The CIDI is a fully standardised, structured interview for the assessment of psychiatric disorders according to DSM-II-R and proposed ICD-10 criteria. The development of this interview has been the collaborative effort of researchers from 18 sites around the world. In a field trial to test the cross-cultural acceptability and reliability of the questions, there was found to be high acceptance and excellent reliability for the substance use questions, problems with the lengthy alcohol section, and difficulties translating relevant substance use concepts into different languages. There is therefore room for further improvement in the substance-related questions. There proved to be differences between ICD-10 and DSM-III-R regarding substance abuse and dependence disorders.

Female genital cutting is a problem that has taken several dimensions and continues to be practiced despite enormous efforts and resources invested by governments,non-governmental organizations (NGOs) and other stakeholders to ensure that the practice is discontinued worldwide. This study was conducted with the primary objective of assessing the views and perceptions of NGOs on the practice of female genital cutting in Nigeria. The study also examines efforts by civil society and the Nigerian government towards combating and eliminating the practice of FMC in Nigeria. Aside from the systematic literature review, a case study of ten NGOs were interviewed on the telephone. Findings indicate that girls being kept pure as virgins, protection of girls' reproductive potential, increase in fertility, aiding marriageability, traditional practice, and keeping with lineage practice are responsibile for the practice in Nigeria. Few theories were reviewed, and research questions were designed in line with the theories. The approaches include the Functionalist theory, cultural relativism, social theory and Feminism.

My thesis is focused on the composition and countries' representation in the professional staff of the World Health Organization. The thesis will analyse the overrepresentation and underrepresentation of the WHO's member states and explain possible patterns in the staff. The thesis will focus on the relationship between the number of Member State's professional staff in the WHO and the state's GDP growth, expenditure on education and population size. My thesis aims to research the characteristics of staff's composition in the WHO. I will analyse professional staff structure and apply the Principal-Agent theoretical framework. The research will show how the state's representation of member states changed over time and see also the gender composition of the Secretariat. The timeline of this work is from 1999 till 2019. The thesis works with official documents from human resources of the WHO and datasets of the World Bank. Analysis of data is provided by the statistical programme SPSS and Microsoft Excel. Key words World Health Organization, representation, professional staff, principal-agent theory, correlation coefficients, regression analysis

Magister Chirurgiae Dentium (MChD) / Occupational hazards are common among many professions and dentistry is no exception. Occupational hazards include percutaneous injuries, inhalation of noxious chemicals, noise and musculoskeletal disorders (MSD). Despite the fact that MSD have been documented to be very prevalent among dentists in various countries, there is a paucity of literature from South Africa. Aim The aim of the present study was to determine the prevalence of musculoskeletal disorders among the dentists in KwaZulu-Natal (KZN), South Africa and to identify risk factors associated with it. The study was a cross-sectional, descriptive one and questionnaires were used to elicit information regarding socio-demographic details, medical history, work history and work-related posture information from dentists based in KwaZulu-Natal. A convenience sample of all qualified dentists in this region who were registered members of the South African Dental Association (SADA) was used. Results One hundred and nine dentists responded to the questionnaire. The response rate was 31%. The majority were male; a third aged between 30 - 39 years and the ratio of females to males was 1:3. Almost all the dentists reported pain in the neck, lower back and shoulder. Less than a quarter of the dentists in KZN reported hand pain, numbness in the hands and a tingling sensation in the hands. More than three quarters reported that they had no negative effects when performing restorative work and scaling and polishing, but 3.1% reported having extreme levels of pain. The most common working position reported was the 2 0' clock position. Nearly three quarters rotated their necks while performing clinical dentistry and a third tilted their shoulders towards their dominant hand. There was no relationship between Body Mass Index (BMI) and whether respondents treated patients while seated or standing and neither was there a relationship between pain in the lower back and BMI. There was a strong association between pain in the neck while performing clinical work and the number of years in practice confounded by age. When compared to other countries the prevalence of MSD is very high. The highest occurrence was for neck, back and shoulder pain. Avoiding these injuries is critical and self-recognition is important in either preventing further injuries or in increasing severity of the condition. The findings of this study suggests that it may be valuable to include ergonomic work practice in the training of dentists and dentists should be involved in a proper exercise routine which should include stretching and weight training to prevent injuries. Regular breaks should be taken to perform stretching exercises in-between the management of patients in order to reduce the risk of MSD.

Magister Chirurgiae Dentium (MChD) / The psychological, social, and cultural aspects of facial and dental attractiveness is an integral part of health care. Lay persons perceptions of facial and dental attractiveness are influenced by many factors including age, gender, geographic location (nationally or international), ethnic status, employment status, cultural differences and social class will effect the social impact of the anomalies. In addition, the public response to dental anomalies will vary according to experience of good health or ill health of the individual, relatives and friends. The perception of malocclusion is often seen differently between orthodontists, patients and lay public. The differing perceptions of patients and dental practitioners may influence the delivery of orthodontic care. It has been reported that 70% of orthodontic treatment is dentist induced and that orthodontic treatment may be undertaken without the patient or parents perceiving a problem with the teeth. (DHSS, Schanscheiff Report, 1986). The thresholds of entry and exit for orthodontic care may be different as perceived by orthodontists and lay persons. Orthodontists may pursue full alignment and perfect occlusion whereas lay persons may accept varying degrees of deviation from normal. This current study has assessed and recorded the differences in opinions of professional orthodontists and lay persons on dento-facial aesthetics, orthodontic treatment need and orthodontic treatment outcome. The study was carried out at the Orthodontic Department, University of Wales, College of Medicine, School of Dentistry. The opinions of 56 lay persons (dental technicians, dental nurses and lay persons not involved in the clinical process) and 97 orthodontists was collected by recording judgements using various patient records as stimuli. For each set of records examined, each member of the panel indicated their opinion using Likert scales. Judgements were made by assessments of 68 study casts in respect of:- * the need for orthodontic treatment on dental health grounds. the need for orthodontic treatment on dental aesthetic grounds. deviation from normal occlusion. the decision whether to treat. ** * In addition, judgements were made on a sample of 50 pairs of outline facial profiles before and after treatment in respect of: * * deviation from normal facial aesthetics comparison of aesthetics pre-treatment and post-treatment. Furthermore, assessments on 50 pairs of pre-treatment and post-treatment study casts in respect of: * * degree of improvement as a result of treatment. acceptability of result. Orthodontists subjective judgements are more reliable than lay persons in their assessments of dental aesthetics, dental health and deviation from normal. The level of agreement for the decision to recommend treatment is similar between orthodontists and lay groups ie. lay persons are as reliable as orthodontists in the decision to recommend treatment. Orthodontists tend to recommend 10 - 12 % more treatment than lay persons. The orthodontist group were more reliable than the lay group in assessing degree of improvement and assessment of outcome. Orthodontists reject approximately 25% of cases deemed acceptable by the lay group. Dental aesthetics appeared to be the most important feature in the assessment of treatment outcome by both orthodontists and lay groups.

>Magister Scientiae - MSc / Background: Despite the effort of scientific research on HIV therapies and to reduce the rate of HIV infection, AIDS still remains one of the major causes of death in the world and mostly in Sub-Saharan Africa. To date, neither a cure, nor an HIV vaccine had been found and the disease can only be managed by using High Active Antiretroviral Therapy (HAART) if detected early. The need for an effective early diagnostic and non-toxic therapeutic treatment has brought about the necessity for the discovery of additional HIV diagnostic methods and treatment regimens to lower mortality rates. Antimicrobial Peptides (AMPs) are components of the first line of defence of prokaryotes and eukaryotes and have been proven to be promising therapeutic agents against HIV. Methods: With the utility of computational biology, this work proposes the use of profile search methods combined with structural modelling to identify putative AMPs with diagnostic and anti-HIV activity. Firstly, experimentally validated anti-HIV AMPs were retrieved from various publicly available AMP databases, APD, CAMP, Bactibase and UniprotKB and classified according to super-families. Hidden Markov Model (HMMER) and Gap Local Alignment of Motifs (GLAM2) profiles were built for each super-family of anti- HIV AMPs. Putative anti-HIV AMPs were identified after scanning genome sequence databases using the trained models, retrieved AMPs and ranked based on their E-values. The 3-D structures of the 10 peptides that were ranked highest were predicted using 1-TASSER. These peptides were docked against various HIV proteins using PatchDock and putative AMPs showing highest affinity and having the correct orientation to the HIV -1 proteins gp 120 and p24 were selected for future work so as to establish their function in HIV therapy and diagnosis. Results: The results of the in silica analysis showed that the constructed models using the HMMER algorithm had better performances compare to that of the models built by the GLAM2 algorithm. Furthermore, the former tool has better statistical and probability explanation compared to the latter tool. Thus only the HMMER scanning results were considered for further study. Out of 1059 species scanned by the HMMER models, 30 putative anti-HIV AMPs were identified from genome scans with the family specific profile models after elimination of duplicate peptides. Docking analysis of putative AMPs against HIV proteins showed that from the 10 best performing anti-HIV AMPs with the highest Escores, molecules 1,3, 8 and 10 firmly binds the gp120 binding pocket at the VIN2 domain and at the point of interaction between gp120 and T cells, with the 1st and 3rd highest scoring anti-HIV AMPs having the highest binding affinities. However, all 10 putative anti-HIV AMPs bind to the N-terminal domain of p24 with large surface interaction, rather than the C-terminal. Conclusion: The in silica approach has made it possible to construct computational models having high performances, and which enabled the identification of putative anti-HIV peptides from genome sequence scans. The in silica validation of these putative peptides through docking studies has shown that some of these AMPs may be involved in HIV/AIDS therapeutics and diagnostics. The molecular validation of these findings will be the way forward for the development of an early diagnostic tool and as a consequence initiate early treatment. This will prevent the invasion of the immune system by blocking the VIN2 domain and thus designing of a successful vaccine with broad neutralizing activity against this domain.

Cardiovascular diseases (CVDs) are a leading cause of death worldwide, emphasizing the need for advanced and effective intervention and treatment measures. Hypertension, a significant risk factor for CVDs, is characterized by reduced vascular compliance in arterial vessels. There is a significant rise in interest in exploring the viscoelastic properties of arteries in the last few years, for the treatment of these diseases. This study aims to develop an experimental setup using 3D Printing Technology to test viscoelastic arterial models for the validation of a diagnostic device for cardiovascular diseases. The research investigates the selection of polymer-based materials that closely mimic the viscoelastic properties of arterial vessels. An experimental setup is designed and fabricated to perform mechanical tests on 3D-printed specimens. The study utilizes a mathematical model to describe the viscoelastic behavior of the materials. The model's predictions are validated using experimental data obtained from the mechanical tests. This study demonstrates the potential of 3D printing technology in fabricating specimens using elastic and flexible resin materials. These specimens closely replicate the mechanical properties of native arteries, offering a tangible platform for controlled mechanical testing. Stress relaxation tests on the3D printed specimens highlight the viscoelastic properties of fabricated materials, shedding light on their behavior under strain. The study goes further to model the mechanics of these materials, utilizing the Fractional Voigt model to capture the intricate balance between elastic and resistive behaviors under varying deformation levels. The results highlight the successful fitting of the Fractional Voigt model to the experimental data, confirming the viscoelastic behavior of the specimens. The obtained values of α and RMSE indicate a good representation of arterial mechanical properties within the viscoelastic arterial model, under different loading conditions. This research contributes to improving cardiovascular device validation and offers a practical and reliable alternative to invasive experiments. Future works include exploring different materials and conditions for arterial modeling and enhancing the precision and scope of the viscoelastic model. Overall, this study advances the understanding of cardiovascular biomechanics, contributing to the development of more effective diagnostic devices for cardiovascular diseases.

No / The current systems of care for dying persons, the people caring for them, and the bereaved operate in ways that frequently lack sufficient sensitivity to their needs. We describe a new model for dying, death, and loss that adopts a public health approach. Specifically, we describe a deliberative process that resulted in a charter for a public health approach to dying, death, and loss. Modeled after the World Health Organization's 1986 Ottawa Charter, our charter includes a call to action. It has the potential to bring about significant change on local, societal, and global levels as exemplified by four projects from three countries. Public health and end-of-life services and organizations need to form partnerships with the community to develop a public health approach to dying, death, and loss. Learning from each other, they will affirm and enhance community beliefs and practices that make death part of life.

This study is about evaluating the effectiveness of training in syndromic management ofSTDs. The purpose of this study was to fmd out to what extent the STD training programme had been implemented. A stratified sample of twenty-two primary health care clinics in the Port Shepstone region was used. Twenty-two professional nurses rendering STD management in the clinics were observed. Data-gathering was done through a clinic inventory obtained by interviewing the sister-incharge, observation of professional nurses providing treatment to STD patients, interviews with professional nurses to assess their knowledge of the syndromic approach, and exit interviews with patients treated at the clinic. The fmdings suggest that certain areas in the STD training need to be emphasized, such as vaginal speculum and bi-manual examinations. It is recommended that certain negative aspects which hinder effective STD management, like staff shortages and lack of equipment be given attention. / Health Studies / M.A. (Health Studies)

This study is about evaluating the effectiveness of training in syndromic management ofSTDs. The purpose of this study was to fmd out to what extent the STD training programme had been implemented. A stratified sample of twenty-two primary health care clinics in the Port Shepstone region was used. Twenty-two professional nurses rendering STD management in the clinics were observed. Data-gathering was done through a clinic inventory obtained by interviewing the sister-incharge, observation of professional nurses providing treatment to STD patients, interviews with professional nurses to assess their knowledge of the syndromic approach, and exit interviews with patients treated at the clinic. The fmdings suggest that certain areas in the STD training need to be emphasized, such as vaginal speculum and bi-manual examinations. It is recommended that certain negative aspects which hinder effective STD management, like staff shortages and lack of equipment be given attention. / Health Studies / M.A. (Health Studies)