Dedicated energy crops have the potential to supply a sustainable biomass feedstock to support the bioenergy industry. However, a major constraint for promoting energy crops has been the availability of land for establishing energy crops. In this study, we developed a spatially-explicit model to identify suitable and economically feasible sites for establishing energy crops based on biomass price, production costs and site-specific biomass productivity. Results from our study provided an objective evaluation of factors that influence the amount and spatial distribution of land suitable for establishing energy crops. In addition, our model had the ability to capture variation across the feasible areas because of changing biomass market and policy conditions. By performing a sensitivity analysis with different market and policy scenarios, we were able to identify the most effective and favorable scenarios that could maximize the available land for producing energy crops.

Lignocellulosic biomass pretreatment is a fundamental step in the production of renewable fuels and chemicals. It is responsible for the disruption and removal of lignin and hemicellulose from the lignocellulosic matrix, improving the enzymatic hydrolysis of cellulose. Alkaline pretreatment has been shown to be successful on agricultural residues and dedicated energy crops. The objective of this study was to evaluate the pretreatment of switchgrass, wheat straw, corn stover, and miscanthus using calcium hydroxide, potassium hydroxide, and sodium hydroxide at the same hydroxyl concentration, 60% moisture content, and two temperatures for seven days. Enzymatic hydrolysis was also performed and the glucose produced measured. The composition of cellulose, hemicellulose, and lignin before and after pretreatment were quantified according to the standard procedures developed by the NREL for biomass. The hydrolysis was performed at 50°C and 150 rpm. The enzyme loading was 60 FPU/g cellulose. Overall, calcium hydroxide pretreatment resulted in the lowest delignification and structural carbohydrates after pretreatment, as well as lowest glucose yield; In addition to having a higher cost and carbon dioxide emission then sodium and potassium hydroxides. Sodium hydroxide and potassium hydroxide had similar performance in terms of composition changes due to pretreatment and glucose yield after enzymatic hydrolysis.

Made available in DSpace on 2015-07-22T20:49:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-10-27 / Objetivo: Comparar a sobrevida de pacientes com recidiva de câncer de ovário que realizaram estudo com 18F FDG PET-CT não dedicado, tomografia computadorizada e marcador CA-125 com as enfermas que se submeteram ao tratamento e seguimento usual com tomografia computadorizada e o marcador CA-125. Metodologia: Estudaram-se pacientes com neoplasia ovariana epitelial maligna no Hospital do Câncer AC Camargo- São Paulo, no período compreendido entre janeiro de 1996 à dezembro de 2003, as quais apresentaram recidiva, comprovada pela cirurgia. Avaliaram-se 44 pacientes (grupo A) que efetuaram exame 18F-FDG em PET-CT não dedicado e 31 doentes (grupo B) que efetuaram o seguimento habitual. Excluíram-se as pacientes em vigência de quimioterapia (menos de 48 horas) da data da realização do exame 18F-FDG em PET-CT não dedicado. Resultados: Pacientes com exames de PET-CT não dedicado (grupo A) apresentaram significante aumento da sobrevida em comparação com o grupo B (p=0.0200). Outrossim, 11 pacientes com estudo anátomopatológico “borderline” apresentaram apenas um exame falso negativo (implantes peritoneais), 10 verdadeiro negativos e 18 verdadeiro positivos. Conclusão: O emprego do FDG-PET-CT não dedicado na avaliação de pacientes com neoplasia ovariana maligna mostrou ser procedimento que resultou em benefícios, interferindo na atitude dos cirurgiões, mormente na recidiva subclínica. Verificou-se maior sobrevida das enfermas após o tratamento da recidiva quando foi identificado pelo FDG-PET-CT não dedicado seja por sítios ou locais insuspeitos ou mesmo pela completa ausência de sintomas e sinais clínicos. / Purpose The aim of this study was to compare the impact of the survival in patients with ovarian cancer recurrence undergoing non-dedicated [18F]FDG PET-CT, CT and serum CA-125 (group A) and patients that were submitted to conventional follow-up with CT and serum CA-125. Methods Patients diagnosed with epithelial ovarian cancer at the AC Camargo Cancer Hospital from January 1996 to December 2003 who presented recurrence (checked by surgery), and performed [18F]FDG PET-CT on a total of 44 patients- group A, and 31 patients -group B undergoing conventional follow up. Patients undergoing chemotherapy less than 48 hours before non-dedicated PET-CT were excluded from the research. Results Patients of Group A presented an increase on their survival rate of 5.94 in comparison with group B (p=0.0200). The 11 borderline patients in group A performed 29 [18F]FDG PET-CT studies with 1 false negative (peritoneal implants), 10 true negatives and 18 true positives. Conclusion Oncologists are used to test several markers in order to perform diagnosis, staging and prognosis, but their real benefit in the treatment is still uncertain. The use of [18F]FDG PET-CT in the evaluation of subclinical ovarian cancer recurrence has been shown to be accurate and presented a rewarding cost-benefit relationship, interfering in the surgeons conduct facing a subclinical recurrence. / TEDE / BV UNIFESP: Teses e dissertações

Bayesian factor analysis - abstract Factor analysis is a method which enables high-dimensional random vector of measurements to be approximated by linear combinations of much lower number of hidden factors. Classical estimation procedure of this model lies on the cho- ice of the number of factors, the decomposition of variance matrix while keeping identification conditions satisfied and on the appropriate choice of rotation for better interpretation of the model. This model will be transferred into bayesian framework which offers the usage of prior information unlike the classical appro- ach. The number of hidden factors can be considered as a random parameter and the dependency of each measurement on at most one factor can be forced by suitable specification of prior distribution. Estimates of model parameters are based on posterior distribution which is approximated by Monte Carlo Markov Chain methods. Bayesian approach solves the problem of selection of the num- ber of factors, the model estimation and the ensuring of the identifiability and the interpretability at the same time. The ability to estimate the real number of hidden factors is tested in a simulation study. 1

Os mercados cada vez mais competitivos fazem com que as empresas busquem novas formas organizacionais e desenvolvam \"capacidades dinâmicas\" a fim de sobreviver no mundo globalizado. Nesse contexto, a inovação se tornou tema central para a competitividade. As fontes de inovação estão cada vez mais diversificadas e dispersas geograficamente, as empresas utilizam fontes internas e externas para o desenvolvimento de soluções inovadoras e modelos de negócios diferenciados. Estudos afirmam, que durante todos os anos, são produzidos milhares de artigos científicos que envolvem a biotecnologia, mostrando que é um dos campos mais promissores do mundo, com implicações importantes para economia global. A biotecnologia é caracterizada por ser baseada na ciência, ser multidisciplinar e o seu desenvolvimento é realizado por meio da interface com diversos atores, sendo altamente dependente do seu ambiente institucional. Assim, dado o contexto da biotecnologia, as lentes da teoria das capacidades dinâmicas são úteis para verificar a construção do conhecimento que conduz ao desenvolvimento de novos produtos, já que as empresas não podem depender somente do desenvolvimento do conhecimento interno, elas devem absorver conhecimentos relevantes de fontes externas. No setor de biotecnologia, verifica-se uma série de casos de alianças para melhoria de competitividade global por meio da inovação em sua forma mais ampla, incluindo desenvolvimento de novos produtos, de novos formatos para negócios, de novos mecanismos organizacionais. Como a capacidade de absorção é vista como um dos elementos das capacidades dinâmicas e tornou-se fator crítico para o sucesso dessas empresas, o presente estudo tem como objetivo verificar se as alianças contribuem para o desenvolvimento da capacidade de absorção e o desempenho inovador das empresas dedicadas à biotecnologia. O estudo é classificado como exploratório-descritivo e foi conduzido em duas etapas: quantitativa e qualitativa. Na etapa qualitativa foram realizados cinco estudos de caso e na quantitativa foram enviados questionários à 270 empresas do setor de biotecnologia, instaladas no Brasil, Portugal e Espanha. Verificou-se, por meio do estudo, a importância das alianças no desenvolvimento das quatro dimensões da capacidade de absorção. Ademais, identificou-se que as alianças também influenciam no desempenho inovador das empresas. Pode-se ainda relatar que a idade das empresas influencia na assimilação do conhecimento e a experiência do gestor influencia tanto a assimilação quanto a transformação do conhecimento. Por fim, verificou-se também que as parcerias no exterior levam as empresas a um desempenho inovador superior. Dessa forma a pesquisa contribuiu para o desenvolvimento da literatura sobre capacidade de absorção, bem como pode auxiliar os gestores das empresas dedicadas à biotecnologia e dos habitats de inovação por meio do modelo proposto para o desenvolvimento da capacidade de absorção e, para o governo, na formulação de políticas e incentivos para o desenvolvimento da biotecnologia. / The increasingly competitive markets mean that companies seek new organizational forms and develop \"dynamic capabilities\" in order to survive in the globalized world. In this context, innovation has become central to competitiveness. Sources of innovation are increasingly diverse and geographically dispersed; companies use internal and external sources for the development of innovative and differentiated business models. Studies claim that during each year produce thousands of scientific articles involving biotechnology, showing that it is one of the most promising fields in the world, with important implications for the global economy. Biotechnology is characterized as a science-based, multidisciplinary and its development is carried out through the interface with different actors, being highly dependent on its institutional environment. Thus, given the biotech context, the dynamic capabilities theory of lenses are useful to verify the construction of knowledge that leads to the development of new products, since it is dependent on new knowledge and business cannot depend on only development of internal knowledge, they must absorb relevant knowledge from external sources. In the biotechnology sector, there are series of alliances to improve global competitiveness through innovation in its broadest form, including development of new products, new formats for business, new organizational mechanisms. As the absorptive capacity has seen as one of the elements of dynamic capabilities and has become critical to the success of these companies, this study aims to determine whether the alliances contribute to the development of absorptive capacity and the innovation performance of dedicated biotechnology firms. The research is classified as exploratory and descriptive study since it was conducted in two phases: quantitative and qualitative. The qualitative analysis was collected from five case studies and quantitative questionnaires were sent to 270 companies in the biotechnology sector, installed in Brazil, Portugal and Spain. It has found the importance of alliances in the development of the four dimensions of absorptive capacity. In addition, we identified also that alliances influence the innovation performance of firms. One can also report that the age of the company influences the assimilation of knowledge and the manager\'s experience influences both the assimilation and the transformation of knowledge. Finally, the study also has found that alliances abroad lead to companies having a higher innovation performance. Thus, the research contributed to the development of literature on absorptive capacity and could assist managers of companies dedicated to biotechnology and innovation habitats through the proposed model to develop absorptive capacity and, to the government, in the formulation of policies and incentives for development of biotechnology.

Timing can be defined as the ability to perceive temporal sequences and regulate timed behaviors. As in other animals, our ability to make accurate time estimations is crucial in order to accomplish several activities. Organisms can process time over a wide range of durations ranging from microseconds to days. In the middle of these extremes is the hundreds of milliseconds to seconds range which is important for many everyday behaviors, such as walking, speaking and dancing. Yet, how this is managed remains poorly understood. Some central issues with regard time processing in this particular time range are whether timing is governed by one, or by several different mechanisms, possibly invoked by different effectors used to perform the timing task, as well as, if cognitive capacities are also involved in rhythmic motor timing. This thesis includes three studies. Study I investigated the effects of short- term practice on a motor timing task. Analyses of the timing variability indicated that a substantial amount of learning occurred in the first hour of practice and declined afterwards, exhibiting no trend for further decrease across the remaining 60 or 210 minutes. This effect was similar across effector, amount of feedback, and interval duration. Our results suggested that training effects influenced mainly motor precision and raised the question of whether motor timing training influenced also cognitive capacities. Study II investigated the relationship between motor timing and cognition. Specifically, participants had to train a sensorimotor synchronization task (SMS) over several days, and the question was whether this training would improve cognitive performance. A near transfer effect was found between the sensorimotor synchronization task and the sustained attention task, indicating that sustained attention is involved in motor timing. Study III compared the timing variability between the eyes and the hands, as a function of four different intervals, in order to examine whether these systems are temporally controlled by the same or different mechanism(s). The results showed several positive correlations in variability, between the eye and the finger movements, which, however, were significant only for the longer intervals. In addition, they were differences in variability between the eye and the hand, for the different interval durations. In general, the pattern of results from these studies suggested that voluntary motor timing is managed by overlapping distributed mechanisms and that these mechanisms are related to systems that manage cognitive processes, such as attention. The results partially explain the well-known relationships between cognitive ability and timing.

Strong ethics are critical to the success of each member of the business world, especially accountants. Because the work of accountants is utilized by both internal and external users and can have such widespread effect on the business community, it is imperative that this work is performed with the utmost accuracy, integrity and morality. The foundation for strong ethics begins before the accountant enters the workforce, and many colleges require dedicated ethics courses for accounting majors. The purpose of this project is to analyze the effectiveness of the ethics instruction, specifically in the absence of a required dedicated ethics course, at East Tennessee State University (ETSU). Two surveys will be administered to a sample of ETSU students in several classes within the undergraduate and graduate accounting programs and the results will be analyzed to determine if students’ understanding of ethics has increased over the semester. The results of this thesis are intended to provide the ETSU College of Business and Technology with vital information about how to improve the ethics instruction for undergraduate accounting students.

The topic of this thesis is the design of a testing device for checking electrical car sockets according customers’ requirements. The electrical socket shall be tested by electrical, mechanical and camera tests. The diploma thesis is divided into two main parts, first is a part describing the basic elements in the construction of electric vehicles, and describing types of electric sockets in electric vehicles, and second, a practical part describing the design of a testing device.

PURPOSE: The purpose of this research was to identify the value of undergraduate nursing student clinical preparation within a dedicated education unit on transition to practice. SPECIFIC AIMS: Describe perceived competence, practice readiness, self-efficacy, job satisfaction, intent-to-stay and orientation length of students who participated in a clinical experience in a dedicated education unit upon graduation, 3- and 6-months employment. Explore new graduate nurses’ perception of the impact of a dedicated education unit clinical experience on transition to practice. Examine relationships between outcome variables. Explore associations between outcome variables and demographic and employment characteristics. FRAMEWORK: This research was guided by Albert Bandura’s Social Learning Theory. DESIGN: This study used a descriptive, longitudinal design with quantitative measures and qualitative interviews. RESULTS: 18 participants provided quantitative data, and five participated in an interview. Competence, practice readiness and job satisfaction were relatively high. Self-efficacy remained essentially unchanged at all three time points. Average orientation length was 13 weeks, with 41.7% reporting their orientation was shorter than planned. At 6-months employment, 91.7% planned to stay in their current position for one year. Competence and Self-efficacy were associated at 3- and 6-months. Prior healthcare work experience was associated with higher competence at 3- and 6-months. Participants valued the experience of working with a preceptor and the supportive learning environment that allowed them to develop technical and professional nursing skills. CONCLUSION: These findings support dedicated education units as having a positive impact on new graduate nurse’s transition to practice.

The primary focus of nursing education in the 21st century is to graduate students with well-developed critical thinking and clinical reasoning skills. This descriptive case study explored the perceptions of 6 faculty and 6 unit staff nurses concerning the assessment of critical thinking and clinical reasoning skills of nursing students in the clinical setting. Benner's novice to expert theory served as the conceptual framework for the research. The guiding research questions focused on faculty and staff perceptions concerning unit staff nurses' level of preparedness to assess the critical thinking and clinical reasoning ability of nursing students, and explored how faculty and unit staff nurses perceived the process of evaluating nursing students' clinical reasoning and critical thinking skills in the clinical setting. Data were collected using semi structured interview questions, then coded and analyzed following Creswell's approach. This analysis identified six themes: (a) lack of consistency, (b) faculty and staff clinical expectations of students, (c) barriers to clinical education, (d) faculty and staff differences in educational definitions, (e) faculty and staff comfort level with students, and (f) resources needed for clinical education. Learning how faculty and staff nurses assess student nurses' ability to demonstrate effective clinical reasoning and critical thinking skills can positively impact social change in nursing education on the local and state level by informing best practice in how critical thinking and clinical reasoning are taught and assessed in nursing education. This facilitates graduating nurses who are prepared to deliver patient care that affect positive outcomes.