Research shows that individuals who had negative encounters in healthcare had significantly less contact with healthcare. Ehlers-Danlos syndrome is a challenge to diagnose and treat. Studies have shown that individuals with Ehlers-Danlos syndrome for these reasons avoid healthcare with the risk of worsening of their own health, something that can depend on negative encounters. The purpose of this study is to give a descriptive overview of how people with Ehlers-Danlos syndrome experience encounters in healthcare. The research questions are “Do individuals with Ehlers-Danlos syndrome experience good access to healthcare?” and “How do individuals with Ehlers-Danlos syndrome experience encounters in healthcare?” An electronic survey was distributed through social media via Ehlers-Danlos national association in Sweden. The number of respondents was 521 of an estimated number of 814 adult individuals with Ehlers-Danlos syndrome in Sweden. The results show that 477 individuals have experienced offensive or reducing behavior from treating physicians. The majority report bad encounters and low availability in healthcare. The result also shows that it takes approximately 15,28 years to diagnose the condition. / Forskning har visat att individer som upplever negativt bemötande inom vården har mindre vårdkontakt. Ehlers-Danlos syndrom är en utmaning för vården att diagnostisera och behandla vilket en studie visar fört med sig att patienterna undviker vården med sämre hälsa som följd, något som kan bero på erfarenheter av negativt bemötande. Syftet med denna studie är att ge en beskrivning av hur individer med Ehlers-Danlos syndrom upplever bemötande inom primärvården. Två frågeställningar formulerades: Upplever individer med Ehlers-Danlos syndrom god tillgänglighet av vård? och Hur upplever individer med Ehlers-Danlos syndrom bemötande inom primärvården?  En elektronisk enkät skickades ut via sociala medier till patientgrupper med Ehlers-Danlos syndrom där Ehlers-Danlos Riksförbund bistod i distribueringen. Antalet som svarade var 521 stycken av ett estimerat antal om 814 vuxna individer med Ehlers-Danlos syndrom i Sverige. Resultatet visar att 477 individer någon gång upplevt kränkande eller förminskande bemötande av behandlande läkare. Majoriteten rapporterar dåligt bemötande och låg tillgänglighet av tider till primärvården. Resultatet visar dessutom att genomsnittstiden för diagnos ligger på 15,28 år.

Des projections réalisées sur les perspectives démographiques et financières de la dépendance prévoient, en France, une nette augmentation de la population des plus de 80 ans, accompagnée d'une multiplication par 2 du nombre de personnes âgées dépendantes entre 2010 et 2060. Afin de gérer l'augmentation du nombre de personnes âgées dépendantes, les EHPAD (Etablissement d'Hébergement pour Personne Agées Dépendantes) sont appelés à améliorer la prise en charge des résidents et à améliorer les conditions de travail du personnel soignant. C'est dans ce contexte, que nous avons développé un système de supervision permettant de détecter, via un ensemble de capteurs, des évolutions du comportement ou encore, le comportement anormal d'une personne âgée. La détection des comportements anormaux dans le cadre de la supervision est un sujet de recherche qui a été largement étudié dans la littérature ; ce qui n'est tout de même pas le cas de l'analyse des variations des activités de la vie de tous les jours, prenant en compte les spécificités du comportement de la personne au cours du temps. Ainsi, nous avons proposé un modèle de Markov, permettant d'apprendre, avec le moins d'a priori possible, le modèle de comportement habituel au sein de la chambre. Le modèle proposé a été testé sur des données acquises en Living Lab (GIS-Madonah). Nous avons également proposé une nouvelle approche pour calculer la distance entre deux modèles de Markov, afin d'évaluer l'évolution du comportement au cours du temps. Ces méthodes devront permettre, non seulement de déterminer la probabilité du comportement actuel de la personne par rapport à son comportement habituel ; mais également, de détecter des évolutions lentes du comportement de la personne. / Due to demographic changes, it is expected that the number of French having over 80 years will increase drastically and the number of dependent elderly people will grow twice between 2010 and 2060. To manage this increasing number of dependent elderly person, nursing homes are required to improve the care of residents and to improve the working conditions of health workers. In this context, we plan to develop a monitoring system, based on a set of sensors, to detect modifications in the behavior of a person, and unusual behavior. Detection of abnormal activities in smart homes is an important topic of research, unlike the detection of the evolutions of behavior, which take into account the specifics activities of the person in time. Thus, we proposed a Markov model which allow to learn the usual behavior in the room, with a reduced number of a priori. The model is try on data acquired on a Living Lab (GIS Madonah). We proposed a new method to compute the distance between two Markov models, to estimate the evolution of the behavior. These methods allow to compute the probability of the current activities with the usual behavior, and the slow evolutions of the behavior.

The topic of my diploma thesis is drawing; it follows from the title ? Utilization of Unusual Drawing Techniques in Art at Elementary School. There are two parts in my diploma thesis? the theoretical one and the practical one. The first chapter introduces the phenomenon of drawing ? it is about drawing, its principles and colours. The second chapter is about Art at school - teacher?s duties, children?s personalities and about Art. At the end of theoretical part there is the third chapter about history of drawing. We can see the differences between historical and current styles of drawing in pictures at the end of the diploma thesis. The practical part is focused methodologically and it shows several techniques which can be inspiration for teachers at elementary school. Several photos of children?s drawings included as attachment to my diploma theses.

Made available in DSpace on 2015-04-11T13:49:11Z (GMT). No. of bitstreams: 1 Sonia Maria Vasques Castro.pdf: 716184 bytes, checksum: e49feb5b8e4a42e6f6eed4aafb8dcc78 (MD5) Previous issue date: 2014-03-25 / The book Sôbolos rios que vão (2010), the Portuguese novelist António Lobo Antunes brings philosophical bias as the theme of death, showing that this is a reality that no one will escape. Besides the philosophical tone raised by theme, the difficulty of reading enjoyment and consequent misunderstanding of the narrative, were the items that guided the interest in investigating the procedures adopted in the language and techniques resulting in her novelistic evident, since the work collapses literary canons hitherto established. The high degree of experimentation with language, which does not take into account the paragraphing, punctuation, capitalization, employment, plot, narrator, time, space, or any other component that integrates the "revenue" behaved the way of narrating the work is presented here as fantastic narrative in current patterns, defended by Karin Volobuef, which states that the fantastic today moved for language. This hypothesis, rooted in ideas of Mikhail Bakhtin, Roland Barthes, Martin Heidegger, Tzvetan Todorov, Karin Volobuef and also relies on other more current voices, among them those of essayists scholars and the work of Lobo Antunes, Ana Paula Arnaut, Ph.D., University of Coimbra and Maria Alzira Pebble, Ph.D., University of Lisbon. / A obra Sôbolos rios que vão (2010), do romancista português António Lobo Antunes, traz como viés filosófico o tema da morte, mostrando que esta é uma realidade da qual ninguém escapará. Além do tom filosófico suscitado pelo tema, a dificuldade de fruição na leitura e aparente incompreensão da narrativa, foram a motivação que guiou o interesse em investigar os procedimentos adotados na linguagem bem como as técnicas romanescas nela evidenciadas, posto que a obra esboroa os cânones literários até então estabelecidos. Por conta do elevado grau de experimentação com a linguagem, que não leva em conta a paragrafação, a pontuação, o emprego de iniciais maiúsculas, trama, narrador, tempo, espaço ou qualquer outro componente que integre as receitas do modo comportado de narrar, a obra é aqui apresentada como narrativa fantástica, nos moldes atuais, defendidos por Karin Volobuef, que afirma que o fantástico hoje se transportou para a linguagem. Essa hipótese, ancorada nas ideias de Mikhail Bakhtin, Roland Barthes, Martin Heidegger, Tzvetan Todorov e outros, apoia-se também em outras vozes mais atuais, dentre elas as das ensaístas e estudiosas da obra de Lobo Antunes, Ana Paula Arnaut, Professora Doutora da Universidade de Coimbra e Maria Alzira Seixo, Professora Doutora da Universidade de Lisboa.

Les séquences riches en guanines, qu’elles soient ADN ou ARN, peuvent former des structures non canoniques à quatre brins appelées quadruplexes de guanines ou G-quadruplexes. Ces structures reposent sur la formation et l’empilement de quartets de guanines ; elles peuvent être trouvées dans de nombreuses régions du génome. Des motifs G-quadruplexes apparaissent fréquemment lors de la sélection d'aptamères par SELEX : on constate un biais dans la proportion de guanines par rapport aux autres nucléotides dans les bases de données regroupant les séquences d'aptamères connus. Nous avons entrepris une analyse systématique, in silico puis in vitro, de motifs aptamères décrits dans la littérature. Nous avons utilisé un algorithme de prédiction actuellement développé au sein du laboratoire dans le but de déterminer quelles sont les séquences susceptibles de former des G-quadruplexes in silico. Afin de vérifier ces prédictions, un test biophysique permettant de cribler rapidement de nombreuses séquences a été mis en place. Nos résultats démontrent que de nombreux aptamères publiés sont susceptibles de se replier en G-quadruplexe. Un autre volet de ce travail concernait la mise en pratique du SELEX avec deux objectifs distincts. Nous avons d'abord effectué une sélection in vitro contre un ligand de G-quadruplexes, afin de préciser quels motifs nucléiques peuvent interagir avec cette molécule. Nous avons réalisé ensuite des expérience de SELEX contre plusieurs G-quadruplexes ADN ou ARN biologiquement pertinents (motif télomérique humain, répétitions minisatellites et séquences présentes dans les UTR de différents ARNm), dans le but d'obtenir des sondes spécifiques de ces conformations. / Guanine-rich DNA or RNA sequences can adopt non-canonical structures composed of four strands called guanines quadruplexes or G-quadruplexes. These structures are made by the formation and stacking of guanine quartets; they can be found in various region of the genome. G-quadruplexes motifs are frequently found during the selection of aptamers by the so-called SELEX method: a bias exists in the proportion of guanines in comparison with other nucleotides in a database gathering together known aptamers sequences. We did an in silico then in vitro systematic analysis of aptameric motifs described in the literature. We used a prediction algorithm currently developed in the laboratory to determine which sequences car form G-quadruplexes in silico. In order to check those predictions, a biophysical test allowing to quickly assay a lot of sequences was set up. Our results demonstrate that a lot of published aptamers are able to fold into G-quadruplexes. Another part of this work is related to the use of the SELEX with two different goals. First of all we did an in vitro selection against a G-quadruplexes ligand, in order to tell exactly which nucleic motifs can interact with this molecule. We then carried out SELEX experiments against several DNA or RNA biologically relevant G-quadruplexes (human telomeric motifs, minisatellite repetitions and sequences from UTR of mRNA), with the aim of getting specific probes for these conformations.

The goal of this thesis is to discuss how unusual delicacies are conceptualized in the perspective of sociocultural anthropology - specifically, in the context of anthropology of food. Unusual delicacies are to be understood as non-traditional, unique, but at the same time, shocking or perceived as "bizarre" meals. The complex description of the individual's experience during the consumption of unusual delicacies will help to analyze what is the overall perception of the experience, its pervasion into self-presentation, as well as what are the main motivations for it. Further, it is discussed what role the unusual delicacies play in the context of exploring foreign countries and whether they possess any cultural and symbolic meaning.

Although s 9 of the new Constitution 1 guarantees the right to life, there is no express provision which abolishes the death sentence. Whereas in the past the death sentence could only be avoided by the exercise of judicial discretion or political and public pressure, its imposition will now have to be entirely re-evaluated. Not only are all the laws of the country subject to the new Constitution, 2 but so too a Constitutional Court will be operational which will have the power to test the constitutionality of any such laws. By looking at the standards and relevant issues which are considered to define the constitutionality of the death sentence internationally, reviewing current application of the death sentence in South Africa, drawing comparisons, and by studying the problems unique to the South African situation, it will be the aim of this dissertation to determine how the death sentence will fare under a Constitutional Court. / Criminal & Procedural Law / LL. M.

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Although s 9 of the new Constitution 1 guarantees the right to life, there is no express provision which abolishes the death sentence. Whereas in the past the death sentence could only be avoided by the exercise of judicial discretion or political and public pressure, its imposition will now have to be entirely re-evaluated. Not only are all the laws of the country subject to the new Constitution, 2 but so too a Constitutional Court will be operational which will have the power to test the constitutionality of any such laws. By looking at the standards and relevant issues which are considered to define the constitutionality of the death sentence internationally, reviewing current application of the death sentence in South Africa, drawing comparisons, and by studying the problems unique to the South African situation, it will be the aim of this dissertation to determine how the death sentence will fare under a Constitutional Court. / Criminal and Procedural Law / LL. M.

The topic of this diploma thesis is compare materials in machine tool structures. The introduction part is about literature retrieval in field of constructional components in machine frames. There are discribe the indiviual parts of machine structures their properties and influence, witch affect their static toughness, stabilty and accuracy of the whole milling machine. The most important part is focused to the materials witch constructions of machine are made from. The main of this thesis is a practical part, where is designed the own model of milling machine solved on the basis of experiences gain. The important choose was appropriate topology and materials witch the machine frame was made.