driven by an energy-dependent mechanism, as statistically significant levels of FITC internalization was seen at 37°C versus 4°C (p-value<0.05 for all treatment groups); moreover, intracellular fluorescence was notably higher (as much as 4-fold) when delivered through novel RGD conjugates as opposed to its free form. Regardless of chain length and the number of hydrophilic linkers, all RGD PAs showed promising results as micellar carriers that can effectively deliver their payload to the target tumor site via receptor mediated endocytosis.

The aim of the study was to develop a platform to monitor and evaluate care homes using heterogeneous data sources for a French startup company. The study found that there was no current system to supervise healthcare resources in these facilities with live data. To address this, a digital platform was proposed that would integrate information from various sources, including IoT devices, existing software systems and digital documents. The proposed platform, which would be built from scratch, includes a data collection and processing system, and a blockchain to store the processed data. The platform would also include a dashboard with features, Key Performance Indicators (KPIs), and graphs for stakeholders to access.   The research would focus on the first two objectives of the proposed platform, which are design a platform for real time access to heterogeneous data sources and generate derivative dataset (generate transformed data set from the primary raw data set) with access but not visibility of the accessible zero knowledge heterogeneous data in secured way. Zero knowledge refers to fetching data from primary data sources and present it to users of in another format which can be understand easily, while hiding actual data and transforming mechanism (Goldreich, 2004). The proposed solution should be versatile and extensible to incorporate additional data sources and generate derivative datasets in a scalable manner. The study concludes that utilizing the Design Science Research Methodology (DSRM) to investigate and identify an ideal solution to the research topics is both challenging and stimulating. Additionally, the findings can be applied by other researchers working in related fields.   In summary, the proposed solution involves the development of a digital platform based on information system theories and technologies that will enrich the area of Information Systems for similar problems. The thesis will evaluate existing research on these theories and technologies and recommend the best solution by integrating the most suitable set of theories and technologies for the given problem. This will provide a practical solution for the immediate needs of the startup company and contribute to future research on similar problems.

Not all companies are equally aggressive in their pursuit of corporate tax avoidance, which explains intensive research on the determinants of tax avoidance. Many determinants have been investigated, but the process of tax avoidance, and the relationships between corporate tax avoidance, longtermism (indicative of a stakeholder-orientated corporate culture), and CEO characteristics (informed by upper-echelon theory), are not yet fully understood. Much of previous research is conceptualised from theories such as principal-agent theory. This study investigates the influence of stakeholder orientation, using corporate culture, on corporate tax avoidance, in response to calls for more research using stakeholder theory. A mixed-method approach is used. The quantitative stream uses regressions to investigate the relationship between corporate tax avoidance, corporate culture, and tax-knowledgeable CEOs, based on a sample of 112 large, listed South African companies, studied over a period of 15 years. The South African setting allows the operationalisation of a tax-knowledgeable CEO, based the homogenous nature of CEOs' qualifications in South Africa, where many are chartered accountants. The results suggest that long-term oriented companies pay more tax on average. The results further suggest that tax knowledgeable CEOs are associated with more tax avoidance. The qualitative stream conducts eleven interviews with corporate tax advisors, showing the influence of corporate culture and CEO characteristics on corporate tax avoidance processes, but also how corporate culture and CEO-characteristics mutually inform each other. Altogether, the evidence indicates that the effect of corporate culture is less static than expected, and that the influence of corporate culture on tax avoidance can transcend the influence of CEO-characteristics, as an upperechelon effect. The interviews suggest mechanisms used by CEOs to influence tax culture, such as the creation of a company-wide awareness of the strategic importance of low effective tax rates. These results also indicate the ethical dilemma faced by executives of large companies when considering the use of tax-deductible corporate social responsibility initiatives, not to benefit shareholders or agents, but rather to benefit society as a corporate stakeholder, when governments would not.

No description available.

This thesis explores how research is implicated in the constitution of post-war environments, and gives an account of being and becoming a researcher in post-war Bosnia. My main contention is that when peace and conflict researchers conduct research in post-war contexts, their presence, practices, and the consequential production of knowledge and representations, have political effects. I argue that the implications of this have not been fully explained, acknowledged, or problematised within Conflict Resolution, which tends to rely on research approaches and assumptions taken from ‘normal’ science. This thesis suggests how reflexivity and alternatives methodologies, including visual research might be used to represent the emotional, sensory, and often intangible elements of post-war realities. It enacts an engagement in the politics of research and uses reflexive writing and visual methods to draw attention to the importance of the relational aspects of research in postwar environments. Visual journeys are also used to argue that visual methods can provide a way of revisiting the epistemological and ontological assumptions about lived experiences and realities in post-war settings. The thesis is based upon one year of ethnographic fieldwork undertaken in Bosnia, and is also informed by eighteen months of volunteer work with a Bosnian Community Centre in Dewsbury, West Yorkshire. / Economic and Social Research Council (ESRC)