The objective of this study was to examine the relationship between intensity of short-range and medium-range capacity management and effectiveness of manufacturing operations. Data were collected to test the null hypothesis which stated that intensity of short-range and medium-range capacity management does not influence manufacturing effectiveness. Intensity of short-range and medium-range capacity management was indicated by the following variables: (1) production standards; (2) priority determination; (3) delivery dates determination; (4) material requirements planning; (5) routing information; (6) capacity utilization; and (7) backlog measurement. Manufacturing effectiveness was indicated by the following variables: (1) delivery dates performance; (2) lead times; (3) subcontract work; (4) direct labor overtime; (5) direct labor efficiency; (6) plant and equipment utilization; and (7) work in process inventory. The population selected to provide data for this study is the manufacturing firms in the State of Texas with five hundred or more employees. Over 42 percent of the eligible firms responded to a six-page questionnaire. Several multivariate techniques were utilized for data analysis: (1) factor analysis; (2) canonical correlation analysis; (3) bivariate correlation; (4) multiple linear regression; (5) cross-tabulation; and (6) analysis of variance. The results of this research did not adequately support the rejection of the null hypothesis. However, they did definitely identify a distinct group of capacity management intensity variables that influence manufacturing effectiveness in specific cases. Intensity variables were placed in three groups that identified how influential they were over the effectiveness measures. The most influential group included the variables: production standards and material requirements planning. The indication for the manufacturing manager is to concentrate on improvements in these areas. Effectiveness variables were also placed in three groups that identified the level at which the variables were influenced by the intensity variables. The highly influenced group included plant and equipment utilization and delivery dates performance.

Whereas general conceptions of Menotti's style are available in various articles, none of the previous writings on this subject have attempted to give a detailed analysis of the techniques and devices used by Menotti in his operas. As has been stated, Menottils greatest asset as a composer of opera is his genius for employing a unique fusion of music and drama. The purpose of this study, then, is to isolate the various concepts and devices of composition used by Menotti and deduce how he has used them to create dramatic impact. The work chosen for this analysis is The Medium, which established Menotti as the foremost composer-librettist of modern opera.1 4 It is felt that this opera offers a cross section of the concepts and devices used in all of the operas composed thus far by Menotti.

This research contributes to the growing body of research on cloud computing and addresses the paucity of research on cloud computing adoption, as well as information systems (IS) and information communication technologies (ICTs) adoption in sub-Saharan Africa. The research addresses the current state of cloud computing adoption in addition to the issues that can encourage or preclude its use by SMEs in sub-Saharan Africa. Further, the research establishes the extent to which cloud computing adoption stimulates small and medium-sized enterprises (SMEs) in sub-Saharan Africa to contribute to development. A qualitative research methodology with an interpretive viewpoint is adopted for this research comprising of two major phases that involved a total of eighteen small and medium sized enterprises (SMEs) in Nigeria. A pilot exploratory study using grounded theory was conducted in the initial phase and the development and refinement of a conceptual framework for analysis and evaluation was carried out in the second phase. The framework is theoretically grounded in the integration of two distinct theoretical traditions, i.e. institutions theory and the capability approach. This is the first research study that employs such a combination to examine cloud computing adoption. This research examines the expectations of cloud users against their fears together with other related influences to draw conclusions regarding the future of cloud computing usage in sub-Saharan Africa. The research found that SMEs considered issues like security, privacy and trust as playing a role in enabling adoption of cloud computing. This is in contrast with SMEs in the global north where these specific issues are discouraging adoption. The research recommends to policy makers and stakeholders interested in developing the cloud infrastructure in sub-Saharan Africa, that there is the need to be cautious in drafting policies (which are non-existent at present). This is in order not to draft policies and regulations with regard to cloud computing usage that will inhibit adoption. Finally, this research presents an incremental model that is used to analyse how cloud service provision was introduced in sub-Saharan Africa. The novel three-stage maturity model identified the incremental approach to the delivery of cloud services in sub-Saharan Africa which started from (i) no local provision, (ii) cloud brokers promoting foreign cloud service provision and (iii) locally-available cloud service provision over a period of three to four years. This research envisages that, with further development of the cloud infrastructure especially in terms of internet connectivity, and improved awareness, more SMEs will adopt cloud computing as part of their IS/ICT strategy.

The drive that initiated this doctoral thesis was the absence of a resource that investigated social trauma’s effect on business ethics; therefore this thesis investigates the relationship between social trauma and business ethics practices aiming to make the first contribution on an academically untouched topic. As in the case of individual psychology, social psychology also examines matters on a case-tocase basis for a clear understanding of the underlying phenomena and complex processes. Hence, considering the past and the current characteristics of Cypriot Turks of North Cyprus, they were chosen as the case study society. In order to explore social trauma’s impact on business ethics, different disciplines were uniquely synthesized through particular lenses; large group psychology, business-government-society relationship and individual ethical decision-making. The absence of previous work in this area suggested exploratory, qualitative research to be the optimum approach. Rich primary and secondary data were collected through interviews, observations, photographs and documents. The resulting data analysis and findings contribute to the current body of research on business ethics, social trauma and business-government-society relationship at the empirical and conceptual levels. The key contribution of this research is to substantiate the link between social trauma and business ethics, and the way social trauma causes unethical behaviour through its effect on the institutions and individual-social interaction. Furthermore, a model of social trauma and business ethics relationship was developed which also provides a framework for potential future research in other social contexts. Even after decades, social trauma can impact on the conduct of business and can interfere with the individual ethical decision-making process in multiple ways; the causes and consequences of this are discussed in depth. The way this impact occurs and its particulars may differ from one large group to another, and this should be noted before the framework is applied to any other society.

This exploratory research considers the difficulties that are associated with understanding market knowledge in a micro firm. The majority of micro firms gain their rewards from mutual beneficial exchange with their customers. The focus of this mutual exchange is often the product that is the basis of their business. The gaining of new customers is often difficult and requires a considerable degree of effort. The standard business approach is to apply cognitive rationality to this task. Some businesses succeed with this approach, but it is possible that other approaches might reveal a greater understanding of the small business situation. Research suggests that small business owners/managers develop tacit utilitarian, cognitively immediate and undetachable knowledge. In a developing business this is contingent with the entrepreneurial task. It can usefully be conjectured that this task is related to the introduction of new business areas. The entrepreneurial task can be seen as involving a qualitative introduction of new business into a market that has not existed before. The situational interplay of these two factors is investigated using a phenomenological research method and deep analysis of a small number of interviews. This research has found evidence that the development of market knowledge in a micro business can result from a leap into a new engagement. The possible grounding for such a leap is explored in the light of the philosophy of Heidegger. Heidegger's philosophy is noted for the exploration of being and time. He adopted hermeneutic and phenomenological approaches to discuss the leap into the grounding question of being. This leap into a new engagement requires a break from the content but not the methods of small business understanding and can be enabled by the developing attunement of the business owner. This is a different method of investigating the nature of market development in the small business. It is expected that this work will be found to be of value when undertaking further research in this business situation.

Exogenous and endogenous cannabinoids have been reported to modulate functional activities of macrophages. It is recognized that macrophages express primarily the CB2 cannabinoid receptor, but recent studies indicate that its expression is differential in relation to activation state with maximal levels occurring when cells are in "responsive" and "primed" states. The functional activities of macrophages when in these states of activation are the most susceptible to the action of cannabinoids, at least in terms of a functional linkage to the CB2. To assess the effect of cannabinoid treatment on macrophage chemotaxis and test the hypothesis that cannabinoids inhibit the chemotactic response of macrophages and microglia to endogenous and exogenous, pathogen-derived stimuli, primary murine peritoneal macrophages and neonatal rat microglia were used. Chemotaxis assays and scanning electron microscopy studies demonstrated that cannabinoids inhibit chemotaxis, a signature activity attributed to "responsive" macrophage-like cells, to the endogenous chemokine RANTES (Regulated upon Activation Normal T-cell Expressed and Secreted) and to Acanthamoeba conditioned medium containing secreted proteases. The partial agonist delta-9-tetrahydrocannabinol (THC), administered in vitro, inhibited the chemotactic response of peritoneal macrophages to the chemokine RANTES and to Acanthamoeba conditioned medium. In vivo treatment with THC also resulted in inhibition of the in vitro chemotactic response of murine peritoneal macrophages to RANTES and amoebic conditioned medium. Pharmacological studies employing cannabinoid receptor agonists and antagonists demonstrated the involvement of CB2 in cannabinoid-mediated inhibition of peritoneal macrophage chemotaxis to RANTES and Acanthamoeba conditioned medium, implying that signaling through cannabinoid receptors may desensitize chemokine receptors. Treatment with cannabinoids had no apparent effect on chemokine receptor mRNA levels, but did enhance CCR5 protein phosphorylation. Macrophage migration to Acanthamoeba conditioned medium may involve activation and signaling through protease activated receptors (PARs), as pathogen-derived proteases have been shown to activate PARs and initiate cellular migration; however, further studies are required to demonstrate PAR activation by amoebic conditioned medium and to assess the effects of cannabinoids on PAR signaling. Acanthamoeba are opportunistic pathogens that cause Granulomatis amoebic encephalitis, an infection of the CNS that is often fatal. THC treatment has been shown to increase mortality to Acanthamoeba infections and is characterized by an absence of granuloma formation. We hypothesize that inhibitory effect of THC on macrophage migration may be a key factor in cannabinoid-mediated immunosuppression. To assess the effect of cannabinoids on microglial migration to Acanthamoeba conditioned medium, chemotaxis assays were performed using primary rat microglia treated with cannabinoids. These studies demonstrated that cannabinoids inhibit microglial chemotaxis to amoebic conditioned medium. Furthermore, the studies demonstrate that cannabinoids, acting through cannabinoid receptors, may cross-talk with a diverse array G-protein coupled receptors so as to modulate responsiveness of macrophage and macrophage-like cells.

This study tests a theoretical model developed to investigate the impact of assimilation of commercial open source enterprise resource planning software (COSES) in small and medium sized enterprises (SMEs). Specifically, the model explains how the top management team’s (TMT’s) information technology (IT) knowledge and experience impact both assimilation and firm performance. The hypotheses were tested using survey data from SMEs that have implemented COSES. Results from structural equation modeling suggest that SMEs benefit, through higher levels of assimilation and performance, from adopting innovative enterprise resource planning (ERP) systems such as COSES when they have a TMT that has experience with and is knowledgeable about technology. The study also highlights the importance of the TMT in facilitating IT assimilation.

The aim of this research is to investigate the influencing factors of price and product policy interdependencies on a standarsided marketing mix management approach within the German foundry industry. The analysis of knowlege of marketing mix management and its processes show that these, despite their benefits, are lacking and have not yet reached marketers' acceptance despite their proven usefulness (Kotler 2009). Scientific discussion is still far from reaching a common agreement on a theoretical model for the management of price and product interdependencies within a standardised marketing mix management approach. Based on a literature review of past empirical work, the author derived factors influencing standardised marketing mix management, discussed their applicability in the case of the German foundry industry and developed a model for standardising the marketing mix management and its price and product policy interdependencies.

L’étude de matériaux thermoélectriques nanocomposites et nanostructurés est en plein essor suite à l’intérêt de multiplier le nombre d’interfaces et de diminuer la taille des objets pour améliorer les performances. Nous avons mis au point une nouvelle méthode de préparation de nanopoudres thermoélectriques de type n (Bi0.95Sb0.05)2(Te0.95Se0.05)3 et de type p (Bi0.2Sb0.8)2Te3, à partir de la fracturation laser en milieu aqueux de poudres de taille micrométrique. La cellule de préparation développée permet d’obtenir par jour environ 200 mg de poudres nanométriques cristallisés présentant la structure cristallographique des poudres initiales et dont la taille moyenne est comprise entre 7 et 12 nm. Les mécanismes mis en jeu dans l’obtention des nanoparticules ont été abordés. Ils dépendent fortement de la densité d’énergie du faisceau laser. Les nanopoudres ont ensuite été mélangées mécaniquement aux poudres micrométriques de même nature et ont été compactées à froid. Les propriétés thermoélectriques (résistivité électrique, pouvoir thermoélectrique, conductivité thermique) des nanocomposites ont été évaluées à température ambiante. Les premiers résultats montrent que même si le pouvoir thermoélectrique est maintenu dans les matériaux nanostructurés et nanocomposites et que la conductivité thermique totale peut, de manière tout à fait exceptionnelle, être diminuée d’un facteur deux, la résistivité électrique obtenue est jusqu’alors trop élevée pour conduire à de bonnes performances en terme de facteur de mérite adimensionnel, par rapport à un matériau massif conventionnel de même composition / The study of thermoelectric nanostructured and nanocomposite materials is expanding because of the interest to multiply the number of interfaces and to decrease the size of the objects in order to improve the thermoelectric performance. We developed a new method to prepare thermoelectric n type (Bi0.95Sb0.05)2(Te0.95Se0.05)3 and p type (Bi0.2Sb0.8)2Te3 nanopowders, from the laser fracture in a liquid medium of powders of micrometric size. The developed cell preparation makes it possible to obtain per day approximately 200 mg of crystallized nanometric powders having the crystallographic structure of the initial powders and whose mean size lies between 7 and 12 nm. The mechanisms concerned in obtaining the nanoparticules were approached. They strongly depend on the density of energy of the laser beam. The nanopowders then were mechanically mixed with the micrometric powders of comparable nature and were cold pressed. The thermoelectric properties (electrical resistivity, thermoelectric power, thermal conductivity) of the nanocomposites were evaluated at room temperature. The first results show that even if the thermoelectric power is maintained in nanostructured and nanocomposite materials and that the total thermal conductivity can, in a completely exceptional way, being decreased by a factor two, the electrical resistivity obtained is hitherto too high to lead to high values of the dimensionless thermoelectric figure of merit, with regard to conventional bulk materials of same composition

L’objet majeur de cette étude est de contrôler la taille de nanoparticules de matériaux à transition de spin (TS), et d’étudier l’influence d’une réduction de taille sur les propriétés de commutation thermique. Plusieurs voies ont été explorées : La première stratégie basée sur la synthèse d’oligomères puis l’assemblage en unités supérieures s’est révélée difficile due à un manque de réactivité. La deuxième approche a consisté à utiliser le confinement moléculaire au sein d’une nanogouttelette pour synthétiser des oligomères de coordination de quelques nanomètres, et mettre en place une véritable “ingénierie moléculaire” en microémulsion. La dernière partie de ce travail est consacrée à la synthèse de particules à TS d’une centaine de nanomètre en milieu micellaire inverse permettant la discussion de l’influence de la taille des particules sur le comportement coopératif. / The main aim of this following study is to control the size of spin crossover nanoparticles, and investigate the influence of size reduction on thermal switch properties. The research has been undertaken along several approaches : Firstly a strategy was developed to build higher dimensionality from synthesized oligomers which revealed difficulties relevant to reactivity. The second approach consisted of using the molecular containment in a nanodrop to synthesize nanometric coordination oligomers and establish a real “molecular engineering” in microemulsion. The last part of this work is devoted to the synthesis of particles with spin crossover property as big as 100 nm in reverse micellar medium allowing the discussion of the interplay of their size with respect to the cooperative behaviour.