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Introduction: Cardiovascular surgery is a relatively young but progressively evolving field in medicine. More specifically, in the past decades, cardiac surgery achieved significant advances in understanding the causes, progression and treatments of ischemic heart disease (IHD). The IHD is the most common coronary disease, and it ranks first in morbidity and mortality in the developed world. It justifies the need for significant fundamental research as well as its study in clinical practice. It now includes specialized cardiovascular centres with the complex specialized treatments. A group of interventional cardiologists capable of performing routine examinations of the coronary veins using selective angiography has been established. They can eventually also perform percutaneous coronary interventions with direct stent implants. Thus the advances have been made in comprehensive indication of the patients towards their optimal treatments under the regime of a cardio-team. Such team comprises of a cardio-surgeon, interventional cardiologist, echocardiography specialist and the attending physician who is usually the cardiologist. The IHD treatments involve preventive cardiology with the regime measures and checks, pharmacotherapy, interventional cardiology and cardiac surgery to spa treatment and...

En informatique, la résolution de problèmes NP-difficiles en un temps raisonnable est d’une grande importance : optimisation de la chaîne d’approvisionnement, planification, routage, alignement de séquences biologiques multiples, inference dans les modèles graphiques pro- babilistes, et même certains problèmes de cryptographie sont tous des examples de la classe NP-complet. En pratique, nous modélisons beaucoup d’entre eux comme un problème d’op- timisation en nombre entier, que nous résolvons à l’aide de la méthodologie séparation et évaluation. Un algorithme de ce style divise un espace de recherche pour l’explorer récursi- vement (séparation), et obtient des bornes d’optimalité en résolvant des relaxations linéaires sur les sous-espaces (évaluation). Pour spécifier un algorithme, il faut définir plusieurs pa- ramètres, tel que la manière d’explorer les espaces de recherche, de diviser une recherche l’espace une fois exploré, ou de renforcer les relaxations linéaires. Ces politiques peuvent influencer considérablement la performance de résolution. Ce travail se concentre sur une nouvelle manière de dériver politique de recherche, c’est à dire le choix du prochain sous-espace à séparer étant donné une partition en cours, en nous servant de l’apprentissage automatique profond. Premièrement, nous collectons des données résumant, sur une collection de problèmes donnés, quels sous-espaces contiennent l’optimum et quels ne le contiennent pas. En représentant ces sous-espaces sous forme de graphes bipartis qui capturent leurs caractéristiques, nous entraînons un réseau de neurones graphiques à déterminer la probabilité qu’un sous-espace contienne la solution optimale par apprentissage supervisé. Le choix d’un tel modèle est particulièrement utile car il peut s’adapter à des problèmes de différente taille sans modifications. Nous montrons que notre approche bat celle de nos concurrents, consistant à des modèles d’apprentissage automatique plus simples entraînés à partir des statistiques du solveur, ainsi que la politique par défaut de SCIP, un solveur open-source compétitif, sur trois familles NP-dures: des problèmes de recherche de stables de taille maximum, de flots de réseau multicommodité à charge fixe, et de satisfiabilité maximum. / In computer science, solving NP-hard problems in a reasonable time is of great importance, such as in supply chain optimization, scheduling, routing, multiple biological sequence align- ment, inference in probabilistic graphical models, and even some problems in cryptography. In practice, we model many of them as a mixed integer linear optimization problem, which we solve using the branch and bound framework. An algorithm of this style divides a search space to explore it recursively (branch) and obtains optimality bounds by solving linear relaxations in such sub-spaces (bound). To specify an algorithm, one must set several pa- rameters, such as how to explore search spaces, how to divide a search space once it has been explored, or how to tighten these linear relaxations. These policies can significantly influence resolution performance. This work focuses on a novel method for deriving a search policy, that is, a rule for select- ing the next sub-space to explore given a current partitioning, using deep machine learning. First, we collect data summarizing which subspaces contain the optimum, and which do not. By representing these sub-spaces as bipartite graphs encoding their characteristics, we train a graph neural network to determine the probability that a subspace contains the optimal so- lution by supervised learning. The choice of such design is particularly useful as the machine learning model can automatically adapt to problems of different sizes without modifications. We show that our approach beats the one of our competitors, consisting of simpler machine learning models trained from solver statistics, as well as the default policy of SCIP, a state- of-the-art open-source solver, on three NP-hard benchmarks: generalized independent set, fixed-charge multicommodity network flow, and maximum satisfiability problems.

The worship experience in The Church of Jesus Christ of Latter-day Saints is inextricably linked to the ward or branch. This thesis examines the development of the Latter-day Saint congregation at the church centers from 1829 to 1846: Palmyra and Fayette, New York; Harmony, Pennsylvania; Kirtland, Ohio; Independence, Liberty and Far West in Missouri; and Nauvoo, Illinois. This work not only documents the creation and development of congregations, but also gives attention to the other important elements developed during the early years that are still associated with modern Latter-day Saint wards: meeting and worship patterns, physical locations where meetings took place, and leadership of local branches and wards. More on parameters and purpose is spelled out in Chapter 1.Each of the next three chapters deals with a time period and place, tracking all four of the elements of emphasis through an era. Chapter 2 briefly discusses meetings and groups before the official organization of the Church, and then continues on to consider the developments made in the three areas considered as Church centers: Fayette and Palmyra in New York and Harmony, Pennsylvania. The bulk of Chapter 2, however, deals with Kirtland, Ohio, which was headquarters for the Church for much of the 1830s.The three counties in Missouri that held the highest concentration of Saints-Jackson, Clay and Caldwell-are the area of study for Chapter 3. Eventually driven not only from all of these counties but also the state of Missouri, the Saints moved on to Illinois, the subject of Chapter 4. Quincy, Illinois was briefly considered the Church center until the purchase of the land that became Nauvoo. The final chapter synthesizes each of the four topics: congregational organization, meeting patterns, local leadership, and meeting places. Consequently, it is a brief overview of what advancements were made across all years and places studied in each area of focus.

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<p>Efficient global dynamic optimization (GDO) using spatial branch-and-bound (SBB) requires the ability to construct tight bounds for the dynamic model. This thesis works toward efficient GDO by developing effective convex relaxation techniques for models with ordinary differential equations (ODEs). In particular, a novel algorithm, based upon a verified interval ODE method and the McCormick relaxation technique, is developed for constructing convex and concave relaxations of solutions of nonlinear parametric ODEs. In addition to better convergence properties, the relaxations so obtained are guaranteed to be no looser than their underlying interval bounds, and are typically tighter in practice. Moreover, they are rigorous in the sense of accounting for truncation errors. Nonetheless, the tightness of the relaxations is affected by the overestimation from the dependency problem of interval arithmetic that is not addressed systematically in the underlying interval ODE method. To handle this issue, the relaxation algorithm is extended to a Taylor model ODE method, which can provide generally tighter enclosures with better convergence properties than the interval ODE method. This way, an improved version of the algorithm is achieved where the relaxations are generally tighter than those computed with the interval ODE method, and offer better convergence. Moreover, they are guaranteed to be no looser than the interval bounds obtained from Taylor models, and are usually tighter in practice. However, the nonlinearity and (potentially) nonsmoothness of the relaxations impedes their fast and reliable solution. Therefore, the algorithm is finally modified by incorporating polyhedral relaxations in order to generate relatively tight and computationally cheap linear relaxations for the dynamic model. The resulting relaxation algorithm along with a SBB procedure is implemented in the MC++ software package. GDO utilizing the proposed relaxation algorithm is demonstrated to have significantly reduced computational expense, up to orders of magnitude, compared to existing GDO methods.</p> / Doctor of Philosophy (PhD)

The air transportation market has been growing steadily for the past three decades since the airline deregulation in 1978. With competition also becoming more intense, airline companies have been trying to enhance their market shares and profit margins by composing favorable flight schedules and by efficiently allocating their resources of aircraft and crews so as to reduce operational costs. In practice, this is achieved based on demand forecasts and resource availabilities through a structured airline scheduling process that is comprised of four decision stages: schedule planning, fleet assignment, aircraft routing, and crew scheduling. The outputs of this process are flight schedules along with associated assignments of aircraft and crews that maximize the total expected profit. Traditionally, airlines deal with these four operational scheduling stages in a sequential manner. However, there exist obvious interdependencies among these stages so that restrictive solutions from preceding stages are likely to limit the scope of decisions for succeeding stages, thus leading to suboptimal results and even infeasibilities. To overcome this drawback, we first study the aircraft routing problem, and develop some novel modeling foundations based on which we construct and analyze an integrated model that incorporates fleet assignment, aircraft routing, and crew pairing within a single framework. Given a set of flights to be covered by a specific fleet type, the aircraft routing problem (ARP) determines a flight sequence for each individual aircraft in this fleet, while incorporating specific considerations of minimum turn-time and maintenance checks, as well as restrictions on the total accumulated flying time, the total number of takeoffs, and the total number of days between two consecutive maintenance operations. This stage is significant to airline companies as it directly assigns routes and maintenance breaks for each aircraft in service. Most approaches for solving this problem adopt set partitioning formulations that include exponentially many variables, thus requiring the design of specialized column generation or branch-and-price algorithms. In this dissertation, however, we present a novel compact polynomially sized representation for the ARP, which is then linearized and lifted using the Reformulation-Linearization Technique (RLT). The resulting formulation remains polynomial in size, and we show that it can be solved very efficiently by commercial software without complicated algorithmic implementations. Our numerical experiments using real data obtained from United Airlines demonstrate significant savings in computational effort; for example, for a daily network involving 344 flights, our approach required only about 10 CPU seconds for deriving an optimal solution. We next extend Model ARP to incorporate its preceding and succeeding decision stages, i.e., fleet assignment and crew pairing, within an integrated framework. We formulate a suitable representation for the integrated fleeting, routing, and crew pairing problem (FRC), which accommodates a set of fleet types in a compact manner similar to that used for constructing the aforementioned aircraft routing model, and we generate eligible crew pairings on-the-fly within a set partitioning framework. Furthermore, to better represent industrial practice, we incorporate itinerary-based passenger demands for different fare-classes. The large size of the resulting model obviates a direct solution using off-the-shelf software; hence, we design a solution approach based on Benders decomposition and column generation using several acceleration techniques along with a branch-and-price heuristic for effectively deriving a solution to this model. In order to demonstrate the efficacy of the proposed model and solution approach and to provide insights for the airline industry, we generated several test instances using historical data obtained from United Airlines. Computational results reveal that the massively-sized integrated model can be effectively solved in reasonable times ranging from several minutes to about ten hours, depending on the size and structure of the instance. Moreover, our benchmark results demonstrate an average of 2.73% improvement in total profit (which translates to about 43 million dollars per year) over a partially integrated approach that combines the fleeting and routing decisions, but solves the crew pairing problem sequentially. This improvement is observed to accrue due to the fact that the fully integrated model effectively explores alternative fleet assignment decisions that better utilize available resources and yield significantly lower crew costs. / Ph. D.

Business plan, franchise, Zverokruh, SLEPT, SWOT

Text in Afrikaans / The purpose of the study is to examine the extent and demands volunteers have in a managerial function. Volunteers are responsible for the management of the branches of the ACVV, functioning in a specific environment. The variables of these environments have a definite influence on the functioning of a branch and place specific demands on the members. The group of respondents consisted of chairpersons of branches of the ACVV in the West Coast region. The findings of the empirical studies are that all levels of the environment bring pressure to bear upon volunteers. The demands placed upon them have a bearing on the managerial tasks and have a negative effect on the willingness of volunteers to serve as board members. It is imperative that training and development of volunteers, in welfare organizations, must be ongoing in order to empower and give them confidence for these managerial tasks. / Social Work / M. Diac. (Social Work)