This thesis presents the effect of dispersion and Multi Access Interference (MAI) of optical fiber on the Bit Error Rate (BER) performance of a Direct Sequence Optical Code Division Multiple Access (DS-OCDMA) network by means of intensity modulation and optical receiver correlators. By using Matlab simulations, Signal-to-Noise Ratio (SNR) versus Received Optical Power (ROP) of an OCDMA transmission system can be evaluated with a so-called 7-chip m-sequence for different numbers of system users. This can be done for the ROP versus BER for various lengths of single mode optical fiber by taking into consideration the dispersion effect in the optical fiber. Matlab simulations can be performed in order to illustrate the reduction of the dispersion index gamma, or to visualize different scenarios, e.g., what amount of transmitted power is required in order to obtain a BER of 10-9 when the length of the optical fiber is increased.

The main focus of this thesis are the economic-theoretical concepts, which in varying degrees contributed to the creation of an official government program of economic reforms in the sixties of the 20th century in Czechoslovakia. The work will mainly analyze the causes of success Šikova reform movement among economists and the Czechoslovak Communist Party leadership. The first part of the study will address the reorientation of foreign trade and economy of Czechoslovakia to the Soviet Union and its satellite countries, as well as the importance of CSR for the functioning of the Council for Mutual Economic Assistance in the fifties. Briefly mentioned is the first attempt at economic reform led by Kurt Rozsypal issues and other proposals for changes in central planning. The crucial part of this work will be devoted to the theoretical designs and directions, which created the preconditions for the implementation of specific economic reforms in the sixties. The treatment of the topic study should answer the questions: What were the other economic programs and their leaders? These protagonists could significantly affect the program or not?

Transforming growth factor-β (TGF-β) signaling is initiated when the ligand binds to type II and type I serine/threonine kinase receptors at the cell surface. Activated TGF-β type I receptors phosphorylate R-Smads which relocate, together with co-Smads, to the cell nucleus and regulate transcription. Enhancement or repression of Smad-specific gene targets leads to intracellular protein compositions which organize functional complexes and thus govern cellular processes such as proliferation, migration and differentiation. TGF-β/Smad signaling relays are regulated by various post-translational modifications. From receptors to gene promoters, intricate interplays between phosphorylation, acetylation, ubiquitination and numerous other modifications, control Smad signaling initiation and duration. However, many steps in the cascade, including receptor internalization, Smad nuclear shuttling and transcriptional termination, still remain elusive. The open gaps in our understanding of these mechanisms most likely involve additional post-translational regulations. Thus, the aim of the present investigation was to identify novel modulators of TGF-β/Smad signaling. In the first part of this thesis, we show the importance of ADP-ribosylation in Smad-mediated transcription. We identified poly(ADP-ribose) polymerase 1 (PARP-1) as a Smad interacting protein. Our work revealed that PARP-1 forms direct interactions with Smad3/4, and PARylates residues in their MH1 domains. This modification restricts Smads from binding to DNA and attenuates Smad-activated transcription. PARylation is reversed by the glycohydrolase PARG. We provide evidence that PARG can de-ADP-ribosylate Smads, which enhances Smad-promoted gene regulation. In the second part, we examine a Smad-dependent gene target of TGF-β signaling, salt inducible kinase 1 (SIK). After induction, SIK cooperates with Smad7 and Smurf2 to downregulate the TGF-β type I receptor. The mechanism relies on both the kinase and UBA domain of SIK as well as the E3-ligase activity of Smurf2. In summary, we have unveiled two enzyme-dependent TGF-β/Smad modulatory mechanisms; SIK promoted receptor turnover and PARP-1/PARG-regulated Smad signaling.

Thesis (DTech (Electrical Engineering))--Cape Peninsula University of Technology, 2011 / Ultrasonic Velocity Profiling (UVP) is both a method and a device to measure an instantaneous one-dimensional velocity profile along a measurement axis by using Doppler echography. UVP is an ideal technique since it is non-invasive, works with opaque systems, inexpensive, portable and easy to implement relative to other velocity profile measurement methods. Studies have suggested that the accuracy of the measured velocity gradient close to wall interfaces need to be improved. The reason for this is due to, depending on the installation method, distortion caused by cavities situated in front of ultrasonic transducers, measurement volumes overlapping wall interfaces, refraction of the ultrasonic wave as well as sound velocity variations. A new ultrasonic transducer, which incorporates a delay line material optimised for beam forming could reduce these problems (Wiklund, 2007). If these could be addressed, UVP could be used for the measurement of velocity profiles in complex geometries (e.g. contractions, valves, bends and other pipe fittings) where the shape of the velocity profile is critical to derive models for estimating fluid momentum and kinetic energy for energy efficient designs. The objective of this research work was to optimise the UVP system for accurate complex flow measurements by evaluating a specially designed delay line transducer and implementing advanced signal processing techniques. The experimental work was conducted at the Material Science and Technology (MST) group at the Cape Peninsula University of Technology (CPUT). This work also formed part of a collaborative project with SIK - The Swedish Institute for Food and Biotechnology. Acoustic characterisation of the ultrasonic transducers using an advanced robotic setup was done at SI K. Different concentrations of the following non-Newtonian fluids exhibiting different rheological characteristics were used for testing: carboxymethyl cellulose (CMC) solutions, kaolin and bentonite suspensions. Water was used for calibration purposes.

Top predators in aquatic ecosystems often have strong top-down effects on the ecosystem. Northern pike (Esox lucius) has been documented to cause whitefish (Coregonus lavaretus) populations to diverge into different ecomorphs. This can facilitate piscivory in other predators as a novel resource becomes available to them in the form of dwarf whitefish. The aim of this study is to examine whether the presence of pike causes Eurasian perch (Perca fluviatilis) to shift their diet from insectivory to piscivory, and whether this is directly driven by whitefish polymorphism. Stomach contents of 147 perch from lakes with and without pikes were analyzed. The results show that the presence of pike has a clear influence on the diet of the perch. In lakes without pike, perch are mostly insectivorous, and in lakes with pike, they are mostly piscivorous. This diet shift appears to be driven by whitefish availability, as a majority of the diet of perch in pike lakes consisted of whitefish, while none of the fish eaten by perch in non-pike lakes was whitefish. In addition, the results showed that perch undergo the diet shift from insectivory to piscivory at a smaller size when coexisting with pike. This study can be added to the growing body of evidence for the ecological significance of pike.

An important question in determining species composition in a lake is what species has had the chance to reach the lake in the first place. The aim of this study was to examine natural stream connectivity limitations for whitefish (Coregonus lavaretus) between lakes, and to contribute to the development and evaluation of GIS-based methods to answer this question. 497 lakes with identified downstream source lakes, were classified as naturally colonized or introduced whitefish populations, reflecting the possibilities for whitefish to reach the lake naturally. Data of maximum stream slope and stream length between each lake pair was generated by Stefan Blumentrath, NINA. Maximum stream slope was measured on two different resolutions of stream length for comparison, one on slope over 10 m and one over 150m. A subset of lakes was manually examined in geographic information systems and compared to maps and aerial photos to evaluate the data and compare the results with the full dataset. False slope maximums were corrected and streams with much human alteration around a possible natural slope maximum was removed from the small dataset. The two datasets were analyzed using logistic regression models. Akaikes information criterion (AIC) showed that the optimal model, for both datasets, was the one using only slope maximum as predictor, and slope over 150m gave better results than 10m. A k50-coefficient, the value of a predictor that results in 50% probability of colonization, was introduced as an approximate of when the predictor forms a connectivity hinder. The k50-corefficient was estimated to 2,08±0,22° (±standard error) for slope over 150m for the big dataset and 2,58±0,20 for the small. Weaknesses in the data were distinguished and improvements for future fish connectivity studies are suggested.