Technological advances have changed the way information is accessed, retrieved, and utilized. The Internet has contributed to greater accessibility of scientific and technical information (STI), particularly in the arena of technical report literature. Technical reports, which communicate the results of research and development activities, are significant indicators of scientific trends because they often represent public and governmental interest in emerging fields of study. Prior to the widespread use of the Internet, technical reports were disseminated in print format with the use of specific, and often limited, distribution lists. However, as technical report literature found a home on the Internet, it became more accessible to the public as a discoverable resource on par with journal literature. This study investigates the transition from the traditional paper distribution to the digital distribution of technical reports beginning in the mid-1990s. Reports produced and distributed by Oak Ridge National Laboratory (ORNL) are examined to determine trends over time and across disciplines. The scientific disciplines of chemistry and engineering are contrasted with respect to citation patterns. A quantitative analysis is used to determine whether citation patterns of technical report literature reflect the transition from print access to digital access. Publication and citation information was collected in 2009 from ISI’s Web of Science product as well as from databases maintained by the Department of Energy’s Office of Scientific and Technical Information (OSTI).

Unregelmäßig erscheinende Berichte über wissenschaftliche Ergebnisse aus den einzelnen Forschungsbereichen der zum HZDR gehörenden Institute.

Unregelmäßig erscheinende Berichte über wissenschaftliche Ergebnisse aus den einzelnen Forschungsbereichen der zum FZD gehörenden Institute.

Unregelmäßig erscheinende Berichte über wissenschaftliche Ergebnisse aus den einzelnen Forschungsbereichen der zum FZR gehörenden Institute.

Made available in DSpace on 2015-07-22T20:49:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-22. Added 1 bitstream(s) on 2015-08-11T03:26:02Z : No. of bitstreams: 1 Publico-12515.pdf: 978359 bytes, checksum: 3be0798a82267f20204fe25244cbed7d (MD5) / Objetivo: Avaliar a evidência de eficácia e segurança do deferasirox para o tratamento da sobrecarga de ferro relacionada à betatalassemia, doença falciforme e síndrome mielodisplásica, em comparação a outros quelantes de ferro disponíveis no Brasil (desferroxamina e deferiprona). Método: Para síntese da evidência foi realizada busca por relatórios de agências de avaliação de tecnologias em saúde e por revisões sistemáticas no Medline (março 2009). Adicionalmente, foi feita busca por ensaios clínicos para atualização da informação disponível. Das referências identificadas, foi selecionado o trabalho de McLeod (2009), por ser uma revisão sistemática e estudo de avaliação econômica elaborado por uma agência de avaliação de tecnologias em saúde de alta confiabilidade. Considerando o contexto econômico local e a disponibilidade dos medicamentos e insumos laboratoriais, a evidência foi adaptada e avaliada criticamente. Resultados: A evidência encontrada é baseada em três ensaios clínicos, de baixa qualidade metodológica, que avaliaram o uso do deferasirox em relação à desferroxamina. Não foram localizados estudos comparativos entre o deferasirox e a deferiprona. Nos ensaios clínicos identificados, a concentração hepática de ferro (exame não disponível no Brasil) foi considerada como desfecho primário, apesar de na prática clínica a quantidade de ferro ser monitorada pela concentração de ferritina sérica. As mudanças na ferritina sérica revelam-se mais favoráveis em pacientes com betatalassemia e doença falciforme (maior prevalência no Brasil) que receberam desferroxamina, do que aqueles que receberam deferasirox. As informações econômicas levantadas indicam que o deferasirox, em comparação a desferroxamina pode ser uma opção custo-efetiva. Conclusões: Como o deferasirox foi introduzido recentemente no mercado brasileiro e é considerado alternativa de tratamento no sistema público de saúde, informações de farmacovigilância precisam ser monitoradas, principalmente no que se refere ao risco de insuficiência renal, citopenias (agranulocitose e trombocitopenia), além de distúrbios gastrointestinais, hepáticos, renais e sanguíneos. / Objectives: to evaluate the evidence on efficacy and safety regarding deferasirox for treatment of iron overload relating to beta-thalassemia, sickle cell disease and myelodysplastic syndrome, in comparison with other iron chelators available in Brazil (deferoxamine and deferiprone). Methods: to produce a synthesis of the evidence, a search was conducted using reports from HTA agencies and systematic reviews in Medline (March 2009). Additionally, a search for clinical trials was conducted to update the information available. Among the references identified, the study by McLeod (2009) was selected because this was a systematic review and economic evaluation produced by a highly trustworthy HTA agency. Considering the local economic context and the availability of medications and laboratory supplies, the evidence was adapted and critically evaluated. Results: the evidence found was based on three clinical trials of low methodological quality that evaluated the use of deferasirox in relation to deferoxamine. No comparative studies between deferasirox and deferiprone were found. In the clinical trials identified, hepatic iron concentration (a test unavailable in Brazil) was taken to be the primary outcome, although in clinical practice, the iron levels were monitored by means of the serum ferritin concentration. The changes in serum ferritin concentration were more favorable among patients with beta thalassemia and sickle cell disease (highest prevalence in Brazil) who received deferoxamine than among those who received deferasirox. Previous economic evaluation suggests that deferasirox may be a cost-effective strategy. Conclusions: since deferasirox was only recently introduced onto the Brazilian market and is considered to be an alternative for treatment within the public healthcare system, drug surveillance information is required, particularly regarding the risks of kidney failure, cytopenia (agranulocytosis and thrombocytopenia) and gastrointestinal, hepatic, renal and blood disorders. / TEDE / BV UNIFESP: Teses e dissertações

Made available in DSpace on 2015-05-14T12:20:04Z (GMT). No. of bitstreams: 1 ArquivoTotalEmerson.pdf: 2207438 bytes, checksum: 95d8b97946407bbf2ae6d83d6280e165 (MD5) Previous issue date: 2013-09-27 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / Information technology has become a critical success factor for companies increasingly dependent on information . This work has as main goal to present the experience of deploying an Integrated Management System ( SIG ) , acquired from the Universidade Federal do Rio Grande do Norte Federal University of Paraíba . The SIG is composed of three main systems : Integrated Management of Academic Activities ( SIGAA ) Integrated Heritage Management, and Contract ( SIPAC ) , Integrated Human Resource Management ( SIGRH ) and the Integrated Administration ( SIGAdmin ), which supports the aforementioned systems . Each contains several modules designed to support the business processes of an administrative and academic institution. This work also describes the methods that were made , based on best practice standards , to provide effective and efficient program implementation . The main problems will be exposed , as well as the benefits from the implementation . With modules already deployed , UFPB is already able to give more flexibility to some processes needed to support the main activities of the institution , and also use a complete tool , able to help in decision-making by senior managers and directors and thus influence , in a positive way , within the context of greater agility and transparency of administrative and academic processes that support them , the lives of thousands of people who , somehow , are related to the institution . / A tecnologia da informação tornou-se um fator crítico de sucesso para as empresas cada vez mais dependentes de informações. Esse trabalho tem como objetivo principal relatar a experiência de implantação do ERP, de nome SIG, adquirido junto à Universidade Federal do Rio Grande do Norte, na Universidade Federal da Paraíba. O SIG é composto de três principais sistemas: Sistema Integrado de Gestão de Atividades Acadêmicas(SIGAA), Sistema Integrado de Patrimônio, Administração e Contrato(SIPAC), Sistema Integrado de Gestão de Recursos Humanos(SIGRH) e do Sistema Integrado de Administração(SIGAdmin), que suporta os sistemas mencionados. Cada um contém diversos módulos, desenvolvidos para suportar os processos de negócios administrativos e acadêmicos de uma instituição. Esse trabalho também relatará os métodos que foram confeccionados, com base em padrões de melhores práticas, para dar eficácia e eficiência ao programa de implantação. Os principais problemas enfrentados serão expostos, assim como as vantagens e as desvantagens provenientes da implantação. Com os módulos já implantados, a UFPB já é capaz de dar mais agilidade a alguns processos necessários para suportar as atividades fins da instituição, e também utilizar uma ferramenta completa, capaz de ajudar na tomada de decisões por parte da alta administração e aos gestores e, assim, influenciar, de forma positiva, dentro do contexto de uma maior agilidade e transparência administrativa de processos acadêmicos e dos que os suportam, na vida de milhares de pessoas que, de algum modo, estão relacionados à instituição.

The diploma thesis aims to elaboration of project documentation for a one-family house reconstruction. The project is based on the local plan of the village Boršov nad Vltavou. Proposal is made in two variations - A and B. Project is worked-out according to the variation A and elaborated in a range for issuing notification of simple building. The house is designed in compliance with the area plan of the municipality and it follows the surrounding building development with its character. Work on the project documentation respected all legal regulations concerning of building design. The drawing part has been processed by visualization cad application.

The subject of diploma thesis is design and static assessment of steel structure of multipurpose hall. Construction is located in the city Brno. The floor plan is rectangular with dimensions 60 x 80 m. Headroom of the structure is 12,5 m and total height is 16,5 m. A main frame is created of arch truss supported by column and truss structure on both sides. The main frames are joined by purlins. Final support structure was selected from two preliminary variants. For the selected variant was made static calculation of main bearing elements including joints and anchoring, technical report, drawings and bill of quantities.

The assignment for the diplomatic work was mentioned in the technological project of the Vila Park in Olomouc. The task was to mention the underground floor of the 2nd dilatation and the building of the apartment house B7 with three floors, which is connected via the basement communication. The content of the technical report in the construction technology project, broader relationships, land-use planning, timeable, equipment design, machine assembly design, technological prescription of waterproof concrete construction, control and test plan, plan and item budget.

The subject of my diploma thesis is to design and assess a multipurpose sports hall in the area of Brno-Bystrc. The shape of the hall is rectangular with dimensions 45 m × 48 m. The roof is designed from an arched truss. The height of the construction is 18 m. Part of the thesis is a technical report which contains details of construction, list of used materials, production and maintenance method. The work also includes the static calculation of supporting elements and joints and the graphical documentation. The valid CSN EN technical standards were used for the design and assessment.