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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Addressing the Reliability and Life Cycle Cost Analysis Problem for Technology and System Developers Early in the DoD System Development Process

Pflanz, Mark 30 January 2006 (has links)
Early in the process of developing or upgrading new weapon systems, Department of Defense (DoD) system and technology developers are faced with decisions regarding which technologies are appropriate for inclusion into the conceptual design. To reduce risk and improve decision making, system and technology developers need a capability to assess the impact of technology reliability on the attributable Operating and Support (O&S) cost of the system. Early understanding of the reliability implications of potential technologies on system O&S cost will help make better informed decisions early in the system development timeline, prior to points of design lock-in. Using a Marine Corps case study and a system dynamics simulation model, this thesis examines the nature of the relationship between component reliability and attributable changes in O&S cost. This thesis also develops a potential analysis methodology repeatable for future use. The modeling results indicate that this relationship is best described as exponential decay, meaning that the savings in O&S cost per system mile is proportional for any fixed incremental change in component reliability. We find these results to be insensitive to changes in preventative maintenance policies, maintenance deferment ratios, and component replacement cost. We completed verification and validation using the case study and existing Marine Corps systems, finding good association between the modeling results and the actual system. This analysis is valuable to the system and technology developer by helping to answer the question: "how reliable is reliable enough in terms of O&S cost" when considering technologies with uncertainties in long-term performance. / Master of Science
12

Avaliação da disponibilidade de sistemas computacionais críticos para o controle do espaço aéreo por meio de modelo analítico da teoria de filas. / Availability assessment of critical computer systems in airspace control by analytical model of queueing theory.

Pizzo, Walter Nogueira 26 June 2008 (has links)
O transporte aéreo e a indústria de sistemas de defesa foram setores pioneiros na utilização de sistemas computacionais críticos, incrementando os níveis de automação nas atividades de controle do espaço aéreo. Com o crescimento desses setores, verificado pela expansão dos números de vôos, volumes de cargas e usuários, assim como pela ampliação e diversidade das operações militares, os sistemas de controle têm assumido maior complexidade técnica, introduzindo novos recursos de automação ou facilidades adicionais de apoio para funções exercidas manualmente. Essa situação tem ampliado a dependência dos serviços prestados, relativamente à disponibilidade dos sistemas computacionais. Diretrizes de projeto e procedimentos operacionais são estabelecidos para manter os níveis de segurança nos casos de falha, no entanto a disponibilidade torna-se parâmetro crítico, na medida em que algumas falhas podem afetar a eficiência nominal da prestação dos serviços. Nesse cenário, este trabalho propõe um modelo para avaliação da disponibilidade de sistemas de controle do espaço aéreo, a partir de recursos de análises da teoria de filas. Inicialmente é citado um modelo geral para análise de disponibilidade de data centers. Em seguida, é apresentada uma extensão do modelo geral para análise da disponibilidade em sistemas de controle do espaço aéreo. Para isso, considerou-se a intervenção humana existente nessa atividade, cujas decisões de controle são exercidas por operadores qualificados (controladores), tanto nas atividades inerentes ao serviço de controle, quanto nos casos de degradação, nos quais os operadores ou técnicos de manutenção assumem alguma tarefa de reparo, decorrente da eventual indisponibilidade de funções do sistema. / Due to the growth in airspace utilization, which can be verified both in terms of the expansions in aerial movements, airports and volumes of transported passengers and cargo, as well as in terms of the expansion of military operations demands and diversity, airspace control activities have been increasing their technical complexity, introducing new features into the existent automation systems or creating additional resources for the automation of some functions previously performed by human operators. This situation has increased the dependence on the availability of the computer systems involved in the services provided by control centers. Project directives and operational procedures are established in order to maintain the safety integrity levels of the systems, in case any failure occurs. However, the availability becomes a critical parameter, once failure events can force an undesirable state of degraded operation, jeopardizing the nominal capacity of the services being performed through any controlled airspace. In this scenario, this work presents an availability model for the computer systems used in airspace control centers, based on analysis from queuing theory. A general model is first presented, referencing a case study that describes the use of queuing models to access the availability of generic data centers. Further considerations are introduced to extend this general model in order to propose its application for the specific computer systems used in airspace control centers, where operational control relies on human activities. In this case, system operation involves intensive use of human-machine interfaces (HMI), for the regular control services provided, and additional technical or operational maintenance activities, occasionally imposed to repair a momentary loss of any function of the system.
13

Avaliação da disponibilidade de sistemas computacionais críticos para o controle do espaço aéreo por meio de modelo analítico da teoria de filas. / Availability assessment of critical computer systems in airspace control by analytical model of queueing theory.

Walter Nogueira Pizzo 26 June 2008 (has links)
O transporte aéreo e a indústria de sistemas de defesa foram setores pioneiros na utilização de sistemas computacionais críticos, incrementando os níveis de automação nas atividades de controle do espaço aéreo. Com o crescimento desses setores, verificado pela expansão dos números de vôos, volumes de cargas e usuários, assim como pela ampliação e diversidade das operações militares, os sistemas de controle têm assumido maior complexidade técnica, introduzindo novos recursos de automação ou facilidades adicionais de apoio para funções exercidas manualmente. Essa situação tem ampliado a dependência dos serviços prestados, relativamente à disponibilidade dos sistemas computacionais. Diretrizes de projeto e procedimentos operacionais são estabelecidos para manter os níveis de segurança nos casos de falha, no entanto a disponibilidade torna-se parâmetro crítico, na medida em que algumas falhas podem afetar a eficiência nominal da prestação dos serviços. Nesse cenário, este trabalho propõe um modelo para avaliação da disponibilidade de sistemas de controle do espaço aéreo, a partir de recursos de análises da teoria de filas. Inicialmente é citado um modelo geral para análise de disponibilidade de data centers. Em seguida, é apresentada uma extensão do modelo geral para análise da disponibilidade em sistemas de controle do espaço aéreo. Para isso, considerou-se a intervenção humana existente nessa atividade, cujas decisões de controle são exercidas por operadores qualificados (controladores), tanto nas atividades inerentes ao serviço de controle, quanto nos casos de degradação, nos quais os operadores ou técnicos de manutenção assumem alguma tarefa de reparo, decorrente da eventual indisponibilidade de funções do sistema. / Due to the growth in airspace utilization, which can be verified both in terms of the expansions in aerial movements, airports and volumes of transported passengers and cargo, as well as in terms of the expansion of military operations demands and diversity, airspace control activities have been increasing their technical complexity, introducing new features into the existent automation systems or creating additional resources for the automation of some functions previously performed by human operators. This situation has increased the dependence on the availability of the computer systems involved in the services provided by control centers. Project directives and operational procedures are established in order to maintain the safety integrity levels of the systems, in case any failure occurs. However, the availability becomes a critical parameter, once failure events can force an undesirable state of degraded operation, jeopardizing the nominal capacity of the services being performed through any controlled airspace. In this scenario, this work presents an availability model for the computer systems used in airspace control centers, based on analysis from queuing theory. A general model is first presented, referencing a case study that describes the use of queuing models to access the availability of generic data centers. Further considerations are introduced to extend this general model in order to propose its application for the specific computer systems used in airspace control centers, where operational control relies on human activities. In this case, system operation involves intensive use of human-machine interfaces (HMI), for the regular control services provided, and additional technical or operational maintenance activities, occasionally imposed to repair a momentary loss of any function of the system.
14

Building a contingency menu using capabilities-based planning for Homeland Defense and Homeland Security /

Goss, Thomas Joseph, January 2005 (has links) (PDF)
Thesis (M.A. in Security Studies (Homeland Security and Defense))--Naval Postgraduate School, 2005. / Title from title screen (viewed Apr. 12, 2006). "March 2005." Includes bibliographical references (p. 69-72) Also issued in paper format.
15

The distribution of CRISPR-Cas systems is affected by interactions with DNA repair pathways / La distribution des systèmes CRISPR-Cas est affectée par leurs interactions avec les systèmes de réparation de l’ADN

Bernheim, Aude 23 November 2017 (has links)
Les systèmes CRISPR-Cas confèrent aux bactéries une immunité adaptative contre les éléments génétiques mobiles jouant ainsi un rôle important dans l’évolution bactérienne. Cependant, moins de la moitié des génomes bactériens encodent des systèmes CRISPR-Cas ; cela, malgré la protection qu’ils confèrent et leur haut taux de transfert horizontal. Des hypothèses telles que le coût des phénomènes d’auto-immunité ou de posséder des défenses adaptatives plutôt qu’innées ont été mises en avant pour expliquer ce paradoxe. Je propose une nouvelle hypothèse complémentaire : le contexte génétique jouerait un rôle important dans la fixation d’un système CRISPR-Cas après son transfert. Plus précisément, j’ai étudié comment les interactions entre les systèmes de réparation de l’ADN et les CRISPR-Cas influencent la distribution de ces derniers. Pour cela, j’ai d’abord examiné finement la distribution des systèmes CRISPR-Cas dans les génomes bactériens. J’ai ensuite analysé les co-occurences des systèmes de réparation de l’ADN et des CRISPR-Cas et démontré l’existence d’associations positives et négatives entre eux. Enfin, je me suis concentrée sur une des associations négatives découvertes pour valider mes prédictions expérimentalement et comprendre les mécanismes moléculaires sous-jacents. Mes travaux permettent de mieux comprendre les interactions complexes entre systèmes de réparation de l’ADN et CRISPR-Cas et démontrent la nécessite d’accommodation des CRISPR-Cas à un contexte génétique pour être sélectionnés et maintenus dans les génomes bactériens. / CRISPR-Cas systems confer bacteria and archea an adaptative immunity against phages and other invading genetic elements playing an important role in bacterial evolution. Only 47% of bacterial genomes harbor a CRISPR-Cas system despite their high rate of horizontal transfer. Hypothesis such as the cost of autoimmu- nity or the trade off between a constitutive or an inducible defense system have been put forward to explain this paradox. I propose that the genetic background plays an important role in the process of maintaining a CRISPR-Cas system af- ter its transfer. More precisely I hypothesized that CRISPR-Cas systems interact with DNA repair pathways. To test this idea, we detected DNA repair pathways and CRISPR-Cas systems in bacterial genomes and studied their co-occurences. We report both positive and negative associations that we interpret as poten- tial antagonistic or synergistic interactions. We then focused on one interaction to validate our result experimentally and explored molecular mechanisms behind those interactions. My findings give insights on the complex interactions between CRISPR-Cas systems and DNA repair mechanisms in bacteria and provide a first example on the necessity of accommodation of CRISPR-Cas systems to a specific genetic context to be selected and maintained in bacterial genomes.
16

A plm implementation for aerospace systems engineering-conceptual rotorcraft design

Hart, Peter Bartholomew 08 April 2009 (has links)
The thesis will discuss the Systems Engineering phase of an original Conceptual Design Engineering Methodology for Aerospace Engineering-Vehicle Synthesis. This iterative phase is shown to benefit from digitization of Integrated Product&Process Design (IPPD) activities, through the application of Product Lifecycle Management (PLM) technologies. Requirements analysis through the use of Quality Function Deployment (QFD) and 7 MaP tools is explored as an illustration. A "Requirements Data Manager" (RDM) is used to show the ability to reduce the time and cost to design for both new and legacy/derivative designs. Here the COTS tool Teamcenter Systems Engineering (TCSE) is used as the RDM. The utility of the new methodology is explored through consideration of a legacy RFP based vehicle design proposal and associated aerospace engineering. The 2001 American Helicopter Society (AHS) 18th Student Design Competition RFP is considered as a starting point for the Systems Engineering phase. A Conceptual Design Engineering activity was conducted in 2000/2001 by Graduate students (including the author) in Rotorcraft Engineering at the Daniel Guggenheim School of Aerospace Engineering at the Georgia Institute of Technology, Atlanta GA. This resulted in the "Kingfisher" vehicle design, an advanced search and rescue rotorcraft capable of performing the "Perfect Storm" mission, from the movie of the same name. The associated requirements, architectures, and work breakdown structure data sets for the Kingfisher are used to relate the capabilities of the proposed Integrated Digital Environment (IDE). The IDE is discussed as a repository for legacy knowledge capture, management, and design template creation. A primary thesis theme is to promote the automation of the up-front conceptual definition of complex systems, specifically aerospace vehicles, while anticipating downstream preliminary and full spectrum lifecycle design activities. The thesis forms a basis for additional discussions of PLM tool integration across the engineering, manufacturing, MRO and EOL lifecycle phases to support business management processes.

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