• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 316
  • 113
  • 91
  • 76
  • 36
  • 22
  • 12
  • 8
  • 7
  • 5
  • 5
  • 5
  • 4
  • 3
  • 2
  • Tagged with
  • 861
  • 861
  • 142
  • 124
  • 121
  • 112
  • 111
  • 101
  • 97
  • 85
  • 82
  • 80
  • 73
  • 67
  • 66
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
111

Evaluation of a Water Budget Model for Created Wetland Design and Comparative Natural Wetland Hydroperiods

Sneesby, Ethan Paul 04 April 2019 (has links)
Wetland impacts in the Mid-Atlantic USA are frequently mitigated via wetland creation in former uplands. Regulatory approval requires a site-specific water budget that predicts the annual water level regime (hydroperiod). However, many studies of created wetlands indicate that post-construction hydroperiods frequently are not similar to impacted wetland systems. My primary objective was to evaluate a water budget model, Wetbud (Basic model), through comparison of model output to on-site water level data for two created forested wetlands in Northern Virginia. Initial sensitivity analyses indicated that watershed curve number and outlet height had the most leverage on model output. Addition of maximum depth of water level drawdown greatly improved model accuracy. I used Nash-Sutcliffe efficiency (NSE) and root mean squared error (RMSE) to evaluate goodness of fit of model output against site monitoring data. The Basic model reproduced the overall seasonal hydroperiod well once fully parameterized, despite NSE values ranging from -0.67 to 0.41 in calibration and from -4.82 to -0.26 during validation. For RMSE, calibration values ranged from 5.9 cm to 12.7 cm during calibration and from 8.2 cm to 18.5 cm during validation. My second objective was to select a group of "design target hydroperiods" for common Mid-Atlantic USA wetland types. From > 90 sites evaluated, I chose four mineral flats, three riverine wetlands, and one depressional wetland that met all selection criteria. Taken together, improved wetland water budget modeling procedures (like Wetbud) combined with the use of appropriate target hydroperiod information should improve the success of wetland creation efforts. / Master of Science / Wetlands in the USA are defined by the combined occurrence of wetland hydrology, hydric soils, and hydrophytic vegetation. Wetlands serve to retain floodwater, sediments and nutrients within their landscape. They may serve as a source of local groundwater recharge and are home to many endangered species of plants and animals. Wetland ecosystems are frequently impacted by human activities including road-building and development. These impacts can range from the destruction of a wetland to increased nutrient contributions from storm- or wastewater. One commonly utilized option to mitigate wetland impacts is via wetland creation in former upland areas. Regulatory approval requires a site-specific water budget that predicts the average monthly water levels (hydroperiod). A hydroperiod is simply a depiction of how the elevation of water changes over time. However, many studies of created wetlands indicate that post-construction hydroperiods frequently are not representative of the impacted wetland systems. Many software packages, called models, seek to predict the hydroperiod for different wetland systems. Improving and vetting these models help to improve our understanding of how these systems function. My primary objective was to evaluate a water budget model, Wetbud (Basic model), through comparison of model output to onsite water level data for two created forested wetlands in Northern Virginia. Initial analyses indicated that watershed curve number (CN) and outlet height had the most influence on model output. Addition of a maximum depth of water level drawdown below the ground surface greatly improved model accuracy. I used statistical analyses to compare model output to site monitoring data. The Basic model reproduced the overall seasonal hydroperiod well once inputs were set to optimum values (calibration). Statistical results for the calibration varied between excellent and acceptable for our selected measure of accuracy, the root mean squared error. My second objective was to select a grouping of “design target hydroperiods” for common Mid-Atlantic USA wetland types. From > 90 sites evaluated, I chose four mineral flats, three riverine wetlands, and one depressional wetland that met all selection criteria. Taken together, improved wetland water budget modeling procedures (like Wetbud) combined with the use of appropriate target hydroperiod information should improve the success of wetland creation efforts.
112

MATLODE: A MATLAB ODE Solver and Sensitivity Analysis Toolbox

D'Augustine, Anthony Frank 04 May 2018 (has links)
Sensitivity analysis quantifies the effect that of perturbations of the model inputs have on the model's outputs. Some of the key insights gained using sensitivity analysis are to understand the robustness of the model with respect to perturbations, and to select the most important parameters for the model. MATLODE is a tool for sensitivity analysis of models described by ordinary differential equations (ODEs). MATLODE implements two distinct approaches for sensitivity analysis: direct (via the tangent linear model) and adjoint. Within each approach, four families of numerical methods are implemented, namely explicit Runge-Kutta, implicit Runge-Kutta, Rosenbrock, and single diagonally implicit Runge-Kutta. Each approach and family has its own strengths and weaknesses when applied to real world problems. MATLODE has a multitude of options that allows users to find the best approach for a wide range of initial value problems. In spite of the great importance of sensitivity analysis for models governed by differential equations, until this work there was no MATLAB ordinary differential equation sensitivity analysis toolbox publicly available. The two most popular sensitivity analysis packages, CVODES [8] and FATODE [10], are geared toward the high performance modeling space; however, no native MATLAB toolbox was available. MATLODE fills this need and offers sensitivity analysis capabilities in MATLAB, one of the most popular programming languages within scientific communities such as chemistry, biology, ecology, and oceanogra- phy. We expect that MATLODE will prove to be a useful tool for these communities to help facilitate their research and fill the gap between theory and practice. / Master of Science
113

Improving Runoff Estimation at Ungauged Catchments

Zelelew, Mulugeta January 2012 (has links)
Water infrastructures have been implemented to support the vital activities of human society. The infrastructure developments at the same time have interrupted the natural catchment response characteristics, challenging society to implement effective water resources planning and management strategies. The Telemark area in southern Norway has seen a large number of water infrastructure developments, particularly hydropower, over more than a century. Recent developments in decision support tools for flood control and reservoir operation has raised the need to compute inflows from local catchments, most of which are regulated or have no observed data. This has contributed for the motivation of this PhD thesis work, with an aim of improving runoff estimation at ungauged catchments, and the research results are presented in four manuscript scientific papers.  The inverse distance weighting, inverse distance squared weighting, ordinary kriging, universal kriging and kriging with external drift were applied to analyse precipitation variability and estimate daily precipitation in the study area. The geostatistical based univariate and multivariate map-correlation concepts were applied to analyse and physically understand regional hydrological response patterns. The Sobol variance based sensitivity analysis (VBSA) method was used to investigate the HBV hydrological model parameterization significances on the model response variations and evaluate the model’s reliability as a prediction tool. The HBV hydrological model space transferability into ungauged catchments was also studied.  The analyses results showed that the inverse distance weighting variants are the preferred spatial data interpolation methods in areas where relatively dense precipitation station network can be found.  In mountainous areas and in areas where the precipitation station network is relatively sparse, the kriging variants are the preferred methods. The regional hydrological response correlation analyses suggested that geographic proximity alone cannot explain the entire hydrological response correlations in the study area. Besides, when the multivariate map-correlation analysis was applied, two distinct regional hydrological response patterns - the radial and elliptical-types were identified. The presence of these hydrological response patterns influenced the location of the best-correlated reference streamgauges to the ungauged catchments. As a result, the nearest streamgauge was found the best-correlated in areas where the radial-type hydrological response pattern is the dominant. In area where the elliptical-type hydrological response pattern is the dominant, the nearest reference streamgauge was not necessarily the best-correlated. The VBSA verified that varying up to a minimum of four to six influential HBV model parameters can sufficiently simulate the catchments' responses characteristics when emphasis is given to fit the high flows. Varying up to a minimum of six influential model parameters is necessary to sufficiently simulate the catchments’ responses and maintain the model performance when emphasis is given to fit the low flows. However, varying more than nine out of the fifteen HBV model parameters will not make any significant change on the model performance.  The hydrological model space transfer study indicated that estimation of representative runoff at ungauged catchments cannot be guaranteed by transferring model parameter sets from a single donor catchment. On the other hand, applying the ensemble based model space transferring approach and utilizing model parameter sets from multiple donor catchments improved the model performance at the ungauged catchments. The result also suggested that high model performance can be achieved by integrating model parameter sets from two to six donor catchments. Objectively minimizing the HBV model parametric dimensionality and only sampling the sensitive model parameters, maintained the model performance and limited the model prediction uncertainty.
114

Análise de Sensibilidade Topológica / Topological Sensitivity Analysis

Novotny, Antonio André 13 February 2003 (has links)
Made available in DSpace on 2015-03-04T18:50:29Z (GMT). No. of bitstreams: 1 Apresentacao.pdf: 103220 bytes, checksum: c76acce6b0debd619e9db9533aa20f11 (MD5) Previous issue date: 2003-02-13 / Conselho Nacional de Desenvolvimento Cientifico e Tecnologico / The Topological Sensitivity Analysis results in a scalar function, denoted as Topological Derivative, that supplies for each point of the domain of definition of the problem the sensitivity of a given cost function when a small hole is created. However, when a hole is introduced, it is no longer possible to stablish a homeomorphism between the domains. Due to this mathematical difficulty the Topological Derivative may become restrictive, nevertheless be extremely general. Thus, in the present work it is proposed a new method to calculte the Topological Derivative via Shape Sensitivity Analysis. This result, formally proved through a theorem, leads to a simpler and more general methodology than the others found in the literature. The Topological Sensitivity Analysis is performed for several Engineering problems, and the obtained results are used to improve the design of mechanical devices by introducing holes. The same theory developed to calculate the Topological Derivative is used to determine the sensitivity of the cost function when a small incrustation is introduced in each position of the domain, resulting in a novel concept denoted as Configurational Sensitivity Analysis, being discussed some possible applications in the context of Inverse Problems and modelling of phenomena that experiment changes in the physical properties of the medium. Thus, the methodology developed in the present work results in a framework with potential applications in Topology Optimization, Inverse Problems and Mechanical Modelling, which may be seen, from now on, not only as a method to calculate the Topological Derivative, but as a promising research area in Computational Modelling. / A análise de Sensibilidade Topológica resulta em uma função escalar, denominada Derivada Topológica, que fornece para cada ponto do domínio de definição do problema a sensibilidade de uma dada função custo quando um pequeno furo é criado. No entanto, ao introduzir um furo, não é mais possível estabelecer um homeomorfismo entre os domínios envolvidos. Devido a essa dificuldade matemática a Derivada Topológica pode se tornar restritiva, não obstante seja extremamente geral. No presente trabalho, portanto, é proposto um novo método de cálculo da Derivada Topológica via Análise de Sensibilidade à Mudança de Forma. Este resultado, formalmente demonstrado através de um teorema, conduz a uma metodologia mais simples e geral do que as demais encontradas na literatura. A Análise de Sensibilidade Topológica é então realizada em diversos problemas da Engenharia e os resultados obtidos são empregados para melhorar o projeto de componentes mecânicos mediante a introdução de furos. A mesma teoria desenvolvida para calcular a Derivada Topológica é utilizada para determinar a sensibilidade da função custo ao introduzir uma pequena incrustação numa dada posição do domínio, resultando em um novo conceito denominado Análise de Sensibilidade Configuracional, sendo discutidas suas possíveis aplicações no contexto de Problemas Inversos e de modelagem de fenômenos que experimentam mudanças nas propriedades físicas do meio. Assim, a metodologia aqui desenvolvida é uma ferramenta em potencial tanto de Otimização Topológica quanto de Problemas Inversos e de Modelagem Mecânica, podendo ser vista, a partir de agora, não somente como um método de cálculo da Derivada Topológica, mas como uma promissora área de pesquisa em Modelagem Computacional.
115

Análise de Sensibilidade Topológica / Topological Sensitivity Analysis

Antonio André Novotny 13 February 2003 (has links)
The Topological Sensitivity Analysis results in a scalar function, denoted as Topological Derivative, that supplies for each point of the domain of definition of the problem the sensitivity of a given cost function when a small hole is created. However, when a hole is introduced, it is no longer possible to stablish a homeomorphism between the domains. Due to this mathematical difficulty the Topological Derivative may become restrictive, nevertheless be extremely general. Thus, in the present work it is proposed a new method to calculte the Topological Derivative via Shape Sensitivity Analysis. This result, formally proved through a theorem, leads to a simpler and more general methodology than the others found in the literature. The Topological Sensitivity Analysis is performed for several Engineering problems, and the obtained results are used to improve the design of mechanical devices by introducing holes. The same theory developed to calculate the Topological Derivative is used to determine the sensitivity of the cost function when a small incrustation is introduced in each position of the domain, resulting in a novel concept denoted as Configurational Sensitivity Analysis, being discussed some possible applications in the context of Inverse Problems and modelling of phenomena that experiment changes in the physical properties of the medium. Thus, the methodology developed in the present work results in a framework with potential applications in Topology Optimization, Inverse Problems and Mechanical Modelling, which may be seen, from now on, not only as a method to calculate the Topological Derivative, but as a promising research area in Computational Modelling. / A análise de Sensibilidade Topológica resulta em uma função escalar, denominada Derivada Topológica, que fornece para cada ponto do domínio de definição do problema a sensibilidade de uma dada função custo quando um pequeno furo é criado. No entanto, ao introduzir um furo, não é mais possível estabelecer um homeomorfismo entre os domínios envolvidos. Devido a essa dificuldade matemática a Derivada Topológica pode se tornar restritiva, não obstante seja extremamente geral. No presente trabalho, portanto, é proposto um novo método de cálculo da Derivada Topológica via Análise de Sensibilidade à Mudança de Forma. Este resultado, formalmente demonstrado através de um teorema, conduz a uma metodologia mais simples e geral do que as demais encontradas na literatura. A Análise de Sensibilidade Topológica é então realizada em diversos problemas da Engenharia e os resultados obtidos são empregados para melhorar o projeto de componentes mecânicos mediante a introdução de furos. A mesma teoria desenvolvida para calcular a Derivada Topológica é utilizada para determinar a sensibilidade da função custo ao introduzir uma pequena incrustação numa dada posição do domínio, resultando em um novo conceito denominado Análise de Sensibilidade Configuracional, sendo discutidas suas possíveis aplicações no contexto de Problemas Inversos e de modelagem de fenômenos que experimentam mudanças nas propriedades físicas do meio. Assim, a metodologia aqui desenvolvida é uma ferramenta em potencial tanto de Otimização Topológica quanto de Problemas Inversos e de Modelagem Mecânica, podendo ser vista, a partir de agora, não somente como um método de cálculo da Derivada Topológica, mas como uma promissora área de pesquisa em Modelagem Computacional.
116

Robust design : Accounting for uncertainties in engineering

Lönn, David January 2008 (has links)
This thesis concerns optimization of structures considering various uncertainties. The overall objective is to find methods to create solutions that are optimal both in the sense of handling the typical load case and minimising the variability of the response, i.e. robust optimal designs. Traditionally optimized structures may show a tendency of being sensitive to small perturbations in the design or loading conditions, which of course are inevitable. To create robust designs, it is necessary to account for all conceivable variations (or at least the influencing ones) in the design process. The thesis is divided in two parts. The first part serves as a theoretical background to the second part, the two appended articles. This first part includes the concept of robust design, basic statistics, optimization theory and meta modelling. The first appended paper is an application of existing methods on a large industrial example problem. A sensitivity analysis is performed on a Scania truck cab subjected to impact loading in order to identify the most influencing variables on the crash responses. The second paper presents a new method that may be used in robust optimizations, that is, optimizations that account for variations and uncertainties. The method is demonstrated on both an analytical example and a Finite Element example of an aluminium extrusion subjected to axial crushing. / ROBDES
117

Computational Journalism: from Answering Question to Questioning Answers and Raising Good Questions

Wu, You January 2015 (has links)
<p>Our media is saturated with claims of ``facts'' made from data. Database research has in the past focused on how to answer queries, but has not devoted much attention to discerning more subtle qualities of the resulting claims, e.g., is a claim ``cherry-picking''? This paper proposes a Query Response Surface (QRS) based framework that models claims based on structured data as parameterized queries. A key insight is that we can learn a lot about a claim by perturbing its parameters and seeing how its conclusion changes. This framework lets us formulate and tackle practical fact-checking tasks --- reverse-engineering vague claims, and countering questionable claims --- as computational problems. Within the QRS based framework, we take one step further, and propose a problem along with efficient algorithms for finding high-quality claims of a given form from data, i.e. raising good questions, in the first place. This is achieved to using a limited number of high-valued claims to represent high-valued regions of the QRS. Besides the general purpose high-quality claim finding problem, lead-finding can be tailored towards specific claim quality measures, also defined within the QRS framework. An example of uniqueness-based lead-finding is presented for ``one-of-the-few'' claims, landing in interpretable high-quality claims, and an adjustable mechanism for ranking objects, e.g. NBA players, based on what claims can be made for them. Finally, we study the use of visualization as a powerful way of conveying results of a large number of claims. An efficient two stage sampling algorithm is proposed for generating input of 2d scatter plot with heatmap, evalutaing a limited amount of data, while preserving the two essential visual features, namely outliers and clusters. For all the problems, we present real-world examples and experiments that demonstrate the power of our model, efficiency of our algorithms, and usefulness of their results.</p> / Dissertation
118

The determinants of voter turnout in OECD : An aggregated cross-national study using panel data

Olsén Ingefeldt, Niclas January 2016 (has links)
This paper examines in a descriptive manner how two groups of variables, institutional and socio-economic, correlate with voter turnout respectively and if their magnitude have changed over time in OECD countries. Previous research is often based on data from the 70’s and 80’s. Since then, voter turnout in democratic countries has decreased and more citizens do not use their fundamental democratic right of being involved in the process of choosing their representatives. To answer the paper hypotheses i.e. analyzing what factors that correlates with voter turnout, panel data between 1980 and 2012 are used which is estimated by an OLS approach. The outcome of the empirical estimations indicates that 13 out of 19 variables have a significant relationship with turnout. Most of the variables magnitudes are a bit lower than previous literature. From the time sensitivity analysis the result indicates that voters are less influenced by the significant variables that focus on the voting cost. It seems that voters in the 21st century meet voting costs in different manner than previously.
119

Analys av solelinstallationer på olika fastighetstyper : En studie om möjligheter och hinder

Nilsson, Sanna January 2016 (has links)
Generering av el med hjälp av solen står idag för en väldigt liten andel av Sveriges totala genereringav el. För att komma upp till en högre nivå krävs inte enorma solcellsparker över hela Sverige, utan tvärtom skulle det kunna gå att använda redan befintliga tak. Det förhållandet är bara ett av flera som påvisar behovet av större kunskapsspridning om dagens energisystem och solcellsteknik. Det finns också ett behov av ökad kunskap om karaktäristiska svenska hus- och taktyper och om vad som är möjligt att göra med varierande slag av solcellsteknik, för att konvertera de olika hustypernas tak till en liten energikälla. Ren solenergi kan inte ensam konkurrera ut fossila bränslen, men det finns god potential för en mycket högre andel av den än vad som är installerat idag. Wallenstam AB är ett energimedvetet fastighetsbolag som bland annat är verksamma i Göteborg. Deras intresse av förnybar energi och av att ersätta fossilt bränsle med mer miljövänlig teknik gav upphov till ett samarbete mellan författaren och Wallenstam AB. Arbetets första del syftar till att inbringa mer och fördjupad kunskap inom ämnet solceller och solcellsanläggningar. Syftet med arbetets andra del är att undersöka vilka möjligheter och hinder det finns med solcellsinstallationer på några olika typiska svenska fastighetstyper. En projektering genomförs på tre olika fastighetstyper i Göteborgsområdet; en industri/kontorslokal, ett modernt flerbostadshus och en fastighet i centrala Göteborg med både bostäder och kommersiell verksamhet. Målet är att utifrån varje fastighets förutsättningar finna den eller de mest lämpade solcellspanelerna för respektive fastighet med avseende på ekonomisk fördelaktighet, estetik samt i vad som är tekniskt möjligt utifrån exempelvis tidigare installerade energisystem. Rapporten och dess resultat är skapat utifrån litteraturstudier, platsbesök på fastigheter, mätningar på ritningar och satellitkartor, beräkningar för hand, samt modellering i PVsyst. Fortlöpande diskussion med personer inom solenergibranschen har också hållits. För att beräkna respektive anläggnings elproduktionskostnad samt för känslighetsanalyser används en webbaserad beräkningsapplikation, tillhörande rapporten El från nya och framtida anläggningar 2014. Huvudresultat är att endast två av de tekniskt möjliga anläggningarna har en elproduktionskostnad som är i närheten av det jämförande elpriset på 0,75 kr/kWh. Det är de polykristallina solcellsanläggningarna på Kvillebäcken 3:1 och Mölnlycke 1:1. Beräkningarna visar på att anläggningarna med polykristallina solcellspaneler på Kvillebäcken 3:1 och Mölnlycke Fabriker 1:1 är riktigt konkurrenskraftiga om kalkylräntan sänks från 4 % till 2 %, eller om investeringskostnaderna minskar med 15 %. På fastigheten Inom Vallgraven 26:8 ligger samtliga elproduktionskostnader över en krona per kilowattimme, men installation av solcellsteknik på en sådan central byggnad skulle kunna ha ett marknadsföringsvärde. / Generation of electricity by use of solar irradiation is today a very small part of the total electricity generation in Sweden. It is not necessary to build a great amount of solar parks all over Sweden to reach a higher level, it could instead be possible by using already existing rooftops. That is one of the situations that indicates the need of a greater knowledge dissemination, about today’s energysystem and the technology of photovoltaics. It also exists a demand of knowledge about characteristic Swedish houses and rooftops. To convert the different kinds of rooftops to small powersources, there is also a demand of knowledge about installations that is possible to do with different kinds of photovoltaics. Although, solar power alone cannot compete with fossil fuels, but it should have a good possibility to reach a much higher level than what exists today. Wallenstam AB is anenergy-conscious company within the real estate business in Gothenburg. Their interests in renewable energy and their ambition to replace fossil fuel with more environment-friendly technology facilitated this cooperation.The first part of the report aims to get more and deeper knowledge about the subject photovoltaics and solar plants. The second part of the report aims to investigate what possibilities and impediments there is with photovoltaic installations at different kinds of typical Swedish houses. A planning work is made at three different types of buildings in the area of Gothenburg. One at an industry/office space, one at a modern apartment block and one at a central building in Gothenburg that has both apartments and commercialized activity. The goal is to find the most suitable photovoltaic installation to each of the three buildings, based on economic advantageousness, appearance and esthetic, and the possibilities with the technology of earlier installed energy systems.The report and the result are formed on the basis of literature studies, site visits at the buildings, measurements at drawings and satellite maps, calculations by hand and modelling in the software PVsyst. Many discussions with people in the solar energy industry were also held. To calculate the Levelized Cost Of Energy (LCOE) and to perform the sensitivity analysis, a web-based calculator was used. The web-based calculator belongs to the report El från nya och framtida anläggningar 2014. The main result shows that only two of the possible photovoltaic installations gets a LCOE that is competitive relative the comparative electricity price at 0,75 SEK/kWh. Installations with polycrystalline solar panels at Kvillebäcken 3:1 and Mölnlycke 1:1. The result also shows that the two installations with polycrystalline solar panels at Kvillebäcken 3:1 and Mölnlycke Fabriker is really competitive if the capital interest rate is reduced from 4 % to 2 %, or if the investment cost isreduced by 15 %. At the property Inom Vallgraven 26:8, the LCOE for all possible installations are over one Swedish krona per kilowatt hour, but an installation with solar panels at a central building like that could have a marketing value. It would also show Wallenstams standpoint for renewable energy, new technology and a sustainable energy system.
120

Statistical Approaches for Handling Missing Data in Cluster Randomized Trials

Fiero, Mallorie H. January 2016 (has links)
In cluster randomized trials (CRTs), groups of participants are randomized as opposed to individual participants. This design is often chosen to minimize treatment arm contamination or to enhance compliance among participants. In CRTs, we cannot assume independence among individuals within the same cluster because of their similarity, which leads to decreased statistical power compared to individually randomized trials. The intracluster correlation coefficient (ICC) is crucial in the design and analysis of CRTs, and measures the proportion of total variance due to clustering. Missing data is a common problem in CRTs and should be accommodated with appropriate statistical techniques because they can compromise the advantages created by randomization and are a potential source of bias. In three papers, I investigate statistical approaches for handling missing data in CRTs. In the first paper, I carry out a systematic review evaluating current practice of handling missing data in CRTs. The results show high rates of missing data in the majority of CRTs, yet handling of missing data remains suboptimal. Fourteen (16%) of the 86 reviewed trials reported carrying out a sensitivity analysis for missing data. Despite suggestions to weaken the missing data assumption from the primary analysis, only five of the trials weakened the assumption. None of the trials reported using missing not at random (MNAR) models. Due to the low proportion of CRTs reporting an appropriate sensitivity analysis for missing data, the second paper aims to facilitate performing a sensitivity analysis for missing data in CRTs by extending the pattern mixture approach for missing clustered data under the MNAR assumption. I implement multilevel multiple imputation (MI) in order to account for the hierarchical structure found in CRTs, and multiply imputed values by a sensitivity parameter, k, to examine parameters of interest under different missing data assumptions. The simulation results show that estimates of parameters of interest in CRTs can vary widely under different missing data assumptions. A high proportion of missing data can occur among CRTs because missing data can be found at the individual level as well as the cluster level. In the third paper, I use a simulation study to compare missing data strategies to handle missing cluster level covariates, including the linear mixed effects model, single imputation, single level MI ignoring clustering, MI incorporating clusters as fixed effects, and MI at the cluster level using aggregated data. The results show that when the ICC is small (ICC ≤ 0.1) and the proportion of missing data is low (≤ 25\%), the mixed model generates unbiased estimates of regression coefficients and ICC. When the ICC is higher (ICC > 0.1), MI at the cluster level using aggregated data performs well for missing cluster level covariates, though caution should be taken if the percentage of missing data is high.

Page generated in 0.4694 seconds