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Generation of foam cells, an essential step for reverse cholesterol transport (RCT) studies, uses the technique of receptor dependent macrophage loading with radiolabeled acetylated Low Density Lipoprotein (Ac-LDL). In this study, we used the ability of a biologically relevant detergent molecule, Lysophosphatidylcholine (Lyso PtdCho), to form mixed micelles with cholesterol or cholesteryl ester (CE) to generate macrophage foam cells. Fluorescent or radiolabelled cholesterol / Lyso PtdCho mixed micelles were prepared and incubated with RAW 264.7 or mouse peritoneal macrophages. Results showed that such micelles were quite stable at 4°C and retained the solubilized cholesterol during one month storage. Macrophages incubated with cholesterol or CE (unlabeled, fluorescently labeled or radiolabeled) / Lyso PtdCho mixed micelles accumulated CE as documented by microscopy, lipid staining, labeled oleate incorporation, and by thin layer chromatography (TLC). Such foam cells unloaded cholesterol when incubated with high density lipoprotein (HDL) and not with oxidized HDL (Ox-HDL). We propose that stable cholesterol or CE / Lyso PtdCho micelles would offer advantages over existing methods. Oxidative stress is associated with heart failure (HF). Previously our research group observed that the patients with low left-ventricular ejection fraction showed accumulation of high level of oxidized LDL (Ox-LDL) when compared with the heart failure patients with normal range of ejection fraction (EF). HDL is known to be atheroprotective and one of its important antioxidative functions is to protect LDL from oxidative modifications. However, HDL itself undergoes oxidation and Ox-HDL becomes functionally poor. It is expected to have a diminished ability to promote reverse cholesterol transport. Therefore, it was hypothesized that the quality of HDL present in the patients with EF would more compromised than those present in the patients with normal EF. Functionality of HDL was evaluated by measuring its cholesterol efflux capacity from foam cells generated in vitro. Functionality of HDL, which is strongly related to the oxidative modifications of HDL was further estimated by measuring paraoxonase 1 (PON1) enzyme activity associated with HDL. Higher the PON1 activity and RCT ability, better is the functionality of HDL.

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Объектом исследования явились психологические особенности созависимых людей. Предметом исследования стали особенности восприятия отца лицами с различной степенью созависимости. Магистерская диссертация состоит из введения, двух глав, заключения, списка литературы (90 источников) и двух приложений, включающих в себя бланк авторской анкеты и результаты математико-статистического анализа. Объем магистерской диссертации 107 страниц, на которых размещены 14 рисунков и 3 таблицы. Во введении раскрывается актуальность проблемы исследования, разработанность проблематики, ставятся цель и задачи исследования, определяются объект и предмет исследования, формулируются основная и дополнительные гипотезы, указываются методы и эмпирическая база, а также этапы проведения исследования, научная новизна, теоретическая и практическая значимость работы. Первая глава включает в себя обзор иностранной и отечественной литературы по теме образа отца и отцовской роли в воспитании ребенка. Представлены разделы, посвященные исследованию влияния на ребенка образа отца и участия отца в воспитании. Выводы по первой главе представляют собой итоги по изучению теоретического материала. Вторая глава посвящена эмпирической части исследования. В ней представлено описание организации и методов проведенного исследования и результатов, полученных по всем использованным методикам: шкала созависимости Б. Уайнхолд, Дж. Уайнхолд (адаптация А. С. Кочарян, Е. В. Фроловой, Н. А. Смахтиной), методика исследования уровня субъективного контроля (УСК), методика «Диагностика межличностных отношений» Т. Лири, методика «Личностный дифференциал» и авторская анкета. Также в главе представлен анализ результатов исследования. Выводы по главе 2 включают в себя основные результаты эмпирического исследования. В заключении в обобщенном виде изложены результаты теоретической и эмпирической частей работы, а также выводы по выдвинутым гипотезам, обоснована практическая значимость исследования и описаны возможные перспективы дальнейшей разработки данной проблематики. / The object of the study was the psychological characteristics of codependent people. The subject of the study was the peculiarities of the perception of the father by persons with varying degrees of codependency. The master's thesis consists of an introduction, two chapters, a conclusion, a list of references (90 sources) and two appendices, including the author's questionnaire form and the results of mathematical and statistical analysis. The volume of the master's thesis is 107 pages, which contain 14 figures and 3 tables. The introduction reveals the relevance of the research problem, the elaboration of the problem, sets the purpose and objectives of the study, defines the object and subject of the study, formulates the main and additional hypotheses, specifies the methods and empirical base, as well as the stages of research, scientific novelty, theoretical and practical significance of the work. The first chapter includes a review of foreign and domestic literature on the subject of the image of the father and the father's role in the upbringing of a child. The sections devoted to the study of the influence of the father's image on the child and the father's participation in upbringing are presented. The conclusions of the first chapter are the results of the study of theoretical material. The second chapter is devoted to the empirical part of the study. It presents a description of the organization and methods of the research and the results obtained by all the methods used: the scale of codependency B. Weinhold, J. Weinhold (adaptation by A. S. Kocharyan, E. V. Frolova, N. A. Smakhtina), the methodology of the study of the level of subjective control (USC), the methodology of "Diagnostics of interpersonal relations" T. Leary, the methodology of "Personal differential" and the author's questionnaire. The chapter also presents an analysis of the results of the study. The conclusions of Chapter 2 include the main results of an empirical study. In conclusion, the results of the theoretical and empirical parts of the work are summarized, as well as conclusions on the hypotheses put forward, the practical significance of the study is substantiated and possible prospects for further development of this problem are described.

The purpose of this study has been to describe and understand the meaning of adult children´s experience of growing up in a family with addiction. The study is based on a lifeworld phenomenological approach where the adult children have been the focus. The data collection consisted of five open interviews, where the adult children gave their experience of their childhood. The result of the study shows that adult children all have experienced the sense of shame/stigma, de-prioritized, a dysfunctional everyday life, a body that reacts and a body that remembers. This has led to various challenges and consequences while growing up, the adult children have handled this differently according to their own abilities and circumstances. It has also resulted in challenges in adulthood, which also have been handled differently depending on the person. Based on the results, it has been possible to understand the importance of preventive work towards families where there is an addiction problem. Something that further needs continuous research to prevent dysfunctional upbringing.

The purpose of this study is to gain insight into how cost control affects physicians’ performance in terms of motivation and dysfunctional behaviour, and their ability to maintain patient safety. In the study, a qualitative method was used and four participants from Danderyd hospital were interviewed with semi-structured questions to gain material to answer the research question. In order to analyse the data, transcriptions of the interviews were made, and a thematic analysis method was used. Based on the analysis, four main themes emerged; Cost control, Motivation, Change in Behaviour and Patient safety. Among the physicians, results showed that physicians’ performance is negatively affected by cost control, resulting in decreased patient safety. Motivation was found to be indirectly affected and dysfunctional behaviours were found to be negatively affected by cost control. Resulting of cost control, physicians cannot fulfil their ethical obligations and perform more poorly because resources are decreased, primarily due to lack of care beds. Furthermore, the findings indicate that patient safety is negatively affected by the influence of cost control on dysfunctional behaviour. There is no adverse effect of cost control on patient safety when it comes to motivation.

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Yes / We examine how ties with multiple host-country political institutions contribute to MNE subsidiary performance in countries with weak formal institutions. We suggest that forging relationships between subsidiaries and host-country government actors, local chieftains, and religious leaders generates regulative, normative, and cultural-cognitive political resources. We integrate institutional and configuration theories to argue that similarity to an ideal configuration of the three political resources contributes to MNE subsidiary performance, and that the more dysfunctional host country institutions, the greater the impact on performance. We test our hypotheses using primary and archival data from 604 MNE subsidiaries in 23 Anglophone sub-Saharan African countries and find support for our hypotheses. In our conclusion we discuss the wider theoretical, managerial, and public policy implications of our findings.