Thesis (M.H.S.A.)--University of Michigan, 1976.

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Este trabalho analisa o surgimento da \"psicologia social\" francesa na última década do século XIX, através de seus representantes mais conhecidos, Gabriel Tarde (1843-1904) e Gustave Le Bon (1841-1931), mas também de autores que, pertencentes ao mesmo meio, mantiveram com eles afinidades intelectuais, sociais e teóricas. Parto do princípio de que o estudo de um determinado tema, mesmo que não institucionalizado, como é o caso da \"psicologia social\", deve ser compreendido a partir da estrutura do campo intelectual no período, no caso, em processo de autonomização e profissionalização a partir dos anos 80. Isso significa que, no campo disciplinar, a grande referência é o corte entre o pólo universitário e o pólo \"livre\", o que predispôs a disputas diversas por cadeiras e cursos por parte dos representantes das várias matérias ainda não institucionalizadas. A \"psicologia social\" é uma dessas matérias que têm vigência e legitimidade restritas a um determinado grupo e período da história do campo, ou seja, é uma matéria típica de posições intelectualmente dominadas, não universitárias, e cujo fim era o combate pela ascensão à universidade contra o seu principal concorrente, a sociologia durkheimiana. Dado o caráter fluido das definições disciplinares, defino o campo das \"ciências sociais\" pelo combate entre as disciplinas novas - a economia, a psicologia e a sociologia - e delas com as antigas disciplinas - a história e a filosofia - e identifico duas grandes correntes e práticas nas ciências sociais \"livres\": a que pertence ao poder social e a que pertence ao poder intelectual. Em segundo lugar, mostro como essas posições extra-universitárias correspondem a estratégias no campo editorial, tendo em vista que as editoras, revistas e coleções congregaram os grupos interessados nesse combate. Concluo que a \"psicologia social\", por não ter conseguido se instituir como disciplina universitária nesse período, teve sua sobrevivência condicionada à constituição de um público não universitário, através de coleções, de revistas ou de instituições \"livres\" de ensino. Dada a falta de credenciais acadêmicas, a sobrevivência desses grupos no campo intelectual exigiu um investimento brutal em relações sociais. Como corolário desse processo, as representações tenderam a valorizar seja a função técnica seja a missão cultural das ciências sociais em detrimento de sua autonomização no campo científico. É por essa razão que a \"psicologia social\" hipostasiou o papel das elites e da liberdade individual contra as multidões e as determinações coletivas, elaborando uma representação invertida da posição que esses autores ocuparam no campo intelectual. / This thesis analyses the emergency of the French \"social psychology\" in the last decade of the XIXth century, particularly through the work of its most renewed authors, Gabriel Tarde (1843-1904) and Gustave Le Bon (1841-1931), but also through the work of authors who, belonging to the same network, had with them intellectual, social and theoretical identities. I suppose that the study of a theme, even if it is not institucionalized, as it is the case in \"social psychology\", has to be based on the structure of the French intellectual field, which means, from the process of autonomization and profissionalization starting in the 80ies. This implies that, in the disciplinary field, there is a main polarization between the university positions and the \"free\" positions, the last ones fighting for chairs and carreers at the university. The \"social psychology\" is one of those subjects that had legitimity limited to a determined group and period of the history of the field, that means, is a typical subject of intellectual dominated positions, non universitarian, and whose purpose was to win positions against durkheimian sociology. Considering the undefined character of these disciplines, I call \"social sciences\" the battles between the new disciplines - economy, psychology and sociology - and between them and the old and institucionalized ones - history and philosophy - and I identify two main groups and practices in the \"free\" social sciences: the one who belongs to the social power and the one who belongs to the intellectual one. Besides, I show that these extra-universitarian positions correspond to strategies in the editorial field, because the editeurs, reviews and collections have aggregated the same two groups and fights. I concluded that \"social psychology\", for the reason it could not be institucionalized, had to survive in the intellectual field by constructing a public non universitarian through collections, reviews and \"free\" schools. Considering the lack of academic credencials, the surviving of these groups in the intellectual field demanded a brutal investment in social relationships. As a consequence, their representations tended to emphasize the technical function or the cultural mission in social sciences against their autonomization in the scientific field. The result is that \"social psychology\" gave too much value to the role of the elites and of the individual freedom against the crowds and the collective determinations, producing a reversed representation of the position these authors occupied in the intellectual field.

Este trabalho analisa o surgimento da \"psicologia social\" francesa na última década do século XIX, através de seus representantes mais conhecidos, Gabriel Tarde (1843-1904) e Gustave Le Bon (1841-1931), mas também de autores que, pertencentes ao mesmo meio, mantiveram com eles afinidades intelectuais, sociais e teóricas. Parto do princípio de que o estudo de um determinado tema, mesmo que não institucionalizado, como é o caso da \"psicologia social\", deve ser compreendido a partir da estrutura do campo intelectual no período, no caso, em processo de autonomização e profissionalização a partir dos anos 80. Isso significa que, no campo disciplinar, a grande referência é o corte entre o pólo universitário e o pólo \"livre\", o que predispôs a disputas diversas por cadeiras e cursos por parte dos representantes das várias matérias ainda não institucionalizadas. A \"psicologia social\" é uma dessas matérias que têm vigência e legitimidade restritas a um determinado grupo e período da história do campo, ou seja, é uma matéria típica de posições intelectualmente dominadas, não universitárias, e cujo fim era o combate pela ascensão à universidade contra o seu principal concorrente, a sociologia durkheimiana. Dado o caráter fluido das definições disciplinares, defino o campo das \"ciências sociais\" pelo combate entre as disciplinas novas - a economia, a psicologia e a sociologia - e delas com as antigas disciplinas - a história e a filosofia - e identifico duas grandes correntes e práticas nas ciências sociais \"livres\": a que pertence ao poder social e a que pertence ao poder intelectual. Em segundo lugar, mostro como essas posições extra-universitárias correspondem a estratégias no campo editorial, tendo em vista que as editoras, revistas e coleções congregaram os grupos interessados nesse combate. Concluo que a \"psicologia social\", por não ter conseguido se instituir como disciplina universitária nesse período, teve sua sobrevivência condicionada à constituição de um público não universitário, através de coleções, de revistas ou de instituições \"livres\" de ensino. Dada a falta de credenciais acadêmicas, a sobrevivência desses grupos no campo intelectual exigiu um investimento brutal em relações sociais. Como corolário desse processo, as representações tenderam a valorizar seja a função técnica seja a missão cultural das ciências sociais em detrimento de sua autonomização no campo científico. É por essa razão que a \"psicologia social\" hipostasiou o papel das elites e da liberdade individual contra as multidões e as determinações coletivas, elaborando uma representação invertida da posição que esses autores ocuparam no campo intelectual. / This thesis analyses the emergency of the French \"social psychology\" in the last decade of the XIXth century, particularly through the work of its most renewed authors, Gabriel Tarde (1843-1904) and Gustave Le Bon (1841-1931), but also through the work of authors who, belonging to the same network, had with them intellectual, social and theoretical identities. I suppose that the study of a theme, even if it is not institucionalized, as it is the case in \"social psychology\", has to be based on the structure of the French intellectual field, which means, from the process of autonomization and profissionalization starting in the 80ies. This implies that, in the disciplinary field, there is a main polarization between the university positions and the \"free\" positions, the last ones fighting for chairs and carreers at the university. The \"social psychology\" is one of those subjects that had legitimity limited to a determined group and period of the history of the field, that means, is a typical subject of intellectual dominated positions, non universitarian, and whose purpose was to win positions against durkheimian sociology. Considering the undefined character of these disciplines, I call \"social sciences\" the battles between the new disciplines - economy, psychology and sociology - and between them and the old and institucionalized ones - history and philosophy - and I identify two main groups and practices in the \"free\" social sciences: the one who belongs to the social power and the one who belongs to the intellectual one. Besides, I show that these extra-universitarian positions correspond to strategies in the editorial field, because the editeurs, reviews and collections have aggregated the same two groups and fights. I concluded that \"social psychology\", for the reason it could not be institucionalized, had to survive in the intellectual field by constructing a public non universitarian through collections, reviews and \"free\" schools. Considering the lack of academic credencials, the surviving of these groups in the intellectual field demanded a brutal investment in social relationships. As a consequence, their representations tended to emphasize the technical function or the cultural mission in social sciences against their autonomization in the scientific field. The result is that \"social psychology\" gave too much value to the role of the elites and of the individual freedom against the crowds and the collective determinations, producing a reversed representation of the position these authors occupied in the intellectual field.

Les mémoires de Jacques du Clercq appartiennent à l'importante production historiographique qui naît, au milieu du XVe siècle, dans le giron des Valois de Bourgogne. Nous proposons une étude de ce texte en suivant trois axes de recherche principaux. Il s'agit d'abord d'étudier la personnalité de l'auteur inconnu qu'étaient Jacques du Clercq en nous arrêtant, notamment, sur son milieu familial. Il est essentiel, également de jauger ses lectures et donc des sources qu'il utilisa pour disserter sur l'histoire de son temps. Dans un second temps, nous étudions la manière dont il conduit la rédaction de son texte. Enfin, naturellement, il s'agit de s'intéresser, dans une troisième partie, à sa pensée politique. / The memories of Jacques du Clercq belongs to the important historiographical production which is born, in the middle of the XVth century, in the environment of the Valois of Burgundy. We propose a study of this text by following three main areas of research. First, we study the personnality of the unknown author whom was Jacques du Clercq and is family's background. The analyse of his sources of information, which he used to talk about the history of his time, was essential to. In a second part, we study the way he composed his text. Finally, we invoke the problematic of his political thought.

La résistance bactérienne aux antibiotiques est un problème de santé publique mondial principalement lié à un mésusage des antibiotiques (surconsommation et prescription inadéquate).Pour lutter contre cette menace, des recommandations diffusées par les sociétés savantes et des plans d’action ont été mis en place. Même si ils sont nécessaires, ils ne sont pas suffisants pour assurer une amélioration significative de l’usage des antibiotiques. Un fort taux de non-conformité de la prescription antibiotique au regard des recommandations est observé dans les établissements de santé (ES). La mise en place de programmes volontaristes de bon usage antibiotique au sein de chaque ES s’avère essentiel pour améliorer l’usage des antibiotiques : une action sur les comportements des prescripteurs est indispensable, par le biais de différentes stratégies. Qu’elles soient persuasives ou restrictives, celles-ci ont toutes montré leur efficacité, sans entraîner d’effets cliniques néfastes pour les patients (pas d’augmentation de la mortalité ni de la durée de séjour), tout en permettant une réduction des coûts liés aux anti-infectieux.Par le biais de nos travaux, nous avons cherché à étudier le bon usage antibiotique en milieu hospitalier, à l’échelle de différents types d’ES (hôpital local, centre hospitalier régional universitaire, cohorte de 259 ES), et en évaluant l’impact de recommandations nationales ou de programmes et de guides locaux. Ces travaux nous ont permis de constater que la diffusion de recommandations nationales pouvait permettre de réduire les consommations de carbapénèmes, et qu’un programme mené dans un hôpital local pouvait être très efficace pour réduire les consommations de fluoroquinolones, mais également la résistance bactérienne à plus long terme. Des audits ciblés sur la prescription des aminosides et l’antibioprophylaxie chirurgicale ont permis de mettre en évidence des non-conformités récurrentes orientant sur des actions d’amélioration ciblées à mener.En conclusion, ce travail souligne l’importance des programmes de bon usage antibiotique au sein de chaque ES, quel que soit le type et le nombre de lits. En effet, ces programmes venant en appui aux recommandations ont démontré leur efficacité pour réduire les consommations et améliorer la qualité des prescriptions antibiotiques, grâce à leur impact positif sur les comportements des prescripteurs. / Bacterial resistance to antibiotics is a worldwide public health issue which is mainly linked to antibiotic misuse (overconsumption and inappropriate prescription).To fight this threat, recommendations from learned societies and national action plans have been set up. Even if they are necessary, they are not sufficient to provide a significant improvement in the antibiotic use. A high rate of non-compliance with the recommendations is observed among healthcare facilities (HCFs). The setting up of proactive antimicrobial stewardship programs (ASP) among every HCF is essential to improve antibiotic use: an action on prescribers’ behavior is necessary, by using various strategies. These strategies, however persuasive or restrictive, have been shown to be effective, with no clinical negative effects for the patients (no increase in mortality and in length of stay), while reducing anti-infective costs.With this work, we aimed to study the appropriateness of antibiotic use in hospitals, at different HCFs levels (local hospital, university hospital, 259 French HCFs cohort), by assessing the impact of national recommendations or local ASP and guidelines. These studies showed that national recommendations could lead to a reduction in carbapenem consumptions, and that an ASP conducted in a local hospital could be very effective to reduce fluoroquinolones consumptions, and bacterial resistance at a longer term. Targeted audits on aminoglycosides prescription and on surgical antibioprophylaxis have permitted to highlight recurrent non-compliances, guiding improvement measures to set up.In conclusion, this work supports the weight of ASPs among each HCF, whatever type and size. Indeed, these ASPs, set up in support of the national recommendations, have demonstrated their effectiveness in reducing antibiotic consumptions and improving prescription appropriateness, by their positive impact on prescribers’ behaviors.

Tableau d’honneur de la Faculté des études supérieures et postdoctorales, 2014-2015 / Notre mémoire a pour objectif d’identifier et d’analyser les processus de patrimonialisation chez les Sœurs du Bon-Pasteur de Québec. En étudiant les opérations de constitution du patrimoine, cette recherche questionne les enjeux identitaires du patrimoine et la construction d’une identité communautaire. Elle s’intéresse aux initiatives culturelles des religieuses et aux actions d’appropriation et de reconnaissance proposées, d’une prise de conscience patrimoniale à une pratique muséale. L’étude, qui pose un regard ethnologique sur la patrimonialisation, tient compte du discours de la communauté et de sa propre définition du patrimoine. En s’intéressant à l’expérience sensible des religieuses, elle tend à une meilleure compréhension des motivations ayant mené à la constitution d’un patrimoine.

De par leur excellente résolution spatiale et leurs propriétés particulières, les ultramicroélectrodes (UME) constituent des outils de choix pour l'étude de mécanismes biologiques de sécrétion à l'échelle de la cellule unique. En configuration " synapse semi-artificielle ", du fait de la faible distance qui sépare la cellule émettrice de l'UME, les molécules sont libérées dans un faible volume, induisant alors des concentrations suffisamment élevées pour être détectables par électrochimie. Ainsi, les UME offrent la possibiIité de mesurer des flux, même infimes, de molécules électroactives en temps réel. Cette technique analytique a été utilisée, complétée ou adaptée afin d'étudier deux phénomènes biologiques : l'exocytose vésiculaire et le stress oxydant cellulaire. L'analyse ampérométrique de l'exocytose, mécanisme impliqué dans la communication cellulaire, permet l'étude quantitative de la cinétique de libération des molécules intravésiculaires libérées dans le milieu extracellulaire. L'UME, placée dans le milieu extérieur, n'apporte pas d'information quant au statut des vésicules avant la fusion. Pour compléter ces informations, nous avons développé, par des techniques de microfabrication, un microsystème constitué d'électrodes conductrices et transparentes d'ITO permettant un couplage des détections ampérométrique et optique (microscopie TIRF) pour l'étude de la sécrétion des cellules BON BC21. L'ampérométrie à quatre potentiels constants, utilisée au laboratoire pour la détection des ROS/RNS libérées par les macrophages, cellules du système immunitaire, nécessite un grand nombre d'expériences pour s'affranchir de la variabilité cellulaire et des différences de sensibilité des UME. Afin de réduire considérablement le temps d'expérience, nous avons développé un microsystème constitué de quatre chambres de mesure, chacune contenant un jeu de trois électrodes. Ces quatre chambres permettront, à terme, le suivi et la détection simultanée en temps réel des variations de production de H2O2, ONOO-, NO* et NO2- libérées par une cellule.