京都大学 / 新制・課程博士 / 博士(医学) / 甲第24286号 / 医博第4902号 / 新制||医||1061(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 森本 尚樹, 教授 辻川 明孝, 教授 渡邉 大 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

For several hundred years there has been a great deal of emphasis on how industries and businesses may encourage excellent production work that does not harm the environment or the working individual. NKT is a world leader company in cable technology and designs, manufactures, and installs voltage cables. The company includes a department where splicing is performed on cables to extend or repair them. To complete the splicing process, however, the inner most structures of the cable must first be cleaned from a substance called compound. Today, this cleaning process is carried out manually by the workers. Despite the efficient operation of NKT's splice department, various risks have been identified that might have a negative impact on both the worker and the environment. On one hand, there is a risk that the cleaning agent containing a certain amount of unhealthy chemicals will encounter the worker and cause health risks, and on the other hand, chemical leakage may occur on the work surface, resulting in a contaminated work area, and unnecessary material waste. This material waste also adds to less cost-effective operations, since bigger amounts will be required to accomplish the intended work, this in relation to the fact that the process requires a considerable time. Thus, the aim of this degree project is to investigate if streamlining the procedure of cleaning the compound from the conductors in high voltage cables before splicing is possible by developing a mechanical device or replacing the current used solvent or both. The methods used for this project were a combination of the design thinking strategy and participatory action research and to deeply understand the methods, a literature review was also performed. The results obtained were a well-detailed virtual simulation in SolidWorks, a functional alpha prototype, and results from a conductivity measurement for PF-Solvent and Strovels Smådelstvätt 100. Although the first laboratory tests showed equivalent effects for PF-Solvent and Strovels Smådelstvätt 100 regarding the solubility of the compound, PF-Solvent's good conductivity properties wereconfirmed while Strovels Smådelstvätt 100 proved not to be suitable for this cleaning procedure due to the big difference in the values. The results obtained from the sustainability template provided the project with useful guidelines for refining the concept into a long-term solution. Many of the components of the physical product will be built from stainless steel, which will make it simpler to recycle at the end of its useful lifespan. In conclusion, it requires a development of a device that cleans the conductor from the compound. The device / machine can keep the solvent in a special place and at the same time, the worker has more control over how much solvent is used. According to the laboratory tests, the solvent Strovels Smådelstvätt 100 had an equivalent effect on the compound during the same time interval as PF-Solvent. It was also milder from the environmental and health aspects. Furthermore, the development of a mechanical device can contribute to reduced waste of various materials, such as brushes, gloves, and spray bottles, during the procedure. Finally, investing in such a machine can be expensive, but in the long run this investment leads to savings in materials used today. However, a machine procedure involves a large transition that requires a lot of time, resources and planning as it shall be developed through collaborations with different industries.

Part A of two Project Reports; Part B can be found at http://hdl.handle.net/11375/17660 / <p> The recent development of a technique for the synthesis of the molecule 5-(¹⁸F) fluoro-dopa has opened a vast field of research into the study of the intracerebral metabolism. In order to take full advantage of this new tracer compound it will be necessary to use an imaging system which will be capable of providing three dimensional information concerning the rapid changes in activity as the ¹⁸F travels through the brain. This report describes the results os investigations into a possible design for a device which would be capable of this type of dynamic imaging. The design in question employs multiwire proportional chambers (MWPC) as detectors of the .511 MeV gamma rays which result from the annihilation of the positron emitted in the decay of ¹⁸F. </p> <p> For comparison purposes, a breif review of various other types of positron tomographic systems which are presently in use or under development is presented. This review emphasises the resolution, data aquisition speed, and instalation cost for each of these designs. </p> <p> In order to eliminate the need for costly research into the various design aspects of multiwire proportional chambers for use with positron annihilation radiation, the design presented here relies exclusively on methods and designs developed and proven feasible by other groups. These are incorporated into a system to suit the present needs. </p> <p> The design presented uses two pairs of 50x50 cm² MWPC's at 180° to each other and separated by approximately 50 cm. The chambers utilize electromagnetic delay-line readout techniques for the anode and wound bi-filar cathode planes. They are filled with a "magic gas" mixture at a slightly positive pressure. The effeciency of the chambers for .511 MeV photons is increased by employing "sandwich" type converters. Signals from the detectors are transfered to a small computer where they are stored for later tomographic reconstruction off-line. </p> <p> On the basis of the working designs from which the present design has been drawn, one would expect the positron camera to have a sensitivity of better than 1000 counts/second-microcurie. The total costs of development and construction leading up to a working device suitable for clinical use, not including the cost of a dedicated computer, are estimated to be less than seventy five thousand dollars. </p> / Thesis / Master of Engineering (ME)

The effect of coatings on the interfacial strength of a hollow glass microsphere/polyester composite and their capacity to endure thermal stresses were studied by mechanical testing and an active Acoustic Emission (AE) method. AE was postulated to provide more local information at or near the glass/polyester interface due to the sensitivity of elastic waves to the rigidity of polymer chains at the glass sphere/polyester interface compared to mechanical testing. Three frequency ranges identified by multivariate statistics yet consolidated for the initial analysis into a band of 140-240 kHz, were found to be changing with the different coated glass filler for different glass content and heating state. Considering the acoustic behavior of the composites containing different levels of glass sphere content (1-10 vol%), a lower concentration (aminoethylamino)-propyl-trimethoxy silane coated glass (AS6), demonstrated the lowest attenuation after heating (associated with higher interfacial strength). As anticipated, the highest attenuation after heating was observed for uncoated glass (16K) due to expectedly weaker associations. Mechanical testing results after heating were consistent with the AE response for AS6 and 16K for this frequency range. Trends in amplitude for the three narrower, frequency ranges of 130-160 kHz, 180-220 kHz and 230-260 kHz were compared against that of 140-240 kHz and very small differences were observed. It was found that the frequency range of 130-60 kHz was more descriptive of the changes of interfacial strength in composites (at 10 vol%), being consistent with the mechanical test results. Considering the AE response at 130-160 kHz and mechanical data, higher concentration (aminoethylamino)-propyl-trimethoxy silane (AS12), better endured thermal stresses compared to other coatings. A smaller trial looked at the effect of moisture aging and subsequent thermal cycling on the glass/polymer interface strength as another method to perturb the interface. Attenuation for the band of 180-260 kHz was studied for aged versus non-aged composites. The commercial coating, L21 demonstrated a better moisture resistance before and after thermal cycling compared to uncoated glass spheres. An improved evaluation of interfacial strength in glass/polyester was expected using AE technique versus mechanical testing due to its higher sensitivity to changes in internal structure, however; no significant improvement compared to mechanical testing was observed, at least based on the analysis technique currently being used. / Thesis / Master of Applied Science (MASc) / Sheet molded compound (SMC) is a polymer material reinforced by fibers providing a combination of light weight and high mechanical properties and is used in automotive industry. Light weight fillers (hollow glass microspheres) are used to obtain further weight reduction; however, addition of these fillers leads to reduced mechanical properties and further problems during painting process known as ‘paint popping’. The former is due to uncertain interfacial state between polymer and fillers and the latter results from different thermal expansion behavior of the polymer and filler materials while the material is exposed to high temperatures for painting process. This research aims to devise a highly sensitive technique and evaluate its suitability compared to mechanical testing for investigation of the origin of aforementioned problems. Acoustic Emission (AE) is a method with high sensitivity to changes in internal structure of the material which is postulated to provide a better insight on material microstructure compared to more commonly used method i.e. mechanical testing. Use of interfacial controlling agents was examined to reduce the problems as a result of introduction of fillers. The effect of using surface modified fillers and the effect of thermal stresses on material was investigated using AE technique. Application of AE method in this study provided a good insight about the changes in material internal structure; however, it did not demonstrate a significant improvement in detecting the origins of studied problems compared to mechanical testing at least based on the analysis technique used in this study.

There has been little research exploring whether different memory processes (i.e. related to short term memory (STM), working memory (WM) and long term memory (LTM) may be differentially sensitive to representation and processing aspects of compound words. This study investigated how compound words are represented in STM in immediate serial recall tasks and in WM in complex span tasks that combine processing and storage demands. The simple span STM task was comprised of solely a list of memory words, whereas the two complex span WM tasks interleaved sentence processing between presentation of memory words. They varied in the presence of a pause after presentation of each memory word and before onset of the following distractor sentence for processing. The absence of a pause was intended to minimize opportunity for subvocal rehearsal, whereas the presence of a pause encouraged rehearsal. To increase chances of recombination errors for error analyses, lists of memoranda were manipulated so that each set (list) of four compound words contained one “lure” pair (e.g. pinstripe + warhead = pinhead) in which the modifier and head constituents from separate compound words could recombine to form a new, legal word. Recall performance was better in the simple span and complex span pause tasks compared to the complex span no pause task. Whole compound and left constituent frequencies played opposite roles, helping and harming, respectively. Error types reflecting decomposition of the compound words to their constituents were more common in simple span than in complex span. Omissions were more common in complex span. We discuss how different memory processes may be differentially sensitive to representation and processing aspects, and how recall of compound words is affected by various lexical variables. / Thesis / Master of Science (MSc)

京都大学 / 新制・論文博士 / 博士(医学) / 乙第13579号 / 論医博第2301号 / 新制||医||1069(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 古川 壽亮, 教授 大鶴 繁, 教授 平井 豊博 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

This study examines German noun compounds and their translations into Swedish. The aim of the study is to investigate to what extent the nominal compounds of the source text are translated with the same structure in the target text, and what consequences possible paraphrases could have for the target text. The first part of the analysis focuses on how the first constituent of the nominal compound and the complexity of the nominal compound affect the translation strategies. The second part examines ad-hoc compounds and how they are translated from German into Swedish. The material for the study comes from the article “Gesichter der Großstadt“ that appeared in the history magazine Geo Epoche 2021. The analysis was carried out on both a quantitative and a qualitative level.           The quantitative result shows that about 62 % of the source text noun compounds were translated with the same structure in the target language. However, in over a third of the cases, the noun compounds were translated with other structures. The translation strategy “nominal phrase with different attributes” was the second most used translation strategy with about 17 %, and the translation strategy “reduction” was the third most used strategy with about 15 %. However, these strategies were used much more frequently in the translation of complex nominal compounds and ad hoc compounds. This suggests that factors such as complexity and occurrence of a nominal compound affect the translation strategy.

Leptin and its receptor are essential for regulating food intake, energy expenditure, glucose homeostasis and fertility. Mutations within leptin or the leptin receptor cause early-onset obesity and hyperphagia, as described in human and animal models. The effect of both heterozygous and homozygous variants is much more investigated than compound heterozygous ones. Recently, we discovered a spontaneous compound heterozygous mutation within the leptin receptor, resulting in a considerably more obese phenotype than described for the homozygous leptin receptor deficient mice. Accordingly, we focus on compound heterozygous mutations of the leptin receptor and their effects on health, as well as possible therapy options in human and animal models in this review.

The aggressive reduction of feature size in silicon (Si)-based complimentary metal-oxide-semiconductor (CMOS) technology has resulted in an exponential increase in computing power. Stemming from increases in device density and substantial progress in materials science and transistor design, the integrated circuit has seen continual performance improvements and simultaneous reductions in operating power (VDD). Nevertheless, existing Si-based metal-oxide-semiconductor field-effect transistors (MOSFETs) are rapidly approaching the physical limits of their scaling potential. New material innovations, such as binary group IV or ternary III-V compound semiconductors, and novel device architectures, such as the tunnel field-effect transistor (TFET), are projected to continue transistor miniaturization beyond the Si CMOS era. Unlike conventional MOSFET technology, TFETs operate on the band-to-band tunneling injection of carriers from source to channel, thereby resulting in steep switching characteristics. Furthermore, narrow bandgap semiconductors, such as germanium (Ge) and InxGa1-xAs, enhance the ON-state current and improve the switching behavior of TFET devices, thus making these materials attractive candidates for further study. Moreover, epitaxial growth of Ge on InxGa1-xAs results in tensile stress (ε) within the Ge thin-film, thereby giving device engineers the ability to tune its material properties (e.g., mobility, bandgap) via strain engineering and in so doing enhance device performance. For these reasons, this research systematically investigates the material, optical, electronic transport, and heterointerfacial properties of ε-Ge/InxGa1-xAs heterostructures grown on GaAs and Si substrates. Additionally, the influence of strain on MOS interfaces with Ge is examined, with specific application toward low-defect density ε-Ge MOS device design. Finally, vertical ε-Ge/InxGa1-xAs tunneling junctions are fabricated and characterized for the first time, demonstrating their viability for the continued development of next-generation low-power nanoelectronic devices utilizing the Ge/InxGa1-xAs material system. / Doctor of Philosophy / The aggressive scaling of transistor size in silicon-based complimentary metal-oxide-semiconductor technology has resulted in an exponential increase in integrated circuit (IC) computing power. Simultaneously, advances in materials science, transistor design, IC architecture, and microelectronics fabrication technologies have resulted in reduced IC operating power requirements. As a consequence, state-of-the-art microelectronic devices have computational capabilities exceeding those of the earliest super computers at a fraction of the demand in energy. Moreover, the low-cost, high-volume manufacturing of these microelectronic devices has resulted in their nigh-ubiquitous proliferation throughout all aspects of modern life. From social engagement to supply chain logistics, a vast web of interconnected microelectronic devices (i.e., the "Internet of Things") forms the information technology bedrock upon which 21st century society has been built. Hence, as progress in microelectronics and related fields continues to evolve, so too does their impact on an increasingly dependent world. Moore's Law, or the doubling of IC transistor density every two years, is the colloquialism used to describe the rapid advancement of the microelectronics industry over the past five decades. As mentioned earlier, parallel improvements in semiconductor technologies have spearheaded great technological change. Nevertheless, Moore's Law is rapidly approaching the physical limits of transistor scaling. Consequently, in order to continue improving IC (and therefore microelectronic device) performance, new innovations in materials and fabrication science, and transistor and IC designs are required. To that end, this research systematically investigates the material, optical, and electrical properties of novel semiconductor material systems combining elemental (e.g., Germanium) and compound (e.g., Gallium Arsenide) semiconductors. Additionally, alternative transistor design concepts are explored that leverage the unique properties of the aforementioned materials, with specific application to low-power microelectronics. Therefore, through a holistic approach towards semiconductor materials, devices, and circuit co-design, this work demonstrates, for the first time, novel transistor architectures suitable for the continued development of next-generation low-power, high-performance microelectronic devices.

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