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Globalization has transformed the pharmaceutical industry into a vast, interconnected network. However, this complexity has led to inefficiencies in the supply chain, with existing ERP systems struggling to keep up due to their centralized nature, resulting in a lack of transparency and increased errors. This research proposes efficient distributed ledger-based architectures to address these challenges. In Chapter 3, a new transparent supply chain architecture is introduced to eliminate blind spots and enable stakeholders to verify the authenticity of pharmaceutical products. This system creates a secure, single source of truth for the entire lifecycle of medicines, thereby eliminating counterfeits. Chapter 4 focuses on securing the cold pharmaceutical supply chain using IoT and distributed ledgers. The proposed architecture monitors and controls environmental parameters, ensuring safe drug transport. Scalability is addressed with a novel proof of authentication (PoAh) blockchain called EasyChain. In Chapter 5, the serialization of pharmaceutical products is enhanced through digital twinning, providing an efficient and cost-effective solution while complying with regulations. This research aims to create scalable and efficient pharmaceutical supply chains, reducing counterfeits and improving overall security.

No / To investigate the underlying nature of the effects of transcranial magnetic stimulation (TMS) on speed perception, we applied repetitive TMS (rTMS) to human V5/MT+ following adaptation to either fast- (20 deg/s) or slow (4 deg/s)-moving grating stimuli. The adapting stimuli induced changes in the perceived speed of a standard reference stimulus moving at 10 deg/s. In the absence of rTMS, adaptation to the slower stimulus led to an increase in perceived speed of the reference, whilst adaptation to the faster stimulus produced a reduction in perceived speed. These induced changes in speed perception can be modelled by a ratio-taking operation of the outputs of two temporally tuned mechanisms that decay exponentially over time. When rTMS was applied to V5/MT+ following adaptation, the perceived speed of the reference stimulus was reduced, irrespective of whether adaptation had been to the faster- or slower-moving stimulus. The fact that rTMS after adaptation always reduces perceived speed, independent of which temporal mechanism has undergone adaptation, suggests that rTMS does not selectively facilitate activity of adapted neurons but instead leads to suppression of neural function. The results highlight the fact that potentially different effects are generated by TMS on adapted neuronal populations depending upon whether or not they are responding to visual stimuli. / BBSRC

O dilema do prisioneiro é geralmente visto como o ponto de partida para entender o problema da cooperação. Em comparação com o dilema do prisioneiro discreto e iterado, poucos estudos existem sobre o dilema do prisioneiro contínuo e iterado. A maioria dos trabalhos que investigaram o dilema do prisioneiro contínuo e iterado concentrou-se no período de 1990 a 2000, não obtendo resultados conclusivos sobre a melhor estratégia a ser adotada neste tipo de jogo. Duas estratégias diferentes se destacam neste tipo de dilema. A primeira é a estratégia RTS (Raise-the-Stakes) de Roberts e Sherrat (1998) que testa o terreno antes de aumentar os investimentos na relação. A segunda deriva do modelo LRS (Linear Reactive Strategies) de Wahl e Nowak (1999a). Esta última estratégia estando em equilíbrio de Nash cooperativo apresenta três características: (i) generosidade, i.e., investir o máximo possível no início da relação de cooperação; (ii) otimismo, i.e., contar com o melhor cenário para as próximas rodadas, e (iii) intransigência. Esta pesquisa tem como objetivo principal contrapor as estratégias RTS e LRS num dilema do prisioneiro contínuo e iterado, na presença e ausência de ruído, com jogadas simultâneas e alternadas e para diferentes valores do parâmetro w (probabilidade de interagir novamente). Restringimos a nossa análise a um conjunto de seis estratégias: ALLC, ALLD, TFT, RTS, LRS e RTSM. O método utilizado foi o da simulação baseada em agente (ABM) no formato de torneios, semelhante ao de Axelrod (2006), Roberts & Sherratt (1998), Nowak & Sigmund (1992) e Nowak & Sigmund (1993). Utilizamos o software Netlogo e documentamos todo o processo da concepção e construção do modelo por meio da ferramenta TRACE (TRAnsparent and Comprehensive model Evaludation). Os resultados mostram que as estratégias mais cooperativas são mais favorecidas quando o jogo consiste em jogadas alternadas ao invés de simultâneas. A estratégia RTS teve melhor desempenho em jogos simultâneos para valores intermediários de w, na presença ou ausência de ruído. Por sua vez, a estratégia LRS teve melhor desempenho nos jogos simultâneos, na presença ou ausência de ruído, ou alternados e na presença de ruído, em ambos os casos para valores grandes de w / The prisoner\'s dilemma is generally seen as the starting point for understanding the problem of cooperation. In comparison with the discreet and iterated prisoner\'s dilemma, few studies exist on the continuous iterated prisoner\'s dilemma. Most of the works that have investigated the continuous iterated prisoner\'s dilemma has concentrated in the period from 1990 to 2000, not getting conclusive results on the best strategy to be adopted in this type of game. Two different strategies stand out in this kind of dilemma. The first is the RTS strategy (Raise-the-Stakes) of Roberts and Sherrat (1998) that tests the ground before increasing investment in the relationship. The second is the model deriva LRS (Linear Reactive Strategies) de Wahl and Nowak (1999a). This last strategy being in Nash equilibrium cooperative presents three characteristics: (i) generosity, i.e., investing as much as possible at the beginning of the cooperation relationship; (ii) optimism, i.e., rely on the best scenario for the next rounds, and (iii) intransigence. This research has as main goal to reconcile opposing RTS strategies and LRS in a continuous iterated prisoner\'s dilemma, in the presence and absence of noise, with simultaneous moves and alternate and for different values of the parameter w (probability of interacting again). We restrict our analysis to a set of six strategies: ALLC, ALLD, TFT, RTS, LRS and RTSM (halfway between RTS and LRS). The method used was the agent-based simulation (ABM) in tournament format, similar to that of Axelrod (2006), Roberts (1998), Sherratt & Nowak & Sigmund (1992) and Nowak & Sigmund (1993). We use the NetLogo software and document the whole process of design and construction of the tool model TRACE (TRAnsparent and Comprehensive model Evaludation). The results show that most strategies are more favoured unions when the game consists of alternating plays rather than simultaneous. The RTS strategy had better performance in simultaneous games for intermediate values of w, in the presence or absence of noise. In turn, the IRS strategy had better performance when simultaneous games, in the presence or absence of noise, or switched, and in the presence of noise, in both cases, for large values of w

O dilema do prisioneiro é geralmente visto como o ponto de partida para entender o problema da cooperação. Em comparação com o dilema do prisioneiro discreto e iterado, poucos estudos existem sobre o dilema do prisioneiro contínuo e iterado. A maioria dos trabalhos que investigaram o dilema do prisioneiro contínuo e iterado concentrou-se no período de 1990 a 2000, não obtendo resultados conclusivos sobre a melhor estratégia a ser adotada neste tipo de jogo. Duas estratégias diferentes se destacam neste tipo de dilema. A primeira é a estratégia RTS (Raise-the-Stakes) de Roberts e Sherrat (1998) que testa o terreno antes de aumentar os investimentos na relação. A segunda deriva do modelo LRS (Linear Reactive Strategies) de Wahl e Nowak (1999a). Esta última estratégia estando em equilíbrio de Nash cooperativo apresenta três características: (i) generosidade, i.e., investir o máximo possível no início da relação de cooperação; (ii) otimismo, i.e., contar com o melhor cenário para as próximas rodadas, e (iii) intransigência. Esta pesquisa tem como objetivo principal contrapor as estratégias RTS e LRS num dilema do prisioneiro contínuo e iterado, na presença e ausência de ruído, com jogadas simultâneas e alternadas e para diferentes valores do parâmetro w (probabilidade de interagir novamente). Restringimos a nossa análise a um conjunto de seis estratégias: ALLC, ALLD, TFT, RTS, LRS e RTSM. O método utilizado foi o da simulação baseada em agente (ABM) no formato de torneios, semelhante ao de Axelrod (2006), Roberts & Sherratt (1998), Nowak & Sigmund (1992) e Nowak & Sigmund (1993). Utilizamos o software Netlogo e documentamos todo o processo da concepção e construção do modelo por meio da ferramenta TRACE (TRAnsparent and Comprehensive model Evaludation). Os resultados mostram que as estratégias mais cooperativas são mais favorecidas quando o jogo consiste em jogadas alternadas ao invés de simultâneas. A estratégia RTS teve melhor desempenho em jogos simultâneos para valores intermediários de w, na presença ou ausência de ruído. Por sua vez, a estratégia LRS teve melhor desempenho nos jogos simultâneos, na presença ou ausência de ruído, ou alternados e na presença de ruído, em ambos os casos para valores grandes de w / The prisoner\'s dilemma is generally seen as the starting point for understanding the problem of cooperation. In comparison with the discreet and iterated prisoner\'s dilemma, few studies exist on the continuous iterated prisoner\'s dilemma. Most of the works that have investigated the continuous iterated prisoner\'s dilemma has concentrated in the period from 1990 to 2000, not getting conclusive results on the best strategy to be adopted in this type of game. Two different strategies stand out in this kind of dilemma. The first is the RTS strategy (Raise-the-Stakes) of Roberts and Sherrat (1998) that tests the ground before increasing investment in the relationship. The second is the model deriva LRS (Linear Reactive Strategies) de Wahl and Nowak (1999a). This last strategy being in Nash equilibrium cooperative presents three characteristics: (i) generosity, i.e., investing as much as possible at the beginning of the cooperation relationship; (ii) optimism, i.e., rely on the best scenario for the next rounds, and (iii) intransigence. This research has as main goal to reconcile opposing RTS strategies and LRS in a continuous iterated prisoner\'s dilemma, in the presence and absence of noise, with simultaneous moves and alternate and for different values of the parameter w (probability of interacting again). We restrict our analysis to a set of six strategies: ALLC, ALLD, TFT, RTS, LRS and RTSM (halfway between RTS and LRS). The method used was the agent-based simulation (ABM) in tournament format, similar to that of Axelrod (2006), Roberts (1998), Sherratt & Nowak & Sigmund (1992) and Nowak & Sigmund (1993). We use the NetLogo software and document the whole process of design and construction of the tool model TRACE (TRAnsparent and Comprehensive model Evaludation). The results show that most strategies are more favoured unions when the game consists of alternating plays rather than simultaneous. The RTS strategy had better performance in simultaneous games for intermediate values of w, in the presence or absence of noise. In turn, the IRS strategy had better performance when simultaneous games, in the presence or absence of noise, or switched, and in the presence of noise, in both cases, for large values of w

Dans la perspective d’améliorer les cellules du futur, nous avons élaboré respectivement des couches minces de ZnO dopé Mo par la méthode spray pyrolyse et dopé Yb par sputtering. Quel que soit la technique utilisée, toutes ces couches sont polycristallines, transparentes avec des surfaces uniformes. De plus les mesures d’effet Hall montrent une conductivité de type n dans le cas des deux systèmes étudiés. Concernant les films minces de ZnO dopé Mo, les propriétés électriques restent potentiellement intéressantes pour des applications en photovoltaïque en tant que dopant additionnel en plus des terres rares. Quant aux films minces de ZnOYb, les résultats de mesures PL ont clairement mis en évidence un couplage optique entre ZnO et l’Yb avec l’observation d’un photon infrarouge pour un photon UV incident. Ceci suggère que le concept « down-shift » est susceptible d’être validé. / In view of improving the cells of the future, we have elaborated respectively doped ZnO thin films by Mo spray pyrolysis method and doped Yb by sputtering. Whatever the technique used all these layers are polycrystalline, transparent with smooth surfaces. In addition, the Hall effect measurements show an n-type conductivity in the case of two systems studied. On thin films of ZnO doped Mo, the electrical properties are potentially interesting for photovoltaic applications as additional dopant in addition to rare earths. As for thin films ZnOYb, PL measurement results have clearly demonstrated an optical coupling between ZnO and Yb with the observation of a photon infrared photon UV incident. This suggests that the concept of "down-shift" is likely to be validated.

Le travail que j’ai effectué durant ce doctorat est dédié à l’utilisation de l’ultrason des lasers sous haute pression physique. La recherche est construite en utilisant les récentes techniques de mesure de laser ultrasonique dans une enclume de diamant, conduisant à l’exploration de la propagation du son et de sa détermination suivant la vitesse de l’onde acoustique sous ultra-hautes pressions. La diffusion Brillouin a été appliquée ici pour déterminer l’épaisseur de la glace polycristalline compressée dans l’enclume à diamant sous pressions de mégabars. La technique permet d’examiner les caractéristiques des dimensions des inhomogénéités élastiques et la texture de la glace polycristalline, de ce fait ce processus est commun pour les surfaces de l’enclume à diamant avec des sous micromètres de résolution spatiale via les mesures des variations résolues dans le temps sur la vitesse de propagation du pouls acoustique voyageant dans l’échantillon compressé. Ceci a été appliqué pour mesurer la vitesse acoustique dans du H2O à l’état de glace jusqu’à 84 Gpa. La technique d’imagerie développée contient, pour chaque cristallite (ou groupe de cristallites) dans un ensemble homogène chimique transparent, des informations utiles sur son orientation ainsi que sur sa valeur élastique modulée par rapport à la direction de la propagation du son. Cela répand les bases pour une application réussite sur la déformation de solides sous haut-développement de modèles micromécaniques sous la pression à mégabars. Pour une plus longue durée, ce genre d’expériences répandus sur les minéraux de la terre et avec des températures basses ou hautes, assurerait un progrès important dans la compréhension de la construction de la cape terrestre, son évolution ainsi que celle d’autres planètes. / This PhD research work is devoted to the use of laser ultrasound in high-pressure physics. The research is done using the recently established technique of laser ultrasonic measurements in a diamond anvil cell which allows investigation of the sound propagation and determination of the acoustic wave velocities at ultrahigh pressures. Time domain Brillouin scattering was applied here to depth-profiling of polycrystalline aggregate of ice compressed in a diamond anvil cell to megabar pressures. The technique allowed examination of characteristic dimensions of elastic inhomogeneities and texturing of polycrystalline ice in the direction, normal to the diamond anvil surfaces with sub-micrometer spatial resolution via time-resolved measurements of variations in the propagation velocity of the acoustic pulse travelling in the compressed sample. It was applied to measure the acoustic velocities in H2O ice up to 84 Gpa. The developed imaging technique provides, for each crystallite (or a group of crystallites) in chemically homogeneous transparent aggregate, usable information on its orientation as well as on the value of the elastic modulus along the direction of the sound propagation. This extends the basis for a successful application of highly developed micromechanical models of solids deformation at mbar pressure. On long term, such experiments extended to earth’s minerals and high or low temperatures would insure a significant progress in understanding of convection of the earth’s mantle and thus evolution of this and other planets.