The purpose of this study was to evaluate a family camp's performance from a consumer (parent) perspective. An Importance-Performance Analysis was used. Responses averages were plotted on a grid of importance versus performance with the overall means used as cross-hairs to create an action grid of four quadrants: keep-up-the-good-work (high importance/high performance), concentrate-here (high importance/low performance), possible-overkill (low importance/high performance), and low-priority (low importance/low performance). Findings indicated that parents are in large part receiving good performance on the factors that are important to them. Findings identified factors that were important to parents including some factors that camp directors were not previously aware of. Three of the five highest importance factor scores were regarding accommodations (clean facility, restrooms provided, and showers provided). All five of the top performance factor scores were regarding programming details. Implications for family camp providers and recommendations for future research are discussed.

The global population of forcibly displaced people has increased during the last years, due to persecution, conflict, violence, or human rights violations. Since 1997 the number of forcibly displaced people increased from 33.9 million people to 65.6 million at the end of 2016, amongst which 22.5 million are refugees living in refugee camps around the world. These camps are usually hastily built shelters with the main objective to provide immediate protection and safety, therefore these camps rarely have power supply that can satisfy more than the basic, essential needs. However, the average length of time during which a refugee spends in exile is approximately 20 years and in order sustain shelters for such a long time, there is also a need to satisfy the long-term energy demands. The purpose of this thesis is to chart the energy-related problems in refugee camps and to evaluate potential energy supply solutions with respect to given indicators, with a setting in Central- and Eastern Africa. The given indicators are availability, scalability, adoptability, environmental impact and cost. The different energy solutions that are chosen for evaluation are fuel generators, solar power, biogas, wind power and fuel cell. A literature study is conducted with the limitation to mainly examine camps between the equator and southern Europe and where the assumption of every refugee camp having approximately the same problems is made. The literature study of different refugee camps revealed that most energy-related problems could be derived from insufficient energy supply, which results in problems with cooking and lack of lighting. The available energy resources in refugee camps are mainly firewood or charcoal, that emits hazardous gases during combustion. The collection of firewood as well as the lack of lighting also puts people, mainly women and children, at safety risks. Furthermore, the lack of decent lighting also reduces the amount of productive hours. To solve the problems, the evaluation of the chosen energy solutions could work as a foundation for projects on implementing energy systems in a refugee camp setting. The evaluation provides an overview of how the energy solutions works in relation to the given indicators and thus their ability to provide energy in an economic, social and environmental manner. Furthermore, the results from this thesis have been compiled into a project manual, with summarizing tables of each energy solution in regards to the indicators. Every refugee camp has their own needs and conditions that has to be met in order to provide sufficient energy solutions, which makes it difficult to fully assess the evaluated energy solutions. Therefore, there is a need for further work that would include a case study. By conducting a case study, the needs and conditions for the chosen refugee camp can be taken into consideration, thus resulting in a solution that could better meet the demand. In most cases, the energy related problems in refugee camps are not one solution issues but could rather be solved by combining different methods of energy access. The evaluated energy solutions could therefore be combined to meet the demands of refugee camps. / Antalet människor som är på flykt i världen har ökat under de senaste åren på grund av förföljelse, konflikt, våld eller kränkningar av mänskliga rättigheter. Sedan 1997 har antalet människor på flykt ökat från 33,9 miljoner till 65,6 miljoner i slutet av 2016, varav 22,5 miljoner är flyktingar som lever i flyktingläger runt om i världen. Flyktingläger är ofta konstruerade under nödsituationer, där det främsta syftet är att ge omedelbart skydd och säkerhet. Syftet med flyktinglägren är därmed att agera som ett tillfälligt skydd, vilket innebär att de sällan är utrustade med strömförsörjning som kan tillgodose mer än de mest grundläggande och nödvändiga behoven. Trots att lägren är konstruerade som tillfälliga lösningar, tillbringar en flykting i genomsnitt 20 år i exil. För att kunna hålla goda levnadsförhållanden under en sådan lång tid i ett flyktingläger, finns ett behov av att tillgodose lägren med långsiktiga, hållbara energilösningar. Syftet med kandidatexamensarbetet är att kartlägga energirelaterade problem i flyktingläger och att utvärdera potentiella lösningar för energiförsörjning med avseende på givna indikatorer, med fokus på Central- och Östafrika. De angivna indikatorerna är tillgänglighet, skalbarhet, acceptans, miljöpåverkan och kostnad. De olika energilösningarna som utvärderas är bränslegeneratorer, solkraft, biogas, vindkraft och bränsleceller. En litteraturstudie genomförs med den huvudsakliga begränsningen att granska läger mellan ekvatorn och södra Europa och där ett antagande om att varje flyktingläger står inför liknande problem görs. Kartläggningen av energirelaterade problem i flyktingläger visar att de flesta problem kan kopplas till en otillräcklig energiförsörjning, vilket i sin tur resulterar i problem med matlagning samt brist på belysningsmöjligheter. De tillgängliga energiresurserna är huvudsakligen ved eller kol, som vid förbränning avger hälsofarliga gaser. Insamling av ved samt brist på belysning utsätter även invånarna, främst kvinnor och barn, för säkerhetsrisker. Bristen på ordentlig belysning reducerar även antalet produktiva timmar för människorna i ett flyktingläger. För att kunna bidra med en lösning till problemen kan den utförda utvärderingen av de valda energilösningarna användas som en grund för andra projekt, som ämnar att implementera energisystem i flyktingläger. Utvärderingen ger en översikt av hur energilösningarna fungerar i förhållande till de givna indikatorerna och därmed deras förmåga att tillhandahålla energi på ett ekonomiskt, socialt och miljömässigt sätt. Resultaten från kandidatexamensarbetet har även sammanställts i en projektmanual, med en sammanställning för varje energilösning med avseende på indikatorerna. Varje flyktingläger har dock unika behov och förutsättningar som måste tillgodoses för att tillhandahålla tillfredställande energilösningar, vilket försvårar en fullständig bedömning av de utvärderade energilösningarna. Det finns därför ett behov av ytterligare undersökning innefattande en fallstudie som kan ta hänsyn till de behov och förutsättningar som kan finnas. Slutligen kräver de energirelaterade problemen i ett flyktingläger oftast en kombination av olika energilösningar, eftersom att en sådan bättre kan möta ett flyktinglägers energibehov.

This dissertation examines the antecedents to the outdoor education movement that proliferated in the first decades of the twentieth century, arguing that it stemmed from the Romanticism that emerged in the nineteenth century. Drawing on a Romantic approach to pedagogy, early outdoor educators looked to nineteenth-century literature and art as inspiration for their educational methods, curriculum and marketing. Rejecting the concepts of "rugged individualism," these outdoor educators expressed an ideal of "rugged communalism" where concepts of selflessness, community, and democracy became the lessons learned in the outdoors. The first chapter provides an overview of Puritan understanding of the wilderness and corresponding perspectives on childhood and education by drawing on the writings of John Winthrop, Cotton Mather, and Jonathan Edwards as well as John Bunyan's Pilgrim's Progress and the experience of King Philip's War. The Romantic revolution as expressed by Washington Irving, James Fenimore Cooper and others form the basis of the second chapter. Chapter three charts the transformation of American perspectives on wilderness through the visual arts and literature, specifically those writings of Ralph Waldo Emerson and Nathaniel Hawthorne combined with the work of Thomas Cole. This chapter also explores the White Mountain tourist industry as an expression of these ideals. The fourth chapter follows the changing conceptions of childhood throughout the nineteenth century with a focus on the image of the barefoot boy and street urchins. Chapter five discusses the development of a Transcendental pedagogy through the writings and educational experiments of Ralph Waldo Emerson, Bronson Alcott, Margaret Fuller, Henry David Thoreau, and Louisa May Alcott, including the impact of the Temple School and Brook Farm. The second half of the dissertation addresses specific applications of experiential outdoor pedagogy. This includes the Boston Farm School on Thompson Island, Charlesbank and the playground movement in Boston, the North Bennett Street Industrial School's outdoor programs, the relationship between the Grand Army of the Republic and the Boy Scouts of America, and the impact of Dudley Allen Sargent and Sargent Camp.

cAMP receptors contain highly conserved cAMP binding pockets, in part responsible for allosteric activation, yet CBDs exhibit a wide array of cAMP binding affinities. While several cAMP:CBD crystallographic structures have been solved, they are insufficient to explain differences in cAMP:CBD affinities. We hypothesize that it is the position of the apo autoinhibitory equilibrium and/or a change in the state-specific association constants of the active and inactive CBD forms that are primarily responsible for modulating ~1000-fold difference in cAMP affinities. Interestingly, we discovered that PKARIα and HCN2 have comparable state-specific association constants, suggesting that the position of the apo autoinhibitory equilibrium is primarily responsible for the large difference in observed cAMP affinities in these systems. In addition, the individual components of the cAMP binding pocket (i.e. BBR, PBC, and lid) show functional variability across different CBDs. In RIα, both the BBR and lid are dispensable for high affinity cAMP binding, leaving the PBC as the key determinant of cAMP affinity. Interestingly, in addition the PBC:cAMP contact side-chains, non-contact side-chains are also important in modulating cAMP affinity (ie. L201 and Y205). Further dissection of the contributions arising from the apo pre-equilibrium and the cAMP binding pockets is required to better understand cAMP affinity and selectivity. / Thesis / Master of Science (MSc)

Thesis advisor: Charles Hoffman / The second messenger cyclic 3’-5’ adenosine monophosphate (cAMP) signaling pathway plays an important physiological role in many organisms. Cyclic nucleotide phosphodiesterases (PDEs) regulate signal transduction by catalyzing the hydrolysis of cAMP and cGMP allowing for the downregulation of cyclic nucleotide levels. Human PDEs are encoded by 21 genes grouped into 11 families. The biological role of the most recently discovered PDE family (PDE11) remains poorly understood partly due to the lack of selective inhibitors. Mutations in the PDE11A gene have been linked to a wide range of diseases, such as Cushing Syndrome, which is a result of inactivating mutations expressed in adrenocortical tumors. Meanwhile, PDE11 levels are seen to increase in the ventral hippocampus as a function of aging, and is associated with a loss of social memory. Thus, the development of a selective PDE11 inhibitor could provide a potential therapeutic benefit to patients receiving long-term corticosteroid treatment by stimulating cortisol production by the adrenal gland, as well as to aging adults to maintain social memory. To address these needs, candidate PDE11 inhibitors related to a compound discovered by the Hoffman lab in a high throughput screen for PDE11 inhibitors are being synthesized by the Rotella laboratory. I have been evaluating these compounds using two fission yeast-based growth assays in complement with in vitro enzyme assays carried out by Dr. Jeremy Eberhard. Here I describe my role in the project, leading to the identification of a compound, SMQ2-57, which is a selective inhibitor of the PDE11 enzyme whose potency has been confirmed through both yeast-based assays and in vitro enzyme assays. In addition, I have taken both a forward and reverse genetic approach to identify PDE11A4 mutant alleles that confer resistance to inhibitor compounds as such knowledge could guide a rational drug design approach to produce more effective PDE11 inhibitors. Based on our results, SMQ2-57 could serve as a useful tool in understanding the biological role of PDE11. Meanwhile, data from my study of compound resistant mutant PDE11 alleles should allow for the characterization of the physical interaction between PDE11 and its inhibitors in an effort to guide a medicinal chemistry program to develop a more potent and drug-like PDE11 inhibitor. / Thesis (BS) — Boston College, 2023. / Submitted to: Boston College. College of Arts and Sciences. / Discipline: Scholar of the College. / Discipline: Biology.

Surface heterogeneities cause differential heating that can generate mesoscale convective boundaries, sometimes leading to cloud development and enhanced localized precipitation. A preferred cloud pattern has been identified across Maryland and the Delmarva Peninsula region from 1998-2006 through the detection of cumuliform clouds on days when synoptic-scale forcing is weak. Hourly visible Geostationary Operational Environmental Satellite (GOES) imagery data are used to identify convective cloud masses. This allows quantitative description of the frequency and spatiotemporal extent of the clouds, helping forecasters gain insight into when and where they are likely to develop. Despite the inability to determine the underlying causes of the distinct cloud pattern, primarily due to the complex land cover, results indicate that the land receives significantly higher average total cloud cover than the Chesapeake Bay with Delaware receiving the highest average total cloud cover per state. Average total precipitation amounts follow this same trend on synoptically-weak days.

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