Lo scopo della ricerca è stato comprendere il ruolo dei coordinatori nei Servizi Tutela Minori lombardi. Questi middle managers sono il primo riferimento organizzativo e metodologico per gli assistenti sociali, ma allo stesso tempo hanno una responsabilità nei confronti del top management e delle comunità rispetto al buon andamento di questi Servizi. Attualmente la conoscenza scientifica prodotta sul ruolo è scarsa e sembra che esso abbia preso forma prevalentemente nella pratica. Lo studio ha avuto una duplice finalità, sia descrittiva che esplorativa: la prima parte della ricerca ha infatti indagato le caratteristiche socio-demografiche, la qualifica e la carriera dei managers, mentre la seconda ha esplorato la loro opinione sul loro ruolo in termini di competenze richieste, bisogni e risorse. La ricerca ha previsto un'indagine preliminare sui Servizi Tutela Minori lombardi, un questionario on-line indirizzato a tutti i coordinatori attivi in Lombardia, nonchè interviste semistrutturate indirizzate ad un campione di questi managers (18). Due approcci teorici hanno fatto da cornice agli approfondimenti, ovvero gli studi culturali delle organizzazioni e del management (Alvesson e Berg, 1993; Mintzberg, 1980, 2010; Gagliardi e Monaci, 2011) e il Relational Social Work (Folgheraiter, 1998, 2011, 2017). L’integrazione tra queste teorie e i dati raccolti dai managers hanno permesso di delineare le caratteristiche specifiche che il ruolo di coordinatore tutela minori assume nel sistema di Child Protection lombardo e di far emergere la prospettiva dei coordinatori sul proprio lavoro. / The aim of this study was to understand better the role of middle managers in lombard Child Protection services. This managers are the first organizational and methodological reference for social workers, but at the same time they have a responsability towards top management (and communities) in terms of a good service trend. There isn’t so much knowledge about their work and it seems that they have built their role in practice. The study explored the current characterization of managers that are active in lombard Child Protection system and collected their opinions about the role. The study consisted in a preliminary investigation about Child Protection services in Lombardy After this first investigation, the first step was a survey on-line addressed to all the managers that actually works in Lombardy; the second step consisted in semistructured interviews addressed to a sample of these managers (18). The aim of the first part of the research was descriptive (socio-demographic characteristics, qualification and career of the managers) while that of the second part was exploratory (managers opinion about their role in terms of competences requested, needs and resources). The research has combined two theoretical approaches, cultural studies of organizations/management (Alvesson e Berg, 1993; Mintzberg, 1980, 2010; Gagliardi e Monaci, 2011) and Relational Social Work (Folgheraiter, 1998, 2011, 2017): the integration of them allowed the identification of specific characteristics of child protection middle managers and their point of view about their job.

Il lavoro di ricerca qui proposto si inserisce nel filone delle ricerche sulla mobilità intragenerazionale appena esposto. Questo tema è ampiamente affrontato negli studi che si occupano dell’analisi del mercato del lavoro e dei suoi cambiamenti avvenuti nel corso del secolo scorso. Tuttavia, la gran parte della letteratura si concentra sull’ingresso o sull’uscita delle donne dal mondo lavorativo tralasciando lo studio delle loro effettive possibilità di sperimentare un cambiamento di posizione occupazionale. Rispetto agli studi già condotti in questo ambito, riteniamo possa essere interessante aggiungere all’analisi delle carriere femminili anche altri aspetti. Un primo ambito di analisi è l’influenza della posizione occupazionale dei mariti e dei padri sulla carriera delle donne. Un altro ambito riguarda l’influenza di due eventi familiari di particolare rilevanza, quali il matrimonio e la nascita di un figlio, sull’abbandono del mondo del lavoro e sulla chance di cambiamento della posizione occupazionale delle donne. Con il primo interrogativo di ricerca, ci proponiamo di indagare se, nel corso del ventesimo secolo, si siano modificati i modelli di mobilità di carriera in Italia. La seconda domanda di ricerca cercherà invece di capire come gli eventi familiari - matrimonio e nascita di un figlio - influiscano sulla partecipazione delle donne al mercato del lavoro. Infine, con la terza domanda di ricerca, ci chiediamo come gli eventi sopra esposti influenzino le opportunità di carriera delle stesse. Per rispondere agli interrogativi indicati, prenderemo in considerazione lo studio sia dei fattori inerenti la dimensione individuale, sia di quelli specifici riguardanti l’ambito strutturale. L’analisi di questa ultima sfera permetterà di porre attenzione sui cambiamenti che hanno interessato, a partire dagli anni cinquanta del secolo scorso, il sistema produttivo italiano e le modifiche riguardanti i meccanismi di regolamentazione nei rapporti di impiego. Per quanto riguarda, invece, la dimensione individuale, ci si propone di studiare in profondità alcune caratteristiche sociodemografiche dei soggetti, come il genere, la coorte di nascita e il titolo di studio: quelle che gli studiosi di questo ambito ritengono fondamentali per capire come si strutturano le disuguaglianze. Per raggiungere il nostro obiettivo è stata presa in considerazione l'Indagine Longitudinale delle Famiglie Italiane (ILFI 1997-2005) e sono stati utilizzati una pluralità di strumenti statistici, quali tavole di mobilità, tecniche di event history analysis, modelli log-lineari e modelli di regressione logistica. Rispetto al primo interrogativo di ricerca, il quadro che emerge dalle nostre analisi mostra che nel nostro paese sono presenti contenuti tassi di mobilità di carriera e che nel corso delle coorti sia possibile rilevare solo una lieve variazione rispetto alle opportunità di cambiamento di classe per gli individui. Prendendo in considerazione il secondo interrogativo proposto, abbiamo potuto constatare come siano soprattutto le donne maggiormente istruite a rimanere nel mercato del lavoro, anche in occasione del matrimonio e della nascita di un figlio. La possibilità di lavorare solo per una parte della giornata (usufruendo, quindi, di contratti part-time) sembra leggermente favorire la conciliazione tra famiglia e lavoro. All'opposto, abbiamo riscontrato una maggiore propensione all'abbandono nei casi in cui le garanzie legislative del lavoro vengono a mancare. La posizione lavorativa del partner ha mostrato di avere un importante ruolo. Così, il vantaggio relativo del marito sulla moglie porta quest'ultima ad abbandonare il mercato del lavoro per occuparsi, con molte probabilità, al lavoro domestico. Infine è apparso evidente che la nascita del primo figlio ha una forte spinta a uscire dal mercato.

Gamma-ray and Fluorescence Lifetime Spectroscopies are driving the development of non-imaging silicon photon sensors and, in this context, Silicon Photo-Multipliers (SiPM)s are leading the starring role. They are 2D array of optical diodes called Single Photon Avalanche Diodes (SPAD)s, and are normally fabricated with a dedicated silicon process. SPADs amplify the charge produced by the single absorbed photon in a way that recalls the avalanche amplification exploited in Photo-Multiplier Tubes (PMT)s. Recently 2D arrays of SPADs have been realized also in standard CMOS technology, paving the way to the realization of completely custom sensors that can host ancillary electronic and digital logic on-chip. The designs of scientific apparatus have been influenced for years by the bulky PMT-based detectors. An overwhelming interest in both SiPMs and CMOS SPADs lies in the possibility of displacing these small sensors realizing new detectors geometries. This thesis examines the potential deployment of SiPM-based detector in an apparatus built for the study of the Time-Of-Flight (TOF) of Positronium (Ps) and the displacement of 2D array of CMOS SPADs in a lab-on-chip apparatus for Fluorescence Lifetime Spectroscopy. The two design procedures are performed using Monte-Carlo simulations. Characterizations of the two sensor have been carried out, allowing for a performance evaluation and a validation of the two design procedures.

Intracellular chloride and pH are fundamental regulators of neuronal excitability and they are often co-modulated during excitation-inhibition activity. The study of their homeostasis requires simultaneous measurements in vivo in multiple neurons. Combining random mutagenesis screening, protein engineering and two-photon-imaging this thesis work led to the discovery of new chloride-sensitive GFP mutants and to the establishment of ratiometric imaging procedures for the quantitative combined imaging of intraneuronal pH and chloride. These achievements have been demonstrated in vivo in the mouse cortex, in real-time monitoring the dynamic changes of ions concentrations during epileptic-like discharges, and in glioblastoma primary cells, measuring osmotic swelling responses to various drugs treatment.

The mutation/deletion of the hereditary material in the cell nuclei is a chronic biochemical hazard; in fact, nuclear DNA faces tens of lesions from metabolic intermediates, hydrolytic reactions and external vectors a minute. The canonical lesions of DNA involve the DNA backbone as well as the nucleic bases and are mostly associated with reversible chemical modifications. However, the radiation field from beams of accelerated ions accounts for a dense streak of collisions and reactions with the DNA molecule, thereby achieving lethal clusters of elemental lesions. Double strand breaks (DSB), i.e., the cleft of the DNA backbone over both strands, are hazardous fractures of the chromatin fold associated with the radiation field, underlying cytotoxic outcomes and chromosomal aberrations. Eukaryotic cells, however, rejoin the fractured DNA moieties from DSB events via an apt enzymatic machinery, or the DDR. Prior to the deployment of enzymatic effectors, host enzyme sensors engage the DNA termini in reversible supramolecular assemblies, which requires that the fractured DNA moieties be fully exposed. The in silico assessments of the early layout of DNA lesions by radiations have defined DSBs as the closely associated modifications of the DNA backbone by means of “coarse” criteria, that is, within an arbitrary distance of the two clefts. However, the diverse DSB motifs, i.e. at a strand break distance of zero to several nucleotides, account for a different contact interface between the DNA termini, thus modulating the dynamics of the lesion sites. Moreover, it is reckoned that in the absence of excess external stimuli, far-distanced DSBs may not fracture the broken DNA moieties by thermal dissociation, within the characteristic timescales of the DDR activity. This thesis elaborate tackles the in silico assessment of the distribution of DSBs in a chromatin-like fold and the local mechanical strain enforced by blunt DSBs, by means of state-of-the-art Monte-Carlo track structure tools and classical molecular dynamics. We infer that i) a Poisson fit describes the spectrum of DSB motifs by the direct effect of accelerated hydrogen ions (H+) at a Bragg peak relevant energy range (500 keV - 5 MeV) and, notably, we observe a bias towards short-distanced, staggered DSBs; ii) the nucleosome fold, i.e. the elemental unit of the chromatin hierarchical framework, exerts an excess kinetic barrier on the disruption of DSBs, which is not observed in linear DNA, mediated by the contact interface between DNA and the core histone fold. In conclusion, we remark that in the absence of further data from in vitro and in vivo assessments, the (kinetic, thermodynamic) inferences about the thermal and mechanical resilience of broken DNA frameworks are as reliable as the force fields underneath; in fact, it is debated whether all-atom force fields and water models overestimate the force of the intermolecular contacts and over-stabilize the DNA double helix.

No description available.

Nursing homes are complex healthcare settings that take care of older adults with sever cognitive and physical impairments. Given the conditions of the patients, nursing homes can be considered end-of-life contexts. There, the care work that aim to mitigate and treat the conditions of the patients it is the result of the collaboration between the care professionals and the relatives of the patients. Indeed, when the patients are very old adults in a end-of-life situation, the provision of care often involves a family caregiver as the main point of contact for the healthcare service. However, caring for institutionalized older adults is known to be a complex issue both for the families of the older adults and the care professionals. Over the last few years, there has been an increasing interest in this topic primarily due to a growing older population and, hence, a heightened need of research contributions in this area. Previous studies on caregiving for older adults living in nursing homes recognize the necessity to support professionals’ work practices to ameliorate their working conditions, and decrease the risk of burnout and job dissatisfaction, as well as to relieve the families of the patients from the burden of caring for their loved ones. Yet, the literature shows a lack of solutions in terms of technologies for this kind of environments. In this thesis we report an extensive study and analysis we performed within a network of six and nursing homes located in the northern Italy.We investigated the practice of caregiving within the nursing homes. In particular, we focused on the work practices of care professionals, and on the relational issues between the care professionals and the families of the patients. We conducted, first, an exploratory study to comprehend the nature of our research context. Afterwards, we carried out a series of participatory design sessions and validation workshops to elicit the requirements for the development of a new technology platform to support the collaboration between care professionals and relatives of older patients. The outcomes of this work shed new light on the opportunities of using ICT solutions to improve relations and information sharing among caregivers. Indeed, our findings state that the organizational and relational complexity of nursing homes emphasize how poor communication practices hinder the collaboration and the mutual understanding between the relatives of the patients and the care professional. As a result, we deliver a series of functional requirements for the development of a technology platform that aims to support relationships, communication, and coordination among care professionals, and between care professionals and families of the patients.

Looking at state of the art of optical devices, it is evident that glass-based rare-earth-activated optical structures represent the technological pillar of a huge number of photonic applications covering Health and Biology, Structural Engineering, Environment Monitoring Systems, Lighting, Laser sources and Quantum Technologies. Among different glass-based systems, a strategic place is assigned to transparent glass-ceramics, nanocomposite materials, which offer specific characteristics of capital importance in photonics. Following this strategy, this PhD thesis exploits tin dioxide (SnO2)-based glass-ceramic activated by erbium ions (Er3+) to put the basis for the fabrication of solid state and integrated lasers. The research discussed in my PhD thesis gives a possible solution to two crucial and decisive points in the development of an optically pumped rare-earth-based laser: (i) the low absorption cross section of the rare-earth ions; (ii) the writing of channels and mirrors in the case of waveguide integrated laser, thanks to the demonstration of two innovative and unique characteristics of SnO2-based transparent glass-ceramics, i.e. luminescence sensitizing and photorefractivity. The role of SnO2 nanocrystals as rare-earth ion luminescence sensitizers allows to overcome the low absorption cross section of the Er3+ ion. The photorefractivity in range of 10-3 of SiO2-SnO2:Er3+ glass-ceramics allows applying the robust direct laser photoinscription technique on the systems to fabricate Bragg gratings and channel waveguides for waveguide integrated lasers. Based on an application-oriented approach, a comprehensive study on SiO2-SnO2:Er3+ glass-ceramic planar waveguides and monoliths, has been carried out. The work covers different research stages and aspects from the material preparation to a complete assessment of systems for the applications employing a rich number and variety of experimental techniques. The energy transfer from SnO2 to Er3+ and the efficient pumping scheme exploiting SnO2 as Er3+ luminescence sensitizers were demonstrated. The relaxation dynamic of the electronic states as well as the location of the dopant and density of states are discussed, and a specific modeling has been developed to the proof of concept realization of the considered devices. The obtained photorefractivity in range of 10-3 allowed the inscription of gratings on the fabricated SiO2-SnO2:Er3+ planar waveguides using UV laser direct writing technique. Exploiting the robust femtosecond laser micromachining, the optical waveguides were inscribed in the fabricated SiO2-SnO2:Er3+ monolithic squares. Another important outcome of this research is the design of a solid state laser with lateral pumping scheme and of an integrated waveguide laser in two different distributed feedback structures using all the parameters measured during the experimental activity.

Biological materials such as wood show outstanding properties due to the self assembly of components from molecular to macroscopic size. An emerging nanotechnology-based strategy consists of the isolation of biological components with size in the range from nanometers to micrometers and of the design of human-driven assembly processes to obtain multifunctional materials. The aim of this thesis was to isolate cellulose nanocrystals, with dimensions of around 4-5 nm in width and some hundred nanometers in length, and investigate their assembly processes through weak interactions among them and with small molecules, like water or ions. Knowing their interaction properties and self-assembly is indeed fundamental in order to fully exploit the potential of nanocellulose in its recently emerging applications. In particular, I focused on cellulose nanocrystals supramolecular self-organization both in absence and presence of water, studying cellulose nanocrystals-based films and hydrogels. In dry conditions, the self-assembly of cellulose nanocrystals on a polylactic support was demonstrated to form few micrometers thick films, characterized by a densely packed arrangement of the crystals leaving elongated cavities of about 0.31 nm cross section between them. These cavities provide the pathway for gaseous 2H2 diffusion. Conversely, these films are impermeable barriers for the transport of gaseous molecules such as O2 and CO2. In aqueous solution, instead, cellulose nanocrystals undergo sonication- or cation-assisted entanglement, forming soft hydrogels. Na+, Ca2+ and Al3+ crosslink the nanocrystals and produce stable hydrogels with structurally ordered domains in which water is confined. Since the gelation process is diffusion controlled, small hydrogel objects with different size and shape have been designed by the coordination-driven assembly of supramolecular rod-like cellulose crystallites, using ionotropic gelation as a methodological approach and Ca2+ as a gelling agent. In parallel to material characterization, particular attention was devoted to the possible exploitation of cellulose nanocrystals-based materials in the biomedical field. In this regard, toxicity studies were performed both on the individual nanocrystals and on the films and hydrogels resulting from their assembly. Moreover, a hybrid cellulose-nanocrystals/chitosan material was developed and characterized, which shows some potential to be used as therapeutic delivery system in the gastrointestinal tract. Indeed, though a mould assisted gelation process, composite hydrogels can be produced, which are degraded by human digestive enzymes and release a model protein according to a biphasic kinetic profile.

Cosmologies of destinations investigates some commonly neglected dimensions of forced migration. It examines the key symbolic structures and social mechanisms which encourage and sustain the mobility trajectories of Eritreans from their home country to Ethiopia, Sudan, Italy and beyond. The central argument is that, in refugee-producing countries which suffer from protracted crisis and livelihood disruption, refugee movements become much more than a form of reactive mobility. Within these communities, becoming a refugee is not only a way to escape oppressive conditions but also the outcome of socially and symbolically embedded strategies aimed at personal realization and family well-being. Building on a multi-sited ethnography of the everyday life of Eritrean refugees in a number of settings (including homes, refugee camps, urban squats, and other settings of sociability) in their home country as well as in Ethiopia, Sudan and Italy, the thesis explores the range of social and economic resources needed to circumvent legal and geographic borders, and the moral and cultural norms that underpin these practices. It contributes to the theorization of refugee mobility, which is currently somewhat underdeveloped, by providing a framework to analyse high-risk forced migration, based on an emic understanding and systematic description of the living conditions, life aspirations and risk perceptions of Eritreans in their home country and in transit to Europe. The study feeds into the broader debate on the blurring boundaries between labour and forced migration by emphasising the social and cultural, along with the structural, determinants of mobility and immobility. The thesis is divided into five chapters. The first analyses the conditions that make exit a widespread and legitimate, albeit controversial, option for young people in Eritrea. The second chapter provides accounts of refugees' everyday lives in the first safe countries (Ethiopia and Sudan), chronicling the dynamics that trigger secondary movements towards Europe. The third analyses the lives of Eritrean refugees in Italy, documenting the conditions that activate further mobility within Europe. The fourth chapter describes the migratory infrastructures that allow for these refugee movements, including the role played by transnational marriages, smugglers and family networks. The final chapter provides a micro-analysis of decision-making, aimed at explaining the willingness of refugees to take great risks at different stages of the migration process. A methodological note narrates how the research was carried out in the various sites and analyses the implications of multi-sited ethnographic fieldwork with refugees.