According to the Centers for Disease Control, roughly 9.4% of the US population is diabetic, and at least 35% of the US population has metabolic syndrome. These diseases are associated with increased mortality risk, reduced quality of life, and altered taste perception of foods. With increased occurrence of these metabolic diseases, there is a greater need for research oriented towards using lifestyle modifications to combat illness. A relationship between flavanol consumption, health benefits, and taste perception has been well documented. Dietary flavanols are secondary plant metabolites that exist naturally in a wide array of polymerization states. The mechanisms behind the protective effects of flavanols are not entirely understood, particularly when considering how the mean degrees of polymerization (mDP), or average compound size, impacts the health benefits. Moreover, it is known that flavanol mDP influences the sensory attributes of flavanol-rich foods including bitterness and astringency. It is known that obesity and sensitivity to bitterness both influence perception of certain taste attributes such as sweetness and bitterness. The influence of these bitter and astringent sensations determined by flavanol mDP on consumer preferences for flavanol-rich products remains unknown. These influences on preference pose potential barriers to consumption, resulting in the loss of health benefits. The objectives of the research detailed here were i) to determine the effect of dietary consumption of small to medium-sized flavanols on markers of metabolic syndrome that were brought on by diet-induced obesity, ii) to determine how flavanol mDP influences the consumer perception and liking of flavanol-rich, wine-like products based on differences in consumer phenotype, and iii) to explore the potential to manipulate mDP of wine using traditional winemaking techniques. By way of an in vivo mouse model, it was observed that regardless of mDP, flavanols delivered at low dose, as part of a high-fat diet, reduced adipose-derived inflammatory cytokine production but did not prevent associated weight and fat gain. This suggests that small to medium sized flavanols may, at low dose, delay the onset of the pro-inflammatory state, which could ultimately protect against metabolic derangements associated with obesity and diabetes. Regarding the consumer acceptance of wine-like products made from flavanols of different mDP, and therefore different in bitterness and astringency intensity, it was observed in a consumer panel (n = 102) that when segmenting the panelists by body fat % and BMI classification, increased adiposity was associated with decreased ability to differentiate wine samples made with flavanols of different mDP. Moreover, differences in liking and ability to differentiate bitterness and astringency intensities were not as pronounced when segmenting the panelists based on bitterness sensitivity. This suggests that obesity may impact preference for flavanol-rich foods more so than sensitivity to flavor attributes associated with these products. Finally, in an exploratory effort to manipulate mDP of red and rosé wines using traditional winemaking techniques, no differences in mDP were observed in young wines, but significant differences in flavanol concentration were detected. It is hypothesized that aging of these wines could lead to greater differences in mDP, especially for those that had a high flavanol concentration at baseline. Future work will continue to build off these studies so that flavanol-rich products such as red wine can be optimized for health benefits and consumer acceptability of dietary polyphenols. / Ph. D. / According to the Centers for Disease Control, roughly 9.4% of the US population is diabetic, and at least 35% of the US population has metabolic syndrome. These diseases are associated with increased mortality risk, reduced quality of life, and altered taste perception for certain food types. With increased occurrence of these metabolic diseases, there is a greater need for research oriented towards using lifestyle modifications to combat illness. Dietary flavanols, which are potent antioxidants derived from plants, are being explored for their ability to mitigate chronic disease. They exist naturally in a wide variety of sizes and structures depending on plant of origin, growing conditions, and food processing conditions. It is believed that the size of these compounds impacts their health effects and influences their taste profile; smaller compounds are more bitter while larger compounds are more astringent. The purpose of this research was to determine the effect of flavanol supplementation on markers of the metabolic syndrome and how differences in taste due to differences in flavanol size influence consumer liking and perception of winelike products. It was determined in this study that dietary flavanols, delivered at low dose in the context of a high-fat diet can slightly improve fasting blood glucose levels and prevent inflammation. When examining consumer preferences for wines made from dietary flavanols that are distinctly different in terms of bitterness and astringency, it was determined that overall, consumers liked wines that were less intense in terms of bitterness and astringency. However, when examining consumers classified as having a high body fat percentage or high BMI, their ability to differentiate the wines was decreased compared to lean counterparts. These findings suggest that dietary flavanol supplementation at a physiologically relevant dose may improve symptoms of diabetes and metabolic syndrome. Future work confirming these observations in humans is warranted, as are studies devoted to better understanding of the taste preferences of the obese population. This will allow for optimization of flavanol-rich foods that maximize health benefit while also being palatable to consumers.

Similarities and differences between obesity and addiction are a prominent topic of ongoing research. We conducted an activation likelihood estimation meta-analysis on 87 studies in order to map the functional magnetic resonance imaging (fMRI) response to reward in participants with obesity, substance addiction and non-substance (or behavioural) addiction, and to identify commonalities and differences between them. Our study confirms the existence of alterations during reward processing in obesity, non-substance addiction and substance addiction. Specifically, participants with obesity or with addictions differed from controls in several brain regions including prefrontal areas, subcortical structures and sensory areas. Additionally, participants with obesity and substance addictions exhibited similar blood-oxygen-level-dependent fMRI hyperactivity in the amygdala and striatum when processing either general rewarding stimuli or the problematic stimuli (food and drug-related stimuli, respectively). We propose that these similarities may be associated with an enhanced focus on reward – especially with regard to food or drug-related stimuli – in obesity and substance addiction. Ultimately, this enhancement of reward processes may facilitate the presence of compulsive-like behaviour in some individuals or under some specific circumstances. We hope that increasing knowledge about the neurobehavioural correlates of obesity and addictions will lead to practical strategies that target the high prevalence of these central public health challenges.

The purpose of the project has been to offer parents an easier everyday life with the help of research, where they can follow their child's growth curve in a new and innovative way. The whole project resulted in a simple product consisting of a measuring tool connected with a smartphone application where the measurement parameters of weight, length and waist measurement will be visualized in an educational way. With a new way of keeping track of growth parents will never again have to consider centimeters and kilograms, but at the same time be aware of unhealthy patterns. The product is called VELOX and offers customer and user convenience, time saving, simplicity and risk reduction during growth. The vision is to offer the product as a free kit for all families with children through the child healthcare centers.

Bmi-1 é uma proteína do grupo Polycomb capaz de induzir atividade de telomerase, levando à imortalização de células epiteliais. As células, quando imortalizadas, se tronam mais susceptíveis a danos em dupla fita (double-strand breaks (DSB))e a recombinação homóloga é uma das duas vias de reparo dos DSBs. Dentre os genes reguladores da recombinação homóloga temos o BRCA-1, que está envolvido na resposta ao dano associado à proteína RAD51, que por sua vez se acumula rapidamente nos focos de dano ao DNA após a sinalização do H2AX, que têm se mostrado um excelente marcador de dano celular por se acumular rapidamente nos focos de lesão, desencadeando o processo de reparo. Topoisomerase III (TopoIII) remove intermediários da recombinação homóloga antes da segregação de cromossomos, prevenindo danos à estrutura do DNA celular. O papel das proteínas envolvidas na recombinação homóloga, em carcinomas ductais invasores positivos para o BMI-1, necessita ser investigado. Utilizando-se tissue microarrays contendo 239 casos de carcinomas ductais mamários primários, foi analisada a expressão imunoistoquímica de BMI-1, receptor de estrógeno, receptor de progesterona, HER-2, Ki67, p53 e BRCA-1, H2AX, RAD51 e topoisomerase III. Positividade para o Bmi-1 foi encontrada em 66 casos (27.6%). A positividade imunoistoquímica do BMI-1 relacionou-se a RE (p=0,004), RP (p<0,001), Ki-67 (p < 0,001), p53 (p=0,003), BRCA-1(p= 0,003), H2AX (p= 0,024) e TopoIII (p < 0,001). Concluindo, nossos resultados mostraram haver relação entre o BMI-1 e genes reguladores da HR, sugerindo que a positividade de BMI-1 pode ser um importante evento na recombinação homóloga em carcinomas ductais invasores da mama. / Bmi-1 is a Polycomb group protein which is able to induce telomerase activity, enabling the immortalization of epithelial cells. Immortalized cells shown more susceptible to double-strand breaks (DSB) and the homologous recombination (HR) are one of DSB repair pathways. Among the regulatory genes in HR, there is BRCA1, involved in the response to DNA damage associated with the RAD51 protein, which accumulates in DNA damage foci after signaling H2AX. H2AX has also been shown to be a good marker of DNA damage. Topoisomerase III (TopoIII) removes HR intermediates before the segregation of chromosomes, preventing damage to the structure of the cellular DNA. The role of proteins involved in HR, in breast carcinomas positive for BMI-1, remains to be investigated. The aim of this study was evaluate the association between BMI-1 and homologous recombination proteins. Using tissue microarrays containing 239 cases of primary breast tumors, the expression of Bmi-1, BRCA-1, H2AX, Rad51, p53, Ki-67, topoisomerase III, RE, RP and HER-2 was analyzed by immunohistochemistry. We observe high expression of Bmi-1 in 66 cases (27.6%). Immunohistochemistry overexpression of BMI-1 was related to RE (p=0,004), RP (p<0,001), Ki-67 (p < 0,001), p53 (p=0,003), BRCA-1(p= 0,003), H2AX (p= 0,024) and TopoIII (p < 0,001). Our results showed a relation between the expression of BMI-1 and HR regulatory genes, suggesting that overexpression of Bmi-1 is an important event in breast cancer homologous recombination.

Bmi-1 é uma proteína do grupo Polycomb capaz de induzir atividade de telomerase, levando à imortalização de células epiteliais. As células, quando imortalizadas, se tronam mais susceptíveis a danos em dupla fita (double-strand breaks (DSB))e a recombinação homóloga é uma das duas vias de reparo dos DSBs. Dentre os genes reguladores da recombinação homóloga temos o BRCA-1, que está envolvido na resposta ao dano associado à proteína RAD51, que por sua vez se acumula rapidamente nos focos de dano ao DNA após a sinalização do H2AX, que têm se mostrado um excelente marcador de dano celular por se acumular rapidamente nos focos de lesão, desencadeando o processo de reparo. Topoisomerase III (TopoIII) remove intermediários da recombinação homóloga antes da segregação de cromossomos, prevenindo danos à estrutura do DNA celular. O papel das proteínas envolvidas na recombinação homóloga, em carcinomas ductais invasores positivos para o BMI-1, necessita ser investigado. Utilizando-se tissue microarrays contendo 239 casos de carcinomas ductais mamários primários, foi analisada a expressão imunoistoquímica de BMI-1, receptor de estrógeno, receptor de progesterona, HER-2, Ki67, p53 e BRCA-1, H2AX, RAD51 e topoisomerase III. Positividade para o Bmi-1 foi encontrada em 66 casos (27.6%). A positividade imunoistoquímica do BMI-1 relacionou-se a RE (p=0,004), RP (p<0,001), Ki-67 (p < 0,001), p53 (p=0,003), BRCA-1(p= 0,003), H2AX (p= 0,024) e TopoIII (p < 0,001). Concluindo, nossos resultados mostraram haver relação entre o BMI-1 e genes reguladores da HR, sugerindo que a positividade de BMI-1 pode ser um importante evento na recombinação homóloga em carcinomas ductais invasores da mama. / Bmi-1 is a Polycomb group protein which is able to induce telomerase activity, enabling the immortalization of epithelial cells. Immortalized cells shown more susceptible to double-strand breaks (DSB) and the homologous recombination (HR) are one of DSB repair pathways. Among the regulatory genes in HR, there is BRCA1, involved in the response to DNA damage associated with the RAD51 protein, which accumulates in DNA damage foci after signaling H2AX. H2AX has also been shown to be a good marker of DNA damage. Topoisomerase III (TopoIII) removes HR intermediates before the segregation of chromosomes, preventing damage to the structure of the cellular DNA. The role of proteins involved in HR, in breast carcinomas positive for BMI-1, remains to be investigated. The aim of this study was evaluate the association between BMI-1 and homologous recombination proteins. Using tissue microarrays containing 239 cases of primary breast tumors, the expression of Bmi-1, BRCA-1, H2AX, Rad51, p53, Ki-67, topoisomerase III, RE, RP and HER-2 was analyzed by immunohistochemistry. We observe high expression of Bmi-1 in 66 cases (27.6%). Immunohistochemistry overexpression of BMI-1 was related to RE (p=0,004), RP (p<0,001), Ki-67 (p < 0,001), p53 (p=0,003), BRCA-1(p= 0,003), H2AX (p= 0,024) and TopoIII (p < 0,001). Our results showed a relation between the expression of BMI-1 and HR regulatory genes, suggesting that overexpression of Bmi-1 is an important event in breast cancer homologous recombination.

Många drabbas av social ångest. Vikt och kroppsuppfattning relaterar till social ångest men sambandet behöver tydliggöras. Syftet med studien var att se hur mycket av variationen i social ångest över tid som kan förklaras av vikt-, och kroppsrelaterade mått, samt undersöka könsskillnader. Studien var longitudinell och baserades på en enkätundersökning vid två insamlingstillfällen med ett års mellanrum (N=361). Resultatet visade att upplevd övervikt, felaktigt upplevd övervikt, kön och kroppsnöjdhet tillsammans förklarade 7 % av variationen i social ångest över tid. Tjejer som var missnöjda med sina kroppar löpte ökad risk att rapportera högre grad av social ångest vid tidpunkt 2. Slutsatsen är att tjejer och killar har olika relation till sina kroppar vilket bör beaktas vid behandling och prevention. / Many people suffer from social anxiety. There is a relationship between weight and body perception connected to social anxiety but the link needs to be sorted out. The aim with our study was to clarify to what extent social anxiety is due to weight and body related concerns and to examine gender differences. The study was longitudinal and based on a survey performed at two occasions with one year interval (N=361). The result showed that perceived overweight, incorrectly perceived overweight, gender and body satisfaction predicts 7 % of the variety in social anxiety one year ahead. Girls who were dissatisfied with their bodies ran an increased risk reporting a higher level of social anxiety at the second occasion. Conclusively, as girls' and boys' relationships with their bodies differ, this findings should be considered in treatments and preventive programs.

目前，台灣整型、塑身的潮流已不分性別且日趨普遍化，觀察其原因除了吸引異性之外，美麗對就業、工作職位之升等似乎亦有直接關係。國外研究發現，外表與個人在職場上的表現息息相關，但台灣研究漂亮經濟的相關文獻少之又少，針對個人體型、相貌對其工作職位之影響的實證研究更是付之闕如，促使筆者意欲去驗證，台灣的勞動市場中，外表是否為影響個人事業的重要變數，以彌補現有文獻之不足。然而，由於研究資源不足，本文僅以太子汽車工業股份有限公司之員工為研究對象，以BMI值及相貌作為個人外表的衡量指標，進行外表與個人職位高低是否相關的初探性研究。 本文將男性非銷售人員、女性非銷售人員、及銷售單位人員區分為三種模型，並以最小平方法（OLS）對各解釋變數的影響方向加以估計。實證結果發現，男性非銷售人員之年齡、婚姻、教育、年資對其職位階級都有正向的助益；相貌方面也的確存在“貌醜懲罰”、“貌美獎勵”的傾向，即越英俊的男性非銷售人員，其職位便相對越高。至於國小以下子女數及BMI值過輕對工作職位則有負面影響。 在女性非銷售人員部分，已婚及教育程度越高者，其職位相對越高；國小以下子女數對女性職業地位則有不利之影響。至於年齡及年資都未如男性非銷售人員般與個人職位呈正相關，此估計結果可能代表，太子汽車工業股份有限公司存在「玻璃天花板」現象。最後，體型相貌變數皆與女性非銷售人員之職位高低無關。 在銷售單位方面，不區分性別一同估計的結果得出，婚姻、教育程度對銷售單位員工職位有正向效果；國小以下子女數及BMI值過輕則有負面影響。而BMI值過輕者可能是受消費者歧視所累，間接導致其難以獲致較高的職位。 / This study attempts to investigate the relationship between Body Mass Index, physical attractiveness and an employee’s position in Taiwan for the sake of being the supplement to the existing literatures related to this research field which primarily consider gender differences. The research object comes form the data bank of Prince Motor Corporation. The total number of sample used in this study is 754 and the empirical employed in this study is OLS Model. The findings suggest that age, marital status, education, experience, and physical attractiveness have a positive effect on men’s positions in non-sales department; number of children under age 12 and being underweight, a negative effect. For women in non-sales department, positions are significantly and positively affected by marital status and education, negatively affected by number of children under age 12. Finally, in sales department, the employees who are married and have higher education definitely are in higher position. Number of children under age 12 and being underweight have a negative effect on sales people’s position.

In children the way of life, nutrition and recreation changed in recent years and as a consequence body composition shifted as well. It is established that overweight belongs to a global problem. In addition, German children exhibit a less robust skeleton than ten years ago. These developments may elevate the risk of cardiovascular diseases and skeletal modifications. Heredity and environmental factors as nutrition, socioeconomic status, physical activity and inactivity influence fat accumulation and the skeletal system. Based on these negative developments associations between type of body shape, skeletal measures and physical activity; relations between external skeletal robustness, physical activity and inactivity, BMI and body fat and also the progress of body composition especially external skeletal robustness in comparison in Russian and German children were investigated. In a cross-sectional study 691 German boys and girls aged 6 to 10 years were examined. Anthropometric measurements were taken and questionnaires about physical activity and inactivity were answered by parents. Additionally, pedometers were worn to determinate the physical activity in children. To compare the body composition in Russian and German children data from the years 2000 and 2010 were used. The study has shown that pyknomorphic individuals exhibit the highest external skeletal robustness and leptomorphic ones the lowest. Leptomorphic children may have a higher risk for bone diseases in adulthood. Pyknomorphic boys are more physically active by tendency. This is assessed as positive because pyknomorphic types display the highest BMI and body fat. Results showed that physical activity may reduce BMI and body fat. In contrast physical inactivity may lead to an increase of BMI and body fat and may rise with increasing age. Physical activity encourages additionally a robust skeleton. Furthermore external skeletal robustness is associated with BMI in order that BMI as a measure of overweight should be consider critically. The international 10-year comparison has shown an increase of BMI in Russian children and German boys. Currently, Russian children exhibit a higher external skeletal robustness than the Germans. However, in Russian boys skeleton is less robust than ten years ago. This trend should be observed in the future as well in other countries. All in all, several measures should be used to describe health situation in children and adults. Furthermore, in children it is essential to support physical activity in order to reduce the risk of obesity and to maintain a robust skeleton. In this way diseases are able to prevent in adulthood. / Die Lebens- und Ernährungsweise sowie die Freizeitaktivitäten von Kindern haben sich im Laufe der letzten Jahre verändert. Daraus resultieren Veränderungen der Körperzusammensetzung. Es ist hinreichend bekannt, dass Übergewicht ein globales Problem ist. Des Weiteren weisen deutsche Kinder ein weniger robustes Skelett auf als noch vor 10 Jahren. Diese Entwicklungen können zu unterschiedlichen Erkrankungen des Herz-Kreislauf-Systems bzw. des Skelettsystems führen. Neben genetischen Faktoren haben Umweltfaktoren wie Ernährung, sozialer Status, die körperliche Aktivität bzw. Inaktivität einen Einfluss auf die Fettakkumulation und das Skelettsystem. Aufgrund der negativen Entwicklungen wurden daher die Zusammenhänge zwischen dem Körperbautyp, Skelettmaßen und der körperlichen Aktivität; die Beziehungen zwischen der äußeren Skelettrobustizität, der körperlichen Aktivität bzw. Inaktivität, dem BMI und dem Körperfettanteil sowie die Entwicklung der Körperzusammensetzung insbesondere die äußere Skelettrobustizität von russischen Kindern im Vergleich zu deutschen Kindern überprüft. In einer Querschnittstudie wurden 691 Jungen und Mädchen im Alter von 6 bis 10 Jahren aus Berlin und Brandenburg untersucht. Es wurden anthropometrische Messungen vorgenommen, Fragebögen bezüglich der sportlichen Aktivität und Inaktivität beantwortet sowie ein Schrittzähler zur Bestimmung der körperlichen Aktivität von den Kindern getragen. Für den internationalen Vergleich der Körperzusammensetzung wurden Daten aus den Jahren 2000 und 2010 von deutschen und russischen Kindern verwendet. Es konnte gezeigt werden, dass der pyknomorphe Körperbautyp die höchste und der leptomorphe Typ die niedrigste äußere Skelettrobustizität aufweisen. Leptomorphe Kinder könnten daher das höchste Risiko für Knochenerkrankungen im Erwachsenenalter aufweisen. Tendenziell zeigen pyknomorphe Jungen eine höhere körperliche Aktivität als die anderen Typen. Dies ist positiv zu bewerten, da die pyknomorphen Typen den höchsten BMI und Körperfettanteil besitzen. Wie die Resultate ergeben, kann die körperliche Aktivität zur Reduktion bzw. Inaktivität zur Erhöhung des BMIs und des Körperfettanteils führen. Die körperliche Inaktivität steigt mit zunehmendem Alter. Die körperliche Aktivität unterstützt weiterhin den Aufbau eines robusten Skeletts. Die äußere Skelettrobustizität ist ebenfalls positiv mit dem BMI assoziiert, so dass dargelegt werden konnte, dass der BMI als Maß für Übergewicht kritisch betrachtet werden sollte. Im internationalen 10-Jahresvergleich zeigt sich eine Zunahme des BMIs bei russischen Kindern und deutschen Jungen. Zurzeit weisen die russischen Kinder immer noch ein robusteres Skelett auf als die Deutschen jedoch ist das Skelett bei russischen Jungen weniger robust als noch vor 10 Jahren. Diese negative Entwicklung sollte weiterhin beobachtet werden auch in anderen Ländern. Alles in allem, sollten immer mehrere Maße zur Beschreibung des Gesundheitszustandes herangezogen werden. Weiterhin ist einer Förderung der körperlichen Aktivität bei Kindern notwendig, um zum einen das Risiko für Übergewicht zu minimieren und zum anderen ein robustes Skelett aufzubauen, um somit Erkrankungen im Erwachsenenalter vorzubeugen.

Abstract   Aims and objectives. To examine whether an intervention with carbohydrate- counting at onset of type 1 diabetes in children, has had any effect on metabolic indicators such as HbA1c , BMI-sds and total daily insulin / kg, 2 months and 1 year after onset by age and gender .Background. The pediatric department at the university hospital of Norrland in Umeå (NUS), has since several years a higher average HbA1c among children 0-17 years, compare with pediatric departments in the rest of Sweden.  Therefore, in autumn 2011, an intervention was made to teach children with diabetes and their parents to count carbohydrates from the onset of diabetes. Using this method they can regulate their insulin doses depending on the amount of carbohydrates they are eating. Design. This is an empirical registry study done on the basis of a quantitative method. It is retrospective controlled non- randomized with comparison group .Methods. The study included 46 children aged 0-17 years diagnosed with type 1 diabetes. Those who fell ill in 2009 (n=22) did not learn to use carbohydrate counting and served as a control group. The intervention group were diagnosed 2011-2012, (n=24), began using carbohydrate counting at the onset of diabetes.Results. The study shows with significant security that carbohydrate counting lowers HbA1c two months and one year after onset of type 1 diabetes. No significant difference was found in BMI-sds. The study shows no significant difference in HbA1c between the sexes.Conclusion.  Carbohydrate-counting from onset of diabetes gives a significant reduction of HbA1c without affecting BMI-sds significantly.Relevance to clinical practice. It is important that health professionals continue to teach and support families in carbohydrate counting from the onset of diabetes.Keywords. children, HbA1c, BMI- sds , type 1 diabetes , carbohydrate counting

Made available in DSpace on 2016-08-19T12:59:17Z (GMT). No. of bitstreams: 1 Dissertacao-AllannePereiraAraujo.pdf: 10380773 bytes, checksum: d164f581706013a6ea4ad9cfa61ad26f (MD5) Previous issue date: 2015-12-17 / Objective. This study aims to examine the association maternal nutritional status on the size of the newborn. Methodology. Cohort study of 1365 pregnant women and their newborns, who attended the St. Louis BREEZE research - MA. Data were collected in 2010 and 2011 and were applied two questionnaires: one during the prenatal and the other was applied after delivery. The main explanatory variable was the body mass index (BMI) before pregnancy. This was classified as underweight/normal weight, overweight and obesity. From the theoretical assumptions, a theoretical model was proposed by directed acyclic graphs (DAGs English): 1) Total effects (ET) adjusted to economic class, education, marital status, maternal age and occupation, 2) direct effect (ED) adjusted to economic class, education, marital status, maternal age, occupation, alcohol and maternal smoking, high blood pressure during pregnancy and conducting prenatal care. Data were analyzed using multiple linear regression with BMI as the outcome of the newborn (NB). Results. The infants had birth average BMI of 13.4 ± 1.7 kg / m2.As for the pre-pregnancy BMI and BMI RN, association was observed in the model proposed by DAG to full effect. However, for the direct effects model, the type of delivery and the realization of prenatal were protective factors to the increase of the BMI RN: ED (p = <0,001; Coef .: 0,51; CI: 0,31 ; 0,70), ED (p: 0,027; Coef: -. 1,88; CI: -3,55, -0,21). However, schooling between 8-11 years of study in all models (ET and ED) were protective factor for increasing RN BMI. As for the pre-pregnancy BMI and BMI RN, is observed even as overweight (p: 0,008; Coef .: 0,08: CI: -0,06; 1,84) and obesity (p : 0,009; Coef .: 0,89; CI: -0,09, 1,86) pre-pregnancy increase the RN BMI also increases. Conclusion. Overweight and pre-gestational obesity appears to be associated with BMI RN such associations underscore the need for early prenatal care and continuing to pregnant women, which may contribute to reducing maternal and child mortality rates and other adverse developments that context. / Objetivo. O presente estudo tem por objetivo analisar a associação entre estado nutricional pré-gestacional e o índice de massa corporal do recém-nascido. Metodologia. Estudo de coorte que envolveu 1365 gestantes e seus recém-nascidos, que participaram da pesquisa BRISA de São Luís - MA. Os dados foram coletados no ano de 2010 e 2011 e aplicaram-se dois questionários: um por ocasião do pré-natal e o outro após o parto. A variável explanatória principal foi o Índice de Massa Corporal (IMC) pré-gestacional. Este foi classificado em magreza/eutrofia, sobrepeso e obesidade. A partir dos pressupostos teóricos, um modelo teórico foi proposto pelos gráficos acíclicos direcionados (do inglês DAGs): 1) efeito total (ET) ajustado para classe econômica, escolaridade, situação conjugal, idade materna e ocupação, 2) efeito direto (ED) ajustado para classe econômica, escolaridade, situação conjugal, idade materna, ocupação, etilismo e tabagismo materno, hipertensão e diabetes mellitus na gestação e número de consultas realizadas durante o pré-natal. Os dados foram analisados por regressão linear múltipla tendo como desfecho o IMC do recém-nascido (RN). Resultados. Os RN tiveram IMC ao nascer médio de 13,4 ± 1,7 kg/m2. Quanto ao IMC pré-gestacional e sua relação com o IMC do RN, foi observada associação no modelo proposto pelo DAG para efeito total. Porém, para o modelo de efeito direto, o parto vaginal e a realização de pré-natal foram fatores de proteção ao aumento do IMC do RN: ED (p: <0,001; Coef.: 0,51; IC: 0,31;0,70), ED (p: 0,027; Coef.:-1,88; IC: -3,55;-0,21). A escolaridade entre 8 a 11 anos de estudo, em todos os modelos (ET e ED), foi fator de proteção para o aumento do IMC do RN. Quanto ao IMC pré-gestacional e o IMC do RN, observa-se ainda que à medida que o sobrepeso (p: 0,008; Coef.: 0,08: IC: 0,06;1,84) e a obesidade (p: 0,009; Coef.: 0,09; IC: 0,09;1,86) pré-gestacionais aumentam, o IMC do RN também aumenta. Conclusão. O sobrepeso e a obesidade pré-gestacionais parecem estar associados a valores elevados de IMC do RN, tais associações ressaltam a necessidade de assistência pré-natal precoce e contínua às gestantes, o que poderá contribuir para redução dos índices de morbimortalidade materno-infantil e demais evoluções desfavoráveis nesse contexto.