Thesis (M.S.)--Oregon State University, 2010. / Printout. Includes bibliographical references (leaves 69-72). Also available on the World Wide Web.

Thesis (Ph.D.) - University of Queensland, 2004. / Includes bibliography.

Thesis (Ph. D.)--University of Florida, 1984. / Description based on print version record. Typescript. Vita. Includes bibliographical references (leaves 125-142).

The aim of my work was to analyze how three bloggers, who lost a child to sud- den infant death syndrome SIDS, used different rituals and coping strategies in their blogs. I analyzed how these mothers, through blogging on the Internet, ex- press their grief, what kind of rituals they have performed in the grieving process, and whether these rituals can be seen as part of a coping strategy to deal with the grief. My analysis was based on a deductive approach with the help of the coping theory which MarieAnne Ekedahls (2001) used in her research and the theories about ritualization which Carin Åblad Lundström (2010) used in her. In my analy- sis, I made a transverse text analysis using the analysis program Open Code. I used Open Code to structure and upload my material, and analyzed it along Eke- dahls (2001) coping theory and Åblad Lundström (2010) theories about ritualiza- tions as a coping strategy when dealing with SIDS. The essay was divided into three different parts. Part I was based on Ekedahls (2001) coping model to analyze how the bloggers produce various coping strate- gies in their texts. The conclusion was that all coping strategies were prominent in the blogs. Part II, in which Åblad Lundström’s (2010) model was used, estab- lished that ritualization was useful when dealing with death. The rituals were thus also the prominent component in all of the three blogs on a religious, private and social level, and both in private and in public. Finally, these two theories were combined in Part III, where it was possible to conclude that the appropriate rituals could be connected with one or more of the designed coping strategies. Coping strategies involve either preserving or reconstructing methods and ways of mov- ing on, while rituals result in a contact with the individual's inner or outer worlds. In this way, it was possible to see rituals as a coping strategy. Both coping strate- gies and rituals were combined, so none of the bloggers used only one strategy or ritual, but used many of them when dealing with death.

94f. / Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-03-08T14:40:28Z No. of bitstreams: 1 Jamilly%20Dias%20dos%20Santosseg.pdf: 1233139 bytes, checksum: 994f8ab66286afdd209b346a7bce84f2 (MD5) / Approved for entry into archive by Vania Magalhaes(magal@ufba.br) on 2013-03-14T12:39:10Z (GMT) No. of bitstreams: 1 Jamilly%20Dias%20dos%20Santosseg.pdf: 1233139 bytes, checksum: 994f8ab66286afdd209b346a7bce84f2 (MD5) / Made available in DSpace on 2013-03-14T12:39:10Z (GMT). No. of bitstreams: 1 Jamilly%20Dias%20dos%20Santosseg.pdf: 1233139 bytes, checksum: 994f8ab66286afdd209b346a7bce84f2 (MD5) Previous issue date: 2011 / O objetivo do trabalho é verificar empiricamente qual o impacto dos Fundos Soberanos de Riqueza (FSR – RN) de recursos naturais sobre a estabilidade econômica. Os fundos soberanos de recursos naturais têm sido um mecanismo utilizado pelas economias ricas em recursos naturais para gerir as receitas provenientes da exploração desses recursos, com objetivos que vão desde poupança para gerações futuras, incremento da taxa de retorno das reservas internacionais e apoio a projetos socioeconômicos, principalmente em infraestrutura, à estabilização econômica. Os efeitos dos FSR - RN podem ser tanto estabilizadores como desestabilizadores sobre variáveis macroeconômicas. Desse modo, o trabalho analisa se os FSR – RN podem ou não reforçar o papel das reservas internacionais sobre a volatilidade cambial. Para tanto, serão analisados os objetivos declarados pelos fundos soberanos, o histórico de constituição desses fundos em seus países, os tipos de fundos existentes e sua classificação. A fundamentação teórica do problema de pesquisa está baseada nas teorias do Sudden Stops e do Motivo Precaução. De acordo com o Motivo Precaução, a demanda por ativos no exterior leva em consideração que a posse de bens estrangeiros altera a probabilidade e a magnitude de Sudden Stops, ou seja, da parada súbita do influxo de capitais. Nesse contexto, o trabalho apresenta os efeitos estabilizadores e desestabilizadores dos fundos de recursos naturais sobre as economias de seus países. Para testar os efeitos do FSR - RN sobre a estabilidade cambial dos países, será utilizado um modelo de painel dinâmico, estimado através dos métodos Arellano e Bover (1995). O principal resultado é que os FSR - RN possuem efeito estabilizador sobre as economias que possuem exploração de recursos naturais em suas fronteiras. / Salvador

Soybean (Glycine max [L.] Merr.) cultivars differ in their resistance to sudden death syndrome (SDS). The syndrome is caused by root colonization by Fusarium virguliforme (ex. F. solani f. sp. glycines). Breeding for improve SDS response has proven challenging, possible due to interactions among the 18 known loci for resistance. Four loci for resistance to SDS (cqRfs to cqRfs3) were found clustered within 20 cM of the rhg1 locus underlying resistance to soybean cyst nematode (SCN) on chromosome 18. Another locus on chromosome 20 (cqRfs5) was reported to interact with this cluster. The aims of this study were to compare the inheritance of resistance to SDS in a near isogenic line (NIL) population that was fixed for resistance to SCN but still segregated at 2 of the 4 loci (cqRfs1 and cqRfs) for resistance to SDS on chromosome 18; to examine the interaction with the locus on chromosome 20; and to identify candidate regions underlying quantitative trait loci (QTL). Used were a near isogenic line population derived from residual heterozygosity in an F5:7 recombinant inbred line EF60 1-40; SDS response data from 2 locations and years; four microsatellite markers and six thousand SNP markers. Polymorphic regions were found from 2,788 to 8,938 Kbp on chromosome 18 and 33,100 to 34,943 Kbp on chromosome 20. Both regions were significantly (0.005 < P > 0.0001) associated with resistance to SDS. A fine map was constructed that Mendelized the three loci. Substitution maps suggested the two loci on chromosome 18 were actually 3 loci (cqRfs, cqRfs1 and cqRfs19). Candidate genes for cqRfs19 were identified in a small region of the genome sequence of soybean. An epistatic interaction was inferred where the allele of loci on chromosome 18 determined the value of the locus on chromosome 20. It was concluded that SDS loci are both complex and interacting which may explain the slow progress in breeding for resistance to SDS.

In response to the augmented haemodynamic load placed upon the heart by intense and prolonged exercise, various forms of physiological remodelling are elicited. The resultant cardiac structural, functional and electrical adaptations are coined the athlete’s heart. Due to the nature of the remodelling, in some cases these adaptations may however overlap with the diagnostic criteria for varying pathological conditions, often related to sudden cardiac death. Several variables are associated with the athlete’s heart including age, sex, sport, body size, and ethnicity. Ethnicity is of particular importance as athletes of an African/Afro-Caribbean ethnicity demonstrate a greater prevalence of abnormal changes suggestive of pathology. There is however paucity in the literature of the athlete’s heart among other ethnicities. For this reason Study 1 investigated the impact of Arabic ethnicity upon the structure, function and electrophysiology of the heart in male athletes. Study 1 identified that while Arabic athletes had larger hearts than Arabic controls, they had significantly smaller hearts than their Black and Caucasian athletic counterparts. While Black athletes had a significantly greater prevalence of training unrelated/abnormal ECG findings, Arabic and Caucasian both had similar levels of training unrelated/abnormal findings, suggesting the European Society of Cardiology guidelines for ECG interpretation in athletes are applicable for the ethnicity. Study 2 investigated another important facet of the athlete’s heart, which is body size. Study 2 identified that while there was a progressive relationship between body size and cardiac dimensions, the previously identified upper limits of cardiac structural remodelling were applicable even among those with a body surface area (BSA) over 2.3m2. Among the cohort of athletes with a BSA >2.3m2, Black athletes demonstrated significantly greater wall thickness’ than Caucasian and Arabic athletes. The second aspect to the thesis highlighted how the findings of Study 1 and 2 impact upon pre-participation screening. While debate still exists around the most effective methodology to screen for pathological cardiac conditions, several organisations mandate the use of the echocardiography alongside the resting 12-Lead ECG. Study 3 established that should echocardiography be limited to use as a follow up investigation, significant cost benefits could be elicited (47% reduction). The premise of this significant cost reduction was that no pathological case was identified by echocardiography in isolation. While still found to be useful in confirming pathology, significantly, in our study the investigation failed to identify two cases of hypertrophic cardiomyopathy. Study 4 investigated the implications of adopting modified ECG interpretation guidelines in light of the criticism that ECG screening should be avoided due to a high false positive rate. Utilising an ethnically diverse cohort, Study 4 demonstrated that using the ‘Refined’ criteria reduced the false positive rate from 22% when using the 2010 ESC guidelines to 5%. Importantly both criteria achieved 100% sensitivity, highlighting the importance of the ECG in cardiovascular screening.

Made available in DSpace on 2014-06-11T19:23:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-12-07Bitstream added on 2014-06-13T20:29:49Z : No. of bitstreams: 1 braganholi_df_me_araiq_parcial.pdf: 104237 bytes, checksum: e3996c0a9549c5f5ea02263aa29adb8f (MD5) Bitstreams deleted on 2014-10-03T16:24:42Z: braganholi_df_me_araiq_parcial.pdf,Bitstream added on 2014-10-03T16:27:39Z : No. of bitstreams: 2 braganholi_df_me_araiq_parcial.pdf.txt: 24116 bytes, checksum: 4311db628427328ebb1b15b5edcab15d (MD5) 000694394.pdf: 608461 bytes, checksum: dceff09293ceb64124b8735297fa48e3 (MD5) Bitstreams deleted on 2014-10-03T16:33:16Z: 000694394.pdf,Bitstream added on 2014-10-03T16:43:30Z : No. of bitstreams: 2 braganholi_df_me_araiq_parcial.pdf.txt: 24116 bytes, checksum: 4311db628427328ebb1b15b5edcab15d (MD5) 000694394.pdf: 608461 bytes, checksum: dceff09293ceb64124b8735297fa48e3 (MD5) Bitstreams deleted on 2014-10-03T16:48:56Z: 000694394.pdf,Bitstream added on 2014-10-03T16:49:47Z : No. of bitstreams: 1 000694394.pdf: 608461 bytes, checksum: dceff09293ceb64124b8735297fa48e3 (MD5) Bitstreams deleted on 2014-10-27T11:47:10Z: 000694394.pdf,Bitstream added on 2014-10-27T11:48:05Z : No. of bitstreams: 1 000694394.pdf: 608461 bytes, checksum: dceff09293ceb64124b8735297fa48e3 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Morte súbita cardíaca (MSC) é um dos maiores problemas de saúde pública no mundo, afetando cerca de 335 mil pessoas por ano nos EUA e aproximadamente 712 pessoas por dia no Brasil, predominantemente na faixa etária mais produtiva. Principalmente em jovens, as causas são desordens cardíacas com anormalidades estruturais e arritmogênicas de origens genéticas; além disso, alguns medicamentos podem influenciar na susceptibilidade a MSC ou a doenças cardiovasculares. Como a morte pode ocorrer num período máximo de uma hora após o início dos sintomas e não ser decorrente de trauma ou violência, o diagnóstico da causa de morte pode ser dificultado. A análise genética nestes casos é muito útil para ajudar a identificá-la e informar aos parentes próximos sobre um possível fator genético de risco pré-existente. Este trabalho propôs padronizar as reações de PCR e SNaPshot em multiplex para analisar 11 SNPs (single nucleotide polymorphisms) relacionados à MSC (NEWTON-CHEH et al. 2009) em grupos de familiares brasileiros com histórico de insuficiência cardíaca para uma futura utilização na Genética Forense e Médica, entretanto, o multiplex contendo 8 SNPs mostrou ser mais eficiente . Para tanto, amostras foram coletadas de indivíduos com histórico familiar de: coronariopatia, cardiomiopatia hipertrófica ou familiar próximo que sofreu ataque cardíaco e, indivíduos sem este histórico utilizados como controles. As análises não apresentaram diferenças significativas entre o grupo de indivíduos com histórico e controle, mas, os dados são compatíveis com as freqüências conhecidas dos SNPs. Também identificou-se um provável fator hereditário para o SNP rs4725982 em uma das famílias / Sudden cardiac death (SCD) is a major public health problems worldwide, affeting about 335,000 people per year in the U.S. and approximately 712 people per day in Brazil, predominantly in the most productive age group. Especially in young people, the causes are structural abnormalities of cardiac disorders and genetic origins of arrhythmogenic, in addition, some medications may influence susceptibility to SCD or cardiovascular disease. As death can occur whitin a maximum of one hour after onset of symptoms and not be due to trauma or violence, the diagnosis of the cause of the death can be difficult. Genetic analysis in these cases is very useful to help identify them and inform close relatives about a possible genetic risk factor pre-existing. This work proposed to standardize the PCR and SNaPshot multiplex to analyze 11 SNPs (single nucleotide polymorphisms) related to the SCD (NEWTON-CHEH et al. 2009) in Brazilian familial groups with a history of heart failure for future use in Forensic Genetics and Medical. For this, samples were collected from individuals with a family history of heart disease, hypertrophic cardiomyophathy or close relative who suffered a heart attack, and individuals without this history used as controls. The analysis showed no siginificant differences between the group of the individuals with a history and control, but the data are compatible with the frequencies of known SNPs. It also identified a probable hereditary factor for the SNP rs4725982 in one of the studied families

Orientador: Regina Maria Barretto Cicarelli / Banca: Rogério Nogueira de Oliveira / Banca: Greiciane Gaburro Panetto / Resumo: Morte súbita cardíaca (MSC) é um dos maiores problemas de saúde pública no mundo, afetando cerca de 335 mil pessoas por ano nos EUA e aproximadamente 712 pessoas por dia no Brasil, predominantemente na faixa etária mais produtiva. Principalmente em jovens, as causas são desordens cardíacas com anormalidades estruturais e arritmogênicas de origens genéticas; além disso, alguns medicamentos podem influenciar na susceptibilidade a MSC ou a doenças cardiovasculares. Como a morte pode ocorrer num período máximo de uma hora após o início dos sintomas e não ser decorrente de trauma ou violência, o diagnóstico da causa de morte pode ser dificultado. A análise genética nestes casos é muito útil para ajudar a identificá-la e informar aos parentes próximos sobre um possível fator genético de risco pré-existente. Este trabalho propôs padronizar as reações de PCR e SNaPshot em multiplex para analisar 11 SNPs (single nucleotide polymorphisms) relacionados à MSC (NEWTON-CHEH et al. 2009) em grupos de familiares brasileiros com histórico de insuficiência cardíaca para uma futura utilização na Genética Forense e Médica, entretanto, o multiplex contendo 8 SNPs mostrou ser mais eficiente . Para tanto, amostras foram coletadas de indivíduos com histórico familiar de: coronariopatia, cardiomiopatia hipertrófica ou familiar próximo que sofreu ataque cardíaco e, indivíduos sem este histórico utilizados como controles. As análises não apresentaram diferenças significativas entre o grupo de indivíduos com histórico e controle, mas, os dados são compatíveis com as freqüências conhecidas dos SNPs. Também identificou-se um provável fator hereditário para o SNP rs4725982 em uma das famílias / Abstract: Sudden cardiac death (SCD) is a major public health problems worldwide, affeting about 335,000 people per year in the U.S. and approximately 712 people per day in Brazil, predominantly in the most productive age group. Especially in young people, the causes are structural abnormalities of cardiac disorders and genetic origins of arrhythmogenic, in addition, some medications may influence susceptibility to SCD or cardiovascular disease. As death can occur whitin a maximum of one hour after onset of symptoms and not be due to trauma or violence, the diagnosis of the cause of the death can be difficult. Genetic analysis in these cases is very useful to help identify them and inform close relatives about a possible genetic risk factor pre-existing. This work proposed to standardize the PCR and SNaPshot multiplex to analyze 11 SNPs (single nucleotide polymorphisms) related to the SCD (NEWTON-CHEH et al. 2009) in Brazilian familial groups with a history of heart failure for future use in Forensic Genetics and Medical. For this, samples were collected from individuals with a family history of heart disease, hypertrophic cardiomyophathy or close relative who suffered a heart attack, and individuals without this history used as controls. The analysis showed no siginificant differences between the group of the individuals with a history and control, but the data are compatible with the frequencies of known SNPs. It also identified a probable hereditary factor for the SNP rs4725982 in one of the studied families / Mestre

A doenÃa de Chagas à um dos principais problemas mÃdico-sociais do Brasil. A morte sÃbita à um dos fenÃmenos clÃnicos caracterÃsticos da doenÃa de Chagas desde suas descriÃÃes iniciais. Mais de 50% da mortalidade nos pacientes com doenÃa de Chagas sÃo atribuÃveis à morte sÃbita cardÃaca. O cardiodesfibrilador implantÃvel (CDI) tornou-se a principal estratÃgia terapÃutica para prevenÃÃo de morte sÃbita. Contudo, a eficÃcia e a seguranÃa de se tratar o paciente chagÃsico com o CDI foi avaliada em poucos estudos observacionais. O objetivo do presente trabalho foi avaliar as caracterÃsticas clÃnicas, epidemiolÃgicas e a evoluÃÃo de pacientes com cardiopatia chagÃsica crÃnica e desfibrilador cardÃaco implantÃvel no Estado do CearÃ. Delineamento, populaÃÃo e mÃtodos: estudo retrospectivo, descritivo e analÃtico. A populaÃÃo consistiu de pacientes chagÃsicos com CDI por profilaxia primÃria ou secundÃria de morte sÃbita, atendidos em Ãnico hospital universitÃrio de referÃncia. Para anÃlise comparativa, foram incluÃdos pacientes com cardiopatia isquÃmica e CDI por profilaxia primÃria ou secundÃria de morte sÃbita. Os desfechos analisados foram: terapia apropriada (choque apropriado e terapia antitaquicardia), choque apropriada, mortalidade geral e sobrevida livre de eventos (choque apropriado, terapia apropriada ou Ãbito). Resultados: foram avaliados 146 pacientes, sendo 63 (42,5%) chagÃsicos com a mediana do tempo de seguimento de 27 meses (Q1=9,0 e Q3=47) e 83 (57,5%) isquÃmicos com a mediana do tempo de seguimento de 35 meses (Q1=22 e Q3=59). A taxa de mortalidade anual, a incidÃncia de morte sÃbita, a incidÃncia de tempestade arrÃtmica e a incidÃncia de choque inapropriados foram semelhantes nos dois grupos. Os pacientes isquÃmicos eram em mÃdia 10 anos mais velhos que os chagÃsicos (p<0,001). Observou-se terapia apropriada deflagrada pelo CDI em 27 (42,9%) pacientes chagÃsicos e 14 (16,9%) isquÃmicos (p=0,001). Choque apropriado foi observado em 23 (36,5%) pacientes chagÃsicos e 14 (16,9%) isquÃmicos. A cardiopatia chagÃsica aumentou em 2,07 vezes (IC 95%: 1,02-4,17) o risco de o paciente receber terapia apropriada. A classe funcional (I a IV), a fraÃÃo de ejeÃÃo (normal ou disfunÃÃo leve à severa) e o tipo de prevenÃÃo nÃo foram preditores de choque ou terapia apropriada nos pacientes com cardiopatia chagÃsica. NÃo houve diferenÃa significativa no tempo de sobrevida entre os pacientes chagÃsicos e os isquÃmicos. A sobrevida livre de eventos (choque, terapia apropriada e Ãbito) foi similar nos dois grupos (chagÃsicos e isquÃmicos). NÃo houve nenhuma morte sÃbita durante o seguimento dos pacientes chagÃsicos. A baixa escolaridade (HR=4,6 IC 95%;1,6-13,3) e a fraÃÃo de ejeÃÃo do ventrÃculo esquerdo menor que 30% (HR=6,3 IC 95%: 1,2-31,7) estiveram associadas de forma significante com o desfecho de Ãbito. ConclusÃes: a maior frequÃncia de pacientes chagÃsicos com registro de terapia apropriada e choque apropriado à consistente com a presenÃa de um substrato arritmogÃnico mais grave nessa patologia. Apesar dessa maior frequÃncia, nÃo houve nenhuma morte sÃbita no seguimento, o que sugere a efetividade do CDI nos pacientes chagÃsicos. A ausÃncia de diferenÃa na taxa de terapia apropriada ou choque apropriado entre os chagÃsicos com e sem disfunÃÃo ventricular sugere que a FEVE nÃo deveria ser usada como critÃrio preponderante e decisivo de indicaÃÃo do cardiodesfibrilador nesses pacientes. / Chagas disease is one of the major social-medical problems of Brazil. Sudden death is one of the clinical phenomena characteristic of the Chagas disease since their initial descriptions. More than 50% of mortality in patients with Chagas disease are attributable to sudden cardiac death. The Implantable Cardioverter-defibrillator (ICD) has become the main therapeutic strategy for prevention of sudden death. However, the efficacy and safety of treating Chagas patients with CDI was assessed in a few observational studies. The aim of this paper was to evaluate the clinical, epidemiological and outcome of patients with chronic Chagas heart disease and implantable cardioverter-defibrillator in the state of CearÃ. This was retrospective, descriptive and analytical study. The population consisted of chagasic patients with ICD for primary or secondary prevention of sudden death, enrolled at a sole university hospital. For comparative analysis, we included patients with ischemic cardiomyopathy and ICD for primary or secondary prevention of sudden death. The outcomes analyzed were: appropriate therapy (shock therapy and appropriate antitachycardia), appropriate shock, mortality and event-free survival (appropriate shock, appropriate therapy or death). Results: 146 patients were evaluated, 63 (42.5%) chagasic patients with median follow-up time of 27 months (Q1 = 9.0 and Q3 = 47) and 83 (57.5%) with a median of ischemic follow-up time of 35 months (Q1 = Q3 = 22 and 59). The annual mortality rate, the incidence of sudden death, the incidence of arrhythmic storm and the incidence of inappropriate shock were similar in both groups. The ischemic patients were on average 10 years older than the Chagas patients (p <0.001). Observed appropriate therapy triggered by CDI in 27 (42.9%) chagasic patients and 14 (16.9%) ischemic (p = 0.001). Appropriate shock was observed in 23 (36.5%) chagasic patients and 14 (16.9%) ischemic. Chagas heart disease increased by 2.07 times (95% CI: 1.02 to 4.17) the risk of the patient receiving appropriate therapy. The functional class (I to IV), ejection fraction (normal or mild dysfunction to severe) and type of prevention were not predictors of shock or appropriate therapy in patients with Chagas heart disease. There was no significant difference in survival time between patients with Chagas disease and the ischemic ones. The event-free survival (shock, appropriate therapy and death) was similar in both groups (Chagas disease and ischemic). There was no sudden death during follow-up of patients with Chagas disease. The low educational level (HR = 4.6 95% CI 1.6 to 13.3) and the ejection fraction of the left ventricle less than 30% (HR = 6.3 95% CI 1.2 to 31.7) were associated significantly with the outcome of death. Conclusions: The higher frequency of appropriate shock therapy in chronic Chagas disease is consistent with the presence of an arrhythmogenic substrate. Despite this higher frequency, there was no sudden death following, which suggests the effectiveness of ICD in patients with Chagas disease. The lack of difference in the rate of appropriate therapy or appropriate shock among chagasic patients with and without ventricular dysfunction suggests that LVEF should not be used as a preponderant and decisive criterion of the defibrillator indication in these patients.