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Interactive scheduling and visualisation / Interactive scheduling and visualisationSkalický, Tomáš January 2012 (has links)
The goal of this thesis was to design and implement a graphical tool for visualization and editing of schedules which would provide a function for automatic repairing of violated constraints in the schedule. The resulting application called a Gantt Viewer is integrated to the FlowOpt project that represents a complex solution for modeling workflows, creation of schedules from them and analysis of these schedules. The application has been developed with the focus on intuitiveness of the user interface and performance during the management of large schedules. It enables the user to visualize extended manufacturing schedules thanks to the cooperation with other modules of the FlowOpt project. Moreover, the Gantt Viewer incorporates a repair tool exploiting a new Repair-DTP algorithm which is both introduced and demonstrated in this work.
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Avaliação da resposta imunológica humoral, em animais de experimentação, induzida pela combinação da vacina DTP-Hib com as vacinas meningocócicas B e C conjugada, desenvolvidas em Bio-ManguinhosMartins, Fernanda Otaviano January 2011 (has links)
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Previous issue date: 2011 / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. / A combinação de vacinas é uma estratégia de grande relevância para o Programa
Nacional de Imunizações. Através dela, é possível aumentar a proteção a múltiplas doenças
em uma única vacina, bem como diminuir as constantes visitas ao posto de saúde. Contudo,
uma das desvantagens em relação a esse tipo de estratégia é a possibilidade de ocorrer
interferência antigênica entre os seus componentes,o que pode resultar na diminuição da
resposta imunológica. Devido a este fato, foi realizada uma combinação com vacinas já
presentes no calendário brasileiro de imunizações (DTP-Hib) a vacinas experimentais em
desenvolvimento em Bio-Manguinhos (meningocócica B e meningocócica C conjugada),
com a finalidade de apresentar uma nova perspectivade produto a esta unidade bem como
estabelecer a correlação antigênica entre esses componentes, comparando metodologias já
padronizadas para este fim à metodologia alternativa (ELISA), além de avaliar a
pirogenicidade e a interferência entre os componentes vacinais utilizados na combinação.
A resposta imunológica aos componentes vacinais foiavaliada em camundongos
suíços, NIH e cobaias Short-Hair pelo ELISA (VME, polissacarídeo C, PRRP, Bordetella
pertussis) e os testes de soroneutralização in vivo(componentes tetânico e diftérico).
Todos os componentes vacinais avaliados pelo ELISA induziram soroconversão nos
animais 30 dias após a última imunização. Quando comparadas à vacina combinada
completa, somente a resposta imunológica ao polissacarídeo C sofreu interferência de
algum componente vacinal. Após novas combinações davacina meningocócica C
conjugada às outras vacinas, pode-se concluir que avacinas DTP e Hib interagem
positivamente na resposta daquela vacina. Em relação à soroneutralização in vivo, houve
uma diminuição da potência dos componentes tetânicoe diftérico quando cobaias Short-Hair
foram imunizadas com a vacina DTP-Hib combinada às vacinas meningocócicas B e C
conjugada. Em contrapartida, na quantificação de IgG total em camundongos suíços
imunizados com as duas combinações (DTP-Hib e DTP-Hib/B/C), não ocorreu diferença
significativa entre os dois grupos. O teste de pirogenicidade realizado em coelhos
comprovou que, quando combinadas entre si, às vacinas são capazes de aumentar a
temperatura destes animais, provavelmente, devido àpresença de Bordetella pertussise
VME de Neisseria meningitidisgrupo B.
Apesar de não ter sido possível à comparação com ostestes padronizados, o ELISA
mostrou-se muito satisfatório na pesquisa da resposta imunológica em camundongos.
Embora preliminares, os resultados são muito importantes, pois introduzem novas
perspectivas para a realização de outras combinações que atendam as demandas
requisitadas pelo Programa Nacional de Imunizações. / The combination of vaccines is a great relevance strategy to the National
Immunization Program. It enables increase protection to multiple diseases in a single
injection, as well as reduces constant visits to health care. However, a disadvantage of this
strategy is antigenic interference among vaccine components, resulting in immune response
decreased. Due to this fact, a combination between vaccines of Brazilian immunization
calendar (DTP-Hib) and experimental vaccines developed in Bio-Manguinhos
(meningococcal B and meningococcal C conjugate) wasperformed, in order to present a
new perspective of product to this unit and establish the antigenic correlation of these
components, comparing standardized methodologies with alternative methodology (ELISA),
besides evaluating pyrogenicity and interference ofcombined vaccine components.
The immune response to vaccine components was evaluated in Swiss and NIH
mice and Short-Hair guinea pigs by ELISA (OMV, polysaccharide C, PRP, Bordetella
pertussis) and in vivoneutralization test (tetanus and diphtheria components).
All vaccine components assessed by ELISA induced seroconversion rates 30 days
after the last immunization in animals. The complete combined vaccine, interfered in the
immune response to polysaccharide C. After new combinations of meningococcal C
conjugate vaccine to other vaccines, we concluded that DTP and Hib vaccines induce a
positive interaction in immune response to that vaccine. Regarding in vivoneutralization,
there was a decrease of tetanus and diphtheria components potency when Short-Hair guinea
pigs were immunized with DTP-Hib combined to B and C meningococcal conjugate vaccines.
In contrast, when total IgG in Swiss mice immunizedwith the two combinations (DTP-Hib
and DTP-Hib/B/C) was quantified, no significant difference was observed. Pirogenicity test in
rabbits proved that complete combined vaccine increase the temperature of these animals,
probably due to the presence of Bordetella pertussisand Neisseria meningitidisgroup B
outer membrane vesicle.
Although it was not possible comparision with standardized test, ELISA was a
satisfactory test in studing immune response in mice. Although preliminary, the results are
important because introduce new perspectives for other combinations could be done to
atempt the required demands of National Immunization Program.
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Lesk a bída DTP: desktop publishing a běžná praxe českých vydavatelství / The splendors and miseries of DTP: desktop publishing and common practice of Czech publishing housesFalta, Matěj January 2020 (has links)
Diploma thesis Te splendors and miseries of DTP: desktop publishing and common practice of Czech publishing houses tries to map the current technical and personnel aspect of the DTP departments within Czech publishing houses. It uses a quantitative method of questionnaire survey. In the practical part of the research, it managed to obtain data from nine of the ten selected publishers. It was chosen on the basis of their readership with the help of data from the Union of Publishers. Undoubtedly, the main contribution of this thesis is the topic itself - text focuses on a group of media professionals, who are crucial for proper functioning of the print media, although it is constantly overlooked by academia. Tis diploma thesis does not bring any revolutionary knowledge about the feld of print media in the Czech Republic, although with the obtained data it is possible to at least partially analyze jobs and style of work of media professionals in DTP departments. Te work is a small quantitative contribution to the academic discussion, which unfortunately is not currently taking place, although it should.
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Synthesis of Novel Hydrogen-Bonding Unit for Organic Field-Effect TransistorsJin, Jiyang 10 June 2016 (has links)
No description available.
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An Evaluation Platform for Semantic Web TechnologyÅberg, Cécile January 2006 (has links)
The vision of the Semantic Web aims at enhancing today's Web in order to provide a more efficient and reliable environment for both providers and consumers of Web resources (i.e. information and services). To deploy the Semantic Web, various technologies have been developed, such as machine understandable description languages, language parsers, goal matchers, and resource composition algorithms. Since the Semantic Web is just emerging, each technology tends to make assumptions about different aspects of the Semantic Web's architecture and use, such as the kind of applications that will be deployed, the resource descriptions, the consumers' and providers' requirements, and the existence and capabilities of other technologies. In order to ensure the deployment of a robust and useful Semantic Web and the applications that will rely on it, several aspects of the technologies must be investigated, such as whether the assumptions made are reasonable, whether the existing technologies allow construction of a usable Semantic Web, and the systematic identification of which technology to use when designing new applications. In this thesis we provide a means of investigating these aspects for service discovery, which is a critical task in the context of the Semantic Web. We propose a simulation and evaluation platform for evaluating current and future Semantic Web technology with different resource sets and consumer and provider requirements. For this purpose we provide a model to represent the Semantic Web, a model of the evaluation platform, an implementation of the evaluation platform as a multi-agent system, and an illustrative use of the platform to evaluate some service discovery technology in a travel scenario. The implementation of the platform shows the feasibility of our evaluation approach. We show how the platform provides a controlled setting to support the systematic identification of bottlenecks and other challenges for new Semantic Web applications. Finally, the evaluation shows that the platform can be used to assess technology with respect to both hardware issues such as the kind and number of computers involved in a discovery scenario, and other issues such as the evaluation of the quality of the service discovery result.
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Compliant Behaviors for Remote Robotic OperationsPokharna, Rahul Kishor 25 January 2022 (has links)
No description available.
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Análise da temperatura axilar e da febre verificadas em um ensaio clínico com vacinas / Analysis of axillary temperature and fever observed in a clinical trial of vaccinesSantos, Eliane Matos dos January 2009 (has links)
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Previous issue date: 2009 / Objetivos: Analisar a temperatura axilar no estudo da vacina contra difteria, tétano, o componente pertussis e hemófilo (DTP/Hib), a frequência de febre e a associação dos eventos adversos. Analisar a metodologia para verificação da temperatura corpórea e febre utilizada em diferentes estudos clínicos com a vacina DTP/Hib. Materiais e métodos: Este trabalho é baseado em dados obtidos do Estudo de imunogenicidade e reatogenicidade de vacina combinada contra difteria, tétano, pertussis e hemófilo tipo b: validação clínica de produto produzido totalmente no Brasil, com 1000 lactentes, realizado no município do Rio de Janeiro, no ano de 2006. Foi analisada a temperatura axilar nos tempos 3, 6, 12, 24, 48 e 72 horas após a vacinação. Foram analisadas as associações entre os eventos adversos locais e eventos adversos sistêmicos. Resultados: A freqüência de febre foi de 53,4 por cento após a primeira dose, 39,9 por cento após a segunda dose e 31,5 por cento após a terceira dose nas 24 horas após a vacinação. A freqüência de febre foi diminuindo com a aplicação das doses. Não houve padrão de associação entre os eventos adversos locais e sistêmicos. A mediana da distribuição da temperatura axilar foi maior nostempos 6 e 12 horas após a vacinação. Conclusões: A definição de febre e as metodologias utilizadas nos estudos clínicos para verificar a temperatura corpórea ainda são heterogêneas, o que dificulta a comparabilidade entre eles. / Objectives: To analyze the axillary temperature in the study of the vaccine DTP/Hib (Martins
et al., 2008), the frequency of fever and the association of the adverse events. To analyze the
methodology for checking of the corporal temperature and fever used in different clinical trial with the vaccine DTP/Hib. Materials and methods: This work is based on obtained data of the “Study of immunogenicity and reactogenicity of vaccine combined against diphtheria, tetanus, pertussis and haemophylus type b: clinical validation of product produced totally in Brazil ”, with 1000 infants,carried out in the local authority of the Rio of January, in the year of 2006. The axillary temperature was analyzed in the times 3, 6, 12, 24, 48 and 72 hours after the vaccination. The associations were analyzed between the adverse local events and adverse systemic events. Results: The frequency of fever was 53.4 % after the first dose, 39.9 % after the second dose and 31.5 % after the third dose in 24 hours after the vaccination. The frequency of fever was lessening with the application of the doses. There was no standard of association between the adverse local events and systemic adverse events. The medium one of the distribution of the axillary temperature was bigger in the times 6 and 12 hours after the vaccination. Conclusions: The definition of fever and the methodologies used in the clinical studies to check the corporal temperature they are still heterogeneous what makes difficult the comparability between them.
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Episódio Hipotônico-hiporresponsivo associado à vacina combinada contradifteria, tétano, pertussis e Haemophilus influenzae tipo b: análise da definição de caso para vigilância / Hypotonic-hyporesponsive episode contradifteria associated with the combined vaccine, tetanus, pertussis and Haemophilus influenzae type b: analysis of the case definition for surveillanceNoronha, Tatiana Guimarães de January 2010 (has links)
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Previous issue date: 2010 / Analisar as vantagens e limitações da definição de caso de episódio hipotônico-hiporresponsivo (EHH) baseada na revisão da literatura, e as implicações para o Sistema de Informação de Eventos Adversos Pós-Vacinação do Programa Nacional de Imunizações. Materias e métodos: Este trabalho é baseado em dados obtidos por um estudo de vigilância ativade eventos adversos pós-imunização com a vacina combinada contra difteria, tétano, coqueluche e Haemophilus influenzae tipo b (DTP/Hib), realizado no município do Rio de Janeiro, no ano de 2004 (VIGAT), cujo objetivo primário era determinar em crianças com menos de 1 ano de idade a incidência do episódio hipotônico-hiporresponsivo (EHH) que se inicia nas primeiras 48 horas após a aplicação da vacina DTP/Hib utilizada pelo Programa Nacional de Imunização. Foram analisados o desempenho das perguntas de triagem para potenciais casos de EHH aplicadas no VIGAT, a reprodutibilidade da sua definição de caso de EHH quando aplicada em diferentes níveis de avaliação, o seu valor preditivo positivo, assim como, o seu desempenho em relação a outras definições de caso presentes na literatura, considerando-se o grau em que esse desempenho afeta a vigilância de eventos adversos associados à vacina DTP/Hib. Foi realizada também uma análise demográfica e dos antecedentes pessoais dos casos de EHH, e da sua possível associação com fatores relacionados à vacina, sua aplicação e outros eventos adversos pós-vacinais (EAPV). Resultados: A freqüência de EHH encontrado no VIGAT foi de 8,1 por 10.000 vacinados (IC95 por cento 4,7 - 13,0 por 10.000). Não houve significância estatística para a associação entre o EHH e o sexo do lactente, baixo peso de nascimento, índice de Apgar abaixo do normal, dose da vacina aplicada e lotes dos componentes vacinais. A febre maior ou igual a 39°C foi considerada como fator de risco para a ocorrência de EHH, encontrando-se associação entre eles com risco relativo de 8,2 (IC 95 por cento = 2,6; 25,7). O valor preditivo positivo da definição de caso do EHH adotada no VIGAT (2004) para o diagnóstico de EHH, quando utilizada pelo coordenador local do estudo foi 0,68 (17/25). Houve 100 por cento de concordância no diagnóstico de EHH entre o Grupo de Revisão de Diagnóstico (GRD) e o Comitê de Monitoramento Externo (CME). O Valor Preditivo Positivo (VPP) das duas perguntas de triagem combinadas foi de 17/47 (36,2 por cento). A concordância entre a definição de caso de EHH do VIGAT e a de Braun et al (1998) foi de 0,84 (kappa = 0,68); de 0,8 (kappa = 0,61) em relação a Brighton (2004); de 0,84 (kappa = 0,66) para Vermeer et al (2006); e de 0,92 (kappa = 0,82) para Brighton (2007). Conclusões: A definição de caso de EHH do VIGAT, norteada por perguntas de triagem de elevada sensibilidade e aplicada por uma equipe capacitada, apresentou bom desempenho na vigilância ativa desse EAPV. Entretanto, observou-se uma dificuldade no processo de diagnóstico de EHH, em função das características inerentes a esse evento, chamando atenção para a necessidade de criterios a avaliação dos dados obtidos por vigilância passiva, principalmente, na comparabilidade entre eles. / Objectives: To analyze the advantages and limitations of the case definition for hypotonichyporesponsive episode (HHE) based on the literature review, and the implications for the Postvaccination Adverse Events (VAE) Information System of the National Immunizations Program. Materials and methods: This work is based on data obtained by an active surveillance study of post-vaccination adverse events with the combined diphtheria-tetanus-whole cell pertussis-
Haemophilus influenzae type b vaccine performed in the Rio de Janeiro municipality in 2004
(VIGAT), whose primary objective was to determine the incidence of hypotonic-hyporesponsive
episode (HHE) that began in the first 48 hours after the application of the DTP/Hib vaccine used
by the National Immunization Program in children under the age of 1 year. The performance of
the screening questions for potentials HHE cases performed in VIGAT were analyzed, the
reproducibility of its definition for HHE cases when performed in different evaluation levels, its
positive predictive value, as well as its performance in relation to other case definitions present in the literature, considering in what degree this performance affects adverse events surveillance associated to the DTP/Hib vaccine. A demographic analysis and of the personal antecedents of HHE cases was also accomplished, and of its possible association with vaccine-related factors, its application and other vaccine adverse events (VAE). Results: The frequency of HHE found in VIGAT was 8.1 for 10,000 vaccinated subjects (CI 95% 4.7 –13.0 for 10,000). There was no statistical significance for the association between HHE and the sex of the infant, low birth weight, below normal Apgar index, dosage of vaccine and lots of vaccinal components. Fever equal to or higher than 39°C was considered as risk factor for the occurrence of HHE, having found an association among them with the relative risk of 8.2 (CI 95% = 2.6; 25.7). The predictive positive value for the HHE case definition adopted in VIGAT (2004) for the HHE diagnosis, when used by the local study coordinator was 0.68 (17/25). There was a 100%
agreement in the HHE diagnosis between the Diagnosis Review Group (DRG) and the External
Monitoring Committee (EMC). The Predictive Positive Value (PPV) of the two combined
screening questions was 17/47 (36.2%). The agreement between the HHE case definition of
VIGAT and of Braun et al (1998) was of 0.84 (kappa = 0.68); 0,8 (kappa = 0.61) in relation to
Brighton (2004); 0.84 (kappa = 0.66) for Vermeer et al (2006); and 0.92 (kappa = 0.82) for
Brighton (2007). Conclusions: The case definition for HHE of VIGAT, orientated by screening
questions of high sensibility and applied by a qualified team, presented good performance in the
active surveillance of that VAE. However, a difficulty was observed in the HHE diagnosis
process, due to the inherent characteristics to that event, highlighting the need for a criterial data evaluation obtained by passive surveillance, mainly, in the comparability among them.
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Service Design / Service DesignFišerová, Barbora Unknown Date (has links)
The diploma thesis describes the design of your own web application within the long-term collaborative project co.llaborate.online. In a small team, we reflect on our own workflow and designer work. Currently, the common goal is the design and development of MVP for processing text, images and other graphic material into any graphic output - graphic editor co.design. As part of the project, we have also focused for a long time on the concept of compatible MVPs for text editing or data management and user research. The starting point of co.llaborate.online is the principle of DRY (Don't repeat yourself) and the principles of web technologies. We test how certain workflows can be automated and facilitate the collaboration of designers, text authors, editors, proofreaders, etc., or emancipate users from unnecessary activities.
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