Orientador: Edison Duarte / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Educação Fisica / Made available in DSpace on 2018-07-24T16:32:50Z (GMT). No. of bitstreams: 1 Leitao_MariaTeresaKrahenbuhl_M.pdf: 3933790 bytes, checksum: 885227c11facc8ce0327208beeb4e597 (MD5) Previous issue date: 1998 / Resumo: Após verificarmos a não existência de dados sobre os procedimentos de ensino do tênis de campo para portadores de comprometimento mental, pensamos na hipótese de um trabalho específico com alunos portadores da Síndrome de Down. O objetivo desta pesquisa foi proporcionar a aprendizagem desta modalidade através de procedimentos adequados e adaptados, respeitando as características individuais dessa população. Participam desta pesquisa 8 sujeitos cujas idades variam entre 9 e 15 anos, divididos em grupos de acordo com seu grau de desenvolvimento e faixa etária, tendo aulas uma vez por semana, com duração de 45 minutos cada. Como procedimento metodológico utilizamos a análise de tarefas, as observações assistemática e participativa, bem como filmagens, fotos e diário de campo, tendo em vista subsídios que complementem a avaliação do trabalho. Podemos concluir, após a sugestão dos procedimentos, que os alunos podem aprender os fundamentos básicos da modalidade, bem como apresentar melhoras em alguns itens relativos ao comportamento adaptativo tais como, autonomia, aptidões sociais, participação comunitária, saúde e segurança e o lazer. A partir deste estudo, novos procedimentos poderão ser investigados, visando favorecer a aprendizagem desta modalidade ainda pouco acessível às minorias / Abstract: After verifying the lack of data regarding procedures for teaching field tennis to mentally-handicapped people, we haveplanned a specific work with students with Down's syndrome. The purpose of the present research was to provide a learning of this sport through adequate adapted procedures which take into account the special characteristics of the subjects. This research was carried out with 8 subjects ages 9 to 15, divided into groups according to their degree of development and age. They all had 45-minute classes once a week. As methodology procedure we have used task analysis, asystematic and participative observations, as well as videotapes, photographs and notes to gather data to complement the evaluation of the work. After the suggestion of the procedures, we can conclude that the students are capable of learnng the basics of the sport, as well as improving some aspects regarding adaptive behavior such as autonomy, social aptitude, community participation, health and safety, and leisure. This research may be used as a starting point to the investigation of new procedures, aiming at supporting the learning of tennis, which is still somewhat inaccessible to minorities / Mestrado / Atividade Fisica e Adaptação / Mestre em Educação Física

Orientador: Gil Lucio Almeida / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia / Made available in DSpace on 2018-07-26T00:28:28Z (GMT). No. of bitstreams: 1 Marconi_NadiaFernanda_M.pdf: 7770096 bytes, checksum: 55abeef1b751afc2abb6eef97b3a5bb3 (MD5) Previous issue date: 2000 / Resumo: Neste trabalho, investigamos o efeito do feedback intrínseco nos padrões cinemáticos, cinéticos e eletromiográficos em movimentos de reversão do braço. Estes movimentos foram realizados em três distâncias angulares (108°, 126° e 144°) e em três orientações espaciais (180°, 90° e 0°) por indivíduos neurologicamente normais e portadores da síndrome de DoWIl. As distâncias angulares foram defmidas com base na quantidade de deslocamento do cotovelo. Durante a realização das tarefas, os indivíduos não tiveram a informação visual do braço. Para identificar a quantidade correta de deslocamento do cotovelo, os indivíduos tiveram que comparar as informações provenientes de um goniômetro fixo nesta articulação, com um conjunto de luzes, as quais acendiam com o aumento do deslocamento do cotovelo em extensão. Indivíduos neurologicamente normais apresentaram um acoplamento entre variáveis intrínsecas (i.e. atividade eletromiográfica, torques musculares) e extrínsecas (velocidade linear do dedo indicador). Do ponto de vista do controle motor, este acoplamento simplificaria o número de variáveis que o Sistema Nervoso teria que controlar durante a execução dos movimentos. Este acoplamento entre variáveis intrínsecas e extrínsecas foi denominado como "Building Block Strategy". Além disso, indivíduos neurologicamente normais, modularam as atividades eletromiográficas e os torques musculares com o aumento da distância do movimento de acordo com as regras previstas pela "Speed Insensitive Hyphotesis" (Gottlieb, et aI., 1989). Esta modulação da atividade eletromiográfica e das forças musculares foi independente da orientação espacial. Indivíduos portadores da síndrome de DO / Abstract: ln this study, we investigated the effect of the intrinsic feedback in the kinematic, kinetic and, eletromyographic (EMG) pattems in reversal movements of the armo This movements were performed in three angular distances (l08°, 126° and 144°) and in three spatial orientations (180°, 90° and 0°), by normal (NN) and Down Syndrorne (DS) individuaIs. The angular distances were defined based in the quantity of the elbow excursion. During the performance of the tasks, the subjects did not have the visual information of the armo To identify the correct quantity of the elbow excursion, the subjects had to associate the information provided ITom the goniometer placed on their joint with a visual information from ligths, which tumed on with the increase ofthe elbow excursion. Normal individuaIs showed a coupling between intrinsic (i. e. muscle activity, musc1e torque) and extrinsic (linear veIocity ofthe fingertip) variables. From the motor control point of view, this coupling reduces the number of the variables that the Central Nervous System (CNS) had to control during the execution ofmovements. This coupling between intrinsic and extrinsic variables was denominated here "Building Block Strategy". However, normal individuaIs modulated the EMG activities and the musc1e torques with an increase in the angular distance, according to the "Speed lnsensitive Hyphotesis" (Gottlieb et aI, 1989). DOVvTI syndrome individuaIs also were able to perfom the proposed task, however, they showed subtle differences in the manner they controled the movements. First, the coupling between intrinsic and extrinsic variables was less significant for this population. Second, they were 'unable to modulate the EMG activities and the musc1e torques with an increase in the angular distance as observed for the NN individuaIs. Third, this individuais showed co activation pattems of the agonist and antagonist muscles. ln this way, we can conc1ude that the conclude that the "Building Block Strategy" can not be considered an universal strategy to be applied to alI populations. Regarding the accuracy of the movements, both groups obtained similar quantities of error when performing reversal movements using just the intrinsic feedback. This found suggests that the CNS does not use this type of information to controI the movements / Mestrado / Fisiologia / Mestre em Biologia Funcional e Molecular

Cette thèse porte sur l'étude de nanofils silicium réalisés par approche top-down. Elle s'inscrit dans le contexte de la miniaturisation des composants et la compréhension du transport dans les systèmes 1D. Deux voies de fabrication sont envisagées: la lithographie par AFM (Microscope à Force Atomique) et la lithographie électronique. Cette dernière étant plus reproductible, les dispositifs finaux sont fabriqués par cette technique, à partir d'un substrat SOI et plusieurs étapes de gravure et métallisation. L'étude des nanofils par mesures l(V) nous permet de mettre en évidence une zone déplétée à l'interface Si/SiO2 natif. Grâce à l'utilisation de nanofils de largeurs et de longueurs différentes, nous sommes capables de déterminer la largeur de la zone déplétée, la densité d'états d'interface ainsi que le niveau de dopage des nanofils. L'évolution de la résistance des nanofils avec la température est également étudiée et montre une dépendance associée à la diffusion des phonons de surface. Trois applications sont ensuite décrites : un décodeur, un commutateur de courant et un capteur biologique. En effet, la gravure locale des nanofils conduit à une modulation de la bande de conduction, rendant possible la réalisation d'un décodeur. D'autre part, la fabrication de croix à base de nanofils et de grilles latérales à proximité des croix qui contrôlent le passage du courant dans les différentes branches permet de former un commutateur de courant. Enfin, grâce au rapport important de la surface par rapport au volume des nanofils et leur bonne fonctionnalisation chimiques, ceux-ci sont utilisés pour détecter électriquement des interactions biologiques (détection de l'ovalbumine). / This work focuses on the study of silicon nanowires made by a top-down approach. The context of the study is the miniaturisation of the components and the understanding of the transport in 1D systems. Two fabrication approaches are studied : AFM lithography (Atomic Force Microscope) and e-beam lithography. The latter being more reproducible, the final devices are fabricated by this technique using a SOI substrate and multiple steps of etching and metallization.Transport characterization of the Si nanowires allows us to highlight a depleted area at the interface Si/native SiO2. Using nanowires with different widths and lengths, we can determine the depletion width, the surface state density as well as the doping level of the nanowires. The evolution of the nanowires resistance with temperature is also investigated, showing a dependence associated with surface phonons scattering. In the last chapter, three applications are described : a decoder, a current switch and a biosensor. The use of a local etching allows the modulation of the conduction band of the nanowires, opening the way to build a decoder using two local gates. Crossbar structures, where lateral gates which can derive the current in the di_erent branches, lead to the fabrication of a current switch. Finally, thanks to the large surface to volume ratio in these structures, the nanowires are used to detect electrically the interactions between molecules (ovalbumine detection).

Memoria para optar al título de Arquitecto

Orientador : Mathias Vitti / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-07-15T11:35:43Z (GMT). No. of bitstreams: 1 NiccoliFilho_WalterDomingos_M.pdf: 1690833 bytes, checksum: 6c98ea7935b361d592b96c83bdc1359b (MD5) Previous issue date: 1986 / Resumo: Foram analisados eletromiograficamente os musculos masseteres direito e esquerdo em 15 indivíduos portadores da Síndrome de Down, em varios movimentos mandibulares e comparando os resultados com aqueles de indivíduos normais. Os dados obtidos mostraram qu~: (1) nos movimentos de abertura da boca, propulsão, lateral idade direita e esquerda da mandíbula, não houve diferenças significantes nos resultados eletromiogrãficos entre indivíduos normais e os portadores da Síndrome de Down; (2) nos movimentos de mastigação molar direita e esquerda, incisiva e oclusão cêntrica forçada, houve redução dos potenciais eletromiogrãficos para os indivíduos portadores da Síndrome de Down quando comparados aos indl víduos "normais; (3) o padrão de coordenação dos indivíduos Portadores da Sindrome de Down foi diferente daquele observado em inividuos normais; (4) demonstrou este estudo que a IIhipotonia" presente nos indivíduos portadores da Sindrome de Down,po de ser detectada pelo exame eletromiogrãfico, quando comparado a indivíduos normais / Abstract: An electromyographicstudy of the right and left masseter muscles, in various mandibular movements, was performed i n 15 individuals bea ) ring Down's Syndrome. The results werecomparedwith the same movements in normal individuals. The data showed that: (1) significant differences were not seen in the following moveme'nts: Right lateral, left lateral, protrusion, and opening of the mouth; (2 ) the individuals with Down's Syndrome showéd a decreasein the electromyographic potentials during right and left molar mastication, incisor masticationand forced centric occlusion; ( 3) the muscular coordination pattern in the mongolic individuals was different from that of the normal ones; (4) this study also showed that a general muscular hypotony was characteristic feature of the individuals with Down's Syndrome, as revealed by electromyography / Mestrado / Mestre em Biologia e Patologia Buco-Dental

Orientador : Luis Alberto Magna / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-07-17T05:25:22Z (GMT). No. of bitstreams: 1 Norato_DeniseYvonneJanovitz_D.pdf: 1682814 bytes, checksum: b7c6233719cbeba0f77201b3710a331e (MD5) Previous issue date: 1987 / Resumo: O presente trabalho consiste na avaliação dos niveis eritrocitarios das isozimas da anidrase carbonica assim como da atividade total desse enzima...Observação: O resumo, na integra, podera ser visualizado no texto completo da tese digital / Abstract: The complete abstract is available with the full electronic digital thesis or dissertations / Doutorado / Doutor em Medicina

No description available.

Purpose: To describe communication profiles in children with velocardiofacial syndrome (VCFS) compared with children with Down syndrome. Methods: Four children with VCFS and four children with Down syndrome underwent cognitive and speech and language assessment. Results: Communication profiles of children with Down syndrome showed a flat profile, indicating all measures were similar and delayed relative to chronological age. Children with VCFS showed vocabulary, pattern of sound types, and Mean Babbling Length below cognitive and other language ages. Conclusion: Communication profiles of children with VCFS differed qualitatively and quantitatively from children with Down syndrome and support the hypothesis that some children with VCFS present with a profile of communication impairment that may be distinctive to the syndrome.

Indiana University-Purdue University Indianapolis (IUPUI) / The mongoloid face and craniofacial skeleton has been characterized by many investigators using clinical impressions and soft tissue measurements on living and autopsy material. Few studies have included data derived from cephalometric radiographs. The present study was designed to describe the mongoloid face and cranial base and to analyze the data. Twenty mongoloid children ranging in age from three years to 12 years, and their siblings were selected for study. A control group of children were selected on the basis of their essentially normal occlusion and facial skeleton. The data obtained from the cephalometric radiographs were analyzed in three ways. Each of the three groups of children, normal, mongoloid and their siblings were divided into four age groups, approximately three, five, seven and 11 years of age and means for the individual measurements were calculated. The sibling measurements were "corrected” to the age of the mongoloid child using the growth progression data from the normal children. The mean measurements of the “corrected” siblings and mongoloids were then compared using “t” tests for statistical significance. All children were then divided into three comparison pairs, normal-sibling, normal-mongoloid, and mongoloid-sibling, and the cephalometric measurements subjected to a multivariate, step-wise regression analysis. The growth of the maxillae and mandible were retarded in the Mongoloid children. The maxilla and mandible were positioned anteriorly under the cranial base.

Indiana University-Purdue University Indianapolis (IUPUI) / The relationship between gene copy number and protein expression levels has not thoroughly been examined in humans or mouse models of Down syndrome (DS) in relationship to developmental changes in the trisomic brain. Found on human chromosome 21 (Hsa21) and triplicated in DS, Dual-specificity tyrosine-phosphorylated regulated kinase 1A (DYRK1A) has been linked in DS to neurological deficits by restricting cell growth and proliferation. Little information exists regarding DYRK1A during perinatal development and how its expression may lead to cognitive deficits, and none exists that explores the gene-to-protein relationship during these critical time periods. This study aims to 1) Quantify variable DYRK1A expression across development as a function of age, sex, and brain region in trisomic Ts65Dn mice compared to euploid counterparts and 2) establish that the spatiotemporal pattern of developmental DYRK1A in the brain is not influenced solely by gene copy number, and that reduction of Dyrk1a in euploid and trisomic mice does not result in a corresponding global reduction of DYRK1A expression. DYRK1A was quantified in three areas of the postnatal brain at seven ages using the Ts65Dn mouse, the most studied model of DS, and found that trisomic expression is significantly increased on postnatal day ([P]6), declining by the third week to near euploid levels. We also uncovered a sexual dimorphic expression of DYRK1A when comparing animals of different sexes within the same genotype. Data from Dyrk1a knockdown mice indicated that reducing only Dyrk1a in euploid and in otherwise trisomic animals yields highly variable levels of DYRK1A, dependent on sex and tissue type, supporting the non-intuitive relationship between gene dosage and protein expression. These data emphasize the need to understand the age-dependent regulation of antecedent conditions that are causing changes in Dyrk1a expression in the brain.