The atmospheric boundary layer (ABL) is the lowest layer of the atmosphere where surface effects are felt on time scales of about an hour. While its properties are determined by the surface characteristics, season and synoptic conditions, they in turn determine convective cloud properties and are required for the representation of cloud processes in atmospheric models. Further, interaction of the ABL with the surface layer of the ocean is a key component of ocean-atmosphere coupling. ABL characteristics over ocean surrounding the sub-continent become very important for understanding the monsoon processes during the monsoon season because the roots of many monsoon systems, that give rain to India, are over there. In this thesis data used are from three major field experiments namely the Bay of Bengal Monsoon Experiment (BOBMEX, 1999), Arabian Sea Monsoon Experiment (ARMEX, in two phases, ARMEX-I during 2002 and ARMEX-II in 2003), and Continental Tropical Convergence Zone (CTCZ) experiment (Pilot in 2009) which were carried out under the Indian Climate Research Programme (ICRP). While there have been few studies on ABL characteristics for individual cruises, a comprehensive study considering all available radiosonde data from the above cruises has been missing. This study fills this gap and focuses on the vertical structure of ABL using more than 400 high resolution Vaisala GPS radiosonde data collected over Bay of Bengal and Arabian Sea. The study attempts at first to look at the ABL characteristics of individual cruises and then compare and contrast them over the Bay of Bengal and Arabian Sea. ABL height Hm, estimated by using virtual potential temperature (θv) profile, shows diurnal variation during weak phase of convection while maximum in early morning during active phase of convection. Different variables i.e. moist static energy (h), specific humidity (q), convective available potential energy (CAPE), virtual potential temperature (θv) and equivalent potential temperature (θe) also differ during weak and active convection periods. Conserved variables mixing line approach gives the height up to which ground thermals penetrate in the vertical. This height, denoted by MH that represents the actual ABL height, is 2-3 times larger than Hm when shallow convective clouds are present. In general both Hm and MH are 20-30% larger over Arabian Sea compares to that over Bay of Bengal. Comparison of surface convective available potential energy (CAPE) and equivalent potential temperature (θe) between normal and deficit monsoon years shows that convective instability was as large in deficit years. This means that dynamic and not thermodynamics, controlled the occurrence of convection.

Majority of the rain producing monsoon systems in India form or intensify over the Bay of Bengal and move onto the land. We expect the air-sea interaction to be a crucial factor in the frequent genesis and intensification of monsoon systems over the Bay. Knowledge of air-sea fluxes is essential in determining the air-sea interactions. However, the Bay remains a poorly monitored ocean basin and the state of the near surface conditions during the monsoon months remains to be studied in detail. For example, we do not know yet which among the various flux formulae used in the General circulation models are appropriate over the Bay since there are no direct measurements of surface fluxes here during the peak monsoon months. The present thesis aims towards filing that gap. In this thesis fluxes were computed using the Bulk method, Inertial dissipation method and direct covariance method. The flux comparisons were reasonable during certain flow conditions which are clearly identified. When these conditions are not met the differences among the fluxes from these methods can be larger than the inherent uncertainties' in the methods. Stratification, flow distortion and averaging time are the key variables that give rise to the differences in the fluxes. It is found that there are significant differences in the surface flux estimates computed from different atmospheric General Circulation Model bulk parameterization schemes. In this thesis, the flow gradients are estimated by taking advantage of the natural pitch and roll motion of the ship. A attempt is made to gain insight into the flow distortion and its influence on the fluxes. In our analysis it is found that the displacement of the streamlines is an important component in quantifying flow distortion.

Around Sri Lanka and to the south of India sea surface temperatures (SST) are cooler compared to the surrounding region during summer monsoon. This region where SSTs are relatively cooler is known as the cold pool. Owing to its possible impact on monsoon variability, some studies have been carried out to understand the evolution of cold pool SST during this period. These studies suggest, coastal upwelling along southern coast of Sri Lanka and eastward advection of cooler water contributes to the decrease in SST during summer monsoon. However, the processes leading to the formation of cold pool, still, remain unknown. In this study, we have investigated the mechanism responsible for the formation and maintenance of southern Bay of Bengal (BOB) cold pool using high resolution satellite data, model simulations and in-situ observations for the year 2009. Our study reveals formation of cold pool is dominated by atmospheric processes, whereas oceanic processes dominate its maintenance. Cooling of SSTs during premonsoon and onset phase acts as a prerequisites for the formation of cold pool, which are linked to the reduction in Net Heat flux (NHFX) during theses periods. The changes in NHFX during premonsoon and onset phase are dominated by reduction in Short-wave (SW) radiation associated with strong convective activity over cold pool. Convective activity over the cold pool are associated with the northward movement of Maximum Cloud Zone (MCZ) that forms over Equatorial Indian Ocean (EIO) during these periods. SST within the cold pool after the steady increase during February-April months, cools first during premonsoon rain event and then during monsoon onset. Analysis of high resolution satellite data for the period 2003-2009 suggest that, these sequence of events occurs with minor amount of inter-annual variability. Lead-lag correlation also made it clear that SST response in 5 days to the corresponding variation in atmospheric processes. SST within the cold pool shows several intraseasonal cooling events during the summer mon-soon. Considering that rainfall above the cold pool is very low during the summer monsoon, these cooling events occurring within the summer should be necessary for maintaining the cold pool. The seasonal evolution of SST shows that it continues to decrease till the end of the summer monsoon. In-situ data collected during CTCZ field program in 2009, at two time series locations (TSL) and model simulations were used to determine the processes responsible for such cooling events. To estimate the contribution from advection to the observed SST tendency at fixed location, a measurement stratergy called ‘opertaion advection’ was used in this study. This stratergy involves measurement of oceanographic parameters along four edges from TSL directod along North, South, East and West for estimation of horizontal temperature gradients. Our results from SST cooling events captured by CTD at two fixed locations suggests that horizontal advection and entrainment dominate the SST evolution. Model temperature equation evaluated near the TSLs are convinient with the observations and suggest that atmospheric forcing is not responsible for intraseasonal cooling events.

This thesis shows how the Process Analysis Method (PAM) can be applied to assess technologies used to mitigate arsenic from drinking water in rural India, using a set of sustainability indicators. Stakeholder perspectives, gathered from a fieldwork survey of 933 households in West Bengal in 2012, played a significant role in this assessment. This research found that the ‘Most Important’ issues as specified by the technology users are cost, trust, distance from their home to the clean water source (an indicator of convenience), and understanding the health effects of arsenic. It was also found that none of the ten technologies evaluated are economically viable, as many do not charge user-fees, which creates reliance upon donations to meet recurring costs. Utilisation of a technology is strongly related to sociocultural capital, but in many cases, features that contribute to sociocultural value, like regular testing of the treated water, are not included in the financial budget. It is suggested that increased awareness might change attitudes to arsenic-rich waste and its disposal protocols. This waste is often currently discarded in an uncontrolled manner in the local environment, giving rise to the possibility of point-source recontamination. All technologies proved to have difficulties in dealing with waste, except the Tipot and Dug wells which produce no waste. Of the methods considered, the BESU technology scored highest, but still only with 47-62% of the maximum scores achievable within each domain. This explains the widespread failure of mitigation projects across the region. The indicators and metrics show where improvements can be made. A model scheme based on these findings is outlined which could be applied with the objective of increasing utilisation and improving sustainability. It can be concluded that a product stewardship approach should be taken in regard to design, implementation and operation of the technologies, including the creation of a regulated toxic waste collection and disposal industry.

Exchange of mass (water vapor), momentum, and energy between atmosphere andocean has profound influence on weather and climate. This exchange takes place at the air-sea interface, which is part of the marine atmospheric boundary layer. Various empirical relations are being used for estimating these fluxes in numericalweather and climate models but their accuracies are not sufficiently verified or tested over the Indian Ocean. The main difficulty is that vast areas of open oceans are not easily accessible. The marine environment is very corrosive and unattended long term and accurate measurements are extremely expensive. India has research ships that spend most of their time over the seas around India but that opportunity is yet to be exploited. To address this, an air-sea flux measurement system for operation on board research ships was planned. The system was tested on board Indian Research Vessels ORV SagarKanya during its cruise SK-296 in the Bay of Bengal (BoB) in July-August 2012, and NIO ship Sindhu Sadhana in June-July 2016. The complete set included instruments for measuring wind velocity, windspeed and direction, air and water temperature, humidity, pressure, all components of radiation and rainfall. In addition, ship motion was recorded at required sampling rate to correct for wind velocity. The set up facilitates the direct computation of sensible and latent heat fluxes using the eddy covariance method. In this thesis, design and installation of meteorological and ship motion sensors onboard research ships, data collection and quality control, computation of fluxes of heat, moisture and momentum using eddy covariance method and their comparison with those derived from bulk method are described. A set of sensors (hereafter, flux measuring system) were mounted on a retractable boom, ~7 m long forward of the bow to minimize the flow disturbance caused by the ship superstructures. The wind observed in the ship frame was corrected for ship motion contaminations. During the CTCZ cruise period true mean wind speed was over 10 m/s and true wind direction was South/South-Westerly. True windspeedis computed combiningdata from the anemometer a compass connected to AWS and a GPS. Turbulent fluxes were computed from motion-corrected time-series of high frequency velocity, water vapor, and air temperature data. Covariance latent heat flux, sensible heat flux, and wind stress were obtained by cross-correlating the motion-corrected vertical velocity with fast humidity fluctuations measured with anIR hygrometer, temperate fluctuation from sonic anemometer and motion-corrected horizontal windfluctuations from sonic anemometer, respectively. During the first attempt made in July-August 2012 as part of a cruise of CTCZ monsoonresearch program, observations were mainly taken in the North Bay of Bengal. The mean air-temperature and surface pressure were ~28 Deg C and ~998 hPa, respectively. Relative humidity was ~80%. Average wind speed varied in the range 4-12 m/s. The mean latent heat flux was 145 W/m2 , sensible heat flux was ~3 W/m2 and average sea-air temperature difference was ~ 0.7°C. The Bay of Bengal boundary layer experiment (BoBBLE) was conducted during June-July 2016 and the NIO research ship Sindhu Sadhana was deployed. The same suite of sensors installed during CTCZ were used during BoBBLE. During daytime, peaks of hourly net heat fluxes (Qnet ) were around 600 Wm-2(positive if into the sea), whereas, night time values were around -250 W m-2. Sea surface temperature was always >28°C and maximum air temperature exceeded 29°C. During the experimental period the mean Qnet was around -24 Wm-2 from both eddy covariance and conventional bulk methods, but there are significant differences on individual days.The new flux system gives fluxes which are superior to what was available before.

Abstract The diurnal cycle is a dominant mode of sea surface temperature (SST) variability in trop-ical oceans, that influences air-sea interaction and climate processes. Diurnal variability of SST generally ranges from ~0.1 to 2.0◦C and is controlled by atmospheric fluxes of heat and momentum. In the present study, the response of intraseasonal variability (ISV) of SST in the Bay of Bengal (BoB) to diurnal atmospheric forcings, during the summer monsoon of 2007, has been examined using an Ocean General Circulation Model (OGCM). The model is based on the Modular Ocean Model Version 4 (MOM4p0), having a horizontal resolution of 0.25◦ and 40 vertical levels, with a fine resolution of 5 m in the upper 60 m. Numerical experiments were conducted by forcing the model with daily and hourly atmospheric forcings to examine the SST-ISV modulation with the diurnal cycle. Additional experiments were performed to determine the relative role of diurnal cycle in solar radiation and winds on SST and mixed layer depth (MLD). Since salinity, which is decisive in SST variability, varies meridionally in the BoB, two locations were selected for analyses: one in the northern bay at 89◦E, 19◦N where salinity is lower and the other in the southern bay at 90◦E, 8◦N where salinity is higher, as well as observations are available from Research Moored Array for African-Asian-Australian Monsoon Analysis and Prediction (RAMA) buoy for comparision with model simulation. Diurnal atmospheric forcings modify SST-ISV in both southern and northern bay. SST-ISV in the southern bay, is dominantly controlled by the diurnal cycle of insolation, while in the northern bay, diurnal cycle of insolation and winds have comparable contribution. Diurnal cycle enhanced the amplitude of 3 selected intraseasonal events in the southern bay and 3 out of the 6 events in the northern bay, during the study period. In the southern bay, simulated SST variability with hourly forcing was closer to the observations from RAMA, implying that incorporating the diurnal cycle in model forcing rectifies SST-ISV. Moreover, SST obtained with diurnal forcing consists of additional fluctuations at higher frequencies within and in between intraseasonal events; such fluctuations are absent with daily forcing. The diurnal variability of SST is significant during the warming phase of intraseasonal events and reduces during the cooling phase. Diurnal amplitude of SST decreases with depth; depth dependence also being larger during the warming phase. SST-ISV modulation with diurnal forcing results from the diurnal cycle of upper ocean heat fluxes and vertical mixing. Diurnal warming and cooling result in a net gain or loss of heat in the mixed layer after a day’s cycle. When the retention (loss) of heat in the mixed layer increases with diurnal forcing during the warming (cooling) phase of intraseasonal events, the daily mean SST rise (fall) becomes higher, amplifying the intraseasonal warming (cooling). In the southern bay, SST-ISV amplification is mainly controlled by the diurnal variability of MLD, which modifies the heat fluxes. Increased intraseasonal warming with diurnal forcing results from the increase in radiative heating, due to the shoaling of the daytime mixed layer. Amplified intraseasonal cooling is dominantly con-trolled by the strengthening of sub-surface processes, due to the nocturnal deepening of mixed layer and increased temperature gradients below the mixed layer. In the northern bay, SST-ISV modulation with diurnal forcing is not as large as that in the southern bay. The mean increase in SST-ISV amplitudes with diurnal forcing is ~0.16◦C in the southern bay, while it is only ~0.03◦C in the northern bay. Reduced response of SST-ISV to diurnal forcings in the northern bay is related to the weaker diurnal variability of MLD. Salinity stratification limits diurnal variability of mixed layer in the northern bay, unlike in the southern bay. The seasonal (June - September) mean diurnal amplitude of MLD is ~15 m in the southern bay, while it is reduced to ~1.5 m in the northern bay. Diurnal variability of MLD, spanning only a few meters is not sufficient to create large modifications in mixed layer heat fluxes and SST-ISV in the northern bay. The vertical resolution of the model limits the shallowing of mixed layer to 7.5 m, thus restricting the diurnal variability of simulated MLD.

L’objectif de cette étude est de reconstruire le régime de l’érosion des chaînes himalayennes, et de relier ces paramètres aux variations climatiques globales et à l’intensité de la mousson. Dans ce travail, Les sédiments de 3 carottes prélevées dans la baie du Bengale pendant la mission MONOPOL ont fait l’objet d’analyses minéralogiques (XRD et granulométrie) et géochimiques (majeurs, traces, la composition isotopique du Nd et du Sr). La mise en âge des carottes, est basée sur les enregistrements de δ¹⁸O de foraminifères planctoniques (G. ruber), et des datations au ¹⁴C (AMS). Ces 3 enregistrements sédimentaires couvrent les derniers 180 ka. L'approche multi-traceur menée sur ces carottes, nous donne des informations essentielles sur les sources, afin de reconstruire les changements au cours du temps des sédiments transportés vers la partie proximale du cône sous-marin du Bengale, et de mieux comprendre ses liens potentiels avec les changements climatiques (mousson indienne et/ou des changements au niveau de la mer). Les résultats de cette étude, donnent également des clefs sur les processus d'altération chimique et de la dynamique du transport des sédiments au cours du temps. En outre, une étude à haute résolution, sur un site localisé sur la levée du chenal actif du cône sous-marin fournit des informations sur les changements dans le degré d'altération et la dynamique de transport des sédiments du système himalayen au cours de l'Holocène. Ainsi, il est possible de quantifier l'impact de la mousson d’été sur la sédimentation au niveau de la levée durant cette période climatique. Les résultats de cette étude ont été utilisés pour estimer les changements dans les sources sédimentaires (plaine Indo-Gangétique vs haute-chaine) et retracer l'altération chimique du matériel détritique au sein du bassin versant du système fluviatile du Ganges-Brahmapoutre. / The aim of this study is to reconstruct the erosional history of the Himalayan ranges, in order to connect these parameters to global climatic events and variations in the intensity of the monsoon. In this work, sediments from 3 marine cores collected in the Bay of Bengal, during the MONOPOL cruise were analyzed using mineralogical (XRD and grain-size) and geochemical (major, trace, Nd and Sr isotopic composition) methods. Chronological framework of studied cores were based on δ¹⁸O from planktonic foraminifera (G. ruber), and ¹⁴C ages dating (AMS). These cores cover the last 180 kyr. The multi-proxy approach conducted on these cores, gives us critical information about the source, to reconstruct the temporal variability of sediment export to the proximal northeastern Bengal Fan and its potential links to climatic changes (Indian monsoon and/or sea-level changes). Results also give insights on the chemical weathering processes and the dynamic of transport of the sediments through time as well. Moreover, a high-resolution study, on a site located on the active middle fan channel levee of the fan provides information on changes in the weathering pattern and the dynamic of transport of sediments from the Himalayan system during the Holocene. Thus, it is possible to quantify the impact effect of summer monsoon rainfall during that time interval. These results have been used to assess changes in the sedimentary sources (Indo-Gangetic plain vs highlands) and document the chemical weathering states of the detrital material within the Ganges-Brahmaputra river basin catchment.

[ES] Los estudios sobre los daños en el ADN se han incrementado en las últimas décadas con el fin de profundizar en su implicación en la aparición del cáncer. Entre el gran número de lesiones del ADN, los aductos de tipo eteno han sido objeto de interés debido a su presencia en los tejidos humanos crónicamente inflamados. Asimismo, su cuantificación es útil para su uso como potencial biomarcador del cáncer de colon, próstata, pulmón, etc. Además, estas lesiones presentan propiedades altamente mutagénicas e inducen transiciones de bases o transversiones en las células de mamíferos. Los aductos de tipo eteno se generan principalmente de forma endógena como resultado de la peroxidación lipídica. Este proceso bioquímico produce aldehídos reactivos como el malondialdehído, que pueden combinarse con las bases del ADN creando un anillo exocíclico.Este anillo exocíclico proporciona a la nucleobase un sistema extendido p-conjugado que puede conferirles propiedades ópticas diferentes a las de las bases canónicas, lo que puede suponer una amenaza para la fotoestabilidad del ADN. Las bases canónicas tienen la capacidad de disipar la mayor parte de la energía recibida a través de canales no radiativos eficientes que conducen de nuevo al estado fundamental. Por lo tanto, los estudios sobre las propiedades ópticas de estos aductos etenos son clave para establecer si estas lesiones pueden poner en peligro la relajación eficiente de los estados excitados de las bases y desencadenar una fotorreactividad indeseada del ADN. La primera parte de la tesis trata de evaluar la fotoactividad potencial de estas lesiones del ADN mediante un estudio espectroscópico. En el Capítulo 3 se combinan experimentos de upconversión de fluorescencia en la escala de femtosegundos y cálculos teóricos (en los niveles PCM-TD-DFT y CASPT2/CASSCF) para proporcionar una imagen completa de la relajación de los estados excitados del aducto mutagénico 3,N4-eteno-2'-desoxicitidina (edC). El Capítulo 4 aborda las propiedades fotofísicas de los aductos junto con su fotorreactividad en presencia de fotosensibilizadores comunes como la Rosa de Bengala (RB) y la 4-carboxibenzofenona (CBP), prestando especial atención a la interacción con el 1O2. En condiciones aeróbicas, se observa una interacción con 1O2 para los tres aductos estudiados. Curiosamente, se observan los mismos fotoproductos, las nucleobases originales, para la irradiación en condiciones anaeróbicas, abriendo la posibilidad de un mecanismo mixto de Tipo I y Tipo II cuando se utiliza Rosa de Bengala como fotosensibilizador, y de Tipo I para la 4-carboxibenzofenona. Finalmente, el último capítulo trata de unir todos los conocimientos adquiridos sobre la fotorreactividad de los e-aductos para elegir el mejor cromóforo tratando de optimizar el proceso de reparación observado en el Capítulo 4. Para ello se utilizan sistemas híbridos de nanopartículas metálicas de Ag como matriz de soporte para la Rosa de Bengala. Las NPs metálicas, como las Ag NPs, poseen una resonancia plasmónica superficial localizada (LSPR), este efecto amplifica una gran variedad de fenómenos ópticos que pueden mejorar las propiedades ópticas de la Rosa de Bengala. / [CA] Els estudis sobre els danys en l'ADN s'han incrementat en les últimes dècades amb la finalitat d'aprofundir en la seua implicació en l'aparició del càncer. Entre el gran nombre de lesions de l'ADN, els adductes de tipus eteno han sigut objecte d'interés degut a la seua presència en els teixits humans crònicament inflamats, la qual cosa fa que la seua quantificació siga útil com a potencials biomarcadors del càncer de còlon, pròstata, pulmó, etc. A més, aquestes lesions presenten propietats altament mutagèniques i indueixen transicions de bases o transversions en les cèl·lules dels mamífers. Els adductes de tipus eteno es formen principalment de manera endògena com a resultat de la peroxidació dels lípids. Aquest procés bioquímic produeix aldehids reactius com el malondialdehid, que poden combinar-se amb les bases de l'ADN creant un anell exocíclic. Aquest anell exocíclic proporciona a les nucleobases un sistema estés p-conjugat que pot conferir-les propietats òptiques diferents a les de les bases canòniques, i que poden suposar una amenaça per a la fotoestabilitat de l'ADN. Les bases canòniques tenen la capacitat de dissipar la major part de l'energia d'excitació a través de canals no radiatius eficients que condueixen de nou a l'estat bàsic. No obstant això, els estudis sobre les propietats òptiques d'aquests adductes de tipus eteno són fonamentals per a deixar clar si aquestes lesions poden posar en perill aquesta relaxació eficient i desencadenar una fotoreactivitat indesitjada de l'ADN. La primera part de la tesi tracta d'estimar el potencial fotoactiu d'aquestes lesions de l'ADN mitjançant un estudi espectroscòpic. En el Capítol 3 es combinen experiments de "upconversió" de fluorescència en una escala de femtosegons i càlculs teòrics (en els nivells PCM-TD-DFT i CASPT2/CASSCF) per a proporcionar una imatge completa de la relaxació dels estats excitats del adducte mutagènic 3,N4-eteno-2'-desoxicitidina (edC). El Capítol 4 aborda les propietats fotofísiques dels adductes restants juntament amb el seua fotoreactivitat en presència d'alguns fotosensibilitzadors comuns com la Rosa de Bengala (RB) i la 4-carboxibenzofenona (CBP), prestant especial atenció a la interacció amb el 1O2. S'observa la interacció amb 1O2 per als tres adductes estudiats. Curiosament, s'observa la mateixa formació de nucleobases per a la irradiació en condicions anaeròbiques, obrint la possibilitat d'un mecanisme mixt de Tipus I i Tipus II quan s'utilitza Rosa de Bengala com fotosensibilitzador i de Tipus I per a la 4-carboxibenzofenona. Finalment, l'últim capítol tracta d'unir tots els coneixements adquirits sobre la fotoreactivitat dels adductes de tipus eteno per a triar el millor cromòfor tractant d'optimitzar el procés de reparació observat en el Capítol 4. Per a això s'utilitzen sistemes híbrids de nanopartícules metàl·liques de Ag com a matriu de suport per a la Rosa de Bengala. Les NPs metàl·liques, com les de Ag, posseeixen ressonància plasmónica superficial localitzada (LSPR), aquest efecte amplifica una gran varietat de fenòmens òptics que poden millorar les propietats òptiques de la Rosa de Bengala. / [EN] Studies dealing with DNA damages have increased during the last decades in order to get more insight into their involvement in the appearance of cancer. Among the large number of DNA lesions, etheno adducts have been the matter of interest because of their presence in chronically inflamed human tissues, making their quantification useful as potential biomarkers for cancer of colon, prostate, lung, etc. Moreover, these lesions exhibit highly mutagenic properties and induce base transitions or transversion in mammal cells. Etheno adducts are mainly formed endogenously as a result of lipid peroxidation. This biochemical process produces reactive aldehydes such as malondialdehyde, which can combine with DNA bases creating the exocyclic ring. This exocyclic ring provides to the nucleobases an extended p- conjugated system that might confer them optical properties different from those of the canonical bases, and can pose a threat to the DNA photostability. Canonical bases have the ability to dissipate most of the excitation energy through efficient nonradiative channels leading back to the ground state. However, the studies about the optical properties of this etheno adducts are basics to make it clear whether these lesions can jeopardize this efficient relaxation and trigger undesired DNA photoreactivity. The first part of the thesis establishes the potential photoactivity of these DNA lesions through a spectroscopic study. Chapter 3 joints femtosecond fluorescence upconversion experiments and theoretical calculations (at the PCM-TD-DFT and CASPT2/CASSCF levels) to provide a comprehensive picture of the mutagenic etheno adduct 3,N4-etheno-2'-deoxycytidine (edC) excited states relaxation. Chapter 4 addresses the photophysical properties of the adducts together with its photoreactivity in the presence of some common photosensitizers as Rose Bengal and 4-carboxybenzophenone, paying a special attention to interaction with 1O2. Interaction with 1O2 is observed for the three studied e-adducts. Interestingly, the same nucleobase formation is detected for irradiation under anaerobic conditions, opening the possibility of a mixed Type I and Type II mechanism when Rose Bengal is used as photosensitizer, and Type I for 4-carboxybenzophenone. Finally, the last chapter takes advantage of all the gained knowledge about the photoreactivity of e-adducts to choose the best chromophore and optimize the repair process observed in Chapter 4. To achieve this, hybrid systems of Ag metal nanoparticles are used as a support matrix for the Rose Bengal. Metal NPs, such as Ag NP, possess localized surface plasmon resonance (LSPR). This effect amplifies a wide variety of optical phenomena that can enhance the Rose Bengal optical properties. / Lizondo Aranda, P. (2022). Photoreactivity of DNA Etheno Adducts: Spectroscopic and Mechanistic Study [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/189688

Fruit de négociations longues et ardues, la Convention des Nations Unies sur le droit de la mer signée en 1982 est sans doute l’un des traités multilatéraux les plus réussis sur le plan international. Pierre angulaire de la Convention, l’attribution du statut de « patrimoine commun de l’humanité » aux fonds marins et leur sous-sol situés au-delà des limites de la juridiction nationale ainsi qu’à leurs ressources a constitué une innovation majeure dans le domaine du droit international. Le succès de la Convention tient notamment au fait qu’elle a établi un cadre institutionnel sans précédent chargé de la mise en œuvre de la Convention et incarné par trois institutions : l’Autorité internationale des fonds marins, la Commission des limites du plateau continental et le Tribunal international du droit de la mer. Dotées de statuts juridiques divers et de compétences différentes, ces institutions fonctionnent depuis l’entrée en vigueur de la Convention en 1994. Vingt-et-un ans après sa fondation, il convient d’examiner ce cadre institutionnel dans son ensemble et d’évaluer sa mise en œuvre pour mieux comprendre le rôle complémentaire des institutions. Cette étude porte un regard critique sur la genèse, la nature, le fonctionnement et la pratique des institutions, et s’attache à les considérer dans leur interaction et leur interdépendance. Identifier les insuffisances institutionnelles et interinstitutionnelles, ainsi que les défis auxquels les institutions sont confrontées est un préalable indispensable à la recherche de solutions efficaces et viables pour surmonter les difficultés rencontrées, à la mise en œuvre harmonieuse de la Convention et à la concrétisation du concept fondamental de patrimoine commun de l’humanité. Dans cette perspective, l’importance du Tribunal dans son rôle de garant de l’intégrité de la Convention et le pouvoir créateur du juge international face aux lacunes conventionnelles méritent une attention toute particulière. / The result of protracted and arduous negotiations, the United Nations Convention on the Law of the Seasigned in 1982 is undoubtedly one of the most successful multilateral treaties at the international level. The principle of the common heritage of mankind, represented by the seabed, ocean floor and subsoil and their resources beyond the limits of national jurisdiction, is the cornerstone of the Convention and constituted a major innovation in international law. The success of the Convention lies, in particular, in the establishment of an unprecedented institutional framework, which is incarnated by three institutions: the International Seabed Authority, the Commission on the Limits of the Continental Shelf and the International Tribunal for the Law of the Sea. These institutions of diverse legal status are vested with different functions and have been in operation since the entry into force of the Convention in 1994. Twentyone years following its establishment, it is necessary to review this institutional framework as a whole and to assess its implementation in order to better understand the complementary role of the institutions. This study critically examines the genesis, the nature, the functioning and the practice of the institutions throughtheir interaction and their interdependence. Identifying institutional and inter-institutional weaknesses, and the challenges that the institutions face is an indispensable prerequisite for ensuring effective and viablesolutions, the harmonious implementation of the Convention and for giving substance to the principle ofthe common heritage of mankind. In this context, the role of the Tribunal as the guarantor of the integrityof the Convention and the creative power of the international judge merit special attention.