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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Construction, characterization and humoral responses to eukaryotic plasmid expressing the VZV qE antigen

Hasan, Uzma Ayesha January 2000 (has links)
No description available.
2

The Impact of Near-Duplicate Documents on Information Retrieval Evaluation

Khoshdel Nikkhoo, Hani 18 January 2011 (has links)
Near-duplicate documents can adversely affect the efficiency and effectiveness of search engines. Due to the pairwise nature of the comparisons required for near-duplicate detection, this process is extremely costly in terms of the time and processing power it requires. Despite the ubiquitous presence of near-duplicate detection algorithms in commercial search engines, their application and impact in research environments is not fully explored. The implementation of near-duplicate detection algorithms forces trade-offs between efficiency and effectiveness, entailing careful testing and measurement to ensure acceptable performance. In this thesis, we describe and evaluate a scalable implementation of a near-duplicate detection algorithm, based on standard shingling techniques, running under a MapReduce framework. We explore two different shingle sampling techniques and analyze their impact on the near-duplicate document detection process. In addition, we investigate the prevalence of near-duplicate documents in the runs submitted to the adhoc task of TREC 2009 web track.
3

The Impact of Near-Duplicate Documents on Information Retrieval Evaluation

Khoshdel Nikkhoo, Hani 18 January 2011 (has links)
Near-duplicate documents can adversely affect the efficiency and effectiveness of search engines. Due to the pairwise nature of the comparisons required for near-duplicate detection, this process is extremely costly in terms of the time and processing power it requires. Despite the ubiquitous presence of near-duplicate detection algorithms in commercial search engines, their application and impact in research environments is not fully explored. The implementation of near-duplicate detection algorithms forces trade-offs between efficiency and effectiveness, entailing careful testing and measurement to ensure acceptable performance. In this thesis, we describe and evaluate a scalable implementation of a near-duplicate detection algorithm, based on standard shingling techniques, running under a MapReduce framework. We explore two different shingle sampling techniques and analyze their impact on the near-duplicate document detection process. In addition, we investigate the prevalence of near-duplicate documents in the runs submitted to the adhoc task of TREC 2009 web track.
4

Performance Evaluation of Recycled Asphalt Shingles (RAS) in Hot Mix Asphalt (HMA): An Ontario Perspective

Islam, Riyad-UL 07 April 2011 (has links)
Today, a large quantity of waste is generated from the replacement of residential and commercial roofs. Many of the roofs being upgraded with previously constructed from asphalt shingles. Recycled Asphalt Shingles (RAS) contain nearly 30% of asphalt cement by mass, which can be a useful additive to asphalt pavements. In addition, shingles can offer significant potential savings through recycling and recovery as a construction material in flexible pavement. Currently, one and a half million tons of roofing shingle waste is generated each year in Canada related to the replacement of residential and commercial roofs and 90% of this valuable material is sent to landfills. If engineered properly, the addition of RAS into Hot Mix Asphalt (HMA) can provide significant benefits. The University of Waterloo’s Centre for Pavement and Transportation Technology (CPATT) is committed to working with public and private sector partners to develop sustainable technologies for the pavement industry. Using RAS in HMA can lead to economical, environmental and social benefits. Examples of which are reduced waste going to landfills and a reduction in the quantity of virgin material required. This research has involved the Ontario Centres of Excellence (OCE) and Miller Paving Limited. It was conducted to evaluate the performance of HMA containing RAS in both field and laboratory tests. A varying percentage of RAS was added to six common Ontario surface and binder layer of asphalt mixes. The intent was to determine if RAS could be added to improve performance and provide longer term cost savings. Laboratory testing was performed to evaluate the mix behavior. The elastic properties, fatigue life and resistance to thermal cracking were all evaluated at the CPATT laboratory. The characteristics of the mixes were evaluated by carrying out Dynamic Modulus, Resilient Modulus, Flexural Fatigue and Thermal Stress Restrained Specimen Test (TSRST) tests following American Association of State Highway and Transportation Officials (AASHTO) and American Society for Testing and Materials (ASTM) standards. Field test sections were constructed from HMA containing RAS to monitor the pavement behavior under natural environmental and traffic loading conditions. Evaluation of the field sites was performed using a Portable Falling Weight Deflectometer (PFWD) and carrying out distress surveys following the Ministry of Transportation Ontario (MTO) guidelines. The results to date show the sections performing very well with minimal to no distress developing. The results of the laboratory testing and field performance evaluations have shown encouraging results for the future use of RAS in HMA. If RAS can properly be engineered into HMA it can be a useful additive in both the surface and binder layers of the flexible pavement structure. Ultimately, the use of RAS in HMA can provide both an environmentally friendly and cost effective solution to the Ontario paving industry.
5

Evaluation of the Effect of Recycled Asphalt Shingles on Ontario Hot Mix Pavement

Ddamba, Shirley Jacqueline 23 September 2011 (has links)
Due to the 15-20 year life span of roofing shingles, 1.5 million tonnes of asphalt roofing shingles are being demolished and replaced annually in Canada from both residential and commercial facilities. These roofing shingles are manufactured from very high quality materials which are considered a valuable by-product. Recycled Asphalt Shingles (RAS), a product containing approximately 30% asphalt cement by mass, is a valuable additive to Hot Mix Asphalt (HMA) pavements and a potential savings for the construction industry. Recycling of demolished asphalt shingles is a significant new step forward in abating the need to put the waste into landfills. This re-use creates a great opportunity in reducing materials being dumped at landfills while providing an additive to HMA mixtures for paving. Therefore, this leads to economic, environmental, and social benefits for all the stakeholders and road users such as reduced need for landfill space, conservation of virgin materials and environment, and financial saving. The research involved evaluating the use of demolished shingles in six typical Ontario Hot Mix Asphalt (HMA) mixtures; HL 3 (1.5% RAS, 13.5% RAP), binder layer mixes SP19 (6% RAS, and 3% RAS, 25% RAP), surface layer mixes SP12.5 FC 1(3% RAS, 17% RAP) and SP12.5 FC2 (6% RAS and 3% RAS, 12% RAP). The six HMA mixes were also designed to contain Recycled Asphalt Pavement (RAP). This further complicated the research as both RAP and RAS were added. All mixes were designed and tested at CPATT laboratory; in addition a test section was paved at the CPATT Test Track. This research involved both laboratory and field evaluations of mixes containing RAS to develop pavement performance modeling for all six mixes using the updated Mechanistic-Empirical Pavement Design Guide (MEPDG). A life-cycle assessment of the six HMA mixes was performed to quantify the environmental impacts using the Pavement Life-Cycle Assessment Tool for Environmental and Economic Effects (PaLATE) and rigorous economic costs/benefits were assessed using Life Cycle Cost Analysis (LCCA). Calibrations of models for Ontario conditions were completed. Test slabs were also constructed to simulate climatic changes by running freeze-thaw cycles based on weather data over the past ten years. Three field test sections located in the Town of Markham and one at the CPATT Test Track were monitored and assessed under as part of the research. Regular pavement condition assessments were carried out on all the test sections by performing non-destructive tests using a Portable Falling Weight Deflectometer (PFWD) and distress survey in accordance with the Ministry of Transportation (MTO) guidelines. The CPATT Test Track was evaluated with both the PFWD and surface distresses, whereas only distress surveys were performed on the three residential streets in the Town of Markham. The evaluations demonstrated that the pavements were in good conditions throughout the monitoring period of the research (four years for the three residential streets in the Town of Markham and two years for the CPATT Test Track). The structural analysis using the MEPDG indicated that Mix 3: SP19 3% RAS and 25% RAP had the best performance followed by Mix 2: SP19 6% RAS when considering all factors in the Life-Cycle Assessment. Mix 3 exhibited maximum savings on environmental emissions, energy and water usage, best adoptability to climatic change and skid resistance properties with minimal life cycle costs. The pavement performance and life-cycle assessment modeling demonstrated encouraging results for the use of RAS in HMA pavements from which guidelines were developed for its use. It is important to note that careful mix design should be carried out when RAS is added to HMA especially when RAP is also used. This includes measuring of all key properties especially at low and high temperatures. In short, RAS can be a valuable additive in both surface and binder layers of HMA pavements. It provides an environmentally friendly and cost-effective innovation for the Ontario paving industry and can be considered for usage elsewhere with appropriate engineering.
6

Performance Evaluation of Recycled Asphalt Shingles (RAS) in Hot Mix Asphalt (HMA): An Ontario Perspective

Islam, Riyad-UL 07 April 2011 (has links)
Today, a large quantity of waste is generated from the replacement of residential and commercial roofs. Many of the roofs being upgraded with previously constructed from asphalt shingles. Recycled Asphalt Shingles (RAS) contain nearly 30% of asphalt cement by mass, which can be a useful additive to asphalt pavements. In addition, shingles can offer significant potential savings through recycling and recovery as a construction material in flexible pavement. Currently, one and a half million tons of roofing shingle waste is generated each year in Canada related to the replacement of residential and commercial roofs and 90% of this valuable material is sent to landfills. If engineered properly, the addition of RAS into Hot Mix Asphalt (HMA) can provide significant benefits. The University of Waterloo’s Centre for Pavement and Transportation Technology (CPATT) is committed to working with public and private sector partners to develop sustainable technologies for the pavement industry. Using RAS in HMA can lead to economical, environmental and social benefits. Examples of which are reduced waste going to landfills and a reduction in the quantity of virgin material required. This research has involved the Ontario Centres of Excellence (OCE) and Miller Paving Limited. It was conducted to evaluate the performance of HMA containing RAS in both field and laboratory tests. A varying percentage of RAS was added to six common Ontario surface and binder layer of asphalt mixes. The intent was to determine if RAS could be added to improve performance and provide longer term cost savings. Laboratory testing was performed to evaluate the mix behavior. The elastic properties, fatigue life and resistance to thermal cracking were all evaluated at the CPATT laboratory. The characteristics of the mixes were evaluated by carrying out Dynamic Modulus, Resilient Modulus, Flexural Fatigue and Thermal Stress Restrained Specimen Test (TSRST) tests following American Association of State Highway and Transportation Officials (AASHTO) and American Society for Testing and Materials (ASTM) standards. Field test sections were constructed from HMA containing RAS to monitor the pavement behavior under natural environmental and traffic loading conditions. Evaluation of the field sites was performed using a Portable Falling Weight Deflectometer (PFWD) and carrying out distress surveys following the Ministry of Transportation Ontario (MTO) guidelines. The results to date show the sections performing very well with minimal to no distress developing. The results of the laboratory testing and field performance evaluations have shown encouraging results for the future use of RAS in HMA. If RAS can properly be engineered into HMA it can be a useful additive in both the surface and binder layers of the flexible pavement structure. Ultimately, the use of RAS in HMA can provide both an environmentally friendly and cost effective solution to the Ontario paving industry.
7

Evaluation of the Effect of Recycled Asphalt Shingles on Ontario Hot Mix Pavement

Ddamba, Shirley Jacqueline 23 September 2011 (has links)
Due to the 15-20 year life span of roofing shingles, 1.5 million tonnes of asphalt roofing shingles are being demolished and replaced annually in Canada from both residential and commercial facilities. These roofing shingles are manufactured from very high quality materials which are considered a valuable by-product. Recycled Asphalt Shingles (RAS), a product containing approximately 30% asphalt cement by mass, is a valuable additive to Hot Mix Asphalt (HMA) pavements and a potential savings for the construction industry. Recycling of demolished asphalt shingles is a significant new step forward in abating the need to put the waste into landfills. This re-use creates a great opportunity in reducing materials being dumped at landfills while providing an additive to HMA mixtures for paving. Therefore, this leads to economic, environmental, and social benefits for all the stakeholders and road users such as reduced need for landfill space, conservation of virgin materials and environment, and financial saving. The research involved evaluating the use of demolished shingles in six typical Ontario Hot Mix Asphalt (HMA) mixtures; HL 3 (1.5% RAS, 13.5% RAP), binder layer mixes SP19 (6% RAS, and 3% RAS, 25% RAP), surface layer mixes SP12.5 FC 1(3% RAS, 17% RAP) and SP12.5 FC2 (6% RAS and 3% RAS, 12% RAP). The six HMA mixes were also designed to contain Recycled Asphalt Pavement (RAP). This further complicated the research as both RAP and RAS were added. All mixes were designed and tested at CPATT laboratory; in addition a test section was paved at the CPATT Test Track. This research involved both laboratory and field evaluations of mixes containing RAS to develop pavement performance modeling for all six mixes using the updated Mechanistic-Empirical Pavement Design Guide (MEPDG). A life-cycle assessment of the six HMA mixes was performed to quantify the environmental impacts using the Pavement Life-Cycle Assessment Tool for Environmental and Economic Effects (PaLATE) and rigorous economic costs/benefits were assessed using Life Cycle Cost Analysis (LCCA). Calibrations of models for Ontario conditions were completed. Test slabs were also constructed to simulate climatic changes by running freeze-thaw cycles based on weather data over the past ten years. Three field test sections located in the Town of Markham and one at the CPATT Test Track were monitored and assessed under as part of the research. Regular pavement condition assessments were carried out on all the test sections by performing non-destructive tests using a Portable Falling Weight Deflectometer (PFWD) and distress survey in accordance with the Ministry of Transportation (MTO) guidelines. The CPATT Test Track was evaluated with both the PFWD and surface distresses, whereas only distress surveys were performed on the three residential streets in the Town of Markham. The evaluations demonstrated that the pavements were in good conditions throughout the monitoring period of the research (four years for the three residential streets in the Town of Markham and two years for the CPATT Test Track). The structural analysis using the MEPDG indicated that Mix 3: SP19 3% RAS and 25% RAP had the best performance followed by Mix 2: SP19 6% RAS when considering all factors in the Life-Cycle Assessment. Mix 3 exhibited maximum savings on environmental emissions, energy and water usage, best adoptability to climatic change and skid resistance properties with minimal life cycle costs. The pavement performance and life-cycle assessment modeling demonstrated encouraging results for the use of RAS in HMA pavements from which guidelines were developed for its use. It is important to note that careful mix design should be carried out when RAS is added to HMA especially when RAP is also used. This includes measuring of all key properties especially at low and high temperatures. In short, RAS can be a valuable additive in both surface and binder layers of HMA pavements. It provides an environmentally friendly and cost-effective innovation for the Ontario paving industry and can be considered for usage elsewhere with appropriate engineering.
8

Herpes zoster risk and vaccination in inflammatory bowel disease patients

Clemens, Dylan James 24 October 2018 (has links)
Patients with inflammatory bowel disease, particularly those on systemic immunosuppression, have been shown to be at increased risk of herpes zoster infection. Herpes zoster (also known as shingles) is a condition resulting from reactivation of varicella zoster virus (VZV), which causes chickenpox. VZV reactivation is thought to be due to impairment of cell-mediated immunity. Some immunosuppressive agents have been shown to be associated with higher risk for herpes zoster reactivation than others. Until recently, the only vaccine for herpes zoster was a live-attenuated vaccine, which is contraindicated in most immunosuppressed IBD patients due to their immunosuppressive therapy. Recently, an inactivated subunit vaccine has been developed and investigated for use in immunocompetent adults, as well as select groups of immunocompromised individuals. This novel vaccine has not yet been studied in IBD patients but holds promise for use in this population. The proposed study is a single-center prospective pilot study comparing immunogenicity and safety of the inactivated herpes zoster vaccine in patients with IBD (ulcerative colitis or Crohn’s disease) treated with high-level combination immunosuppression (both anti-TNF biologics and immunomodulators) to those not on systemic immunosuppressive therapy (5-aminosalicylates or no treatment). Investigators will compare cell-mediated responses between groups using an intracellular cytokine staining assay with flow cytometry assessed prior to vaccination and at four time points up to 12 months after completion of the immunization sequence. Adverse effects will also be monitored. This study will help to identify whether the novel herpes zoster vaccine is immunogenic and safe for use in IBD patients and whether these parameters are significantly impacted by intensity of immunosuppressive treatment. An additional goal is to provide preliminary data with which to develop future studies of vaccine immunogenicity and efficacy in this target population.
9

Formula??o e caracteriza??o de mat?rias-primas para revestimento cer?mico Semi-Poroso com adi??o de chamote de telhas / Formulation and characterization of raw materials for Semiporous ceramic coating and roofing tile Chamote

Castro, Raimundo Jos? de Sousa 26 March 2008 (has links)
Made available in DSpace on 2014-12-17T14:06:46Z (GMT). No. of bitstreams: 1 RaimundoJSC.pdf: 1462699 bytes, checksum: cac59ec25bd8ba4355dbea19489431b4 (MD5) Previous issue date: 2008-03-26 / The ceramics industry in Piau? is nowadays with 55 industries where 11 are in Teresina which is the mainstream of the state, producing 55 million shingles; in which 10 % is of this production is wasted being sometimes thrown on the margins of rivers, roads and highways provoking an environmental degradation. The main goal of this work is to verify the potential of producing semi porous ceramic using grog of shingles, on the first part of this work bodies-of-proof were produced from a basic formula of an industry, doping it with 5 %, 10 %, 15 % and 20 % in mass and in the second part of this work some bodies-of-proof were produced from a formula where one raw material was substituted by 50 % of grog and another substituting it all by grog, bodies-of-proof made of a basic formula previously announced was used for experiment control.The grog and the raw materials were characterized by: particle size analysis , thermal differential analysis, X ray diffraction , X ray fluorescence, an thermal gravimetric analysis and rational analyses. The bodies-of-proof were sintetisized in an industrial oven obeying the normal cycle adopted by an industry, with peak temperatures of 1135 oC and a fast burning cycle of 25 minutes having as energetic fuel liquefied petroleum gas . The pieces that were obtained by this were submersed in rehearsed physics of: water absorption of, apparent specific mass, apparent porosity, lineal retraction, rupture tension to the flexural and dilatometry; mineralogical analysis for X ray diffraction; and microstructural for electronic microscope of sweeping. For all the formulas with addition of grog, superior priorities to the requested by the requirements for semi porous and for the formula to F2-2,5 superior priorities to standard formulas which justifies the incorporation of the shingles in mass for the semi porous ceramic / A ind?stria de cer?mica vermelha Piauiense, atualmente com 55 ind?strias onde 11 somente em Teresina sendo o maior p?lo do Estado, produz pouco mais de 55 milh?es de telhas, das quais aproximadamente 10 % dessa produ??o s?o desperdi?adas sendo ?s vezes jogadas ?s margens dos rios e estradas, provocando uma degrada??o ambiental. O objetivo deste trabalho ? verificar a potencialidade de se produzir revestimento cer?mico semi-poroso utilizando chamote de telhas, na primeira parte do trabalho foram produzidos corpos-de-prova a partir da formula??o b?sica de uma ind?stria de revestimento, dopando-a com 5 %, 10 %, 15 % e 20 % em massa, e uma segunda parte deste trabalho foram produzidos corpos-de-prova a partir de uma formula??o onde se substitu?a uma das mat?rias-prima por 50 % de chamote e outra substituindo a mesma totalmente por chamote, sendo usado para controle do experimento corpos-de-prova confeccionados a partir de uma formula??o b?sica citada anteriormente. O chamote e as mat?rias-prima foram caracterizados por: an?lise granulom?trica, an?lise t?rmica diferencial, an?lise termogravim?trica difra??o de raios X, fluoresc?ncia de raios X, e an?lise racional. Os corpos-de-prova foram sinterizados em forno industrial de rolo, obedecendo ao ciclo adotado por uma ind?stria de revestimento, com temperatura de pico igual a 1135 ?C e ciclo de queima r?pido de 25 min, tendo como matriz energ?tica o g?s liquefeito de petr?leo. As pe?as assim obtidas foram submetidas aos ensaios f?sicos de: absor??o de ?gua, massa espec?fica aparente, porosidade aparente, retra??o linear, tens?o de ruptura ? flex?o e dilatometria; an?lise mineral?gica por difra??o de rios X; e microestrutural por microsc?pio eletr?nico de varredura. Obteve-se para todas as formula??es com adi??o de chamote, propriedades superiores ?s das exigidas pelas normas em vigor para revestimento semi-poroso e para a formula??o F2-2,5 propriedades superiores ? formula??o padr?o o que justifica a viabilidade da incorpora??o do rejeito de telhas em massa para revestimento cer?mico semi-poroso
10

Structure-Property Relationships to Understand Comprehensive Rejuvenation Mechanisms of Aged Asphalt Binder

January 2020 (has links)
abstract: This research focused on the structure-property relationships of a rejuvenator to understand the comprehensive rejuvenation mechanism of aged asphalt binder. Aged asphalt such as recycled asphalt shingles (RAS) and reclaimed asphalt pavement (RAP) contain various amounts of asphalt binder. However, the asphalt binder in RAS and RAP is severely aged and inferior in properties compared to a virgin binder. To address this issue, liquid additives have been used under the general title of rejuvenators. That poses an additional challenge associated with the lack of clear metrics to differentiate between softeners and rejuvenators. Therefore, there is a need for a thorough study of rejuvenators. In this study, diverse-sourced rejuvenators have been used in RAS and RAP-modified binders as well as laboratory-prepared aged binders. The properties of the rejuvenated aged binder were characterized at a macro-level and molecular level. The study showed that the performance of the RAS-modified binder was significantly improved after bio-modification by a bio-rejuvenator. This study further evaluated laboratory-prepared aged asphalt rejuvenated with different rejuvenators. The results found that oxidized bitumen became soft after adding rejuvenators, regardless of their source. Molecular dynamics simulation showed that the effective rejuvenator restored the molecular conformation and reduced the size of asphaltene nanoaggregates. The study results showed that due to the specific chemical composition of certain rejuvenators, they may negatively impact the durability of the mixture, especially about its resistance to moisture damage and aging. Computational analysis showed that while the restoration capacity of rejuvenators is related to their penetration into and peptizing of asphaltene nanoaggregates, the durability of the restored aged asphalt is mainly related to the polarizability values of the rejuvenator. Rejuvenators with lower polarizability showed better resistance to aging and moisture damage. In summary, this study develops the rheology-based indicators which relate to the molecular level phenomenon in the rejuvenation mechanism. The rheology-based indicators, for instance, crossover modulus and crossover frequency differentiated the rejuvenators from recycling agents. Moreover, the study found that rejuvenation efficiency and durability are depended on the chemistry of rejuvenators. Finally, based on the learning of chemistry, a chemically balanced rejuvenator is synthesized with superior rejuvenation properties. / Dissertation/Thesis / Doctoral Dissertation Civil, Environmental and Sustainable Engineering 2020

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