Debris-slides are one of the most frequently occurring geological hazards in metasedimentary rocks of the Anakeesta ridge in Great Smoky Mountains National Park (GRSM), which often depends on the influence of multiple causing factors or geo-factors such as geological structures, slope, topographic elevation, land use, soil type etc. or a combination of these factors. The main objective of the study was to understand the control of geo-factors in initiating debris-slides using different knowledge and data-driven methods in GIS platform. The study was performed in three steps: (1) Evaluation of geometrical relationship between geological discontinuity and topographic orientation in initiation of debris-slides, (2) Preparation of knowledge-driven debris-slide susceptibility model, and (3) Preparation of data-driven debris-slide susceptibility models and compare their efficacy. Performance of the models were evaluated mostly using area under Receiver Operating Characteristic (ROC) curve, which revealed that the models were statistically significant.

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第21010号 / 医博第4356号 / 新制||医||1028(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 井上 治久, 教授 村井 俊哉, 教授 林 康紀 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Chromatin remodelers utilize the energy derived from ATP hydrolysis to mobilize nucleosomes. ISWI remodelers mobilize and evenly space nucleosomes to regulate gene expression. ISW2, an ISWI remodeler in yeast, has been shown to reposition nucleosome near promoter regions and represses both mRNA and antisense non coding RNA transcription. ISW2 is composed of four subunits and the catalytic Isw2 subunit consists of several conserved domains. The highly conserved ATPase domain is present at the N-terminus whereas the conserved HAND, SANT and SLIDE domain are towards the carboxyl terminal end of Isw2. Nucleosome mobilization by ISW2 requires both extranucleosomal DNA and the N-terminal tail of histone H4. DNA crosslinking and peptide mapping revealed that the ATPase domain contacts nucleosome two helical turns away (SHL2) from dyad to a site close to the H4 tail, whereas the HAND, SANT and SLIDE domain contact a 30bp stretch of DNA comprising the edge of nucleosome and ~20bp of extranucleosomal DNA. The ATPase domain and the C-terminal domains were investigated for their role in regulation of ISW2 activity both in-vitro and in-vivo. It appears that there are distinct modes of ISW2 regulation by these domains. Mutation of a patch of five acidic amino acids on the region of ATPase domain that contact SHL2 was found to be crucial for both ISW2 remodeling and nucleosome stimulated ATPase activity. Acidic patch mutant ISW2 was unable to mobilize nucleosome or hydrolyze ATP in absence of H4 tail. This indicates that the region of ATPase domain contacting nucleosome at SHL2 and H4 tail act in two separate and independent pathways to regulate ISW2 remodeling. Both HAND and SLIDE domain were shown to crosslink entry/exit site and linker DNA respectively. The roles of C-terminal domains were investigated either by deletion of the individual domain or mutation of conserved basic residues on the surface of these domains that are suspected to interact extranucleosomal with DNA. Deletion of HAND domain had minimal effect on in vitro ISW2 activity, however whole genome transcription analysis revealed one key role of this domain in ISW2 regulation. In absence of HAND domain, ISW2 had minimal role on repression of genes that were RPD3 (co-factor) dependent, however significantly derepressed genes that were RPD3 independent. At these loci, nucleosome positions were altered and ISW2 recruitment was reduced in absence of a functional HAND domain. Thus the HAND domain regulates recruitment and remodeling of ISW2 at those genes where ISW2 acts independent of other cofactors. The SANT domain, C-terminal to HAND domain, appears to control the "step size" of nucleosome remodeling and was found to be required for processive nucleosome remodeling by ISW2. Both H4 tail and SANT domain appear to control two distinct stages of ISW2 remodeling. A long alpha helical spacer separates SANT domain from SLIDE domain. SLIDE domain was found to be the protein-protein interaction domain that interacts with accessory Itc1 subunit to maintain ISW2 complex integrity. The two ways by which SLIDE domain regulate ISW2 is by binding or recruitment of ISW2 to promoter regions and additionally by binding independent regulation of both ATPase and remodeling activity. The remodeling mechanism of ISW2 was further compared with another ISWI type remodeler in yeast, Isw1a; using time resolved nucleosome remodeling combined with high resolution site specific histone DNA crosslinking at six different nucleosomal positions to track the movement of the nucleosomes. Nucleosome remodeled by the same remodeler showed discontinuous nucleosome movement between two tracking points indicating formation of small "bulges". One key difference in remodeling mechanism was that although both ISW2 and Isw1a moved nucleosomes towards longer linker DNA, only Isw1a remodeled nucleosomes "backtracked" ~11bp during remodeling. Backtracking of remodeling was prominently observed at nucleosomal regions in close proximity to translocase binding sites suggesting the potentially different mechanisms shared by similar remodeling complexes.

A new geologic map of the Deer Point 7.5' quadrangle located in the southern region of Capitol Reef National Park in south-central Utah provides stratigraphic and structural detail not previously available. The Deer Point quadrangle was mapped at a scale of 1:24,000 and is the fourth geologic map completed at this scale in Capitol Reef National Park. Twelve Quaternary units and eighteen bedrock formations and members are exposed in the Deer Point quadrangle. Bedrock formations range in age from Triassic to Cretaceous. The details not available on previous geologic maps include: four alluvial terrace units, two lacustrine units, two mass movement units, and members of the Moenkopi, Chinle, and Carmel Formations. Historically the Page Sandstone has been mapped as part of the Navajo Sandstone or the Carmel Formation. This map identifies the Page Sandstone as a separate and independent unit. The Deer Point quadrangle is cross cut by a portion of a Laramide-age, basement cored, NNW-SSE trending asymmetrical anticline called the Waterpocket Fold. Strikes and dips measured throughout the Deer Point quadrangle identify the vergence of the anticline as eastward with a maximum dip of 49˚ on the forelimb and 7˚ on the backlimb. The maximum dip on the forelimb dramatically decreases in the southern quarter of the quadrangle to 15˚.The Utah Geological Survey is mapping the Hite Crossing 30' x 60' quadrangle at a scale of 1:62.500. The Deer Point quadrangle is one of 32 quadrangles that comprise the Hite Crossing quadrangle. The Utah Geological Survey is working to establish erosion rates on the Colorado Plateau. To do this, they are dating alluvial terrace deposits. Within the Deer Point quadrangle four new terrace levels have been identified that could help with this research. Additional research could use these terrace deposits to better understand erosion rates in the Deer Point quadrangle and the broader Colorado Plateau. Numerous mass movement deposits are found within the Deer Point quadrangle. The largest has been named the Red Slide. Several aspects of the Red Slide are identified including classification, breakaway zone, source, deposit size, composition, debris flow path and depositional history. The Red Slide has been classified as a debris flow. The breakaway zone is a concave cliff 1.5 miles (2.4 km) to the west of the debris flow's present location. The flow's scarp is no longer identifiable. The source of the debris flow material is the Chinle Formation and Wingate Sandstone. The Red Slide deposit covers an area of over 16.6 million ft2 (~1.5 million m2). The toe of the debris flow is 1 mile (1.6 km) wide. The estimated maximum thickness of the debris flow is sixty meters. The Red Slide is composed of fine-grained, clay- and silt- sized material, and a small amount of angular pebble- to cobble-sized limestone clasts from the Owl Rock Member of the Chinle Formation. Boulder- to sand-sized grains from the Wingate Sandstone are scattered throughout the deposit with the larger grains forming inversely grading packages. The Red Slide likely occurred as a series of large debris flows, not one catastrophic event, although they may have occurred at about the same time.

In tropical and subtropical countries with bad infrastructure there exists diseases which are often neglected and untreated. Some of these diseases are caused by parasitic intestinal worms which most often affect children severely. The worms spread through parasite eggs in human stool that end up in arable soil and drinking water. Over one billion people are infected with these worms, but medication is available. The problem is the ineffective diagnostic method hindering the medication to be distributed effectively. In the process of designing an automated microscope for increased effectiveness the solution for marking out the stool sample on the microscope slide is important for decreasing the time of diagnosis. This study examined the active contour model and four different semantic segmentation networks for the purpose of delineating the stool sample from the other parts of the microscope slide. The Intersection-over-Union (IoU) measurement was used to measure the performance of the models. Both active contour and the networks increased the IoU compared to the current implementation. The best model was the FCN-32 network which is a fully convolutional network created for semantic segmentation tasks. This network had an IoU of 95.2%, a large increase compared to the current method which received an IoU of 77%. The FCN-32 network showed great potential of decreasing the scanning time while still keeping precision of the diagnosis.

Coating onto a moving substrate several films simultaneously on top of each other is a challenging exercise. This is due to the fact, depending on operating conditions (thickness and velocity of individual layers and the physical properties of the coating fluids), flow instabilities may arise at the interfaces between the layers and on the top layer. These instabilities ruin the application of the final multi-layered coating and must be avoided. This research addresses this coating flow situation and seeks to develop guidelines to avoid these instabilities. Following a critical literature survey, this thesis presents a novel experimental method that visualises multi-layered coating flow down an inclined multi-slot die. The visualisation is obtained using a unique configuration including a high-speed camera, telecentric objective lens and illumination. The results show for a single layer, as the die angle and Reynolds number increases, the flow becomes more unstable and for a dual layer flow, as Re increases the peak to peak amplitude and the frequency decreases at the free surface and interface. The latter was unexpected and does not conform with existing literature. The triple layer results show either a monotonically increasing or increasing from first to second layer viscosity stratifications are the most stable flows along with flow heights in the first and second layers of <22% and >18% of the total thickness respectively, which concur with current literature. The visualisation additionally obtained other instabilities including single layer back-wetting and vortices, and multilayer slot invasion with the findings concurring with current literature. / EPRSC/Tata Steel Industrial CASE Studentship; EP/J501840/1

Submitted by Franciele Moreira (francielemoreyra@gmail.com) on 2018-02-01T12:11:45Z No. of bitstreams: 2 Dissertação - Marciley da Silva Reis - 2016.pdf: 9579105 bytes, checksum: fb4c3cd2dad09fc199576680551d0c82 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-02-02T09:43:01Z (GMT) No. of bitstreams: 2 Dissertação - Marciley da Silva Reis - 2016.pdf: 9579105 bytes, checksum: fb4c3cd2dad09fc199576680551d0c82 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2018-02-02T09:43:01Z (GMT). No. of bitstreams: 2 Dissertação - Marciley da Silva Reis - 2016.pdf: 9579105 bytes, checksum: fb4c3cd2dad09fc199576680551d0c82 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-12-30 / Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq / This master thesis deals with educational processes in music related to the trombone in Brazil through the identification, selection and analysis of pedagogical practices, as well as the evidence and the formation process of the Brazilian Trombone School. The theoretical contribution is supported by Leão (2013) - music research methodology, Freire (2011), Tardif (2000 and 2002) and Gauthier (2013) - education - Shigunov Neto & Maciel (2008) and Amorim (2012) - society and culture -, as well as other works that focus on and discuss the musical and trombonistic knowledge and practices, such as Santos (1999 and 2016), Gagnard (1974), Kemp (1995) and Costa (1999). Within an interpretive perspective of research, the philosophical approach used was hermeneutics, combined with the qualitative paradigm, also using quantitative resources. In addition, the research had a descriptive and historical character, pointing to educational experiences through interviews and data in order to systematize the teaching-learning approaches of the Brazilian trombone aspect. In order to answer questions about the Brazilian Trombone School and its artistic- instrumental construction processes in relation to teaching and learning, the research was conducted in two stages: bibliographical survey and field research. This fact was justified by the fact that, up to the present moment, there is still no systematization of this process, nor cataloging of documents referring to its description, and, as such, of the pedagogical practices employed. It was believed that this systematization could contribute positively to the didactic- methodological orientation, being able to suggest resolutions for possible pedagogical problems. The methodological process of this research was based on bibliographic review and data collection. Thus, data obtained from oral sources (10 Brazilian trombonist teachers interviewed), theoretically based, served to discuss the teaching-learning process of the trombone. For the empirical analysis, for the application of the questionnaires, renowned trombonist teachers of recognized trombone study centers in Brazil were selected and interviewed, for which the same questionnaire was applied in a semi-open format, with a pre-elaborated script of Questions that specially questioned about the specificities of the musical experience, the knowledge about the study in Brazil and its pedagogical practices. This research was validated (ensuring confidentiality and reliability - in addition to legal and moral protection of the researched and the researcher) of the Informed Consent Term - TCLE (in compliance with the legal terms and the Ethics Committee - CEP). This dissertation is justified by the social relevance of the theme for music education and contemporary society at this time of changes in the public educational policies that reach the teaching of music in Brazil. Through the verification of all content, it was possible to conclude on the existence of the Brazilian Trombone School and its level of development, as well as on the methods, methodologies, strategies, and participants that act in the implementation of the same. It is estimated that the results of the final product can contribute to the advancement of knowledge in the area of music and education, and to the affirmation/strengthening of the Brazilian Trombone School. / Esta dissertação trata dos processos educacionais em música referentes ao trombone no Brasil, através da identificação, seleção e análise das práticas pedagógicas, bem como a evidenciação e o processo de formação da Escola Brasileira de Trombone. O aporte teórico está sustentado em Leão (2013) – metodologia de pesquisa em música–, Freire (2011), Tardif (2000 e 2002) e Gauthier (2013) – educação –, Shigunov Neto & Maciel (2008) e Amorim (2012) – sociedade e cultura –, além de outros trabalhos que focam e discutem os saberes e práticas docentes musicais e trombonísticas, como Santos (1999 e 2016), Gagnard (1974), Kemp (1995) e Costa (1999). Dentro de uma perspectiva interpretativa de pesquisa, a abordagem filosófica utilizada foi a hermenêutica, combinado com o paradigma qualitativo, usando também recursos do quantitativo. Além disso, a investigação apontou experiências educativas através de entrevistas e dados no intuito de sistematizar as abordagens de ensino-aprendizagem da vertente brasileira de trombone. Procurando responder questões acerca da Escola Brasileira de Trombone e seus processos de construção artístico-instrumental com relação ao ensino-aprendizagem, conduziu-se a investigação em duas etapas: levantamento bibliográfico e pesquisa de campo. Tal fato se justificou por, até o presente momento, ainda não existir uma sistematização desse processo, nem catalogação de documentos referentes à sua descrição, e, tampouco das práticas pedagógicas empregadas. Acreditou-se que essa sistematização pudesse contribuir positivamente com a orientação didático-metodológica, podendo sugerir resoluções para eventuais problemáticas pedagógicas. O processo metodológico desta pesquisa se deu a partir revisão bibliográfica e coleta de dados. Assim, os dados obtidos através das entrevistas (10 professores trombonistas brasileiros entrevistados), fundamentados teoricamente, serviram para discutir o processo de ensino-aprendizagem do trombone. Para a análise, relativo à aplicação dos questionários, foram selecionados e entrevistados professores- trombonistas, de renome, de reconhecidos centros de estudo de trombone no Brasil, para os quais se aplicou um mesmo questionário em formato semiaberto, com roteiro pré-elaborado de perguntas que questionaram especialmente as especificidades da vivência musical, o conhecimento sobre o estudo no Brasil e suas práticas pedagógicas. Esta pesquisa valeu-se (assegurando confidencialidade e confiabilidade – além de proteção legal e moral do pesquisado e do pesquisador) do Termo de Consentimento Livre Esclarecido – TCLE (em conformidade com os termos legais e o Comitê de Ética – CEP). Esta dissertação empenha relevância social para o tema, para a educação musical e para a sociedade contemporânea nesse momento de mudanças nas políticas públicas educacionais que atingem o ensino da música no Brasil. Concluiu-se que a Escola Brasileira de Trombone existe e está operante e desenvolvendo práticas pedagógicas relevantes. Assim, apurou-se, também, sobre o seu nível de desenvolvimento, bem como constatou-se sobre os métodos, metodologias, estratégias, e participantes que atuam (atuaram) na implementação da mesma. Estima-se que os resultados do produto final possam contribuir para o avanço do conhecimento na área de música e educação [musical], e para o afirmação/fortalecimento da Escola Brasileira de Trombone.

Im Fokus dieser Arbeit stehen Dämpfungseffekte schwingfähiger Mikroelektromechanischer Systeme (MEMS), die nach dem kapazitiven Wirkprinzip arbeiten. Die verschiedenen Dissipationsprozesse und die zugehörigen analytischen Modelle sowie numerischen Berechnungsmöglichkeiten auf physikalischer Ebene werden vorgestellt und mit eigenen experimentellen Ergebnissen verglichen. Der Schwerpunkt liegt dabei auf der fluidischen Dämpfung im Kontinuum und bei leichter Verdünnung, was bei den meisten kapazitiven MEMS den dominierenden Verlusteffekt darstellt.:1 Überblick 2 Grundlagen zur Beschreibung von Mikrosystemen 3 Herstellung und Charakterisierung 4 Fluidische Dämpfung 5 Weitere dissipative Effekte mikromechanischer Systeme 6 Zusammenfassung und Ausblick / This thesis focuses on damping effects of vibrational micro-electromechanical systems (MEMS) with capacitive working principle. The different dissipation processes and the associated analytical models as well as numerical calculation possibilities on a physical level are presented and compared to own experimental results. The main emphasis is on fluidic damping in the continuum regime and with slight rarefaction, which is the dominant loss effect in most capacitive MEMS.:1 Überblick 2 Grundlagen zur Beschreibung von Mikrosystemen 3 Herstellung und Charakterisierung 4 Fluidische Dämpfung 5 Weitere dissipative Effekte mikromechanischer Systeme 6 Zusammenfassung und Ausblick

This study seeks to prove the usefulness of the Multichannel Analysis of Surface Waves (MASW) method as complementary data to conventional geotechnical and geological data in the characterization of areas of landslide risk. The setting is located in a low income housing neighborhood in the city of Campos do Jordão, state of São Paulo, Brazil. The area was devastated by numerous landslides between December 1999 to January 2000 after heavy rainfall in the area. The landslides in this area are known to be shallow. Refraction and MASW surveys were performed in this research and then processed to obtain seismic velocity profiles of the subsurface. In order to better identify the fundamental mode of the Rayleigh wave, separate surveys isolating the vertical and radial components of the Rayleigh wave were performed. By comparing the inverted shear wave ( ) and compressional wave ( ) profiles with the already known geotechnical and geological data of the site, a better understanding of the geological interfaces that constitute the landslide prone area is obtained. / Este estudo busca demonstrar a aplicabilidade do método de análise multicanal de ondas superficiais (MASW) e a importância da integração de seus resultados com os da investigação geológica-geotécnica para a caracterização de áreas sujeitas a deslizamentos de terra. O local de estudo situa-se em uma área residencial com precárias condições de infraestrutura urbana na cidade de Campos do Jordão, estado de São Paulo, Brasil. Na área houve vários episódios de escorregamento entre dezembro de 1999 e janeiro de 2000 após a ocorrência de chuvas intensas. Os escorregamentos nesta área são classificados como rasos. Nesta pesquisa foram realizados ensaios de sísmica de refração e MASW e gerados perfis e seções de velocidade de propagação das ondas sísmicas. Para obter uma melhor identificação do modo fundamental da onda Rayleigh foram realizadas diferentes aquisições visando ao registro das componentes vertical e radial do movimento da onda. A integração dos perfis de velocidades da onda cisalhante (VS) e da onda compressional (VP) com os dados geológicos e geotécnicos obtidos anteriormente permitiu aprimorar o mapeamento das interfaces geológicas importantes para o estudo dos processos de escorregamento do local.

This study seeks to prove the usefulness of the Multichannel Analysis of Surface Waves (MASW) method as complementary data to conventional geotechnical and geological data in the characterization of areas of landslide risk. The setting is located in a low income housing neighborhood in the city of Campos do Jordão, state of São Paulo, Brazil. The area was devastated by numerous landslides between December 1999 to January 2000 after heavy rainfall in the area. The landslides in this area are known to be shallow. Refraction and MASW surveys were performed in this research and then processed to obtain seismic velocity profiles of the subsurface. In order to better identify the fundamental mode of the Rayleigh wave, separate surveys isolating the vertical and radial components of the Rayleigh wave were performed. By comparing the inverted shear wave ( ) and compressional wave ( ) profiles with the already known geotechnical and geological data of the site, a better understanding of the geological interfaces that constitute the landslide prone area is obtained. / Este estudo busca demonstrar a aplicabilidade do método de análise multicanal de ondas superficiais (MASW) e a importância da integração de seus resultados com os da investigação geológica-geotécnica para a caracterização de áreas sujeitas a deslizamentos de terra. O local de estudo situa-se em uma área residencial com precárias condições de infraestrutura urbana na cidade de Campos do Jordão, estado de São Paulo, Brasil. Na área houve vários episódios de escorregamento entre dezembro de 1999 e janeiro de 2000 após a ocorrência de chuvas intensas. Os escorregamentos nesta área são classificados como rasos. Nesta pesquisa foram realizados ensaios de sísmica de refração e MASW e gerados perfis e seções de velocidade de propagação das ondas sísmicas. Para obter uma melhor identificação do modo fundamental da onda Rayleigh foram realizadas diferentes aquisições visando ao registro das componentes vertical e radial do movimento da onda. A integração dos perfis de velocidades da onda cisalhante (VS) e da onda compressional (VP) com os dados geológicos e geotécnicos obtidos anteriormente permitiu aprimorar o mapeamento das interfaces geológicas importantes para o estudo dos processos de escorregamento do local.