The work provides an overview of different integrated optical amplifiers. Semiconductor optical amplifiers and fiber amplifiers are described, as well as devices that utilize non-linear effects, nanocrystalline materials, or photonic crystals. Dielectric materials that are doped with rare-earth ions are considered more thoroughly. After a review of the principles of their optical activity the general mechanisms of excitation and emission are described. Materials aspects regarding the spectral range, their fabrication and the solubility of the dopants follow. An erbium-doped alumina waveguide amplifier, reported earlier in the literature, is chosen as an example to demonstrate the feasibility of such components. A theoretical model of the population densities of the energy levels is derived for the simulation. By numerical methods the non-linear system of the rate equations is solved and the stability of the steady state is shown. The simulation of the amplifier demonstrates the dependence of the gain of both the excitation energy and the z-coordinate. Moreover, the superiority of an excitation wavelength of 980 nm compared to 1530 nm is shown. With the model the literature data could be reproduced. / Die Arbeit gibt einen Überblick über verschiedene Möglichkeiten der Realisierung integriert-optischer Wellenleiterverstärker. Ausgehend von optischen Halbleiter- und Faserverstärkern werden einführend ebenso Anordnungen beschrieben, die nichtlineare Effekte sowie nanokristalline Materialien und photonische Kristalle nutzen. Besondere Bedeutung kommt dielektrischen Materialien zu, die mit optisch aktiven Dotanden, bevorzugt Seltenerdionen, versehen sind. Hierbei werden die Ursachen für die optische Aktivität der Lanthanide sowie die generellen Mechanismen der Anregungs- und Emissionsprozesse beschrieben. Aspekte der Materialauswahl, vor allem hinsichtlich des verwendeten Spektralbereiches sowie bezüglich ihrer Herstellung und der Löslichkeit der Dotanden schließen sich an. Anhand eines Literaturbeispiels wird die Realisierbarkeit eines erbiumdotierten Aluminiumoxid-Wellenleiterverstärkers demonstriert. Hierfür wird ein Modell zur Simulation der Besetzungsdichten der angeregten Energieniveaus abgeleitet und mittels numerischer Methoden das sich ergebende, nichtlineare System der Ratengleichungen gelöst, wobei besonders die Stabilität des stationären Besetzungszustandes herausgearbeitet wird. Die Simulation der Verstärkeranordnung zeigt zum einen die Abhängigkeit der Verstärkung von der z-Koordinate sowie der Pumpleistung; zum anderen wird deutlich, dass die Anregung bei 980 nm der Variante bei 1530 nm überlegen ist. Mit dem verwendeten Modell konnten die Literaturdaten reproduziert werden.

Electro-Magnetic Interference(EMI) degrades the perfomance of electronic systems. So, Amplifiers which are the basic building blocks used in the front-end of analog and mixed-signal Integrated Circuits (ICs) must be evaluated for EMI. This work introduces the most intriguing figure of merit, Electro-Magnetic Interference Rejection Ratio (EMIRR) to measure the EMI immunity of precision Instrumentation Amplifiers (INAs) that helps to select the EMI robust INAs for EMI critical applications. In this work, a new EMIRR measurement setup is implemented to measure the immunity of INAs for conducted EMI ranging from 10 MHz to 3 GHz. The shift in the DC offset voltage generated at the output of the INA due to RF rectification, is used to compute EMIRR. As part of the setup, the hardware evaluation board is designed and an automation test software is developed to run EMIRR measurements. Furthermore, EMIRR measurements are performed on several INAs with different specifications to compare and rank them on their EMI immunity levels. Additionally, with the help of EMIRR metric, suitable INAs for developing EMI-sensitive applications are proposed. Finally, the influence of amplifier bandwidth, the input capacitance, 50 Ω termination at the end of RF input trace, INA package parasitics and EMI filter bandwidth on EMIRR is analyzed with the measurement results.

The work provides an overview of different integrated optical amplifiers. Semiconductor optical amplifiers and fiber amplifiers are described, as well as devices that utilize non-linear effects, nanocrystalline materials, or photonic crystals. Dielectric materials that are doped with rare-earth ions are considered more thoroughly. After a review of the principles of their optical activity the general mechanisms of excitation and emission are described. Materials aspects regarding the spectral range, their fabrication and the solubility of the dopants follow. An erbium-doped alumina waveguide amplifier, reported earlier in the literature, is chosen as an example to demonstrate the feasibility of such components. A theoretical model of the population densities of the energy levels is derived for the simulation. By numerical methods the non-linear system of the rate equations is solved and the stability of the steady state is shown. The simulation of the amplifier demonstrates the dependence of the gain of both the excitation energy and the z-coordinate. Moreover, the superiority of an excitation wavelength of 980 nm compared to 1530 nm is shown. With the model the literature data could be reproduced. / Die Arbeit gibt einen Überblick über verschiedene Möglichkeiten der Realisierung integriert-optischer Wellenleiterverstärker. Ausgehend von optischen Halbleiter- und Faserverstärkern werden einführend ebenso Anordnungen beschrieben, die nichtlineare Effekte sowie nanokristalline Materialien und photonische Kristalle nutzen. Besondere Bedeutung kommt dielektrischen Materialien zu, die mit optisch aktiven Dotanden, bevorzugt Seltenerdionen, versehen sind. Hierbei werden die Ursachen für die optische Aktivität der Lanthanide sowie die generellen Mechanismen der Anregungs- und Emissionsprozesse beschrieben. Aspekte der Materialauswahl, vor allem hinsichtlich des verwendeten Spektralbereiches sowie bezüglich ihrer Herstellung und der Löslichkeit der Dotanden schließen sich an. Anhand eines Literaturbeispiels wird die Realisierbarkeit eines erbiumdotierten Aluminiumoxid-Wellenleiterverstärkers demonstriert. Hierfür wird ein Modell zur Simulation der Besetzungsdichten der angeregten Energieniveaus abgeleitet und mittels numerischer Methoden das sich ergebende, nichtlineare System der Ratengleichungen gelöst, wobei besonders die Stabilität des stationären Besetzungszustandes herausgearbeitet wird. Die Simulation der Verstärkeranordnung zeigt zum einen die Abhängigkeit der Verstärkung von der z-Koordinate sowie der Pumpleistung; zum anderen wird deutlich, dass die Anregung bei 980 nm der Variante bei 1530 nm überlegen ist. Mit dem verwendeten Modell konnten die Literaturdaten reproduziert werden.

Die vorliegende Arbeit ist der analytischen Untersuchung und Weiterentwicklung von Methoden und Schaltungen zur Einstellung der Signalphase und -amplitude gewidmet. Hierbei wird zum Ziel gesetzt, die Leistungsfähigkeit dieser Schaltungen als analoge Hochfrequenz-Baugruppen in Empfangs- und Sendeschaltkreisen mit einem vergleichbaren oder geringerem schaltungstechnischen Aufwand und Strombedarf zu verbessern und dies anhand von Implementierungsbeispielen zu bestätigen. Die Dämpfungsglied-Topologien , T, überbrücktes T und X werden modelliert und hinsichtlich der Phasenbeeinflussung analysiert, sodass eine Bewertung ihrer Eignung durchgeführt werden kann. Weiterhin wird ein innovativer Ansatz zur Linearisierung der Steuerkennlinie vorgestellt und mit Hilfe einer Beispielschaltung mit einem Phasenfehler von 3 ° und einem Steuerlinearitätsfehler von 0,35 dB innerhalb der 1 dB Grenzfrequenz und einem Steuerbereich von 20 dB nachgewiesen. Die Arbeit bietet darüber hinaus eine analytische Betrachtung zu aktiven steuerbaren Verstärkern, welche die besondere Eignung der Gilbert-Zelle aufzeigt und eine geeignete Ansteuerschaltung ableitet. Am Beispiel nach diesem Prinzip entworfener Schaltkreise werden Phasenfehler von nur 0,4 ° innerhalb eines besonders hohen Stellbereichs von 36 dB demonstriert, wodurch eine Vergrößerung des Stellbereichs um den Faktor 4 und eine Verbesserung des Phasenfehlers um den Faktor 2 im Vergleich zum Stand der Technik erreicht wurde. Es wird der Zirkulator-Phasenschieber maßgeblich durch eine neuartige geeignete Ansteuerung verbessert. Damit werden die sonst für die Amplitudenbeeinflussung im Wesentlichen verantwortlichen Varaktoren überflüssig, ohne dabei den schaltungstechnischen Aufwand zu erhöhen. Eine Messung der entsprechenden Schaltung bestätigt dies mit einem Amplitudenfehler von nur 0,9 dB für einen Phasenstellbereich von 360 °, was einer Verringerung des Fehlers um den Faktor 3 im Vergleich zu herkömmlichen Zirkulator-Phasenschiebern entspricht. Abschließend wird der Funktionsnachweis mehrerer entworfener Vektor-Modulatoren mit einer effektiven Genauigkeit von bis zu 6 bit in Einzelschaltungen, Hybridaufbauten und schließlich im Rahmen eines vollständig integrierten Empfängerschaltkreises erbracht. Dieser erzielt eine Verdopplung der Reichweite bei einer um nur 35% höheren Leistungsaufnahme gegenüber einem herkömmlichen Kommunikationsverfahren (SISO). / The present work is dedicated to the investigation and enhancement of amplitude and phase control methods and circuits. The aim is to enhance the performance of these circuits in modern radio frequency transceivers with a comparable or even lower effort and power consumption. A prove of concept will be delivered with implementation examples. By means of models of the passive attenuator topologies , T, bridged-T and X, a thorough analysis is performed in order to compare them regarding their impact on the signal phase. Additionally, a novel approach to increase the control linearity of the attenuators is proposed and verified by measurements, showing a phase error of 3 ° and a control linearity error of 0,35 dB at the 1 dB corner frequency, successfully. The work also presents an investigation on variable gain amplifiers and reveals the superior performance of the Gilbert cell with respect to low phase variations. A cascode biasing circuit that supports these properties is proposed. Measurements prove this concept with relative phase errors of 0,4 ° over a wide attenuation control range of 36 dB thus cutting the error by half in a four times wider control range. The circulator based phase shifting approach is chosen and improved significantly by means of tuning the transconductor instead of the varactors thus removing their impact on signal amplitude. The approach is supported by measurements yielding an amplitude error of only 0,9 dB within a phase control range of 360 ° which corresponds to an improvement by a factor of three compared to recent circulator phase shifters. Finally, the design of several vector modulator topologies is shown with hardware examples of single chips, hybrid printed circuit boards and highly integrated system level ICs demonstrating a full receiver. By using improved variable gain amplifiers, an effective vector modulator resolution of 6 bit without calibration is achieved. Furthermore, a multiple-input multiple-output system is demonstrated that doubles the coverage range of common SISO systems with only 35% of additional power consumption.

This work presents design and full implementation of a fast switchable and band-tunable 5 - 7.5 GHz low noise amplifier (LNA) in a 45nm CMOS SOI technology. The target application are wake-up receivers that employ aggressive duty cycling. Based on a cascode topology, the LNA utilizes a transformer for its 50 input matching as well as a balun with a capacitor bank to realize 8 digitally selectable bands. According to measurement results, the fabricated LNA exhibits a voltage gain of 18 - 21 dB while drawing a current of merely 2.2mA from a 1V supply. At all the 8 bands from 5 to 7.5 GHz, the input reflection coefficient lies below -8 dB, and the noise figure ranges from 7.8 to 6.2 dB. The LNA is able to settle in less than 9.5 ns

This work was performed in the framework of two application-oriented research projects that focus on the generation and evaluation of fluorescent Saccharomyces (S.) cerevisiae-based sensor and reporter cells for white biotechnology as well as the extension of the conventional single-cell/single-construct principle of ordinary yeast biosensor approaches. Numerous products are currently generated by biotechnological processes which require continuous and precise process control and monitoring. These demands are only partially met by physical or physiochemical sensors since they measure parameters off-line or use surrogate parameters that consequently provide only indirect information about the actual process performance. Biosensors, in particular whole cell-based biosensors, have the unique potential to near-line and long-term monitor parameters such as nutrient availability during fermentation processes. Moreover, they allow for the assessment of an analyte’s biological relevance. Prototype yeast sensor and reporter strains derived from common laboratory strains were transformed with multicopy expression plasmids that mediate constitutive or inducible expression of a fluorescence reporter gene. Performance of these cells was examined by various qualitative and quantitative detection methods – representative of putative transducer technologies. Analyses were performed on the population level by microplate reader-based fluorometry and Western blot as well as on the single-cell level by fluorescence microscopy and flow cytometry. ‘Signature’ promoters that are activated or repressed during particular nutrient-limited growth conditions were selected in order to generate yeast nutrient sensor strains for monitoring the biological availability of nitrogen, phosphorus or sulphur. For each category, at least one promoter mediating at least threefold changed green fluorescence levels between sensor cells in non-limited and nutrient-limited conditions was identified. Sensor strains were evaluated in detail regarding sensitivity, analyte selectivity and the ability to restore basic fluorescence after shift from nutrient-limited to non-limited conditions (regeneration). The applicability for bioprocess monitoring purposes was tested by growth of yeast nutrient sensor cells in microalgae media and supernatants. Despite successful proof of principle, numerous challenges still need to be solved to realise prospective implementation in this field of white biotechnology. The major drawback of plasmid-borne detection constructs is a high fluorescence variance between individual cells. By generation of a nitrogen sensor strain with a genome-integrated detection construct, uniform expression on the single-cell level and simultaneous maintenance of basic properties (ability of fluorescence induction/regeneration and lack of cross-reactivity) was achieved. However, due to the singular detection construct per cell, significantly weaker overall fluorescence was observed. The traditional single-cell/single-construct approach was expanded upon in two ways. Firstly, a practical dual-colour sensor strain was created by simultaneous, constitutive expression of a red fluorescence reporter gene in green fluorescent nitrogen sensor cells. Secondly, an innovative cellular communication and signal amplification system inspired by the natural S. cerevisiae pheromone system and mating response was established successfully. It features the yeast pheromone alpha-factor as a trigger and alpha-factor-responsive reporter cells which express a fluorescence reporter gene from the pheromone-inducible FIG1 promoter as an output signal. The system was functional both with synthetic and cell-secreted alpha-factor, provided that recombinant cells were deleted for the alpha-factor protease Bar1p. Integration of amplifier cells which secrete alpha-factor in response to stimulation with the pheromone itself could increase the system\'s sensitivity further. Signal amplification was demonstrated for phosphorus sensor cells as a proof of concept. Therefore, the alpha-factor-based cellular communication and signal amplification system might be useful in applications that suffer from poor signal yield. Due to its modular design, the system could be applied in basically any cell-based biosensor or sensor-actor system. Immobilisation of the generated sensor and reporter cells in transparent natural polymers can be beneficial considering biosensor fabrication. Functionality of sensor and reporter cells in calcium-alginate beads or nano-printed arrays was successfully demonstrated. For the latter setup, fluorescence scanning and software-assisted fluorescence quantification was applied as a new detection method. In an experiment using an agarose-based two-compartment setup proposed by Jahn, 2011, properties of the alpha-factor-based cellular communication and signal amplification system after immobilisation were tested. These studies provide an initial experimental basis for an appropriate geometry of miniaturised immobilisation matrices with fluorescent yeast sensor and reporter cells in prospective biosensor designs.

Die vorliegende Arbeit behandelt integrierte Hochvolt-Schaltungen für die Ansteuerung elektrostatisch arbeitender Mikroaktoren und Mikroaktorarrays. Im Besonderen wird auf die Gesichtspunkte der Treiberschaltungen von Torsionsspiegelarrays eingegangen. Es werden verschiedene Verstärkerbetriebsarten und Schaltungsvarianten hinsichtlich der Ansteuerung kleiner kapazitiver Lasten beurteilt. Für die hocheffiziente Signalübertragung zwischen Low-Side und High-Side in geschalteten Hochvolt-Verstärkern wird ein neuer dynamischer Level-Shifter vorgestellt. Anhand eines gebondeten Mikroelektronik-Mikromechanik-Aufbaus für ein Hadamard-Transformations-Spektrometer werden die speziellen Aspekte des Elektronikentwurfs für ein System-in-Package aufgezeigt. Als Entwurfsgrundlage wird ein Überblick über die wesentlichen Isolationstechnologien für integrierte Hochvolt-Schaltungen und über die Bauelementemodellierung in einer SOI-Technologie ausgearbeitet. Außerdem werden die Vor- und Nachteile der wichtigsten Antriebsprinzipien von Mikroaktoren zusammengefasst.

The human sense of hearing is characterized by its exquisite sensitivity, sharp frequency selectivity, and wide dynamic range. These features depend on an active process that in the inner ear boosts vibrations evoked by auditory stimuli. Spontaneous otoacoustic emissions constitute a demonstrative manifestation of this physiologically vulnerable mechanism. In the cochlea, sensory hair bundles transduce sound-induced vibrations into neural signals. Hair bundles can power mechanical movements of their tip, oscillate spontaneously, and operate as tuned nonlinear amplifiers of weak periodic stimuli. Active hair-bundle motility constitutes a promising candidate with respect to the biophysical implementation of the active process underlying human hearing. The responsiveness of isolated hair bundles, however, is seriously hampered by intrinsic fluctuations. In this thesis, we present theoretical and experimental results concerning the noise-imposed limitations of nonlinear amplification by active sensory hair bundles. We analyze the effect of noise within the framework of a stochastic description of hair-bundle dynamics and relate our findings to generic aspects of the stochastic dynamics of oscillatory systems. Hair bundles in vivo are often elastically coupled by overlying gelatinous membranes. In addition to theoretical results concerning the dynamics of elastically coupled hair bundles, we report on an experimental study. We have interfaced dynamic force clamp performed on a hair bundle from the sacculus of the bullfrog with real-time stochastic simulations of hair-bundle dynamics. By means of this setup, we could couple a hair bundle to two virtual neighbors, called cyber clones. Our theoretical and experimental work shows that elastic coupling leads to an effective noise reduction. Coupled hair bundles exhibit an increased coherence of spontaneous oscillations and an enhanced amplification gain. We therefore argue that elastic coupling by overlying membranes constitutes a morphological specialization for reducing the detrimental effect of intrinsic fluctuations.

This work presents the design of two compact multi-standard low-noise amplifier (LNA) in a 28 nm low-power bulk CMOS process. The transistor parameters were optimized by the Gₘ/ID method taking into account the parasitics and the behavior of highly scaled transistors. To cover the industrial science medical (ISM)-bands around 2.4 and 5.8 GHz, the WLAN band as well as the Kᵤ band a bandwidth enhancement is required. Two versions of LNAs, one with vertical inductors and one with active inductors, are implemented and verified by measurements. The noise figure (NF) exhibits 4.2 dB for the LNA with active inductors and 3.5 dB for the LNA with vertical inductors. The voltage gain reaches 12.8 and 13.4 dB, respectively, with a 3 dB-bandwidth of 20 GHz. Both input referred 1-dB-compression points are higher than 212 dBm making the chips attractive for communication standards with high linearity requirements. The chips consume 53 mW DC power and the LNA with active inductors occupies a core area of only 0.0018 mm², whereas the version with vertical inductors requires 0.021 mm².

The human sense of hearing is characterized by its exquisite sensitivity, sharp frequency selectivity, and wide dynamic range. These features depend on an active process that in the inner ear boosts vibrations evoked by auditory stimuli. Spontaneous otoacoustic emissions constitute a demonstrative manifestation of this physiologically vulnerable mechanism. In the cochlea, sensory hair bundles transduce sound-induced vibrations into neural signals. Hair bundles can power mechanical movements of their tip, oscillate spontaneously, and operate as tuned nonlinear amplifiers of weak periodic stimuli. Active hair-bundle motility constitutes a promising candidate with respect to the biophysical implementation of the active process underlying human hearing. The responsiveness of isolated hair bundles, however, is seriously hampered by intrinsic fluctuations. In this thesis, we present theoretical and experimental results concerning the noise-imposed limitations of nonlinear amplification by active sensory hair bundles. We analyze the effect of noise within the framework of a stochastic description of hair-bundle dynamics and relate our findings to generic aspects of the stochastic dynamics of oscillatory systems. Hair bundles in vivo are often elastically coupled by overlying gelatinous membranes. In addition to theoretical results concerning the dynamics of elastically coupled hair bundles, we report on an experimental study. We have interfaced dynamic force clamp performed on a hair bundle from the sacculus of the bullfrog with real-time stochastic simulations of hair-bundle dynamics. By means of this setup, we could couple a hair bundle to two virtual neighbors, called cyber clones. Our theoretical and experimental work shows that elastic coupling leads to an effective noise reduction. Coupled hair bundles exhibit an increased coherence of spontaneous oscillations and an enhanced amplification gain. We therefore argue that elastic coupling by overlying membranes constitutes a morphological specialization for reducing the detrimental effect of intrinsic fluctuations.