Orientador: Lilia Freire Rodrigues de Souza Li / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-24T11:40:45Z (GMT). No. of bitstreams: 1 Simoes-Brandao_JoyceMaradeAbreu_M.pdf: 2725392 bytes, checksum: d1962906bda18ae22f1e17fa97566158 (MD5) Previous issue date: 2013 / Resumo: Os pacientes com mielomeningocele apresentam baixa estatura com frequência bem mais elevada do que a população geral. Duas questões se destacam: as variáveis que influenciam o processo de crescimento e as medidas antropométricas, visto que as deformidades ortopédicas comuns a essa população limitam a obtenção de dados fidedignos. Objetivo: Analisar as variáveis relacionadas à ocorrência de baixa estatura em crianças com mielomeningocele. Avaliar se existe equivalência entre a altura e métodos antropométricos alternativos, que seriam utilizados quando o ortostatismo não for viável. Método: Estudo analítico transversal com 260 crianças, entre 3 e 9 anos, sendo 125 com mielomeningocele (grupo MMC) e 135 sem deficiências físicas (grupo controle). Em ambos os grupos foram avaliados: peso, altura, comprimento, envergadura, medida do braço, peso ao nascimento, história pregressa de patologias, condição socioeconômica e hospitalizações anteriores. No grupo MMC foram investigadas: infecções de repetição, presença de hidrocefalia e malformação de Chiari, nível neurológico da lesão medular e classificação funcional, ocorrência de deformidades ortopédicas, desenvolvimento puberal, idade óssea, malformações e desvios da coluna, avaliação laboratorial (hormônios da tireóide, função renal, IGF1 e IGFBP3). Foram calculadas estaturas estimadas utilizando equação de Stevenson e regressão linear. As estaturas foram comparadas pelo método Bland-Altman. As variáveis independentes foram avaliadas individualmente por regressão logística simples e as que obtiveram p-valor <0.25 foram incluídas na análise de regressão logística para determinar sua associação com a baixa estatura. As variáveis com p-valor <0.1 permaneceram no modelo final. Resultados : No grupo MMC foram 52 meninos e 73 meninas, com média de 6.6 anos e desvio-padrão (DP) 2.1 anos. No grupo controle foram 72 meninos e 63 meninas, média de idade 6.9 anos e DP 2 anos. Na análise do grupo controle, os resultados não mostraram diferenças entre altura, envergadura e estatura estimada por regressão linear pela envergadura e pelo braço (0.0cm, p=0.942, p=0.990 e p=0.999, respectivamente), entretanto revelou-se significativa para a diferença entre altura, comprimento (2.0cm/p<0.001) e estatura estimada por Stevenson (0.8cm/p=0.019). Observamos as seguintes prevalências de baixa estatura, de acordo com a medida utilizada como referência, no grupo MMC: 34% (altura), 47.2% (comprimento) e 16.5% (envergadura) e no grupo controle: 3%, 0.7% e 3.7%, para altura, comprimento e envergadura, respectivamente. A presença de lesão medular alta (p<0.09), gênero feminino (p<0.059), baixo peso a nascimento (p<0.071) e valores de IGF1 abaixo da mediana (p<0.054) foram significativamente associados à baixa estatura em análise de regressão logística multivariada. Conclusões: Das medidas avaliadas, a comparação da altura com a envergadura (medida direta e estimada) não mostrou diferença média entre as duas medidas e apresentou intervalo de concordância dentro do aceitável, mostrando-se, portanto, adequada para substituir a altura. As meninas com MMC, que tiveram baixo peso ao nascimento, possuem lesões medulares altas e mostram valores mais baixos de IGF-I devem ter acompanhamento mais rigoroso do crescimento, já que possuem risco maior de desenvolver baixa estatura, conforme evidenciado pela regressão logística / Abstract: Individuals with short stature are frequent among patients with mielomeningocele than in general population. Two questions appear to be important in this context: the variables that influence the growth process and appropriate anthropometric measurements must be made, since the orthopedic deformities¿common among this population¿limit the recording of reliable data. Aim: To evaluate whether there is equivalence between height and alternative anthropometric methods that can be used when orthostatism is not feasible, and to determine the variables related to the occurrence of short stature in children with myelomeningocele. Method: In this cross-sectional study, we examined 260 children (aged from 3 to 9 years), including 125 with myelomeningocele (MMC group) and 135 without any physical disabilities (control group). In both groups were evaluated: weight, height, length, arm span, birth weight, history of chronic diseases, socioeconomic status and previous hospitalizations. In the MMC group the following variables were also assessed: recurrent infections, presence of hydrocephalus and Chiari malformation, neurological level, occurrence of orthopedic deformities, pubertal development, bone age, spine malformations and deviations, and laboratory data (thyroid hormones, kidney function, IGF1, and IGFBP3). Heights estimated were calculated according to the equation proposed by Stevenson and the formula developed from linear regression. The heights were compared applying the Bland-Altman method. The independent variables were evaluated individually with simple logistic regression and were included in the logistic regression analysis when p-value <0.25, to determine their association with short stature. Variables with p-value <0.1 remain in the final model. Results: The MMC group included 52 boys and 73 girls, with mean age of 6.6 years and standard deviation (SD) of 2.1 years. The control group included 72 boys and 63 girls, with a mean age of 6.9 years and SD of 2 years. In the analysis of the control group, we observed that there was no significant difference between the height and arm span, and the heights estimated by the arm span and arm measurement (0.0 cm, p=0.942, p=0.990, and p=0.999, respectively). However, the differences between height and length (2.0 cm, p< 0.001) and height estimated by Stevenson (0.8 cm, p=0.019) were significant. Observe the prevalence of short stature in the MMC group, according to the measure used: 34% (height), 47.2% (length) and 16.5% (arm span). In the control group the values were 3%, 0.7% and 3.7% for height, length and arm span, respectively. The presence of high neurological level (p<0.09), female gender (p<0.059), low birth weight (p<0.071) and IGF1 values below the median (p<0.054) were significantly associated with short stature in multivariate logistic regression analysis. Conclusions: From the measures evaluated, the comparison between height and arm span (both direct and estimated measurements) showed no difference with the mean measurements of height, presented an acceptable concordance interval and, thus, appeared to be a suitable substitute. The girls with MMC, which had low birth weight, have high neurological level and show lower levels of IGF1 should have stricter control of growth as they have a higher risk of develop short stature as evidenced by logistic regression / Mestrado / Pediatria / Mestra em Ciências

Title: Selected parameters of gait and foot in consideration of the individual's body height Objectives: This thesis deals with a dependence of the selected gait and foot characteristics on a person's body height. These parameters are compared between a group of men and a group of women. In addition, a validity of selected formulas used for a determination of body height is evaluated. Methods: Mutual relation among the gait and foot characteristics and the individual's body height is observed. The thesis is a descriptive - association research, the comparative method is chosen in the practical part of the thesis. For an objectification of the research, the Plantograph and the 3D kinematic gait analysis performed by Qualysis system was used. Results: It was found out that the selected formulas used for a determination of body height are valid. The best results are brought by the formulas which count with a length of a bare foot, the length of a step and a double-step. On the contrary, the worse results are achieved by using the formulas which count with the dimension of shoe print. A tight dependence of the foot length and the length of the step / double-step on the body height was proven. A minimum dependence of the foot width on the body height was proven. Nevertheless the foot width is verifiably...

Abstract Aim: The aim was to evaluate height measurements made with the single view metrology method and to investigate the influence of standing position and different phases of gait and running on vertical height. Method: Ten healthy men were recorded simultaneously by a 2D web camera and a 3D motion analysis system. They performed six trials, three standing and three during gait and running. The vertical height was measured with the single view metrology method and in Qualisys Track Manager. The results were compared for evaluation. The vertical height in the different postures was compared to the actual height. Results: The measurements made with the single view metrology method were significantly higher than the measurements made with Qualisys Track Manager (p&lt;0.001). The vertical height in the two standing positions was significantly lower than the actual height (p&lt;0.05). The vertical height in midstance was significantly lower than actual height in the walking trials (p&lt;0.05). No significant difference was found between maximum vertical height and actual height during running (p&gt;0.05). Conclusion: The single view metrology method measured vertical heights with a mean error of +2.30 cm. Posture influence vertical body height. Midstance in walking is the position where vertical height corresponds best with actual height, in running it is the non-support phase.

<p><p><strong>Abstract</strong></p><p><strong>Aim: </strong>The aim was to evaluate height measurements made with the single view metrology method and to investigate the influence of standing position and different phases of gait and running on vertical height.</p><p><strong>Method: </strong>Ten healthy men were recorded simultaneously by a 2D web camera and a 3D motion analysis system. They performed six trials, three standing and three during gait and running. The vertical height was measured with the single view metrology method and in Qualisys Track Manager. The results were compared for evaluation. The vertical height in the different postures was compared to the actual height.</p><p><strong>Results: </strong>The measurements made with the single view metrology method were significantly higher than the measurements made with Qualisys Track Manager (p<0.001). The vertical height in the two standing positions was significantly lower than the actual height (p<0.05). The vertical height in midstance was significantly lower than actual height in the walking trials (p<0.05). No significant difference was found between maximum vertical height and actual height during running (p>0.05).</p><p><strong>Conclusion: </strong>The single view metrology method measured vertical heights with a mean error of +2.30 cm. Posture influence vertical body height. Midstance in walking is the position where vertical height corresponds best with actual height, in running it is the non-support phase.</p><p> </p></p><p> </p>

Indiana University-Purdue University Indianapolis (IUPUI) / Recent genome-wide association studies (GWAS) have identified many common genetic variants that are associated with women’s reproductive timing characteristics including ages at menarche and at natural menopause. However, the associations of these variants with other human health related phenotypes such as blood pressure, cancer, diabetes, obesity, and body height growth have not been well studied. No published studies to our knowledge have directly assessed the genetic influence of reproductive timing related variants on the aforementioned common traits. A better understanding of pleiotropic effects of these variants is important because it will help elucidate the precise mechanisms of common traits/diseases such as hypertension which have not been fully understood so far, and give clues for developing better solutions for disease prevention and treatment. We, therefore, conducted three studies to explore genetic variant effects on blood pressure and body height growth. In the first study, we analyzed data from a local cohort of 601 healthy adolescents from Indianapolis schools. Mixed effect model analysis revealed that 11 reproductive related single nucleotide polymorphisms (SNPs) were significantly associated with blood pressure in the study subjects. In order to assess if these genetic effects extended to the adult blood pressure, we performed the second study to investigate the genetic effect on blood pressure in adults. We used the summary statistics obtained from the two large international GWAS consortia, the Blood Pressure Consortium and the ReproGen Consortium. Bivariate analyses showed that more than 100 SNPs were associated with both blood pressure and reproductive timing. As the blood pressure development is closely related to somatic growth, we conducted the third study to exam the genetic effect of reproductive-timing related variants on the linear growth from the aforementioned local cohort. We identified 8 genetic variants significantly associated with the catch-up of linear growth in the study subjects. In conclusion, these three studies collectively provided evidence in support of the pleiotropic effects of the reproductive timing variants, suggesting the common genetic basis underlying the correlated traits. Future research is needed to validate the findings. / 2 years

Three-dimensional (3D) whole body scanners are increasingly used as precise measuring tools for the rapid quantification of anthropometric measures in epidemiological studies. We analyzed 3D whole body scanning data of nearly 10,000 participants of a cohort collected from the adult population of Leipzig, one of the largest cities in Eastern Germany. We present a novel approach for the systematic analysis of this data which aims at identifying distinguishable clusters of body shapes called body types. In the first step, our method aggregates body measures provided by the scanner into meta-measures, each representing one relevant dimension of the body shape. In a next step, we stratified the cohort into body types and assessed their stability and dependence on the size of the underlying cohort. Using self-organizing maps (SOM) we identified thirteen robust meta-measures and fifteen body types comprising between 1 and 18 percent of the total cohort size. Thirteen of them are virtually gender specific (six for women and seven for men) and thus reflect most abundant body shapes of women and men. Two body types include both women and men, and describe androgynous body shapes that lack typical gender specific features. The body types disentangle a large variability of body shapes enabling distinctions which go beyond the traditional indices such as body mass index, the waist-to-height ratio, the waist-to-hip ratio and the mortality-hazard ABSI-index. In a next step, we will link the identified body types with disease predispositions to study how size and shape of the human body impact health and disease.

Title: Comparison of respiratory function in school age children Objectives: The main aims of this study were to estimate influence of age, anthropometric measures, and a type of physical activity on forced vital capacity (FVC), and additionally to create reference values of FVC for children aged 5 to 10 years. Methods: 281 girls and 345 boys were enrolled in this cross-sectional study. Data were obtained during the sport propagation event called Sportacek 2016. Descriptive statistics and regression models were carried out in data processing. Results: Statistically significant influence of body height as well as influence of physical activity in boys' gymnastics on FVC was found. Keywords: respiration, dependence, body height, forced vital capacity

Diss. (sammanfattning) Uppsala : Univ., 2003. / Härtill 5 uppsatser.

Diss. Stockholm : Karolinska institutet, 2007. / S. 1-131: sammanfattning, s. 133-191: 5 uppsatser.

Diss. (sammanfattning) Uppsala : Uppsala universitet, 2007. / Härtill 5 uppsatser.