CONTEXT: Recent studies have considered the role of inflammation in the development of both cardiovascular disease (CVD) and musculoskeletal conditions, such as rheumatoid arthritis. Studies suggest that inflammation plays a significant role in the development of cardiovascular disease. In conditions of chronic pain, as with rheumatoid arthritis, inflammation has also been noted through elevated levels of inflammatory markers. There are currently no studies that examine the possible connection between inflammatory markers related to increased risk of cardiovascular disease and nonspecific chronic musculoskeletal pain (NCMP). OBJECTIVE: The purpose of this study was to determine whether urinary levels of microalbumin (MA) and F2-isoprostanes (F2-isoPs), inflammatory biomarkers associated with increased CVD risk, are elevated in persons with NCMP compared to nonpain case controls. NCMP refers to pain present for more than 3 days per week and for more than 12 weeks. This type of pain is not due to injury but is associated with interference of normal function. DESIGN: Nonrandomized observational study. METHODS: A cross-sectional study with 120 participants (60 pain subjects, 60 nonpain case-controls). A single first-morning void urine sample was collected from each subject. Urine specific gravity and total volume were measured and then a sample was sent to a lab for analysis of MA and F2-isoPs. Inflammatory biomarker levels in the pain and nonpain groups were compared. RESULTS: There were no significant differences in F2-isoPs levels between the chronic pain group (0.65ng/mg ± 0.05) and the nonpain group (0.80ng/mg ± 0.07) (95% CI (-0.32, 0.03)). However, MA levels were significantly higher in the chronic pain group (2.41mg/g ± 0.24) compared to the nonpain group (1.88mg/g ± 0.14) (95% CI (0.34, 1.68)). MACR levels were also significantly higher in the chronic pain group (2.07mg/g ± 0.31) compared to the nonpain group (1.14mg/g ± 0.14) (95% CI (0.32, 1.64)). CONCLUSION: These findings suggest a possible link between at least one inflammatory marker (microalbumin) and NCMP. This in turn allows for a limited but reasonable inference that NCMP may be a risk factor for cardiovascular disease, mediated through the MA inflammatory biomarker. Further research is needed to more fully understand the possible connection between NCMP and CVD.

OBJECTIVE: The purpose of this study was to examine the relationship between strength training and body composition before and after controlling for several covariates. A cross-sectional study including 257 female subjects was conducted. METHODS: Subjects' level of involvement in strength training was determined via questionnaire. Body composition was assessed using dual energy X-ray absorptiometry (DXA). Diet was assessed using 7-d weighed food records. RESULTS: Strong linear relationships between subjects' level of involvement in strength training and body composition were identified. For each additional day of strength training reported per week, body fat was 1.32 percentage points lower (F = 14.8, p = 0.0002) and fat-free mass was 656.4 g (1.45 lb) higher (F = 18.9, p < 0.0001), on average. Likewise, the more time subjects spent lifting and the more intensely they trained, the better their body composition tended to be. Adjusting for differences in age, menopause status, objectively measured physical activity, energy intake, and protein intake tended to weaken each association. Controlling for differences in physical activity weakened each relationship the most. CONCLUSION: Women who strength train regularly tend to have significantly lower body fat percentages and significantly higher levels of fat-free mass compared to their counterparts, regardless of differences in several potential confounding variables.

Downhill treadmill running is a commonly used method to cause exercise-induced muscle damage, especially in rodents. Previous studies have evaluated which muscles in rats are more prone to damage. However research using downhill run mice (DHR) has shown some inconsistencies in which muscle is best analyzed for damage. Purpose: The purpose of this study was to quantify the damage in various muscles in a mouse after a single bout of DHR. Methods: Male FVB mice (5 months) were injected with Evans Blue dye (EBD) and then either used as control (CON) or run downhill (-16°) at 20 meters per minute (m/min) for 30 minutes. Twenty-four hours after exercise, the gastrocnemius, soleus, plantaris, tibialis anterior (TA), quadriceps, and triceps brachii muscles were harvested (n = 6 per group per muscle). Cross-sectional slices were obtained, fixed, and mounted to analyze EBD infiltration, dystrophin (Dys), and centralized nuclei. The samples were then imaged using a fluorescent microscope. The entire sample was captured using 20x magnification, and the total number of cells, EBD+, Dys-, and centralized nuclei, were counted. A blood sample was collected to measure plasma creatine kinase (CK) activity. Results: Total number of cells was not different between groups (p > 0.05). No significant difference in any of the markers of muscle damage was found in any muscle between CON and DHR (p > 0.05). Conclusion: These data suggest that DHR does not induce muscle damage in adult (5 months) male FVB mice.

The contribution of the midfoot in landing mechanics is understudied. Therefore, the main purpose of this study was to quantify midtarsal joint kinematics and kinetics during a barefoot single-leg landing task. A secondary aim of this study was to explore the relationship between static foot posture and dynamic midfoot function. In a cross-sectional study design, 48 females (age = 20.4 ± 1.8 yr, height = 1.6 ± 0.06 m, weight = 57.3 ± 5.5 kg, BMI = 21.6 ± 1.7 kg·m-1) performed drop landings from a height of 0.4 m onto split force platforms. Subjects hung from wooden rings and landed on their dominant leg. Midtarsal joint kinematic and kinetic data were recorded using a motion capture software system in conjunction with a custom multisegment foot model marker set. Arch height index (AHI) for both seated and standing conditions was measured using the Arch Height Index Measurement System (AHIMS). Kinematic data revealed an average sagittal plane midtarsal range of motion (ROM) of 27 degrees through the landing phase. Kinetic data showed that between 7% and 22% of the total power absorption during the landing was performed by the midtarsal joint. Standing AHI was correlated negatively with sagittal plane midtarsal ROM (p = 0.0264) and positively with midtarsal work (p = 0.0212). Standing midfoot angle (MA) was correlated positively with sagittal plane midtarsal ROM (p = 0.0005) and negatively with midtarsal work (p = 0.0250). The midfoot contributes substantially to landing mechanics during a barefoot single-leg landing task. Static foot posture may be a valuable measurement in predicting midfoot kinematics and kinetics.

Sprinters are always looking for an improvement in their time, from the gun going off until the finish. An effective start can lead to reaching top velocity sooner and a decreased finish time. New developments in starting blocks, more specifically the width of the starting block pedal, has allowed for variation in foot placement in the blocks. With the ability to change how wide an athlete can place their feet in the blocks, this study looked at trying to find an optimum spacing for college level sprinters. Thirteen Male College Sprinters (mean age = 23.08 years) participated in this study. Subjects self selected their longitudinal block spacing with 3 different lateral positions being tested. In position 1, the feet were placed as narrow as was allowed by the starting block, simulating the width of a traditional set of blocks. Position 2 was defined by the hip width of the individual, distance between right ASIS to left ASIS. Position 3 was the preferred foot width of the subject as determined by completing a vertical jump. Measurements of peak force on the blocks at the time of the start as well as time to 10 m were taken. Neither peak force nor time to 10 m were different between conditions (p = .887, p = .135). The normal condition, position 1 (20cm), was measured to be the narrowest width with position 3 (mean = 37.6cm) being the widest in all subjects. The use of wider pedals on starting blocks is a fairly new idea in track and field, and is something that many athletes have not had the chance to practice with. Since the older style of starting blocks only allowed for a narrow stance that is what track athletes have become accustomed to and could possibly explain why there was no significant difference seen between the 3 starting positions. More research should be done after a time of adaptation to the new starting blocks by the athletes.

PURPOSE: This study examined the effect of different intensities of acute exercise on attention allocation to visual food cues, postexercise energy intake, and subjective measures of hunger in women. METHODS: This crossover study utilized treatment conditions that were randomized and counter-balanced. Fifty-two adult women, 18-29 years, were compared under three separate conditions: no exercise, 45 min of moderate-intensity exercise at 3.9 METs and 22.5 min of vigorous-intensity exercise at 7.8 METs. To measure attention allocation to visual food cues, participants were shown a passive viewing task consisting of a continual stream of pictures of food (high and low calorie) and nonfood stimuli while brain activity was monitored using an EEG. The late positive potential (LPP) component of the scalp-recorded event-related potential (ERP) was used for data analysis. Postexercise food intake was measured during an ad libitum snack offered at the end of each condition. Subjective ratings of appetite were measured before and immediately after each condition using a visual analog scale (VAS). RESULTS: No significant differences for LPP were found for the condition (no exercise, moderate exercise or vigorous exercise) by picture type (high calorie, low calorie or nonfood) interaction (P = 0.184). Total kcal intake did not differ among the different exercise conditions (P = 0.19). However, even though energy intake did not differ among exercise conditions, low-energy-dense foods were consumed at higher rates compared to high-energy-dense foods after the vigorous (P = 0.0005) and moderate exercise conditions (P = 0.02) compared to the nonexercise condition. Findings from the VAS indicate the moderate exercise session resulted in significantly higher ratings of hunger when compared to the nonexercise (P = 0.04) and vigorous exercise sessions (P = 0.0046). There was also a significant condition (no exercise, moderate exercise or vigorous exercise) by period (pre- or postexercise) interaction found in postexercise ratings of hunger (P = 0.018). The moderate exercise condition reported higher levels of hunger after exercise (P = 0.0002). In addition, findings from the VAS also indicated energy for the moderate exercise condition increased postexercise (P = 0.006) and was higher than either the nonexercise (P = 0.011) or the vigorous exercise conditions (P = 0.017). CONCLUSION: The results of this study demonstrate that an acute bout of moderate exercise may increase subjective hunger and overall energy without increasing the neural response to visual food cues or postexercise energy intake. Furthermore, it also shows that an acute bout of vigorous exercise did not alter neural response to visual food cues, hunger or energy intake postexercise.

The very short-term resistance training (VST) model, utilizing only 2-3 training sessions, has been used to examine early phase skeletal muscle, neural, and performance adaptations. The VST model has previously been used to examine these early phase adaptations in bilateral and unilateral, isometric, isokinetic, and dynamic muscle actions in the limbs of the upper- and lower-body. The bilateral deficit (BLD) is a phenomenon in which the sum of the forces produced unilaterally is greater than the force produced bilaterally during maximal contraction of the limbs. The appearance of a bilateral deficit has been be related to various factors; including training status and mode of training (bilateral versus reciprocal muscle actions). No previous study, however, has examined the effects of VST on the BLD. The VST model has potential implications for examining acute changes in strength and neuromuscular responses of the trained muscles. These adaptations, however, may be specific to unilateral or bilateral training. Therefore, the purposes of this study were to: 1) examine one repetition maximum (1RM) strength and neuromuscular responses (EMG AMP, EMG MPF, MMG AMP, MMG MPF) during the measurement of bilateral and unilateral leg extension exercise before and after dynamic constant external resistance (DCER) VST; 2) examine the magnitude of the BLD; 3) examine the effect of bilateral versus unilateral training on the BLD; and 4) use the neuromuscular responses measured bilaterally and unilaterally to infer about the motor unit activation strategies that may underlie the BLD and changes in 1RM strength. Twenty-four (14 males, 10 females) subjects (mean ± SD age: 23.0 ± 3.2 yr; height: 174.7 ± 8.5 cm; body mass: 75.4 ± 14.1 kg) with no resistance training experience within the last three months were randomly assigned to either the bilateral (BL) training group or the unilateral (UL) training group. The subjects completed a total of seven visits, consisting of a familiarization, pre-test visit, three training visits, and one post-test visit. The pre-test visit was used to record the subject’s electromyographic (EMG) and mechanomyographic (MMG) responses from the right and left vastus lateralis (VL) during bilateral and unilateral seated maximum isometric voluntary contractions (MVIC) and 1RM. Visits four through six were the training sessions, with each subject preforming 5 sets of 6 repetitions utilizing 65% of the 1RM for resistance where the BL group trained both limbs (right and left) at the same time and the UL group trained both limbs separately. Visit seven was the post-test and the same testing procedures as the pre-test visit were followed. Statistical analyses consisted of four-way and three-way mixed model ANOVAs, with follow up three-, two- and one-way repeated measures and/or mixed model ANOVAs, Bonferroni corrected paired, and independent samples t-tests when appropriate. An alpha level of P ≤ 0.05 was considered statistically significant for all ANOVAs. The BL group demonstrated a significant increase (p = 0.006; 6.8%) in BL1RM pre- to post-test, but no change in unilateral summed (US1RM = right + left limb; p = 0.726) 1RM strength. The UL group demonstrated an 8.7% increase in BL strength collapsed across testing mode (BL1RM and US1RM) (p = 0.0001) and UL strength (p = 0.0001) collapsed across limb (UL left + UL right/2) from pre- to post-test. The BL group had a significant (p = 0.001) increase in the BI (indicating a decrease in the BLD) from pre- to post-test, but there was no significant change for the UL group. The BL group demonstrated a significant (p = 0.029) decrease in the EMG mean power frequency (MPF) measurement pre- to post-test, however the UL group showed no change. The unilateral movement, collapsed across limbs (unilateral left and unilateral right) also showed a significant (p = 0.022) decrease in the MMG MPF measurement pre- to post-test, whereas the BL movement showed no change. These findings indicated that BL and UL DCER training increased strength after 3 training sessions. The bilateral DCER training resulted in bilateral, but not unilateral strength increases and unilateral DCER training resulting in both bilateral and unilateral strength increases. However, bilateral training was the only mode of training that significantly decreased the BLD.

Peak barbell velocity is an important determinant of weightlifting performance 2 . However, direct comparisons of this measure between elite men and women weightlifters is limited 7,8 . Therefore, the present study sought to establish a reference of the current status and trajectory of sexbased peak barbell velocity differences among elite weightlifters. This study examined performances of men and women in the 69 kg weight class in order to obviate the influence of body mass on performance. The purpose of this investigation was to help practitioners identify training needs of elite men and women weightlifters to improve weightlifting performance based upon between-group differences in peak barbell velocity.

Previous research has suggested that physical exercise can play a role in not only improving functional performance, but also cognitive function. In this study, adults age 60 and older participated in a health promotion intervention that included two groups: (a) a Bingocize® group, who exercised and learned about relevant health information while playing bingo, and (b) a control group who only learned about relevant health information while playing bingo. The intervention was completed over the course of 10- weeks at community senior centers. Cognitive function, functional fitness, and health knowledge were assessed before and after the intervention to test for improvements. Through the course of the intervention, both the experimental and control groups showed improvements in several areas of cognition as well as functional performance. However, on a few tasks the experimental group showed improvement while the control group did not; specifically, on an updating (cognition) task, and two functional performance tasks (repeated chair stands and arm curls). Both of the groups also showed improvement in knowledge of relevant health information and a measure of patient activation (how confident a person feels in maintaining their personal health). From this, it is suggested that the Bingocize® program may be a promising approach to improving select aspects of cognition and functional performance in older adulthood.

Background: There has been very little research regarding the metabolic health of women during the postpartum period. Metabolic flexibility is the physiological ability to alter substrate oxidation in response to substrate availability and is a good indicator of overall metabolic health. Metabolic flexibility can be assessed by placing metabolic demands on the body and observing metabolic responsiveness- two examples of such metabolic stressors are lipid oxidation rates in response to a high-fat meal and as well as exercise. However, it is unknown whether postpartum women will respond similarly to these two different types of metabolic stressors. This information will allow researchers and clinicians to understand whether postpartum women can be considered more or less metabolically flexible based on one of these tests alone, or if both types of metabolic stress should be incorporated into research designs and/or clinical practice to fully understand one’s metabolic health during this critical time period. Objective: To determine the association between the metabolic responsiveness to a high-fat meal and a 30- minute continuous, moderate-intensity exercise among women during the sixth- month postpartum period. Methods: Seventeen healthy, postpartum women (age: 32 ± 4.5 year; body mass index: 24.74 ± 3.97 kg/m²) participated approximately six months after delivery. Metabolic measurements VO2 and VCO2 (L. min ̄ ¹) were measured and used to calculate the rates of lipid oxidation (g. min ̄ ¹) at baseline, two-hour post consumption of a high-fat meal and during a moderate-intensity exercise for 30-minutes. Results: A correlation was found between the lipid oxidation fold change in response to a high-fat meal and exercise (r= 0.45, p= 0.08; however, it was not statistically significant. There was a significant effect of time on lipid and carbohydrate oxidation rates (p<0.001) during baseline, after consumption of a high-fat meal and during a 30-minute exercise bout. Conclusion: A trending relationship was observed between the metabolic responsiveness to a high-fat meal and a 30-minute moderate-intensity exercise bout among women during the six-month postpartum