京都大学 / 新制・課程博士 / 博士(人間健康科学) / 甲第23828号 / 人健博第99号 / 新制||人健||7(附属図書館) / 京都大学大学院医学研究科人間健康科学系専攻 / (主査)教授 椎名 毅, 教授 杉本 直三, 教授 辻川 明孝 / 学位規則第4条第1項該当 / Doctor of Human Health Sciences / Kyoto University / DFAM

The aim of this work was to understand the physical requirements as well as to develop methodology required to employ Time Resolved Digital Particle Image Velocimetry (TRDPIV) for measuring high speed, high magnification, near wall flow fields. Previous attempts to perform measurements such as this have been unsuccessful because of both limitations in equipment as well as proper methodology for processing of the data. This work addresses those issues and successfully demonstrates a test inside of a transonic turbine cascade as well as a high speed high magnification wall jet. From previous studies it was established that flow tracer delivery is not a trivial task in a high speed high back pressure environment. Any TRDPIV measurement requires uniform spatial seeding density, but time-resolved measurements require uniform temporal seeding density as well. To this end, a high pressure particle generator was developed. This advancement enhanced current capability beyond what was previously attainable. Unfortunately, this was not sufficient to resolve the issue of seeding all together, and an advanced data reconstruction methodology was developed to reconstruct areas of the flow field that where lost do to inhomogeneous seeding. This reconstruction methodology, based on Proper Orthogonal Decomposition (POD), has been shown to produce errors in corrected velocities below tradition spatial techniques alone. The combination of both particle generator and reconstruction methodology was instrumental for successfully acquiring TRDPIV measurements in a high speed high pressure environment such as a transonic wind tunnel facility. This work also investigates the development of a turbulent wall jet. This experiment helped in demonstrating the capability of taking high speed high magnification TRDPIV measurements. This experiment was very unique in that it is one of only a few experiments that studied the developing region of these jets. The Reynolds number ranged for this experiment from 150 – 10,000 which corresponded to velocities of 1 - 80 m/s. The results from this experiment showed good agreement with currently published time averaged data. Using scaling laws for fully developed jets a new scaling law was found for the developing region of the jet that could be applied to all Reynolds numbers in this study. A temporal investigation was also carried out using the temporal coefficients from POD. A vortex identification scheme was also applied to all of the Reynolds numbers showing clear trends as Reynolds number increased. / Master of Science

No / Purpose. To determine whether gait alterations due to monocular spherical lens blur were a safety strategy or driven by lens magnification. Methods. Adaptive gait and visual function were measured in 10 older adults (mean age, 74.9 4.8 years) with the participants' optimal refractive correction and when monocularly blurred with 1.00 DS and 2.00 DS lens over the dominant eye. Adaptive gait measurements for the lead and trail foot included foot position before the raised surface, toe clearance of the raised surface edge, and foot position on the raised surface. Vision measurements included binocular visual acuity, contrast sensitivity, and stereoacuity. Results. Equal levels of monocular positive and negative spherical lens blur led to very different stepping strategies when negotiating a raised surface. Positive blur lenses led to an increased vertical toe clearance and reduced distance of the lead foot position on the raised surface. Negative lenses led to the opposite of these changes. Conclusions. Findings suggest that step negotiation strategies were driven by the magnification effect provided by the spherical lenses. Steps appeared closer and larger with magnification from positive lenses and further away and smaller with minification from negative lenses and gait was adjusted accordingly. These results suggest that previously reported adaptive gait changes to monocular spherical lens blur were not safety strategies as previously suggested but driven by lens magnification. The significance of these findings in terms of prescribing large refractive changes in frail older patients is discussed.

No / Intervention trials that reduce visual impairment in older adults have not produced the expected improvements in reducing falls rate. We hypothesised that this may be caused by adaptation problems in older adults due to changes in magnification provided by new spectacles and cataract surgery. This study assessed the effects of ocular magnification on adaptive gait in young and older adults. Methods: Adaptive gait was measured in 10 young (mean age 22.3 ± 4.6 years) and 10 older adults (mean age 74.2 ± 4.3 years) with the participants' habitual refractive correction (0%) and with size lenses producing ocular magnification of ±1%, ±2%, ±3%, and ±5%. Adaptive gait parameters were measured when participants approached and stepped up onto a raised surface. Results: Adaptive gait changes in the young and older age groups were similar. Increasing amounts of magnification (+1% to +5%) led to an increased distance of the feet from the raised surface, increased vertical toe clearance and reduced distance of the lead heel position on the raised surface (p < 0.0001). Increasing amounts of minification (¿1% to ¿5%) led to the opposite of these changes (p < 0.0001). Adaptation to ocular magnification did not occur in the short term in young or older adults. Conclusion: The observed adaptive gait changes were driven by the magnification changes provided by the size lenses. The raised surface appeared closer and larger with magnification and further away and smaller with minification and gait was adjusted accordingly. Magnification may explain the mobility problems some older adults have with updated spectacles and after cataract surgery.

In the semestral thesis is given basic methods of non-contact measurement heart rate. There is explained Eulerian video magnification method deals with the visualization of the pulse in the videosequence of face. The semestral thesis describes algorithm Viola-Jones face detection in images and algorithm Kanade-Lucas-Tomasi for tracking faces in the videosequence. Part of the work includes design and realization of measurement. There is explained realization of the program and documented execution results, which are discussed. From the results it is designed to guide for optimal recording.

Purpose: To determine whether symptoms of dizziness and fall rates change due to routine cataract surgery and to determine the influence of visual and refractive factors on these common problems in older adults. Methods: Self-reported dizziness and falls were determined in 287 subjects (mean age of 76.5±6.3 years, 55% females) before and after routine cataract surgery for the first (81, 28%), second (109, 38%) and both eyes (97, 34%). Six-month falls rates were determined using self-reported retrospective data. Dizziness was determined using the short-form of the Dizziness Handicap Inventory. Results: The number of patients with dizziness reduced significantly after cataract surgery (52% vs. 38%; χ2 = 19.14 , p < 0.001), but the reduction in number of patients who fell in the 6-months post surgery was not significant (23% vs. 20%; χ2= 0.87, p=0.35). Multivariate logistic regression analyses found significant links between post-operative falls and change in spectacle type (increased risk if switched into multifocal spectacles). Post-operative dizziness was associated with changes in best eye visual acuity and changes in oblique astigmatic correction. Conclusions: Dizziness is significantly reduced by cataract surgery and this is linked with improvements in best eye visual acuity, although changes in oblique astigmatic correction increased dizziness. The lack of improvement in falls rate may be associated with switching into multifocal spectacle wear after surgery.

Les différentes et nombreuses études menées sur le biface depuis le XIXème siècle, révèlent une multiplicité de fonctions potentielles, donnant l’image d’un outil polyfonctionnel. Néanmoins, cette vision est biaisée et découle de l’absence de corrélation entre les données issues des analyses fonctionnelles et la classification typologique en vigueur. Ainsi l’objectif de ce travail est de constituer des groupes d’outils bifaciaux aux potentiels fonctionnels communs et de les rattacher, quand cela est possible, à un mode d’action spécifique. Pour cela, ce travail se propose de corréler les données productionnelles et fonctionnelles par le biais d’une analyse structurelle, expérimentale et tracéologique. Cette dernière a été effectuée aux dépens de 5 séries de bifaces provenant de 4 sites du Sud-Est de la France, datés du Pléistocène moyen. Les résultats obtenus permettent de mettre en évidence neuf groupes de bifaces avec des potentialités fonctionnelles spécifiques. Parmi ces groupes, trois sont corrélés à des fonctionnements eux-mêmes particuliers. Ainsi, pour les sites étudiés, le terme de biface recouvre a minima trois types d’outils : des outils de coupes rentrantes caractérisés par un tranchant d’angle aigu sur un bord en association avec la pointe ; des outils de coupe en percussion lancée caractérisés par un tranchant transversal sur un support avec une base corticale épaisse ; et des outils portant des traces de percussion sur une pointe robuste associée à une base épaisse et corticale, potentiellement destinés à fouir/creuser. Il apparaît ainsi que, dans le Sud-Est de la France au Pléistocène moyen, le biface n’est pas un outil polyfonctionnel. Le terme recouvre ici plusieurs groupes d’outils bifaciaux aux potentialités fonctionnelles diverses. Deux fonctionnements principaux - translation longitudinale et percussion lancée indirecte - sont associés à des outils bifaciaux présentant des morphologies spécifiques. Il est possible d’observer un usage du façonnage bifacial différent en fonction des gisements. Les différents outils bifaciaux ne sont pas tous représentés de la même manière, reflétant des contraintes extrinsèques ou intrinsèques et ajoutant de la variabilité à la définition de l’Acheuléen. / Since the XIX century dinstinct and numerous studies on bifaces reveal a multiplicity of potential function, giving the impression of a multifunctional tool. However this vision is biased and come from the absence of correlation between data from functional analyses and data from typological classification. Thus the objective of this work is to compose bifacial tool group depending from them potential function and when it’s possible to link them to a specific action.For this purpose, this works intend to correlate productional and functional data by structural, experimental and traceologic analyses. The latter has been done on 5 biface serie from 4 sites in the South-East France, dated from the Middle Pleistocene.Achieved results highlight nine biface groups with specific functional potentiality. Among these groups, three are correlated with particular function. Thus, for the site studied, the term biface cover a least three tools type: “coupe rentrante” tools characterize by an acute angle edge on a board associated with the tip; cutting tools in pitched percussion characterize by a transversal edge on a support with a thick cortical base; and tools bearing percussion marks on a robust tip associate to a thick and cortical base, potentially aim to dig.In the South-East France during the Middle Pleistocene the biface doesn’t appears to be a multifunctional tool. This term cover here different bifacial tool group with diverse functional potentiality. Two principal functions – longitudinal translation and indirect pitch percussion- are associate to bifacial tools presenting specific morphology. It is possible to observe a different use of the bifacial “faconnage” depending the deposit. Bifacial tools are not represent in the same way, reflecting extrinsic or intrinsic constraint and adding variability for the Acheulean definition.

This research was designed to address important issues for the effective prescription of, and training in the use of, magnifiers for reading patients with visual impairment. The emphasis was on the development of simple methods of assessment and training that could be easily implemented, at no great cost, by low vision practitioners in clinical practice. To ensure that the results would be widely applicable, the research focused on subjects with age-related macular degeneration (AMD) using stand magnifiers (being the most common cause of low vision and the most commonly prescribed magnifiers respectively). From this research, modifications to the current methods of reading rehabilitation are suggested to more effectively improve low vision reading for the millions of people with low vision around the world. The magnification and reading performance achieved with the magnifier determined by the fixed acuity reserve method was as valid as that achieved with the magnifier determined by the individual acuity reserve method. The fixed acuity reserve is a simpler method to calculate the required magnification, as it requires only near visual acuity and the patient's goal reading task. This method was primarily used to select the appropriate illuminated stand magnifiers for the subjects participating in the subsequent studies and is recommended for use as the starting point in clinical low vision practice. The main study of this thesis was a longitudinal investigation of the benefit of large print reading practice on reading performance with stand magnifiers. Instead of the intensive training programs on magnifier use which have been suggested by previous studies, this study aimed to investigate the effect of simple large print reading practice, under either full or restricted field of view (the latter simulated by a practice stand), on reading rate with stand magnifiers for subjects with AMD. The experimental hypothesis was that reading practice prior to the prescription of stand magnifiers would improve reading performance with the stand magnifiers for subjects with AMD. As previous studies have shown, reading rate reduced when a stand magnifier was first introduced. One week of reading practice on large print, with or without a reduced field of view, gave an improvement in reading rate with the stand magnifier for passages of text (such that the reading rates with and without magnifiers were not significantly different). There was a suggestion that this practice may give a more rapid improvement in reading rate than that achieved by the control subjects who did not do any large print reading practice, but this did not reach statistical significance. Even very brief reading with the stand magnifiers by the control subjects gave some improvement in reading rate. Therefore, home or in-office reading practice on large print or with magnifiers is recommended for patients with AMD before magnifiers are prescribed. Subjects who had neither reading practice nor exposure to the magnifier prior to its prescription required two weeks practice using their stand magnifiers to achieve their maximum reading rate. This suggests that home practice in using stand magnifiers is beneficial and a follow up visit is recommended two weeks after the provision of a magnifier to assess any change in reading rate. If no improvement in the magnifier reading rate is found or the rate is less than the reading rate on large print without a magnifier, further investigations of the patients' vision and/or their magnifier manipulation strategy are necessary. In the last study, a simple method aimed at alleviating difficulties with magnifier manipulation and navigation, the attachment of a line guide to the base of the stand magnifier, was investigated using both objective methods (recording magnifier movements and reading rate measures) and subjective methods (simple questionnaire). Although there was no improvement in the objective measures of reading or navigation performance with the line guide, more than half of the subjects with low vision preferred to have the line guide on their stand magnifiers. This suggests that the objective measures might not be sensitive enough to predict the subjective response, or that other factors that were not measured in this study influenced subjects' preferences in selecting the line guide (e.g., psychological support provided by the line guide in reading orientation). Clinically, the subjective response of patients to the use of low vision aids as well as their motivation are important criteria for success in low vision rehabilitation. There was a tendency for less experienced users to prefer the line guide to assist their use of the stand magnifier for reading. Therefore, a line guide could be offered as a preliminary training aid when stand magnifiers are first prescribed for AMD patients. Possible improvements to the design of the line guide were identified. Further research is required to assess the benefits of this or similar devices for new magnifier users and to understand the difficulties that people with visual impairment have with page navigation in order to determine improved methods of training navigation strategies. The unique contribution of this study to the field of low vision rehabilitation is that the benefit of short-term reading practice, on large print or with magnifiers, as simple, cheap methods of enhancing reading performance with stand magnifiers was demonstrated. The results of this study have led to the development of recommendations for assessing and training AMD patients who are prescribed stand magnifiers.

Heart Rate Variability (HRV) analysis has been garnering attention from researchers due to its wide range of applications. Medical researchers have always been interested in Heart Rate (HR) and HRV analysis, but nowadays, investigators from variety of other fields are also probing the subject. For instance, variation in HR and HRV is connected to emotional arousal. Therefore, knowledge from the fields of affective computing and psychology, can be employed to devise machines that understand the emotional states of humans. Recent advancements in non-contact HR and HRV measurement techniques will likely further boost interest in emotional estimation through . Such measurement methods involve the extraction of the photoplethysmography (PPG) signal from the human's face through a camera. The latest approaches apply Independent Component Analysis (ICA) on the color channels of video recordings to extract a PPG signal. Other investigated methods rely on Eulerian Video Magnification (EVM) to detect subtle changes in skin color associated with PPG. The effectiveness of the EVM in HR estimation has well been established. However, to the best of our knowledge, EVM has not been successfully employed to extract HRV feature from a video of a human face. In contrast, ICA based methods have been successfully used for HRV analysis. As we demonstrate in this thesis, these two approaches for HRV feature extraction are highly sensitive to noise. Hence, when we evaluated them in indoor settings, we obtained mean absolute error in the range of 0.012 and 28.4. Therefore, in this thesis, we present two approaches to minimize the error rate when estimating physiological measurements from recorded facial videos using a standard camera. In our first approach which is based on the EVM method, we succeeded in extracting HRV measurements but we could not get rid of high frequency noise, which resulted in a high error percentage for the result of the High frequency (HF) component. Our second proposed approach solved this issue by applying ICA on the red, green and blue (RGB) colors channels and we were able to achieve lower error rates and less noisy signal as compared to previous related works. This was done by using a Buterworth filter with the subject's specific HR range as its Cut-Off. The methods were tested with 12 subjects from the DISCOVER lab at the University of Ottawa, using artificial lights as the only source of illumination. This made it a challenge for us because artificial light produces HF signals which can interfere with the PPG signal. The final results show that our proposed ICA based method has a mean absolute error (MAE) of 0.006, 0.005, 0.34, 0.57 and 0.419 for the mean HR, mean RR, LF, HF and LF/HF respectively. This approach also shows that these physiological parameters are highly correlated with the results taken from the electrocardiography (ECG).

One of the basic problems in computer vision is motion detection and analysis in a given scene. This work focuses on detecting small changes in the image by using the moiré phenomenon. The main goal of this thesis is to detect different types of dislocations with algorithms used in computer vision. In this work synthetically created pictures are analysed, which were created with the mathematical model of a pinhole camera.