No description available.

No description available.

A piezoelectric impedance-based structural health monitoring technique was developed at the Center for Intelligent Material Systems and Structures. It has been successfully implemented on several complex structures to detect incipient-type damage such as small cracks or loose connections. However, there are still some problems to be solved before full scale development and commercialization can take place. These include: i) the damage assessment is influenced by ambient temperature change; ii) the sensing area is small; and iii) the ability to identify the damage location is poor. The objective of this research is to solve these problems in order to apply the impedance-based structural health monitoring technique to real structures. First, an empirical compensation technique to minimize the temperature effect on the damage assessment has been developed. The compensation technique utilizes the fact that the temperature change causes vertical and horizontal shifts of the signature pattern in the impedance versus frequency plot, while damage causes somewhat irregular changes. Second, a new impedance-based technique that uses multiple piezoelectric sensor-actuators has been developed which extends the sensing area. The new technique relies on the measurement of electrical transfer admittance, which gives us mutual information between multiple piezoelectric sensor-actuators. We found that this technique increases the sensing region by at least an order of magnitude. Third, a time domain technique to identify the damage location has been proposed. This technique also uses multiple piezoelectric sensors and actuators. The basic idea utilizes the pulse-echo method often used in ultrasonic testing, together with wavelet decomposition to extract traveling pulses from a noisy signal. The results for a one-dimensional structure show that we can determine the damage location to within a spatial resolution determined by the temporal resolution of the data acquisition. The validity of all these techniques has been verified by proof-of-concept experiments. These techniques help bring conventional impedance-based structural health monitoring closer to full scale development and commercialization. / Master of Science

<p dir="ltr">Manganese (Mn) is an essential trace element for humans that functions primarily as a coenzyme in several biological processes such as nerve and brain development, energy metabolism, bone growth and development, as well as cognitive functioning. However, overexposure to environmental Mn via occupational settings or contaminated drinking water can lead to toxic effects on the central nervous systems and cause a Parkinsonian disorder that features symptoms such as fine motor control deficits, dystonia rigidity, speech and mood disturbances, and cognitive deficits summarized under the term “manganism”. Over time, Mn exposure has shifted from acute, high-level instances leading to manganism, to low-level chronic exposure. Considering that Mn exposure is significantly lower than in the past, it is unlikely to expect manganism from chronic Mn exposure under current working conditions. Therefore, there is a need to develop sensitive methods to aid in updating the clinical diagnostic standards for manganism and Mn neurotoxicity as chronic exposure to Mn leads to more subtle symptoms.</p><p><br></p><p dir="ltr">Historically, magnetic resonance imaging (MRI) has been used as a non-invasive tool for detecting excess brain Mn accumulation. Specifically, T1-weighted images show bilateral hyperintensities of the globus pallidus (GP) due to the paramagnetic properties of Mn which increases the MR relaxation rate R1. Although the GP is considered the hallmark of excess brain Mn, this brain area is not necessarily associated with symptoms, exposure, or neuropsychological outcomes. Thus, the focus should not be on the GP only but on the entire brain. With recent advances in quantitative MRI (qMRI), whole brain mapping techniques allow for the direct measurement of relaxation rate changes due to Mn accumulation. The work in this dissertation uses such quantitative techniques and network science to establish novel computational in vivo imaging methods to a) visualize and quantify excess Mn deposition at the group and individual level, and b) characterize the toxicokinetics of excess brain Mn accumulation and the role of different brain regions in the development of neurotoxicity effects.</p><p><br></p><p dir="ltr">First, we developed a novel method for depicting excess Mn accumulation at the group level using high-resolution R1 relaxation maps to identify regional differences using voxel-based quantification (VBQ) and statistical parametric mapping. Second, we departed from a group analysis and developed subject-specific maps of excess brain Mn to gain a better understanding of the relationship between the spatial distribution of Mn and exposure settings. Third, we developed a novel method that combines network science with MRI relaxometry to characterize the storage and propagation of Mn and Fe in the human brain and the role of different brain regions in the development of neurotoxic effects. Lastly, we explore the application of ultra-short echo (UTE) imaging to map Fe content in the brain and compare it against R2* and quantitative susceptibility mapping (QSM).</p><p><br></p><p dir="ltr">Overall, this dissertation is a successful step towards establishing sensitive neuroimaging screening methods to study the effects of occupational Mn exposure. The individual Mn maps offer great potential for evaluating personal risk assessment for Mn neurotoxicity and allow monitoring of temporal changes in an individual, offering valuable information about the toxicokinetics of Mn. The integration of network science provides a holistic analysis to identify subtle changes in the brain’s mediation mechanisms of excess metal depositions and their associations with health outcomes.</p>

Radio repeaters in communication systems are used to extend the coverage where the base stations cannot reach directly, such as indoors, in tunnels, and obstructed mobile reception areas. The repeaters in the downlink receive signals from base stations, amplify them, and then retransmit them. In case of this, the receiving antenna may receive the signals from the transmitting antenna of the repeater, and therefore introduce oscillation. To minimize the oscillation and keep the system stable, there should be a suitable isolation between transmitting and receiving antennas. Isolation margin estimation for wide-band signals can be achieved by applying auto-correlation. However, there are still important applications in narrow-band technologies such as Global Systems for Mobile Communication (GSM). Although the GSM is not the latest technology in communication systems and has been largely surpassed by 3G, 4G, and 5G in terms of data capabilities, it is still widely used in many parts of the world such as commercial voice communication in rural areas, safety-critical transmissions in railways and so on. The auto-correlation functions are hard to use since the auto-correlation response is generally wider than that of wide-band signals. In this project, attempts are made to find more accurate estimation methods. Channel estimation method is chosen as the central focus of this project. This project simulated methods such as frequency correction and channel estimation and evaluated the performance of the algorithms. The simulation results indicate that the channel estimation algorithm performs well when the signal-to-noise ratio is 80dB and the feedback signal power is 55dB lower than the wanted signal. It also provides a result that the estimation results are accurate when the power of the feedback signal is approximately 20dB higher than the noise signal. / Radio repeatrar i kommunikationssystem används för att utöka täckningen där basstationer inte kan nå direkt, såsom inomhus, i tunnlar och i områden med blockerad mobil mottagning. Repeatrarna i nedlänken tar emot signaler från basstationer, förstärker dem och sänder sedan ut dem igen. I detta fall kan den mottagande antennen ta emot signalerna från repeatrarnas sändande antenner och därmed introducera oscillation. För att minimera oscillationen och hålla systemet stabilt bör det finnas en lämplig isolation mellan sändande och mottagande antenner. Isoleringsmarginaluppskattning för bredbandsignaler kan uppnås genom att tillämpa autokorrelation. Det finns dock fortfarande viktiga tillämpningar inom smalbands teknologier som Global System for Mobile Communication (GSM). Även om GSM inte är den senaste tekniken inom kommunikationssystem och har i stor utsträckning överskridits av 3G, 4G och 5G när det gäller datamöjligheter, används det fortfarande i stor utsträckning i många delar av världen, såsom kommersiell röstkommunikation på landsbygden, säkerhetskritiska överföringar inom järnvägar och så vidare. Autokorrelationsfunktionerna är svåra att använda eftersom autokorrelationsresponsen generellt är bredare än för bredbandsignaler. I det här projektet görs försök att hitta mer exakta uppskattningmetoder. Kanaluppskattningsmetoden väljs som den centrala fokusen för detta projekt. Detta projekt simulerade metoder som frekvenskorrigering och kanaluppskattning och utvärderade prestandan hos algoritmerna. Simuleringsresultaten indikerar att kanaluppskattningsalgoritmen fungerar bra när signal-brusförhållandet är 80dB och feedbacksignalens effekt är så låg som 55dB. Den ger också ett resultat som visar att uppskattningsresultaten är korrekta när feedbacksignalens effekt är ungefär 20dB högre än brussignalens.

La Direction générale responsable de l’aide humanitaire de la Commission européenne(DG ECHO) est un acteur particulier des relations internationales. Sa singularité est marquée par une institutionnalisation progressive et par un fonctionnement distinct au sein des institutions européennes.L’étude de la stratégie qu’elle a élaborée pour lutter contre la malnutrition au Sahel révèle tout particulièrement les forces, les faiblesses, mais aussi les opportunités et les contraintes de l’aide humanitaire de la Commission européenne. À la lumière de cette stratégie, la DG ECHO est parvenue à promouvoir une approche crédible et reconnue afin de combattre la malnutrition. Néanmoins, l’enjeu sécuritaire que représente ce phénomène expose les vulnérabilités de la Commission européenne, à plus forte raison dans le contexte volatil du Sahel. Le manque de cohérence des actions extérieures et l’administration de l’Union européenne se révèlent particulièrement contraignants.Pourtant, l’autorité et la maturité dont fait preuve la DG ECHO, notamment dans la dimension nutritionnelle de l’aide, lui offrent la légitimité d’exister et le privilège d’être devenu un acte urfondamental, voire incontournable, du système humanitaire. La plus-value qu’elle apporte repose sur l’expertise de son personnel mais aussi sur un partenariat original avec des opérateurs spécialisés. Au terme de deux décennies d’existence, la DG ECHO s’affirme et exerce une influence croissante sur la scène européenne, où elle contribue à la construction de l’identité de l’Union, mais aussi internationale. / The European Commission Directorate-General for Humanitarian Aid (ECHO) has become a unique actor in international relations. Its singularity is defined by a progressive institutionalisation and a proper functioning within the European institutions. In particular, the study of the strategy ECHO has developed to fight malnutrition in the Sahel reveals the strengths, the weaknesses, the opportunities and the constraints of the European Commission humanitarian aid system. Indeed, ECHO has succeeded in promoting a credible and recognized policy to combat malnutrition. However, the security challenge posed by malnutrition exposes the European Commission’s vulnerabilities, which are heightened in the volatile environment of the Sahel. The lack of coherence of the EuropeanUnion external actions and administration are particularly constraining. Though, the authority and maturity displayed by ECHO, specifically in the nutritional dimensions of aid, has increased its legitimacy to exist and to be a key player in the humanitarian aid system. The added value it provides is based on the expertise of its staff,but also on a unique system of partnerships with specialized operators. Twenty years after its creation, ECHO has asserted itself and has a growing influence on the international and European scene, where it contributes to the construction of the EU identity.

En Imagerie par Résonance Magnétique (IRM), l’augmentation du champ magnétique statique permet en théorie de fournir un rapport signal sur bruit accru, améliorant la qualité des images. L’objectif de l’IRM à ultra haut champ est d’atteindre une résolution spatiale suffisamment haute pour pouvoir distinguer des structures si fines qu’elles sont actuellement impossibles à visualiser de façon non-invasive. Cependant, à de telles valeurs de champs magnétiques, la longueur d’onde du rayonnement électromagnétique envoyé pour basculer les spins des protons de l’eau est du même ordre de grandeur que l’objet dont on souhaite faire l’image. Des phénomènes d’interférences sont observés, ce qui se traduit par l’inhomogénéité de ce champ radiofréquence (RF) au sein de l’objet. Ces interférences engendrent des artefacts de signal et/ou de contraste dans les images IRM, et rendent ainsi leur exploitation délicate. Il est donc crucial de fournir des solutions pour atténuer la non-uniformité de l’excitation des spins, à défaut de quoi de tels systèmes ne pourront atteindre leurs pleins potentiels. Pour obtenir des diagnostics pertinents à très haut champ, il est donc nécessaire de créer des impulsions RF homogénéisant l'excitation de l'ensemble des spins (ici du cerveau humain), optimisées pour chaque individu. Pour cela, un système de transmission parallèle (pTX) à 8 canaux a été installé au sein de notre imageur à 7 Tesla. Alors que la plupart des systèmes IRM cliniques n’utilisent qu’un seul canal d’émission, l’extension pTX permet de jouer différentes formes d’impulsions RF de concert. La somme résultante de ces interférences doit alors être optimisée pour atténuer la non-uniformité observée classiquement. L’objectif de cette thèse est donc de synthétiser ce type d’impulsions, en utilisant la pTX. Ces impulsions auront pour contrainte supplémentaire le respect des limitations internationales concernant l'exposition à des champs radiofréquence, qui induit une hausse de température dans les tissus. En ce sens, de nombreuses simulations électromagnétiques et de températures ont été réalisées en introduction de cette thèse, afin d’évaluer la relation entre les seuils recommandés d’exposition RF et l’élévation de température prédite dans les tissus. Cette thèse porte plus spécifiquement sur la conception de l’ensemble des impulsions RF refocalisantes utilisées dans des séquences IRM non-sélectives, basées sur l’écho de spin. Dans un premier temps, seule une impulsion RF a été générée, pour une application simple : l’inversion du déphasage des spins dans le plan transverse. Dans un deuxième temps, sont considérées les séquences à long train d’échos de refocalisation appliquées à l’in vivo. Ici, l’opérateur mathématique agissant sur la magnétisation, et non pas son état final comme il est fait classiquement, est optimisé. Le gain en imagerie à très haut champ est clairement visible puisque les opérations mathématiques (la rotation des spins) voulues sont réalisées avec plus de fidélité que dans le cadre des méthodes de l’état de l’art. Pour cela, la génération de ces impulsions RF combine une méthode d’excitation des spins avec navigation dans l’espace de Fourier, les kT-points, et un algorithme d’optimisation, appelé Gradient Ascent Pulse Engineering (GRAPE), utilisant le contrôle optimal. Cette conception est rapide grâce à des calculs analytiques plus directs que des méthodes de différences finies. La prise en compte d’un grand nombre de paramètres nécessite l’usage de GPUs (Graphics Processing Units) pour atteindre des temps de calcul compatibles avec un examen clinique. Cette méthode de conception d’impulsions RF a été validée expérimentalement sur l’imageur 7 Tesla de NeuroSpin, sur une cohorte de volontaires sains. / In Magnetic Resonance Imaging (MRI), the increase of the static magnetic field strength is used to provide in theory a higher signal-to-noise ratio, thereby improving the overall image quality. The purpose of ultra-high-field MRI is to achieve a spatial image resolution sufficiently high to be able to distinguish structures so fine that they are currently impossible to view in a non-invasive manner. However, at such static magnetic fields strengths, the wavelength of the electromagnetic waves sent to flip the water proton spins is of the same order of magnitude than the scanned object. Interference wave phenomena are then observed, which are caused by the radiofrequency (RF) field inhomogeneity within the object. These generate signal and/or contrast artifacts in MR images, making their exploitation difficult, if not impossible, in certain areas of the body. It is therefore crucial to provide solutions to mitigate the non-uniformity of the spins excitation. Failing this, these imaging systems with very high fields will not reach their full potential.For relevant high field clinical diagnosis, it is therefore necessary to create RF pulses homogenizing the excitation of all spins (here of the human brain), and optimized for each individual to be imaged. For this, an 8-channel parallel transmission system (pTX) was installed in our 7 Tesla scanner. While most clinical MRI systems only use a single transmission channel, the pTX extension allows to simultaneously playing various forms of RF pulses on all channels. The resulting sum of the interference must be optimized in order to reduce the non-uniformity typically seen.The objective of this thesis is to synthesize this type of tailored RF pulses, using parallel transmission. These pulses will have as an additional constraint the compliance with the international exposure limits for radiofrequency exposure, which induces a temperature rise in the tissue. In this sense, many electromagnetic and temperature simulations were carried out as an introduction of this thesis, in order to assess the relationship between the recommended RF exposure limits and the temperature rise actually predicted in tissues.This thesis focuses specifically on the design of all RF refocusing pulses used in non-selective MRI sequences based on the spin-echo. Initially, only one RF pulse was generated for a simple application: the reversal of spin dephasing in the transverse plane, as part of a classic spin echo sequence. In a second time, sequences with very long refocusing echo train applied to in vivo imaging are considered. In all cases, the mathematical operator acting on the magnetization, and not its final state as is done conventionally, is optimized. The gain in high field imaging is clearly visible, as the necessary mathematical operations (that is to say, the rotation of the spins) are performed with a much greater fidelity than with the methods of the state of the art. For this, the generation of RF pulses is combining a k-space-based spin excitation method, the kT-points, and an optimization algorithm, called Gradient Ascent Pulse Engineering (GRAPE), using optimal control.This design is relatively fast thanks to analytical calculations rather than finite difference methods. The inclusion of a large number of parameters requires the use of GPUs (Graphics Processing Units) to achieve computation times compatible with clinical examinations. This method of designing RF pulses has been experimentally validated successfully on the NeuroSpin 7 Tesla scanner, with a cohort of healthy volunteers. An imaging protocol was developed to assess the image quality improvement using these RF pulses compared to typically used non-optimized RF pulses. All methodological developments made during this thesis have contributed to improve the performance of ultra-high-field MRI in NeuroSpin, while increasing the number of MRI sequences compatible with parallel transmission.

No description available.

Ces travaux de thèse sont consacrés à l’étude, par RMN et spectrométrie de masse, de la caractérisation structurale et la quantification en mélange, de polymères synthétiques à architectures complexes. La caractérisation structurale de copolymères à blocs amphiphiles POE-b-PS a été abordée dans un premier temps par la mise au point d’une nouvelle stratégie, rapide et sans prétraitement, pour la détermination de la masse moyenne en masse par RMN PGSE. La problématique des groupements terminaux fragiles en MALDI-MS, particulièrement cruciale dans le cas de polymères fonctionnalisés par des nitroxydes, a également été traitée. Une approche multidisciplinaire impliquant la RMN, la spectrométrie de masse et la chimie théorique a conduit au développement d’une stratégie de dérivation du groupement terminal labile qui permet la production d’adduits moléculaires intacts MALDI. Par ailleurs, la nécessité de quantifier les impuretés issues de la synthèse de ces macromolécules a conduit au développement d’une stratégie originale, rapide et efficace, basée sur la RMN PGSE. Cette stratégie, qui s’appuie sur la détermination des temps de relaxation magnétique des signaux au cours des expériences, suivie de la renormalisation des intégrales, a notamment soulevé la difficulté de mesurer le temps de relaxation transversale dans le cas de systèmes de spins magnétiquement couplés. Une nouvelle séquence d’impulsions a donc été proposée pour permettre une mesure précise de ce temps de relaxation dans un système de deux spins couplés. / This thesis work deals with two main analytical aspects of PEO-b-PS amphiphilic block copolymers, their structural characterization and their quantitation in mixture, using NMR and mass spectrometry. In a first part, a novel approach was developed for the determination of copolymer weight average molecular weight by PGSE NMR. The issue of MALDI mass analysis of PEO homopolymers functionalized with a labile nitroxide end-group for the purpose of nitroxide mediated polymerization of the PS block was also addressed. A multidisciplinary approach involving NMR, mass spectrometry and theoretical calculation gave rise to an efficient derivatization strategy aimed at allowing intact PEO adducts to be generated by MALDI. In addition, requirement for impurity quantitation in polymer samples led to the development of a rapid and accurate method using PGSE NMR. This approach, based on the measurement of magnetic relaxation times during PGSE experiments to enable signal intensity renormalization, evidenced the issue of transverse relaxation time estimation in the case of coupled spin systems. A novel NMR pulse sequence was hence proposed and successfully applied for accurate measurement of transverse relaxation times in a model case of a two-spin coupled system.

This thesis is concerned with problems of measuring and mapping of magnetic field in MR tomograph, for purpose of magnetic flux density homogeneity optimization. Attention is paid to mapping techniques on rotary symmetric volume and to ways of magnetic fields optimization with utilization of passive and active correction systems. Theoretical analysis of magnetic field decomposition with utilization of spherical harmonics and numerical decomposition is made. Mapping and approximation techniques of basic magnetic field are verified by experiments in the laboratory at the Institute of Scientific Instruments AS CR in Brno.