Plinia edulis (Myrtaceae), espécie arbórea popularmente conhecida como cambucá, é nativa da Mata Atlântica brasileira. Apesar do emprego na medicina tradicional em diversas moléstias, incluindo distúrbios gástricos, não existem estudos relacionando as atividades biológicas e os constituintes químicos da espécie. Esta tese relata a avaliação da gastroproteção, da atividade antioxidante, da citotoxicidade e da mutagenicidade do extrato etanol/água de folhas de P. edulis e das frações. Com o objetivo de correlacionar os metabólitos secundários com a eficácia da droga vegetal na medicina tradicional, o extrato foi submetido à partição e posterior fracionamento cromatográfico. O extrato apresentou atividade gastroprotetora significativa em modelo de indução de úlceras por etanol acidificado em ratos em doses de 100, 200 e 400 mg/kg via oral, sendo mais ativo que o fármaco de referência lansoprazol. Entre as frações, a hexânica (100 mg/kg p.o.) foi a mais eficaz, mas apresentou menor atividade do que o extrato bruto. A gastroproteção do ácido ursólico também foi avaliada, mas embora outros triterpenos sejam conhecidos como gastroprotetores, o ácido ursólico (50 mg/kg p.o.) reduziu a área lesionada, mas não apresentou atividade significativa no modelo empregado. O extrato não evidenciou mutagenicidade na concentração de 20 mg/placa no Ensaio de Ames e apresentou atividade antioxidante pronunciada, com CE50 de 5,75 µg/mL no ensaio com DPPH e valor de ORAC de 3.948 µmol de Trolox/g de extrato. O extrato e as frações foram avaliados quanto à citotoxicidade em linhagens de células tumorais humanas de UACC62 (melanoma), MCF-7 (mama), NCI 460 (pulmão), OVCAR03 (ovário), PC-03 (próstata), HT-29 (cólon), 786-0 (rins), NCI-ADR (mama com fenótipo de resistência a múltiplos fármacos) e linhagem de células normais de ovário de hamster chinês (CHO) in vitro. O extrato e as frações apresentaram citotoxicidade seletiva dose-dependente em células cancerígenas e atividade proliferativa em células normais. A partir das frações de hexano e acetato de etila foram identificados β-amirina, lupeol, β-sitosterol, ácido oleanólico, ácido ursólico, ácido maslínico, ácido corosólico, galato de etila, ácido gálico, quercitrina, miricitrina e quercetina por meio de análises espectrométricas. Estes resultados dão suporte à utilização popular desta espécie e estão provavelmente associados à presença dos flavonóides e triterpenos identificados no extrato. / Plinia edulis (Myrtaceae), an arboreous species popularly known as cambucá, is native in Brazilian Atlantic Rain Forest. Despite its traditional uses in many diseases, which include gastric disorders, no reports are available on the relationship between the biological activities of its extract and its chemical constituents. This thesis reports the evaluations of the the aqueous ethanol extract of leaves of P. edulis and its fractions on gastroprotective effect, antioxidant capacity, cytotoxicity and mutagenicity of. In order to correlate the secondary metabolites and the efficacy of the crude drug in traditional medicine, the extract was submitted to solvent partition followed by chromatographic fractionation. The extract exhibited significant gastroprotective effect on HCl/ethanol-induced ulcers in rats at doses of 100, 200 and 400 mg/kg p.o., even more active than the reference drug lansoprazole. Among the fractions, the hexane fraction (100 mg/kg p.o.) was the most effective, but showed lower activity than the crude extract. In addition, the gastroprotective effect of ursolic acid was evaluated. Although others triterpenes are well known as gastroprotective agents, ursolic acid (50 mg/kg p.o.) reduced the lesion area, but did not show significant activity on this model. The extract did not show mutagenicity at the concentration of 20 mg/plate in the Ames test and exhibited high antioxidant activity, with EC50 of 5.75 µg/mL on the DPPH assay and ORAC value of 3948 µmol Trolox/g of extract. The extract and its fractions were evaluated for cytotoxic activity against human tumour cell lines as UACC62 (melanoma), MCF-7 (breast), NCI 460 (lung, non-small cells), OVCAR03 (ovarian), PC-03 (prostate), HT-29 (colon), 786-0 (renal), NCI-ADR (breast expressing phenotype multiple drugs resistance) and CHO (Chinese Hamster Ovary) normal cell line in vitro. The extract and its fractions showed selectively dose-dependent cytotoxicity against cancer cells and proliferative activity in normal cells. The hexane and ethyl acetate fractions yielded β-amyrin, lupeol, β-sitosterol, oleanolic acid, ursolic acid, maslinic acid, corosolic acid, ethyl gallate, gallic acid, quercitrin, myricitrin and quercetin, which were identified based on spectrometric analyses. These results provide scientific support to the traditional use of this species, which are probably associated with the flavonoids and triterpenoids identified in the extract.

Aufgrund der hohen Prävalenz und Inzidenz von berufsbedingten Hauterkrankungen kommt wirksamen primär-, sekundär- und tertiärpräventiven Interventionen eine große Bedeutung zu. Die Beurteilung der Wirksamkeit ist Aufgabe der Evaluationsforschung, deren Güte sich an wissenschaftlichen, forschungsmethodischen Maßstäben und Kriterien bemisst. Das Ziel der vorliegenden Dissertation ist es, durch drei Untersuchungen dazu beizutragen, bestehende Forschungslücken im Kontext der Wirksamkeitsevaluation von Präventionsmaßnahmen in der Berufsdermatologie zu schließen. Hierfür erfolgt eine Untersuchung und Systematisierung des aktuellen Forschungsstandes anhand theoretisch abgeleiteter Kriterien. Analysiert werden das Interventionsziel, die untersuchten Outcomeparameter, das Evaluationsdesign, die Erhebungszeitpunkte sowie die Objektivität, Reliabilität, Validität und Änderungssensitivität der Erhebungsmethode. Basierend auf diesen Analysen werden Forschungslücken abgeleitet und begründet. Dies bildet den theoretischen Rahmen dieser Dissertation. Die drei durchgeführten Untersuchungen zur Evaluation der Wirksamkeit von präventiven Interventionen werden in diesen theoretischen Rahmen eingeordnet und vor dem Hintergrund der identifizierten Forschungslücken der jeweilige Beitrag zum aktuellen Stand der Forschung begründet. Alle drei Untersuchungen weisen konkrete Zielformulierungen sowie darauf abgestimmte Outcomeparameter auf, die sowohl auf der biomedizinischen als auch auf der psychischen und sozialen Ebene verortet sind. Die besondere Stärke von Untersuchung I liegt in ihrem kontrollierten Studiendesign. Aufgrund der Anzahl und Auswahl der Erhebungszeitpunkte schließen die Untersuchungen I und II Forschungslücken hinsichtlich der Untersuchung der Nachhaltigkeit und des Verlaufs des Interventionseffektes. Untersuchung III zeichnet sich durch eine objektive, reliable, valide und änderungssensitive Erhebungsmethode aus. Aus den drei Untersuchungen sowie aus der vorliegenden Dissertation in ihrer Gesamtheit leiten sich zahlreiche Ansatzpunkte für Forschungsdesiderata ab. Es lässt sich subsumieren, dass es langfristig ausgerichteter Evaluationsstudien bedarf, die eine angemessenen Zahl an Einzelerhebungen einschließen und in deren Rahmen objektive, reliable, valide und änderungssensitive Erhebungsverfahren eingesetzt werden. Ferner sollte künftig vermehrt eine Systematisierung der bislang als äußerst heterogen zu charakterisierenden Outcomeparameter erfolgen, indem die Parameter in einem theoretisch begründeten Rahmen verortet werden. Diese Optimierungen der gegenwärtigen Evaluationskultur dienen nicht nur wissenschaftlich-theoretischen Zwecken, sondern tragen langfristig zur Verbesserung der Versorgungsstrukturen mit Blick auf die Primär-, Sekundär- und Tertiärprävention berufsbedingter Hauterkrankungen bei.

This study evaluates a sex education programme administered in an Indian high school. To this end, a literature search, empirical study and qualitative data were used to measure the effectiveness of the Education for Living programme. Adolescents are blamed for having pennissive attitudes, or for indulging in amoral sexual behaviour without considering the consequences. The fact is, sexual development of young people is affected in a fundamental sense by what is taking place around them. Many of the taboos, which operated in society years ago, have disappeared. This study looks into the history of the South African Indian community. In particular, this study focuses on the community's values, attitudes and traditional practices toward sexuality, sex and marriage. It further highlights how the processes of westemisation and modernisation have eroded many of these aspects of traditional Indian culture. The study concludes by examining the emergence of new-found patterns of behaviour and attitudes. It is not the intention of this study to provide any conclusive documentation on the subject of the Indian adolescent. However the major findings of this study have been fommlated as recommendations and implications for further research. Since sexuality is an ever-changing, life-long experience, there is a need for continuous acquisition of accurate sexual knowledge. Carefully designed programmes may serve to allay fears, dispel myths, diminish confusion, enhance communication within families and promote health and wellbeing across generations. / Social Work / M.A. (SS) (Mental Health)

Text in Afrikaans / Hierdie studie het ten doel gehad om die effek van gesinsgeweld op die Suid-Afrikaanse kind te bepaal. Die Opvoedkundig-Sielkundige Relasieteorie is gebruik in die identifisering van die effek van gesinsgeweld op die kind. Die volgende is in die studie bevind: Die geweldsvraelys kan gebruik word om die effek van gesinsgeweld by die kind te identifiseer en ook as hulpmiddel dien vir die terapeut in die verband. Die Opvoedkundig-Sielkundige Relasieteorie kan gebruik word om die effek van gesinsgeweld by die kind te identifiseer. Kinders wat geaffekteer word deur gesinsgeweld toon sterker deursettingsvermoe en wilskrag ten einde 'n sukses te maak van hulle toekoms en om nie in dieselfde omstandighede te beland nie. Seuns en dogters se emosionele ervarings toon weinig verskille. Relasie met ouers in gesinsverband word negatief be"invloed, terwyl relasie buite gesinsverband positief voorkom. Kinders wat geaffekteer word deur gesinsgeweld kan gehelp word, al is dit om die kind te verwyder uit die omgewing asook met terapie, gesinsterapie, ensovoorts. / The study was conducted to determine the effect of family violence on South-African children. The Education-Psychological Relation theory was used to identify these effects. In the literature, the following was concentrated on: The questionnaire can determine the effects of family violence on a child and assist a psychologist in this regard. Education-Psychological Relation theory can determine the effects of family violence on a child. Children affected by family violence show a stronger determination and willpower to succeed in their future and not to stay in similar situations. The emotional experiences of boys and girls show little difference. Relationships with parents are negatively affected, but relationships outside the family circle tend to be positive, Finally, children affected by family violence can be helped, albeit to remove the child from the enviroment and to use psychological therapy, family therapy, ectera. / Educational Studies / M. Ed. (Guidance and Counselling)

Curative primary health care nurses are the first level of contact with health personnel the patient has when entering the district-driven health system of South Africa. It is imperative that these nurses are competent, or patients may suffer. Several factors exist as barriers to competent curative care. Donabedian's structure-process-outcome framework has been used in the study of these factors. Literature were selected from international and national studies of nursing to discover barriers and enablers in general nursing care but also specifically in curative primary health care. The curative primary health care nurses in the Southern Cape/Karoo region were used as a sample for the study. Data gained from questionnaires were organised to present the findings: Barriers to a curative PHC service seem to be multifactorial, with scarce resources causing great stress for the workforce. This have a negative impact on relationships between employer and employee, CPHCNs and their patients, the type of managing that take place, and the quality of the examination and treatment of patients. Slow changes frustrates workers, causing more stress and poor attitudes, feelings of not being valued, and not being motivated (internally and externally). Enablers examined showed that although the workforce may be discontented and overworked, they still try to deliver their best, with few medical mistakes. Patients still have a lot of respect for their healthcare deliverers, but this trend may not continue for much longer. Patients are already returning more often to clinics, causing even more stress for staff. / Health Studies / M.A. (Health Studies)

Thesis (M.Ed. (Voorligting))--Universiteit van Suid-Afrika, 2002.

Summaries in Engish and Afrikaans / The goal of this research is to evaluate whether a personal and social skills program can effectively be implemented by social workers in a prison. A control- and experimental group were used in a quasiexperimental design. The respondents were twenty-four white, male, sentenced prisoners in Pretoria Central Prison. The Heimler scale for social functioning and the Hudson-scale for family relations are the standard questionnaires, which were utilised to measure results during the pre-testing and post-testing phase. All twenty-four respondents completed the scales during the pre- and post-testing phase. The Wilcoxon t-test and Mann-Whitney U-test were used for statistical purposes. A computer was used to process data. Both measurement scales confirmed positive results. The independent variable, that is, the personal and social skills program had an effect in the desired direction on respondents in the experimental group. The Hudson-scale for interpersonal relationships, however, showed more dramatic results. The results for the control group, showed noticeable decline in both social functioning of the respondents as well as experience of family relationships. / Die doel van hierdie navorsing is om te bepaal of maatskaplike werkers in 'n gevangenis 'n persoonlike en sosiale vaardigheidsprogram effektief kan implementeer. 'n Kontrole- en eksperimentele groep was benut in die uitvoering van 'n kwasi-eksperimentele ontwerp. Die proefpersone was vier-entwintig Blanke, manlike gevangenes te Pretoria-Sentraal Gevangenis. Die Heimler-skaal vir maatskaplike funksionering en die Hudsonskaal vir gesinsverhoudinge was die gestandardiseerde vraelyste, wat gebruik is om die resultate tydens voor- en na-toetsing. Die meetinstrumente is deur al vier-en-twintig respondente voltooi. Die Wilcoxon t-toets en Mann-Whitney U-toets is benut vir statistiese doeleindes. 'n Rekenaar is gebruik om data te verwerk. Beide metingskale het positiewe resultate getoon. Die onafhanklike veranderlike, die persoonlike- en sosialevaardigheidsprogram, het 'n effek in die gewenste rigtings gehad op die proefpersone in die ksperimentele groep, hoewel die Hudson-skaal vir gesinsverhoudinge, meer dramatiese resultate getoon het. Die resultate van die proefpersone in die kontrole groep, het merkbare agteruitgang getoon op beide skale. / Social Sciences / M.A. (Social Work)

The need for an Anthropocentric Development Evaluation stems from the inability of development theory and praxis, which has informed the past Development Decades, to ameliorate abject poverty experienced by most people throughout the world. Emanating from a hermeneutical-interpretist epistemology the fundamental argument of an Anthropocentric Development Evaluation is that people and the crucial aspects of their humanity should be the central focus in development and evaluation processes. Thus, taking the people-centred approach to development as its starting point, an Anthropocentric Development Evaluation draws attention to the marginalised, particularly the poor, the rural poor, resource-poor primary producers, women and their households. An Anthropocentric Development Evaluation also argues for an actor-orientation to Development Evaluation to emphasise the situational, yet individual behaviour, of people. Alongside such an approach, lies the significance of culture and people's knowledge for development, as well as the limitations, risks, uncertainties and vulnerabilities people face as a consequence of their humanity. These may influence the extent to which they participate in spontaneous or imposed development initiatives. An Anthropocentric Development Evaluation then comparatively assesses three sets of similar, yet different, methodologies using people and aspects of their humanity described above as the focus for that assessment. The methodologies assessed include Action Research, Social Impact Assessment and the Complementary Rural Development Field Tools. The purpose of doing so is to obtain a suitable medium through which to test the focus of an Anthropocentric Development Evaluation in a development setting. The testing of an Anthropocentric Development Evaluation in a development setting is done first by providing an Anthropocentric Development Evaluation of aspects of life of people living in the community of Nyanyadu in KwaZulu-Natal. Social Impact Assessments using the focus of an Anthropocentric Development Evaluation are then made of two development initiatives in respect of the people of Nyanyadu. These two initiatives are a nutrition and social development programme and the national land reforms. The purpose of all these evaluations is to examine the extent to which people and their humanity are seen to be crucial in development processes. / Development Administration / D.Litt. et Phil. (Development Administration)

The purpose of the study was to explore and describe the perceptions of adolescents about sexuality and sexually transmitted infections, which probably contribute towards the high incidence of sexually transmitted infections amongst this group.The study was designed as a qualitative, exploratory and descriptive research. A focus group interview and unstructured observation were used to collect data, using a nonprobability snowball sample. The group consisted of 12 male and female adolescents residing in a specific geographical area in Pretoria and attending different high schools. Recommendations made focus on: the approach to sex education programmes factors that need to be addressed in order to improve adolescent sexual health empowerment strategies of teachers, parents and community leaders on adolescent sexuality and sexually transmitted infections so that in turn, they should be able to empower adolescents on their sexual roles and thus make informed choices The impact of implementing the recommendations will benefit individuals, families and communities. / Health Studies / M.A.(Health Studies)

Curative primary health care nurses are the first level of contact with health personnel the patient has when entering the district-driven health system of South Africa. It is imperative that these nurses are competent, or patients may suffer. Several factors exist as barriers to competent curative care. Donabedian's structure-process-outcome framework has been used in the study of these factors. Literature were selected from international and national studies of nursing to discover barriers and enablers in general nursing care but also specifically in curative primary health care. The curative primary health care nurses in the Southern Cape/Karoo region were used as a sample for the study. Data gained from questionnaires were organised to present the findings: Barriers to a curative PHC service seem to be multifactorial, with scarce resources causing great stress for the workforce. This have a negative impact on relationships between employer and employee, CPHCNs and their patients, the type of managing that take place, and the quality of the examination and treatment of patients. Slow changes frustrates workers, causing more stress and poor attitudes, feelings of not being valued, and not being motivated (internally and externally). Enablers examined showed that although the workforce may be discontented and overworked, they still try to deliver their best, with few medical mistakes. Patients still have a lot of respect for their healthcare deliverers, but this trend may not continue for much longer. Patients are already returning more often to clinics, causing even more stress for staff. / Health Studies / M.A. (Health Studies)