This thesis explores the often overlooked nature of public law duty and its relationship with the doctrine of standing in English law. Drawing on English and North American legal tradition and thought, it posits that public law obligations should be reconceived of as fiduciary in nature, vesting correlative enforcement rights in citizens to constrain unlawful exercises of public power. This should correspond to the abolition of standing requirements and recognition of the rights of citizens and interest groups to bring administrative and human rights challenges before the courts. This thesis also aims to achieve some synthesis between liberal normativism and communitarianism by recognizing both the individual and the collective interests at stake in public interest litigation.

It is difficult to think of any activity that does not require some degree of turning. Despite the prevalence of turning in daily activities and the challenge it poses to mobility-impaired individuals such as those with Parkinson’s disease, there is far less known about the multi-segmental control of turning than the control of standing and straight walking especially in elderly individuals and patient populations. The purpose of this thesis was to examine the coordination of body segment reorientation in healthy older adults and people with Parkinson’s disease (PD) during on-the-spot turns when standing and turns initiated when walking. The coordination of body segments was examined for small and large magnitude turns in both populations. PD participants were examined when “off” and “on” dopamine-replacement medication to determine the effects of medication on multi-segmental coordination when turning. The effect of walking velocity on the multi-segmental coordination of turning also was examined in healthy elderly participants for three different walking velocities. This research revealed differences in coordination patterns for standing versus walking turns and for healthy older adults versus persons with PD. Healthy older adults reorient their head, shoulder, and pelvis in unison, followed by mediolateral foot displacement, during standing turns. This coordination pattern was observed for both small and large turns. By contrast, turns initiated by healthy older adults while walking displayed a top-down temporal sequence similar to that reported for healthy young adults, i.e., the head turns first, followed by the shoulder and pelvis, and finally mediolateral displacement of the foot. This is a robust behavior which was not affected by the magnitude of the turn or walking velocity. PD participants (“off” and “on” medication) displayed temporal coordination patterns similar to age-matched healthy older adults for both standing and walking turns. However, PD participants (“off” and “on” medication) differed from healthy older adults with respect to the velocity and magnitude of reorientation of body segments, i.e., spatial parameters of coordination. The peak angular velocity of each body segment was significantly smaller for PD participants than the healthy older adults during both standing and walking turns; this was observed for both small and large magnitude turns. The magnitude of reorientation of each body segment was measured at the onset of mediolateral foot displacement; this measure revealed significantly smaller head and shoulder rotations for PD participants versus healthy older adults during standing turns, but not walking turns. Medication had no significant effect on the temporal or spatial parameters of body segment coordination during standing and walking turns. Medication increased the magnitude of head turn during the 90° standing turns; however, the magnitude of head turn remained smaller than that of healthy older adults. Multi-segmental coordination patterns differ for turns performed when standing (on-the-spot turn) versus when walking. The temporal parameters of these coordination patterns are not influenced by the magnitude of the turn or the velocity of walking and remain intact in Parkinson’s disease. Parkinson’s disease modifies the spatial parameters of coordination; reducing the velocity and early magnitude of reorientation of each body segment. These spatial parameters are not affected by dopaminergic medication.

It is difficult to think of any activity that does not require some degree of turning. Despite the prevalence of turning in daily activities and the challenge it poses to mobility-impaired individuals such as those with Parkinson’s disease, there is far less known about the multi-segmental control of turning than the control of standing and straight walking especially in elderly individuals and patient populations. The purpose of this thesis was to examine the coordination of body segment reorientation in healthy older adults and people with Parkinson’s disease (PD) during on-the-spot turns when standing and turns initiated when walking. The coordination of body segments was examined for small and large magnitude turns in both populations. PD participants were examined when “off” and “on” dopamine-replacement medication to determine the effects of medication on multi-segmental coordination when turning. The effect of walking velocity on the multi-segmental coordination of turning also was examined in healthy elderly participants for three different walking velocities. This research revealed differences in coordination patterns for standing versus walking turns and for healthy older adults versus persons with PD. Healthy older adults reorient their head, shoulder, and pelvis in unison, followed by mediolateral foot displacement, during standing turns. This coordination pattern was observed for both small and large turns. By contrast, turns initiated by healthy older adults while walking displayed a top-down temporal sequence similar to that reported for healthy young adults, i.e., the head turns first, followed by the shoulder and pelvis, and finally mediolateral displacement of the foot. This is a robust behavior which was not affected by the magnitude of the turn or walking velocity. PD participants (“off” and “on” medication) displayed temporal coordination patterns similar to age-matched healthy older adults for both standing and walking turns. However, PD participants (“off” and “on” medication) differed from healthy older adults with respect to the velocity and magnitude of reorientation of body segments, i.e., spatial parameters of coordination. The peak angular velocity of each body segment was significantly smaller for PD participants than the healthy older adults during both standing and walking turns; this was observed for both small and large magnitude turns. The magnitude of reorientation of each body segment was measured at the onset of mediolateral foot displacement; this measure revealed significantly smaller head and shoulder rotations for PD participants versus healthy older adults during standing turns, but not walking turns. Medication had no significant effect on the temporal or spatial parameters of body segment coordination during standing and walking turns. Medication increased the magnitude of head turn during the 90° standing turns; however, the magnitude of head turn remained smaller than that of healthy older adults. Multi-segmental coordination patterns differ for turns performed when standing (on-the-spot turn) versus when walking. The temporal parameters of these coordination patterns are not influenced by the magnitude of the turn or the velocity of walking and remain intact in Parkinson’s disease. Parkinson’s disease modifies the spatial parameters of coordination; reducing the velocity and early magnitude of reorientation of each body segment. These spatial parameters are not affected by dopaminergic medication.

Mobility of the horse to initiate motion from the standing position is examined in this thesis. In particular, the thesis focuses on the study of the mobility of a horse with fixed hooves to the ground, and on how its musculoskeletal system is used to free the legs from restraints. Possible leg patterns to initiate motions are investigated. The breaking forces generated at front and hind hooves during static-pulling and dynamic jerking are evaluated. Design of the restraint system that uses ropes to immobilize certain joints in order to prevent the horse from generating these forces is the main objective of this thesis. Such a system could be applied as an alternative to rather massive mechanical devices, the main purpose of which is to block the breaking forces (which are quite large when fully developed).<p> Analysis of the mobility of the horse is based on the mechanics of a skeletal linkage system driven by muscle forces. Only major muscles involved in fighting the restraints are included in the analysis. The force generation capability of a muscle is determined by physiological cross sectional area (PCSA) of the muscle. Possible leg patterns are predicted with the kinematics analysis considering range of motion at each joint in the legs. Corresponding breaking forces generated in each pattern is evaluated with the kinetics analysis. Relationship between the characteristic parameter of the pattern and the breaking force at hoof are established. <p>The horse's computer model is used to justify the analytical result. Fighting mechanisms of the horse are simulated in the dynamic simulation software package. Patterns and the breaking forces developed by the horse model simulation agree well with the analytical results. To the authors best knowledge, this is the first time a computer model is used in analyzing the method of restraining an animal. <p>The mobility of the animal with hoof restraints and methods to remove mobility were further confirmed with a preliminary animal restraint test conducted on a sheep. The sheep was chosen because the leg patterns to initiate motion on a horse are similar to that of sheep, but the sheep is more convenient to handle. The experiment showed that the mobility of the sheep could be removed completely by restraining its hooves, lower legs, and head with easily attached ropes.

<p>An unresolved problem in evolutionary biology is the nature of forces that maintain standing variation for quantitative traits. In this study we take advantage of newly developed genomic resources to understand how variation is maintained for flower size and fitness components in a natural population of annual Mimulus guttatus in the Oregon Cascades. Extensive inbreeding depression has been documented in this population for fertility and viability (Willis 1999 a,b), while previous biometric experiments have demonstrated that some of the floral variation in this site is due to common alleles perhaps maintained by balancing selection (Kelly and Willis 2001, Kelly 2003). Detailed comparison of the genetic architecture of these two categories of traits can clarify the relative contributions of mutation versus selection in maintaining trait variation within populations as well as the relevance of standing variation for trait diversification. </p><p>We present here the results from a large scale effort to dissect variation for flower size and a suite of genetically correlated traits. In 3 independent F2 mapping populations we mapped QTLs for floral morphology (flower width and length, pistil length, and stamen length), flowering time, and leaf size. We also mapped segregation distortion loci and QTLs for fertility components (pollen viability and seed set) that exhibit inbreeding depression. We compare the genetic architecture of these two sets of traits and find clear differences. Morphological traits and flowering time are polygenic and QTLs are generally additive. In contrast, deleterious QTLs associated with segregation distortion or fertility are partially recessive and include major QTLs. There is also little co-localization between morphological/flowering time and fertility QTLs. The analysis suggests that the genetic basis of segregating variation in morphology is fundamentally different from traits exhibiting inbreeding depression. Further, there is considerable variation in the extant of pleiotropy exhibited by QTLs for morphological traits as well as flowering time and we report that epistasis contributes to the standing variation for these traits. The analysis suggests that the standing variation is relevant for trait diversification and that the variation in floral allometry, plant form, and life history observed in the guttatus species complex could have readily evolved from the standing variation.</p> / Dissertation

名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成4年12月22日 市川真澄氏の博士論文として提出された

Thesis (Ph. D.)--University of Washington, 2002. / Vita. Includes bibliographical references (leaves 130-134).

Quasicrystal is the term used for a solid that possesses an essentially discrete diffraction pattern without having translational symmetry. Compared to periodic crystals, this difference in structure gives quasicrystals new properties that make them interesting to study -- both from a mathematical and from a physical point of view. In this thesis we review a mathematical description of quasicrystals that aims at generalizing the well-established theory of periodic crystals. We see how this theory can be connected to the cohomology of groups and how we can use this connection to classify quasicrystals. We also review an experimental method, NIXSW (Normal Incidence X-ray Standing Waves), that is ordinarily used for surface structure determination of periodic crystals, and show how it can be used in the study of quasicrystal surfaces. Finally, we define the reduced lattice and show a way to plot lattices in MATLAB. We see that there is a connection between the diffraction pattern and the reduced lattice and we suggest a way to describe this connection.

Travel time has generally been regarded as an unproductive period, representing a means-to-an-end in order to engage in activities at specific destinations. Rapid developments in mobile technology have provided people with innovative ways to multi-task and engage in meaningful activities while travelling. Rail transportation specifically, offers passengers advantages over other means of transportation as there is no need to focus on driving tasks. Due to the increase in passenger numbers and limited seating availability in train carriages, over one third of rail passengers are required to stand while travelling (DfT, 2013). The vibration to which rail passengers are exposed has been shown to interfere with the performance of activities and for standing passengers, it is often necessary to use postural supports such as holding on to grab rails or leaning on walls in order to maintain stability. The overall aim of the research is to evaluate the influence of whole-body vibration (WBV) exposure and standing posture on the performance of manual control tasks and the associated subjective workloads experienced by rail passengers. The use of supports, such as a backrest in seated postures, has been found to influence the response of the human body to WBV exposure, yet no reported studies have investigated the effects of postural supports on the response of the body in standing postures. Understanding how the body is affected in these conditions would increase the current state of knowledge on the biomechanical responses of the human body to vibration exposure and provide improved representation of standing postures within vibration standards (for example, ISO2631-4 (2001)) and guidelines for device interface design. A field study, using direct observation, was conducted to assess the behaviour of standing rail passengers and determine the characteristics of typical vibration exposures. This information provided the basis for the design of four subsequent laboratory studies. The main investigations of the laboratory studies were the influence of WBV exposure on objective performance measures, such as task completion time and error rate, and subjective workloads (for example, NASA TLX) for a range of manual control tasks. One of these laboratory studies evaluated the influence of various postural supports (for example, backrests) on the biomechanical responses of standing individuals. Measurements obtained during the field investigation indicated that the vibration exposures did not exceed the EU Physical Agents Exposure Action Value (EAV) and therefore posed little risk of injury. Vibration magnitudes in the horizontal directions (x- and y-axes) were higher than in the vertical direction (z-axis) and it was necessary for standing passengers to alter behaviours and use supports in order to maintain stability while travelling. The results of the laboratory studies indicated that in conditions where decrements in task performance occurred, the extent to which performance was degraded increased progressively with increases in vibration magnitude. There were conditions (for example, in the continuous control task and the Overhead Handle supported posture in the serial control task) where vibration exposure showed no significant influence on performance measures. This suggested that individuals were able to adapt and compensate for the added stress of vibration exposure in order to maintain performance levels however, this occurred at the expense of mental workload. The workload experienced by the participants increased with corresponding increases in magnitude. Vibration frequency-dependent effects in performance and workload were found to match the biomechanical responses (apparent mass and transmissibility) of the human body and resemble the frequency weightings described in the standards (ISO2631-1 (1997)). During the serial control task, the postures which demonstrated the greatest decrements to performance (for example, Lean Shoulder and Lean Back ) corresponded to the same postures that showed the greatest influence on the biomechanical responses of the body. It was concluded therefore, that measurements of the biomechanical responses to WBV could be used to offer predictions for the likelihood of activity interference. Consideration should however, be given to the applicability of this research before these results can be generalised to wider contexts. Further validation is recommended for future work to include different conditions in order to substantiate the findings of this research.

Nackbesvär är vanligt förekommande vid datorarbete. Stående datorarbete har i visats ha en gynnsam effekt på nackbesvär. Nackflexion kan ge en ökad belastning på nacken. Syftet med studien var att jämföra flexion i nacken vid sittande och stående datorarbete för personer som utför datorarbete under en stor del av dagen i sitt ordinarie arbete. Sammanlagt tio personer, åtta kvinnor och två män, som arbetar på en företagshälsovård deltog i studien. De arbetade med datorarbete i växel, kundservice, sjukvårdsrådgivning eller sjuk och frisktjänst (en tjänst där arbetsgivare får hjälp att hantera sjuk och friskanmälningar, sammanställning av sjukskrivningsstatistik samt med rådgivning till sjukskrivna). Nackflexion mättes vid två tillfällen, två timmar per person, sittande och stående under en timme var. Mätningarna gjordes med triaxiala accelerometrar med placering i pannan, över Thorakalkota I samt på utsidan av låret för att säkerställa positionen.  Den relativa vinkeln mellan Thorakalkota I och pannan utgjorde flexionsvinkeln. Ingen 0-position användes vid beräkningen. Resultat: Jämförelsen av nackflexion mellan sittande och stående datorarbete kunde i den här studien inte påvisa någon skillnad mellan de två positionerna (medelvärde för nackflexion i sittande 29,2°, stående 28,1°, p:0,35) . Resultaten i den här undersökningen stödjer behovet av att undersöka fler variablar än nackflexion för belastning av nacken vid stående och sittande datorarbete till exempel om den spänning i nackmuskulaturen som arbete med armarna kan ge skiljer sig mellan de olika positionerna. / Neck pain is frequent during computer work. Standing during computer work has been shown to have a beneficial effect on neck pain. Flexion of the neck may cause an increased load on the neck. The aim of this study was to compare flexion of the neck while sitting and standing during computer work for people who perform computer work during most of the day in their regular work. Ten individuals, eight women and two men, working in an occupational health service participated in the study. They worked with computer work in customer service, healthcare advice or sickness and recovery service (a service where employers get service to carry out sickness and recovery notifications, statistics of sick leaves, and counseling services to persons on sick leave). Neck flexion was measured on two occasions, during two hours per person each time, sitting and standing for one hour each. The measurement was made with triaxial accelerometers placed on the forehead, on Thoracic segment I, and on the outside of the thigh to verify the positions. The relative angle between Thoracic segment I and the forehead formed the flexion angle. No 0-position was used in the calculations. Results: The comparison of neck flexion between sitting and standing computer work, in this study, did not show any difference between the two positions (averaged neck flexion, sitting 29.2°,  standing 28.1°, p:0.35). The result supports the need for more research to examine the load of the neck during standing and sitting computer work examining more variables than neck flexion, for example, if muscular activity in the neck differs between the two positions during arm work.