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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 431 to 440 of 497 (0.056 seconds)Spelling suggestions: "subject:"anda microglia"" "subject:"ando microglia""
| 431 |
Paclitaxel Chemotherapy and Mammary Tumors Independently Disrupt Circadian Rhythmicity in MiceSullivan, Kyle Alexander 06 November 2020 (has links)
No description available.
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| 432 |
Transcriptional and Distributional Profiling of Microglia in Retinal Angiomatous ProliferationSchlecht, Anja, Wolf, Julian, Boneva, Stefaniya, Prinz, Gabriele, Braunger, Barbara M., Wieghofer, Peter, Agostini, Hansjürgen, Schlunck, Günther, Lange, Clemens 07 February 2024 (has links)
Macular neovascularization type 3, formerly known as retinal angiomatous proliferation
(RAP), is a hallmark of age-related macular degeneration and is associated with an accumulation of
myeloid cells, such as microglia (MG) and infiltrating blood-derived macrophages (MAC). However,
the contribution of MG and MAC to the myeloid cell pool at RAP sites and their exact functions
remain unknown. In this study, we combined a microglia-specific reporter mouse line with a mouse
model for RAP to identify the contribution of MG and MAC to myeloid cell accumulation at RAP and
determined the transcriptional profile of MG using RNA sequencing. We found that MG are the most
abundant myeloid cell population around RAP, whereas MAC are rarely, if ever, associated with late
stages of RAP. RNA sequencing of RAP-associated MG showed that differentially expressed genes
mainly contribute to immune-associated processes, including chemotaxis and migration in early RAP
and proliferative capacity in late RAP, which was confirmed by immunohistochemistry. Interestingly,
MG upregulated only a few angiomodulatory factors, suggesting a rather low angiogenic potential. In
summary, we showed that MG are the dominant myeloid cell population at RAP sites. Moreover, MG
significantly altered their transcriptional profile during RAP formation, activating immune-associated
processes and exhibiting enhanced proliferation, however, without showing substantial upregulation
of angiomodulatory factors.
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| 433 |
Harnessing retinal phagocytes to combat pathological neovascularization in ischemic retinopathies?Klotzsche‑von Ameln, Anne, Sprott, David 02 February 2024 (has links)
Ischemic retinopathies (IR) are vision-threatening diseases that affect a substantial amount of people across all age groups worldwide. The current treatment options of photocoagulation and anti-VEGF therapy have side effects and are occasionally unable to prevent disease progression. It is therefore worthwhile to consider other molecular targets for the development of novel treatment strategies that could be safer and more efficient. During the manifestation of IR, the retina, normally an immune privileged tissue, encounters enhanced levels of cellular stress and inflammation that attract mononuclear phagocytes (MPs) from the blood stream and activate resident MPs (microglia). Activated MPs have a multitude of effects within the retinal tissue and have the potential to both counter and exacerbate the harmful tissue microenvironment. The present review discusses the current knowledge about the role of inflammation and activated retinal MPs in the major IRs: retinopathy of prematurity and diabetic retinopathy. We focus particularly on MPs and their secreted factors and cell–cell-based interactions between MPs and endothelial cells. We conclude that activated MPs play a major role in the manifestation and progression of IRs and could therefore become a promising new target for novel pharmacological intervention strategies in these diseases.
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| 434 |
Immunosenescence in Choroidal Neovascularization (CNV): Transcriptional Profiling of Naïve and CNV-Associated Retinal Myeloid Cells during AgingSchlecht, Anja, Thien, Adrian, Wolf, Julian, Prinz, Gabriele, Agostini, Hansjürgen, Schlunck, Günther, Wieghofer, Peter, Boneva, Stefaniya, Lange, Clemens 02 February 2024 (has links)
Immunosenescence is considered a possible factor in the development of age-related macular
degeneration and choroidal neovascularization (CNV). However, age-related changes of myeloid
cells (MCs), such as microglia and macrophages, in the healthy retina or during CNV formation are illdefined.
In this study, Cx3cr1-positive MCs were isolated by fluorescence-activated cell sorting from
six-week (young) and two-year-old (old) Cx3cr1GFP/+ mice, both during physiological aging and
laser-induced CNV development. High-throughput RNA-sequencing was performed to define the
age-dependent transcriptional differences in MCs during physiological aging and CNV development,
complemented by immunohistochemical characterization and the quantification of MCs, as well as
CNV size measurements. These analyses revealed that myeloid cells change their transcriptional
profile during both aging and CNV development. In the steady state, senescent MCs demonstrated
an upregulation of factors contributing to cell proliferation and chemotaxis, such as Cxcl13 and Cxcl14,
as well as the downregulation of microglial signature genes. During CNV formation, aged myeloid
cells revealed a significant upregulation of angiogenic factors such as Arg1 and Lrg1 concomitant
with significantly enlarged CNV and an increased accumulation of MCs in aged mice in comparison
to young mice. Future studies need to clarify whether this observation is an epiphenomenon or a
causal relationship to determine the role of immunosenescence in CNV formation.
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| 435 |
The Role of ApoE and Liver X Receptors in Alzheimer's DiseaseJiang, Qingguang 23 June 2008 (has links)
No description available.
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| 436 |
Mechanisms and Consequences of Microglial Priming and Dysregulated M2a Responses with Age and Central Nervous System InjuryFenn, Ashley M. 04 September 2014 (has links)
No description available.
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| 437 |
Microglia and calcium dysregulation during chronic neuroinflammation and aging:causes and consequencesHopp, Sarah Christine January 2014 (has links)
No description available.
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| 438 |
Immune-to-brain communication driven by sterile lung injuryLitvin, David Gregory, Litvin 31 August 2018 (has links)
No description available.
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| 439 |
Role of Matrix Microenviroment on Neural Stem Cell Phenotype and Differentiation under Healthy and Inflammatory ConditionsFarrell, Kurt W. 02 May 2016 (has links)
No description available.
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| 440 |
DEFINING THE ROLE OF IMMUNE THERAPY IN PEDIATRIC CNS MALIGNANCYDorand, Rodney Dixon, Jr. 13 September 2016 (has links)
No description available.
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