The aim of this thesis is the exterior design of an urban electric vehicle and the implementation of technologies into the proposed design, which is promising for future applications in the automotive industry. The analytical part of this work is concerned with the history of electric vehicles, the available contemporary technologies and further analyses the visual properties of electric vehicles. The design of the electric vehicle is presented in the practical part. The shape and the composition of the vehicle is described in detail, and further the applied technologies, ergonomics and design elements of the electric car are presented.

I chose car design, because I like to discover modern car accidence. I find developmnet in this part of design fascinating. I’d probably have most freedom while designing a sport car, but since its very popular theme among students, I went with car for traveling. At first I wanted to create a futuristic concept. So I mostly did just idea sketching, while focusing on dynamic shape. Later I started to add more functional aspects to the design. I wanted to create automobile, that would bypass private cars and minibuses. I tryed to make my car flexible for traveling even longer distances, also sideseeing and city transport, therefor big part of exteriour is covered by windows, which leads to weaker cabine. Thats why I made firmer side posts to support the roof. While designing I was influenced by recent concepts and latest technologies, that were presented by leading automobile companies, such as electric glas and glas shaping. I believe one of the most interesting parts on my car is the headlights, that are situated under the front window surface. The headlights and also partialy the engine is visible from above through the frontal glass hood.

This Diploma thesis deals with the design of amphibious residential car. The product is first parsed from design, marketing and technical ways. Then on the basis of analysis is designed new design that meets the ergonomic, technical, aesthetic and psychological aspects.

The sharing economy is an evolving economic model that is based on collaboration and sharing access to goods with other people. A leading example of this are car-sharing services, which allow people who are strangers to each other to access a car in return of a fee. Although these services are widely spreading across the globe, there is still a short understanding of the customer motives and barriers to engage in these services. The purpose of this thesis was to explore the factors that affect customer participation in carsharing services including motives and barriers. The study was designed to test and modify an adapted conceptual framework through conducting an abductive qualitative study in the form of semi-structured in-depth interviews with a total of 18 interviewees. The empirical findings of the study suggest that there is a total of 14 relevant factors affecting consumer participation in sharing services: 3 factors were related to consumption trends, 7 factors were identified as motives and 4 as barriers. Among all of these factors, economic motivations were recognized to be the most critical factor for customers. The results of this study are highly relevant to companies which operate car-sharing services when considering customer needs and demands.

El presente trabajo corresponde al curso de Desarrollo de Negocios 2, a lo largo del desarrollo aplicaremos conceptos y herramientas aprendidas a lo largo de la carrera de la Universidad Peruana de Ciencias Aplicadas. Actualmente el Perú presenta un crecimiento paulatino en el parque automotor, con mayor concentración en Lima Metropolitana y Callao. Muestra de ello se puede apreciar a simple vista en la cotidianidad, siendo específicos el tráfico. Service Car Express, plantea la idea de negocios que apunta al sector automotriz, al cuidado de los vehículos y asesoramiento vehicular. Nuestra idea está dirigida al NSE B y C y a personas o empresas que cuenten con vehículos considerados de segunda mano o a aquellos que estén planeando adquirir un vehículo dentro de distritos como Miraflores, Surco, Chorrillos, Barranco, San Miguel, Surquillo y Jesús María. Service Car Express, llega con una propuesta de valor diferente a la que está acostumbrado el cliente, servicios netamente a domicilio buscando reducir el tiempo perdido de nuestros clientes y volviendo esa parte de sus vidas tan tediosa de ir al taller en algo simplemente práctico e innovador, disponible en el momento. Con la finalidad de cumplir esta propuesta de valor, ScarX ha creado un modelo de negocios que a través de la tecnología por aplicativos busca optimizar los tiempos de servicios que pueda brindar a sus clientes, de este modo buscara alcanzar la máxima calidad y perfeccionar sus procesos operacionales identificando y aprovechando todos sus recursos disponibles. / The present work corresponds to the course of Business Development 2, throughout the development we will apply concepts and tools learned throughout the career of the UPC University. Currently, Peru presents a gradual growth in the automotive fleet, with a greater concentration in Lima Metropolitana and Callao. Sample of this can be seen in everyday life, when see traffic everywhere. Service Car Xpress, raises the business idea that points to the automotive sector, car care and vehicle advice. Our idea is directed to B and C socioeconomic status and to people or companies that have vehicles considered second-hand or to those who are planning to acquire a vehicle within districts such as Miraflores, Surco, Chorrillos, Barranco, San Miguel, Surquillo and Jesús María. Service Car Xpress, arrives with a different value proposition, services purely at home trying to reduce the lost time of our customers while they are in workshops, we are going to make it be something simply practical and innovative, available at the time. In order to fulfill this value proposition, ScarX has created a business model that, through technology is going to optimize the time a car service can take. We offer our clients the highest quality in all processes taking advantage of all available resources. / Trabajo de investigación

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Chimeric antigen receptors (CAR) are modular genetically modified receptors that consist of an extracellular antigen binding domain fused to intracellular T-cell signaling domains. CAR therapy broadly consists of engineering a patient’s own T-cells to express a CAR directed against a tumor cell surface antigen. This therapy has been extremely successful in treating B-cell neoplasms by targeting CD19 and is paradigm changing in developing personalized immunotherapy for oncology applications. Although impressive response rates are observed, the durability of therapeutic response remains a concern and relapse mechanisms frequently center around issues of antigen loss. In addition, heterogeneous disease and solid tumors present formidable barriers toward extending the applicability of CAR technology as a result of compounding issues of tumor microenvironment and cell trafficking. In this thesis we review the current thought on the state of CAR therapy and the challenges to therapeutic efficacy, therapeutic manufacture, and clinical safety in the context of each other with an overall emphasis on identifying the fundamental goal of making fit-for-purpose CARs for different diseases.

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