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Synthesis of transition metal phosphate compounds as functional materialsStephanos, Karafiludis 30 May 2024 (has links)
In den letzten Jahrzehnten ist die Rückgewinnung wichtiger Elemente aus Abfallströmen wie Abwässern, Schlämmen und Abraum. Übermäßiger Bergbau, industrielle Prozesse und Überdüngung in der Landwirtschaft setzen Schadstoffe wie Phosphat, Ammonium und Übergangsmetalle in die Umwelt frei und bringen Ökosysteme aus dem Gleichgewicht. In dieser Dissertation wird die Kristallisation von Übergangsmetallphosphatverbindungen (TMPs) aus wässrigen Lösungen untersucht, darunter M-Struvit, M-Dittmarit und M-Phosphat-Octahydrat (NH4MPO4∙6H2O, NH4MPO4∙H2O, M3(PO4)2∙8H2O mit M = Ni, Co, NixCo1-x). Diese kristallinen Phasen ermöglichen die gemeinsame Ausfällung von PO43-, NH4+ und Übergangsmetallen und bieten einen vielversprechenden Weg zur Rückgewinnung von Phosphat und Übergangsmetallen aus industriellen und landwirtschaftlichen Abwässern. TMPs besitzen vielseitige Eigenschaften wie thermische und mechanische Stabilität, einfache Veränderlichkeit und Multifunktionalität, wodurch sie sich für fortschrittliche Energieumwandlungs- und -speicheranwendungen eignen. Deshalb stellt die Synthese von TMPs eine kombinierte Rückgewinnungs- und Upcycling-Methode für fortschrittliche Funktionsmaterialien dar. Detaillierte Untersuchungen des Bildungsprozesses aus wässriger Lösung wurden mit zeitaufgelösten ex- und in-situ-Elektronenbildern, spektroskopischen, spektrometrischen und beugungsbasierten Methoden durchgeführt. Die in dieser Dissertation enthaltenen Ergebnisse geben neue Einblicke in den nicht klassischen Kristallisationsmechanismus von TMPs, der eine kontrollierte Einstellung der Kristallitgröße und -morphologie ermöglicht. Darüber hinaus führt die thermische Behandlung von TMPs zu thermisch stabilen, mesoporösen und/oder protonenleitenden Materialien für elektrochemische Anwendungen. Die Ergebnisse tragen zum grundlegenden Verständnis von Keimbildung und Kristallisationsphänomenen bei und helfen bei der Entwicklung moderner Funktionsmaterialien für elektrochemische Anwendungen. / A critical issue in the 21st century is the recovery of essential elements from waste streams like wastewaters, sludges, and tailings. Excessive mining, industrial processes, and overfertilization in agriculture release pollutants such as phosphate, ammonium, and transition metals into the environment, unbalancing ecosystems. This dissertation investigates the crystallization of transition metal phosphate (TMPs) compounds from aqueous solutions, including M-struvite, M-dittmarite, and M-phosphate octahydrate (NH4MPO4∙6H2O, NH4MPO4∙H2O, M3(PO4)2∙8H2O with M = Ni, Co, NixCo1-x). These crystalline phases allow for the co-precipitation of PO43-, NH4+, and transition metals, providing a promising route for phosphate and transition metal recovery from industrial and agricultural wastewaters. TMPs possess favorable properties like thermal and mechanical stability, tunability, and multifunctionality, making them suitable for advanced energy conversion and storage applications. Accordingly, the synthesis of TMPs represents a combined recovery and upcycling method towards advanced functional materials. Detailed investigations of the formation process from aqueous solution were carried out using time-resolved ex- and in-situ, electron imaging, spectroscopic, spectrometric, and diffraction-based techniques. The results contained in this dissertation reveal new insights into the non-classical crystallization mechanism of TMPs, allowing for controlled adjustment of crystallite size and morphology. Moreover, thermal treatment of TMPs compounds yields thermally stable, mesoporous, and/or proton-conductive materials for electrochemical applications. The findings, on the one hand, can contribute to the fundamental understanding of nucleation and crystallization phenomena in aqueous solutions in general and specifically for metal phosphates. On the other hand, my findings aid applied materials chemistry in the development of advanced functional materials for electrochemical uses.
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Crystal structure prediction : a molecular modellling study of the solid state behaviour of small organic compoundsAsmadi, Aldi January 2010 (has links)
The knowledge of the packing behaviour of small organic compounds in crystal lattices is of great importance for industries dealing with solid state materials. The properties of materials depend on how the molecules arrange themselves in a crystalline environment. Crystal structure prediction provides a theoretical approach through the application of computational strategies to seek possible crystal packing arrangements (or polymorphs) a compound may adopt. Based on the chemical diagrams, this thesis investigates polymorphism of several small organic compounds. Plausible crystal packings of those compounds are generated, and their lattice energies are minimised using molecular mechanics and/or quantum mechanics methods. Most of the work presented here is conducted using two software packages commercially available in this field, Polymorph Predictor of Materials Studio 4.0 and GRACE 1.0. In general, the computational techniques implemented in GRACE are very good at reproducing the geometries of the crystal structures corresponding to the experimental observations of the compounds, in addition to describing their solid state energetics correctly. Complementing the CSP results obtained using GRACE with isostructurality offers a route by which new potential polymorphs of the targeted compounds might be crystallised using the existing experimental data. Based on all calculations in this thesis, four new potential polymorphs for four different compounds, which have not yet been determined experimentally, are predicted to exist and may be obtained under the right crystallisation conditions. One polymorph is expected to crystallise under pressure. The remaining three polymorphs might be obtained by using a seeding technique or the utilisation of suitable tailor made additives.
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Melhoramento da estabilidade física do pró-fármaco 5-Fluorocitosina via cocristalização / Improving the physical stability of the prodrug 5-Fluorocytosine via cocrystal formationSouza, Matheus da Silva 19 December 2018 (has links)
O pró-fármaco antimetabólito 5-Fluorocitosina (5-FC) foi investigado no campo da Engenharia de Cristais (EC) segundo a abordagem de cocristais farmacêuticos, a fim de modular sua baixa estabilidade física em ambientes úmidos, o que leva à incorporação irreversível de uma molécula de água a nível estrutural em condições de armazenamento variáveis. A forma anidra da 5-FC é um análogo fluorado da citosina muito bem conhecido por sua atividade antifúngica e com isto tornou-se um dos insumos farmacêuticos ativos (IFAs) mais utilizados para o tratamento anticâncer direcionado por meio de terapia gênica. Neste estudo, novos cocristais de 5-FC foram obtidos a partir da reação supramolecular deste IFA com o IFA tuberculostático Isoniazida (INH), bem como com outros três coformadores listados como não tóxicos: cafeína (CAF), ácido p-aminobenzóico (PABA) e ácido caprílico (CA). As amostras foram caracterizadas por difração de raios X em monocristal e policristal (DRXM e DRXP), espectroscopia na região do infravermelho (IV) e espalhamento Raman (Raman); assim como pelas técnicas de análise termogravimétrica (TG), calorimetria exploratória diferencial (CED) e microscopia termo-óptica (MTO). A estabilidade física da 5-FC e seus respectivos cocristais foi avaliada em ambiente com aproximadamente 100% de umidade relativa e a solubilidade no equilíbrio medida em meio tamponado a pH 1,2 – mimetizando valores próximos ao do suco gástrico. Os estudos estruturais mostraram que a 5-FC é capaz de formar diferentes homo e heterossíntons que levam à formação de formas multicomponentes estáveis. Dados de IV e Raman forneceram evidências espectroscópicas sobre o envolvimento dos grupos funcionais na manutenção dos principais síntons e, por tanto, do empacotamento cristalino, confirmando assim a natureza neutra necessária para a obtenção de um cocristal. Pelas análises térmicas foi possível observar que todas as amostras apresentaram uma maior preferência pela degradação do que pela mudança da fase sólida para a líquida com o fornecimento de calor, corroborando que as ligações intermoleculares de hidrogênio que mantém estas formas sólidas são fortes. Adicionalmente, constatou-se que os perfis de solubilidade dos quatro cocristais são similares ao IFA de partida, um fármaco classificado como de classe I pelo Sistema Biofarmacêutico, exibindo, assim, alta solubilidade. A instabilidade frente à hidratação bem como sua irreversibilidade foram estudadas por DRXP à temperatura ambiente (25 °C) e por DRXP em função da temperatura (até 150 °C), respectivamente. Nos cocristais, por sua vez, nenhuma transição de fase pode ser assinalada. Deste modo, todos os cocristais de 5-FC aqui reportados mantiveram uma solubilidade aceitável e não hidrataram ou sofreram transição de fase sob condições extremas de armazenamento (estudo de estabilidade acelerada em atmosfera úmida) e muito menos ao final de 12 meses de estoque (estudo de estabilidade a longo prazo), sendo mais estáveis que o IFA 5-FC forma comercializada. Além disso, o cocristal fármaco-fármaco intitulado 5FC-INH é um potencial candidato para o tratamento concomitante de infecções fúngicas, tuberculose e câncer; principalmente de pulmão. / The prodrug antimetabolite 5-Fluorocytosine (5-FC) was investigated in the field of Crystal Engineering (CE) according to the Pharmaceutical Cocrystals approach, in order to modulate its poor physical stability in humid environments, which leads to the irreversible incorporation of a water molecule at structural level under variable storage conditions. 5-FC anhydrous form is a well-known fluorinated analog of cytosine with antifungal activity and it has become one of the most used active pharmaceutical ingredients (IFAs) for anticancer treatment directed through gene therapy. In this study, novel 5-FC cocrystals were obtained from the reaction of 5-FC with the tuberculostatic IFA Isoniazid (INH) as well as with other three coformers listed as nontoxic: caffeine (CAF), p-aminobenzoic acid (PABA) and caprylic acid (CA). The samples were characterized by single-crystal and powder X-ray diffraction (SCXRD and PXRD), spectroscopic (IR and Raman) and thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and Hot-Stage microscopy (HSM) techniques. The physical stability of 5-FC and its cocrystals were evaluated in environment with high relative humidity (approximately 100 %) and the equilibrium solubility was measured in pH 1.2 buffer media – mimicking values close to that of gastric juice. The structural studies show that the prodrug 5-FC is able to form different homo and heterosynthons that lead to the formation of stable multicomponent forms. IR and Raman data provided spectroscopic evidence on the involvement of functional groups in the maintenance of major synthons and crystal packing assembly, thereby confirming the neutral nature required to obtain a cocrystal. From the thermal analyses it was possible to observe that all the samples presented a preference for degradation instead of phase transition form solid to liquid with the heat supply, corroborating the strength of intermolecular hydrogen bonds that maintain these solid forms. Additionally, the solubility profiles were found to be similar to those of the 5-FC API raw material, a Biopharmaceutical System classified as Class I drug, exhibiting high solubility profile. The instability against hydration and its irreversibility was studied by PXRD at room temperature (25 °C) and by PXRD as a function of temperature (up to 150 °C), respectively. In the cocrystals, in turn, no phase transition was found. Thus, all 5-FC cocrystals reported maintained acceptable solubility and did not hydrate or undergo phase transition under extreme storage conditions (accelerated stability study in moist atmosphere) even at the end of 12 months of storage (long-term stability study), being more stable than the commercially available IFA 5-FC. Furthermore, the drug-drug cocrystal (5FC-INH) is a potential candidate for the treatment of concomitantly fungal infections, tuberculosis and cancer, mainly lung cancer.
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Novas formas cristalinas do fármaco anti-HIV lamivudina com ácidos 1,2-dicarboxílicos: preparação, caracterização e solubilidade / New crystal forms of the anti-HIV drug lamivudine with 1,2-dicarboxilic acids: preparation, characterization and solubilitySilva, Cameron Capeletti da 06 March 2014 (has links)
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Previous issue date: 2014-03-06 / Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG / Co-crystallization of active pharmaceutical ingredients has been widely studied lately in order to improve the solid state features of such compounds, for example solubility, and also to protect the intellectual property of such compounds. Multicomponent molecular crystals can be prepared from both supramolecular synthon and screening approaches, which involve the variation of crystallization conditions. In this way, molecular crystal engineering is a strategy to improve solid state properties of drugs related to their efficacies. One branch of the lamivudine crystal engineering deals with its protonable pyrimidine-based nitrogen being a recipe of crystallization with carboxylic acids. Such strategy has yielded several pharmaceutical co-crystals and salts of APIs that have lamivudine-like heterocyclic nitrogens by choosing suitable carboxylic acids as a salt/co-crystal former. In this context and in relation to the drug antiretroviral nucleoside reverse transcriptase inhibitor lamivudine, four new crystalline phases thereof were prepared, their crystal structures were determined by X-ray diffraction by single crystal, and their solubility in water were measured. For the first time it was observed an in-plane pairing of lamivudine with the carboxylate and carboxyl functionalities of a same salt former unit giving rise to a trimer and a tetramer in the structures of lamivudine hydrogen phthalate hemihydrate and lamivudine hydrogen 4,5-dichlorophthalate, respectively. Besides, a new synthon have been found in the first salt. All lamivudine salts were less soluble than the lamivudine form II (free base). The unexpected heterosynthon can be related to the slightly higher solubility of lamivudine hydrogen 4,5-dichlorophthalate when compared to the other salts prepared in this study. / Co-cristalização de insumos farmacêuticos ativos tem sido largamente estudada ultimamente a fim de melhorar as propriedades do estado sólido, como, por exemplo, a solubilidade, e também manter a propriedade intelectual de tais compostos. Cristais moleculares multicomponentes podem ser preparados a partir da abordagem de sínton supramolecular e também através de métodos sistemáticos de investigação laboratorial, o que envolve a variação de condições de cristalização dos fármacos. Neste sentido, a engenharia de cristais moleculares é uma estratégia para aperfeiçoar as propriedades de estado sólido relacionadas às eficácias dos fármacos. Um ramo da engenharia de cristais de lamivudina lida com sua base nitrogenada pirimidina, a qual pode ser protonada, sendo assim um alvo de co-cristalização com ácidos carboxílicos. Tal estratégia tem rendido vários co-cristais e sais de insumos farmacêuticos ativos que possuem nitrogênio heterocíclico como a lamivudina pela escolha adequada de ácidos carboxílicos como um formador de sal/co-cristal. Nesse contexto, e com relação ao fármaco antirretroviral inibidor nucleosídeo de transcriptase reversa, a saber, lamivudina, quatro novas fases cristalinas foram preparadas, suas estruturas cristalinas foram elucidadas por difração de raios X por monocristal, e suas solubilidades em água foram aferidas. Nesse estudo, pela primeira vez foi observado um duplo pareamento da droga com ambas as funcionalidades ácidas do contra-íon originando uma tríade e um tetrâmero planar nas estruturas de biftalato de lamivudina hemidratado e 4,5-diclorohidrogenoftalado de lamivudina, respectivamente. Além disso, um novo sínton foi encontrado no primeiro sal. Todos eles foram menos solúvel do que a forma II da lamivudina (base livre). O inesperado heterosínton pôde ser correlacionado com a solubilidade ligeiramente maior do 4,5-diclorobiftalato de lamivudina quando comparado com os demais sais preparados.
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Pharmaceutical salts of the antidepressants Paroxetine and Fluoxetine, selective serotonin reuptake inhibitors: crystal engineering, solid-state characterization and thermodynamic aspects / Sais farmacêuticos dos antidepressivos Paroxetina e Fluoxetina, inibidores seletivos de recaptação de serotonina: engenharia de cristais, caracterização de estado sólidos e aspectos termodinâmicosCarvalho Júnior, Paulo de Sousa 30 September 2016 (has links)
The development of new solid forms of active pharmaceutical ingredients (API) is relevant both from fundamental as well as industrial perspectives. To this end, Crystal Engineering plays an ever-increasing important role in pharmaceutical sciences. Among the crystal engineering strategy, salt formation is the most important and implemented approach. The salt forms of API could be used to modulate and tuned the solubility and stability of API to provide optimal practical uses. Herein, we report pharmaceutical salts of two Selective Serotonin Reuptake Inhibitor antidepressants used in the treatment of depression and anxiety disorders, Paroxetine (PRX) and Fluoxetine (FLX). For this purpose, salt formers, supramolecular synthesis and crystallization protocols have been driven by the systematization of structural and supramolecular data of molecules and analogues from the Cambridge Structural Database. Paroxetine bromide hemihydrate ((PRXBr)0.5H2O), Paroxetine Nitrate hydrate (PRXNO3H2O) and two polymorphs of Fluoxetine Nitrate (FLXNO3) have obtained. All were characterized by a combination of techniques including Single Crystal X-ray Diffraction, Differential Scanning Calorimetry (DSC), Thermogravimetry analysis (TGA), Hot Stage Microscopy, Fourier transform infrared spectroscopy (IR) and solubility measurements. Since the hydration/dehydration process in APIs induces phase transitions that compromise its efficiency, the structural characterization of (PRXBr)0.5H2O help to understand its reversible dehydration process. Also, this study has implication in the understating of dehydration of isostructural PRX hydrochloride salt. Additionally, the (PRXNO3)H2O have shown the conformational flexibility and supramolecular diversity of PRX. On the other hand, the chirality of FLX is related to two nitrate salt polymorphs. A racemate and a non-centrosymmetric structure with independent enantiomers in the asymmetric unit were obtained for FLXNO3. Their packing have shown the existence of different racemic motifs, resulting in different enantiomer orientations The rare occurrence of racemic systems in non-centrosymmetric space groups becomes this event a noteworthy case. By their physicochemical properties, the polymorphs were monotropically related. The scientific contributions of this thesis show the diversity of the solid forms and define candidates to new antidepressants APIs solid formulations. / O desenvolvimento de novas formas sólidas de ingredientes farmacêuticos ativos (API) é relevante tanto numa perspectiva fundamental como industrial. Para tal, a Engenharia de cristais tem desempenhado um papel importante nas ciências farmacêuticas. Dentre as estratégias, a formação de sais é a abordagem mais importante e implementada. Os sais de APIs são capazes de modular e ajustar a solubilidade e a estabilidade, a fim de proporcionar uso prático. Nesta tese, são reportados sais de dois fármacos Inibidores Seletivos de Recaptação de Serotonina, consolidados no tratamento da depressão e distúrbios de ansiedade, a Paroxetina (PRX) e a Fluoxetina (FLX). Brometo de Paroxetina hemiidratado ((PRXBr)0.5H2O), Nitrato de Paroxetina hidratado (PRXNO3H2O) e polimorfos de Nitrato de Fluoxetina (FLXNO3), síntese e protocolos de cristalização foram cuidadosamente delineados, com base na sistematização de dados estruturais e supramoleculares das moléculas e seus análogos, depositados no Cambridge Structural Database. Todos os sais foram caracterizados por Difração de Raios-X por Monocristal, Calorimetria Explanatória Diferencial (DSC), Análise termogravimétrica (TGA), Termomicroscopia, Espectroscopia vibracional na região do infravermelho (IR) e solubilidade. Considerando que a hidratação/desidratação induz mudanças de fases que comprometem a eficiência do API, a caracterização do (PRXBr)0.5H2O auxiliou no entendimento do processo de desidratação reversível que ocorre para esse fármaco. Estas mudanças de fase resultam também em implicações sobre a compreensão do processo de desidratação do sal isoestrutural de cloreto de PRX hemiidratado. Além disso, por meio da elucidação estrutural do (PRXNO3)H2O, foi possível analisar a diversidade conformacional e supramolecular da PRX. Quanto à FLX, verificou-se que sua quiralidade está relacionada com seu polimorfismo. Um racemato e uma estrutura não centrossimétrica com dois enatiômeros independentes na unidade assimétrica foram obtidos para o FLXNO3. A comparação destas estruturas permitiu mostrar a existência de arranjos supramoleculares racêmicos, constituídos por diferentes orientações de enatiômeros. A rara ocorrência de sistemas racêmicos em grupos espaciais não-centrossimétricos tornou este evento um caso notável. A partir das propriedades físico-químicas, os polimorfos puderam ser monotropicamente relacionados. Os resultados desta tese trazem importantes contribuições científicas para diversidade de formas sólidas e também define novas formulações sólidas para utilização como antidepressivos.
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Solid-State Synthesis of Imide Ligands for the Self-Assembly of Metal-Organic MaterialsPerman, Jason Alexander 01 January 2011 (has links)
In this research project, reduction or complete elimination of organic solvents is explored in the synthesis of cyclic imides using a technique that brings reagents into favorable position to react. Cocrystal Controlled Solid-State Synthesis (C3Sy3), takes advantage of supramolecular interactions such as hydrogen bonding and π-π stacking to form a cocrystal which can sequential be heated to complete the condensation reaction and produce a desirable product. Twenty-five successful condensation reactions result in high and clean yield.
C3Sy3 of cyclic imides with auxiliary hydrogen bonding moieties like carboxylic acid, carboxylate or pyridyl groups are amenable to form additional solid-state materials. These moieties are useful in forming coordinate covalent bonds with metal cations. Using these C3Sy3 synthesized molecules as ligands, various Metal-Organic Materials (MOMs) are self-assembled. These MOMs offer unique qualities owing to the properties of the cyclic imides. With the addition of accessible carbonyl groups, they may participate as hydrogen bond acceptors or hydrophilic groups. Various degrees of rotation of N-phenyl substituents around the imide plane allow for structural flexibility as a route to supramolecular isomers in MOMs. The ease in imide synthesis may allow the fast scale-up of these ligands for industrial application. Similar ligands are generally synthesized by cross-coupling or substitution reactions that require expensive catalyst and various organic solvents.
Metal-organic materials are a class of compounds amenable to crystal engineering owing to the directional coordinate covalent bonds between metal or metal clusters and organic ligands. They are characterized by X-ray diffraction, spectroscopy, volumetric and gravimetric analysis. The C3Sy3 imides were used to construct various MOMs, from discrete nanostructures to extended 3-periodic frameworks that possess viable internal space for applications pertaining to porous materials. Structural characterization by single crystal X-ray diffraction and structure-function relations are addressed. Gas sorption experiments show that many of these materials are structurally robust and retain crystallinity after evacuation. Ion exchange and guest uptake experiments using the synthesized materials demonstrate their potential as agents for sequestration.
The bottom-up synthesis of metal-organics materials is leading the field of crystal engineering with built-in properties, showing promise by combining attributes from both inorganic and organic components.
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Hierarchy of Supramolecular Synthons in the of Design Multi-Component CrystalsKavuru, Padmini 01 January 2012 (has links)
Most of the biological systems in nature are sustained by molecular self-assemblies which are the finest examples of supramolecular architectures. Non-covalent interactions are key concepts which govern these molecular assemblies. Inspired by these examples crystal engineering emerged as an important tool in supramolecular chemistry which aids in the invention of new molecular structures with desired properties. Understanding of how the molecules interact at the molecular levels enables one to rationally design novel solid forms with modulated physicochemical properties. This feature of crystal engineering has heightened its position in materials chemistry and is currently one of the most well studied fields for generating novel compounds with pre-defined composition and supramolecular architectures.
One such class of compounds that has immensely attracted the scientific community and is under continuous study for wider applications is cocrystals. The applications include various interdisciplinary fields such as pharmaceutics, catalysis, organic conductors, explosives etc. Distinctly on the other side, cocrystals also provide a means to discover new supramolecular synthons which is the ultimate key to molecular assembly. Many robust supramolecular synthons have been discovered and hierarchies are also being developed which can serves as a design tool for cocrystal synthesis. The Cambridge Structural Database (CSD) is an important accessory in determining the robustness of a supramolecular synthon but, this does not preclude us from discovering new synthons.
The work presented here explores new persistent supramolecular synthons in polyphenols utilizing the basic concepts of crystal engineering and the CSD statistical analysis. This contribution also includes the implementation of cocrystallization for various categories of compounds which includes nutraceuticals, pharmaceuticals and ionic salts for the design and synthesis of molecular and ionic cocrystals.
Chapter 1 highlights how supramolecular synthon approach can be used to design and synthesize multi-component crystals, namely, cocrystals. The role of the CSD and its importance in crystal engineering has also been discussed. Chapters 2 and 3 focus on new persistent supramolecular synthons in the context of nutraceuticals. The cocrystals isolated in the study are also compared with the existing cocrystals in the CSD supramolecularly in terms of synthon formation. These persistent supramolecular synthons are helpful in developing hierarchies which could be utilized and applied to similar and analogous compounds. The main feature of Chapter 4 is expanding the field of cocrystallization by studying the properties of cocrystals. Some of the properties which have been examined here include effects of cocrystallization on solubility and correlations between the solubility of cocrystal with cocrystal former (CCF) and melting point of the cocrystal. The extension of cocrystals to the active pharmaceutical ingredients (APIs) has been explored in the context of pharmaceutical cocrystals by selecting a BCS class IV drug, hydrochlorothiazide in Chapter 5. Chapter 6 highlights the hybridization of organic and inorganic components for the synthesis of ionic cocrystals and is exemplified by considering lithium salts with achiral and homochiral amino acids for the generation of 1:1 and 1:2 cocrystals.
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Design of metal-organic framework materials based upon inorganic clusters and polycarboxylatesWang, Zhenqiang 01 June 2006 (has links)
Network structures based upon metal-organic backbones represent a new class of functional materials that can be rationally constructed by employing the concepts of supramolecular chemistry and crystal engineering. The modularity of design strategies, the diversity of prototypal structures, and the dynamic features of networks have afforded great advantages over traditional materials syntheses. The research presented in this dissertation is primarily concerned with developing an in-depth understanding of the basic principles that govern the supramolecular behaviors of metal-organic frameworks and gaining an experimental control over the structure and function of these new classes of hybrid materials. The use of rigid and angular organic ligands along with transition metal clusters gives rise to a wide variety of novel metal-organic architectures ranging from zero-dimensional nanostructures to three-dimensional frameworks.
Gas sorption experiments suggest some of these compounds are potentially useful as porous materials. Conformational analysis of these structural models reveals geometrical foundations for the existence of superstructural diversity. Controlled crystallization experiments further indicate synthetic factors that might determine the formation of supramolecular isomers. On the other hand, careful selection of more labile organic components leads to flexible metal-organic frameworks exhibiting dynamic characteristics that have not been observed in their rigid counterparts. The guest-dependent switch-on/off of cavities and the ease of fine-tuning their chemical environments demonstrate the effectiveness of such a strategy in the context of generating tailored functional materials. Discovery and recognition of novel three-periodic metal-organic nets remains a nontrivial exercise.
In this context, rigorous topological analysis assists the understanding of complicated nets and application of geometrical principles facilitates desing of new metal-organic structures. Finally, scaled-up metal-organic frameworks are potentially accessible with the aid of existing prototypal structures and a systematic study on ligand design.
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Investigação de síntons enantioespecíficos na formação de sistemas multicomponentes utilizando-se o fármaco lamivudina: pareamento ácido-base versus a formação de duplex / Investigation of enantioespecific synthons in the formation of multicomponent systems using the drug lamivudine: acid-base pairing versus duplex formationSilva, Cameron Capeletti da 13 December 2017 (has links)
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Tese - Cameron Capeletti da Silva - 2017.pdf: 3293032 bytes, checksum: 714ecd70f3ac6d81018c08280d885007 (MD5)
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Previous issue date: 2017-12-13 / Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG / A branch of lamivudine crystal engineering deals with its protonable pyrimidine-based nitrogen being a recipe of crystallization with acids. In this context and in relation to the drug lamivudine, ten new crystalline phases were prepared and their crystal structures were elucidated by single crystal X-ray diffraction. In addition, two of them were also characterized by infrared spectroscopy (IR) and other three were characterized by TG and DSC thermal analysis. Thus, this study shows an interesting example of chiral recognition even without chiral resolution. Lamivudine (R)-mandelate and (S)-mandelic acid cocrystal of lamivudine (R)-mandelate trihydrate showed the enantiopreference between lamivudine cation and the (R)-mandelandelate anion in both salt and cocrystal of salt phases through the robust synthon 2-aminopyridine-carboxylate. The present study shows how two solid forms of lamivudine with mandelic acid were used as a model to distinguish between the nature of a salt or cocrystal of salt. This happened because specific information obtained from IR spectra allowed the identification of ionized and neutral forms of mandelic acid directly in the spectrum of the cocrystal of salt. Furthermore, the formation of crystalline forms of lamivudine resembling a DNA structure was investigated due to its great structural value. After crystallization experiments three crystalline structures of lamivudine that mimics DNA structure were obtained and named as lamivudine duplex IV, V and VI, respectively. In the duplex IV of lamivudine the counterions are responsible for opening the two strands due to their hydrogen bonding pattern. The theoretical approach has shown that there is not an energetic tendency regarding the formation of lamivudine duplex with aliphatic organic acids or lamivudinium salts with aromatic acid. Thus, the preference of lamivudine in the assembly of double-helix structures with aliphatic organic acids rather than aromatic acids has been rationalized based on the amount of acid used during the synthesis. In addition, four other salts were also prepared by crystallizing lamivudine with the L-tartaric, sulfuric and perchloric acids, where the two-point synthon described by the graph set R22(8) prevailed. On the other hand, in the structure of lamivudine perchlorate monohydrate neither the two-point synthon nor the three-point one was observed. Finally, the first anhydrous polymorph of lamivudine was reported. This new polymorphic phase of lamivudine is anhydrous as well as form II. In addition to being a new solid phase of alleged commercial interest, the polymorphic form IV of lamivudine also reinforces the importance of performing an extensive screening of the crystallization conditions of new crystalline modifications of active pharmaceutical ingredients. / Um ramo da engenharia de cristais de lamivudina lida com sua base nitrogenada pirimidina, a qual pode ser protonada, sendo assim um alvo de cristalização com ácidos. Nesse contexto, e com relação ao fármaco lamivudina, dez novas fases cristalinas foram preparadas e suas estruturas cristalinas foram elucidadas por difração de raios X por monocristal. Além disso, duas delas também foram caracterizadas por espectroscopia no infravermelho (IV) e outras três foram caracterizadas termicamente por TG e DSC. Desse modo, esse estudo mostra o interessante exemplo de reconhecimento quiral mesmo sem resolução quiral. O (R)-mandelato de lamivudina e o co-cristal (S)-mandélico de (R)-mandelato de lamivudina trihidratado revelaram a enantiopreferência da conexão entre o cátion (lamivudina)+ e o ânion (R)-mandelato- em ambas fases de sal e co-cristal de sal através do sínton robusto de dois pontos 2-aminopiridina-carboxilato. O presente estudo mostra que as duas formas sólidas de lamivudina com ácido mandélico foram utilizadas como modelo para distinguir entre a natureza de um co-cristal de sal e de um sal. Isso porque informações específicas obtidas dos espectros de IV tornaram possível identificar ambas as formas ionizadas e neutra do ácido mandélico diretamente no espectro do co-cristal de sal. Ainda, investigou-se a formação de formas cristalinas de lamivudina que se assemelham a estrutura de DNA devido a seu grande valor estrutural. Após os experimentos de cristalização foram obtidas três estruturas cristalinas de lamivudina semelhantes a estrutura de DNA denominadas de dupla hélice de lamivudina IV, V e VI. Na dupla hélice de lamivudina IV os contra-íons são responsáveis pela abertura da dupla fita devido ao seu padrão de ligação de hidrogênio. A abordagem teórica mostrou que não há uma tendência energética com respeito a formação de duplex de lamivudina com ácidos orgânicos alifáticos ou de sais de lamivudina com ácidos aromáticos. Desse modo, a preferência da lamivudina em montar estruturas cristalinas de dupla hélice com ácidos orgânicos alifáticos ao invés de ácidos aromáticos foi racionalizada com base na quantidade de ácido usada durante a síntese. Além disso, também foram preparados outros quatro sais ao cristalizar lamivudina com os ácidos L-tartárico, sulfúrico e perclórico, onde o sínton de dois pontos descrito pelo conjunto gráfico R22(8) prevaleceu. Por outro lado, na estrutura do perclorato de lamivudina monohidratado nem o sínton de dois pontos e nem o de três pontos foram observados. Por fim, o primeiro polimorfo anidro de lamivudina foi reportado. Essa nova fase polimórfica de lamivudina é anidra assim como a forma II. Além de ser uma nova fase sólida de suposto interesse comercial, a forma polimórfica IV de lamivudina também reforça a importância de se realizar uma varredura extensiva das condições de cristalização de novas modificações cristalinas de insumos farmacêuticos ativos.
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Pharmaceutical salts of the antidepressants Paroxetine and Fluoxetine, selective serotonin reuptake inhibitors: crystal engineering, solid-state characterization and thermodynamic aspects / Sais farmacêuticos dos antidepressivos Paroxetina e Fluoxetina, inibidores seletivos de recaptação de serotonina: engenharia de cristais, caracterização de estado sólidos e aspectos termodinâmicosPaulo de Sousa Carvalho Júnior 30 September 2016 (has links)
The development of new solid forms of active pharmaceutical ingredients (API) is relevant both from fundamental as well as industrial perspectives. To this end, Crystal Engineering plays an ever-increasing important role in pharmaceutical sciences. Among the crystal engineering strategy, salt formation is the most important and implemented approach. The salt forms of API could be used to modulate and tuned the solubility and stability of API to provide optimal practical uses. Herein, we report pharmaceutical salts of two Selective Serotonin Reuptake Inhibitor antidepressants used in the treatment of depression and anxiety disorders, Paroxetine (PRX) and Fluoxetine (FLX). For this purpose, salt formers, supramolecular synthesis and crystallization protocols have been driven by the systematization of structural and supramolecular data of molecules and analogues from the Cambridge Structural Database. Paroxetine bromide hemihydrate ((PRXBr)0.5H2O), Paroxetine Nitrate hydrate (PRXNO3H2O) and two polymorphs of Fluoxetine Nitrate (FLXNO3) have obtained. All were characterized by a combination of techniques including Single Crystal X-ray Diffraction, Differential Scanning Calorimetry (DSC), Thermogravimetry analysis (TGA), Hot Stage Microscopy, Fourier transform infrared spectroscopy (IR) and solubility measurements. Since the hydration/dehydration process in APIs induces phase transitions that compromise its efficiency, the structural characterization of (PRXBr)0.5H2O help to understand its reversible dehydration process. Also, this study has implication in the understating of dehydration of isostructural PRX hydrochloride salt. Additionally, the (PRXNO3)H2O have shown the conformational flexibility and supramolecular diversity of PRX. On the other hand, the chirality of FLX is related to two nitrate salt polymorphs. A racemate and a non-centrosymmetric structure with independent enantiomers in the asymmetric unit were obtained for FLXNO3. Their packing have shown the existence of different racemic motifs, resulting in different enantiomer orientations The rare occurrence of racemic systems in non-centrosymmetric space groups becomes this event a noteworthy case. By their physicochemical properties, the polymorphs were monotropically related. The scientific contributions of this thesis show the diversity of the solid forms and define candidates to new antidepressants APIs solid formulations. / O desenvolvimento de novas formas sólidas de ingredientes farmacêuticos ativos (API) é relevante tanto numa perspectiva fundamental como industrial. Para tal, a Engenharia de cristais tem desempenhado um papel importante nas ciências farmacêuticas. Dentre as estratégias, a formação de sais é a abordagem mais importante e implementada. Os sais de APIs são capazes de modular e ajustar a solubilidade e a estabilidade, a fim de proporcionar uso prático. Nesta tese, são reportados sais de dois fármacos Inibidores Seletivos de Recaptação de Serotonina, consolidados no tratamento da depressão e distúrbios de ansiedade, a Paroxetina (PRX) e a Fluoxetina (FLX). Brometo de Paroxetina hemiidratado ((PRXBr)0.5H2O), Nitrato de Paroxetina hidratado (PRXNO3H2O) e polimorfos de Nitrato de Fluoxetina (FLXNO3), síntese e protocolos de cristalização foram cuidadosamente delineados, com base na sistematização de dados estruturais e supramoleculares das moléculas e seus análogos, depositados no Cambridge Structural Database. Todos os sais foram caracterizados por Difração de Raios-X por Monocristal, Calorimetria Explanatória Diferencial (DSC), Análise termogravimétrica (TGA), Termomicroscopia, Espectroscopia vibracional na região do infravermelho (IR) e solubilidade. Considerando que a hidratação/desidratação induz mudanças de fases que comprometem a eficiência do API, a caracterização do (PRXBr)0.5H2O auxiliou no entendimento do processo de desidratação reversível que ocorre para esse fármaco. Estas mudanças de fase resultam também em implicações sobre a compreensão do processo de desidratação do sal isoestrutural de cloreto de PRX hemiidratado. Além disso, por meio da elucidação estrutural do (PRXNO3)H2O, foi possível analisar a diversidade conformacional e supramolecular da PRX. Quanto à FLX, verificou-se que sua quiralidade está relacionada com seu polimorfismo. Um racemato e uma estrutura não centrossimétrica com dois enatiômeros independentes na unidade assimétrica foram obtidos para o FLXNO3. A comparação destas estruturas permitiu mostrar a existência de arranjos supramoleculares racêmicos, constituídos por diferentes orientações de enatiômeros. A rara ocorrência de sistemas racêmicos em grupos espaciais não-centrossimétricos tornou este evento um caso notável. A partir das propriedades físico-químicas, os polimorfos puderam ser monotropicamente relacionados. Os resultados desta tese trazem importantes contribuições científicas para diversidade de formas sólidas e também define novas formulações sólidas para utilização como antidepressivos.
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