Orientador: Maria Aparecida Marques dos Santos Mezzacappa / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-23T19:17:08Z (GMT). No. of bitstreams: 1 Pepino_VanessaCarina_M.pdf: 2632459 bytes, checksum: 83013924ad476cd5cf3c0fa14cffd64d (MD5) Previous issue date: 2013 / Resumo: INTRODUÇÃO: O uso de Terapia Manual (TM) tem aumentado muito nos últimos anos, assim como os estudos científicos nesta área. Porém ainda há pouca comprovação sobre os mecanismos fisiológicos das TM, assim como sua eficácia nos tratamentos. OBJETIVO: O objetivo deste estudo foi identificar os tipos de TM utilizadas em pacientes pediátricos com doenças respiratórias e analisar de forma padronizada a qualidade dessas evidências. MÉTODO: Foi feita uma análise da metodologia dos trabalhos seguindo a Escala PEDro de avaliação, que pontua a qualidade metodológica de ensaios clínicos em fisioterapia, dando uma nota de 0-10. Foi realizada uma pesquisa em três bases de dados, SciELO, PEDro e Medline, buscando por ensaios clínicos que utilizassem algum tipo de TM como intervenção em pacientes pediátricos com doenças respiratórias. Dois avaliadores independentes analisaram os títulos, depois os resumos e selecionaram para estruturação desta revisão os que preencheram os critérios de seleção. RESULTADOS: Foram encontrados 1147 artigos somando as três bases de dados, dos quais 103 foram escolhidos para leitura do resumo e apenas 24 selecionados para leitura do texto na íntegra. Destes, apenas oito preencheram os critérios de inclusão. Dos 16 que foram excluídos, sete não estudaram o tema pesquisado, oito tiveram como amostra pacientes adultos e um tinha como intervenção técnicas de fisioterapia convencional. Dos oito artigos incluídos nesta revisão, cinco envolveram crianças com asma, e o restante com doenças como fibrose cística, bronquiolite e infecções respiratórias recorrentes. Em seis dos oito estudos, algum benefício foi observado com o uso de TM como tratamento coadjuvante, como diminuição de ansiedade, melhora da função pulmonar e da qualidade de vida. Porém, a qualidade metodológica dos estudos mostrou-se deficiente, segundo a escala PEDro de avaliação, sendo que apenas um estudo teve nota acima de cinco. CONCLUSÃO: Mesmo havendo evidências favoráveis, os resultados foram inconsistentes por conta da qualidade metodológica, da pequena quantidade de estudos e pela ausência de homogeneidade entre eles, o que justifica a continuidade das investigações nesta área. Sugere-se para estudos futuros seguir protocolos de pesquisa padronizados , preocupando-se com a qualidade metodológica, para que as indicações destas modalidades terapêuticas sejam baseadas em evidências fortes. / Abstract: INTRODUCTION: Use of Manual Therapy (MT) has increased greatly in recent years, as scientific studies in this area. But there is still little proven about the physiological mechanisms of TM, as well as its effectiveness in treatments. OBJECTIVES: The objective of this study was to analyze the articles found on MT applied in pediatric patients with respiratory diseases, and identifies the types of MT used. METHOD: An analysis of the methodological quality was assessed following the PEDro Scale Assessment, which analyzes the methodological quality of clinical trials in physiotherapy, giving a score of 0-10. We conducted research in three databases, SciELO, MEDLINE and PEDro, looking for trials that used some kind of MT as an intervention in pediatric patients with respiratory diseases. Two independent reviewers examined the titles, abstracts and then selected for the structuring of this review that met the selection criteria. RESULTS: 1147 articles were found by summing the three databases, of which 103 were selected for abstract assessment, and 24 were selected for full text assessment. After a critical analysis, only eight were included and 16 were excluded (seven have not studied the selected subject, eight had as a sample adult patients and one was about conventional physiotherapy). Of the eight studies included in this review, five involved asthmatic children, and the remainder involved children with other pulmonary diseases such as cystic fibrosis, bronchiolitis and recurrent respiratory infections. In six of the eight reports some benefit was observed with the use of MT, such as anxiety reduction, improvement in lung function and quality of life. However, the methodological quality of the studies was found to be deficient, according to PEDro's Assessment Scale and only one study score above five. CONCLUSION: Even though there is positive evidence, the results were inconsistent because of the lack of good-quality studies, the small number of studies and the absence of homogeneity between them, which justifies the continuation of investigations in this area. Future investigations should focus on following guidelines, worrying with methodological quality of the study, so the indications of the treatments associating MT with conventional therapy for pediatric patients with respiratory disease are based on strong evidence. / Mestrado / Saude da Criança e do Adolescente / Mestra em Ciências

Effect of Ankle and Foot joints mobilization on Stability improvement, analyzed by Computerized Dynamic Posturography. The aim of the study was to observe if joint mobilization of ankle and foot joints would improve the stability using the by Computerized Dynamic Posturography (neurocom) as a measurement tool. The methods that are used from the research are based on the knowledge which was obtained during the study of physiotherapy program at FTVS UK. All the participants are between the ages of 20 to 30 years, with no specific diagnose. All the 40 participants were being randomly divide into 2 groups. The control group and the experimental group, each group will have their Stability tested twice on the CPD (NeuroCom). The control group will be measured first, and after 20 minutes they will be measured again without any examination or therapeutic intervention. The experimental group was measured twice, first before the examination of joint play and the therapy, then the examination of joint play was done and any restricted joints were noted and treated, later, the participants were measured again for possible improvement. Joint play examination and therapy take about 20 minutes. Stability analyses take about 20 minutes too. The project doesn't include subjects with severe lower extremity injuries (eg,...

Background: Emerging evidence suggests that cervical and thoracic joint manipulations may be advocated in treating patients with shoulder pain. Objectives: To determine the acute effects of cervical, cervicothoracic, and thoracic joint manipulations on outcomes of self-reported pain and pain pressure threshold in experimentally induced shoulder pain. Design: Repeated measures. Methods: Twenty (20) healthy volunteers were tested on two sessions. Session 1 consisted on baseline assessment of pain pressure threshold testing over the infraspinatus bilaterally and self-reported shoulder pain using the shoulder pain and disability index (SPADI) pain scale. An isokinetic exercise protocol was used to induce delayed onset muscle soreness. In session 2 (24-48 h later), all variables were reassessed before and immediately after a combination of cervical, cervicothoracic and thoracic manipulations. Results: SPADI pain scale scores were significantly different between time points (p < 0.001): the exercise protocol significantly increased reported pain [mean increase 14.1, p < 0.001] while the manipulation significantly decreased reported pain (mean decrease 5.60, p < 0.001)) although pain remained higher than baseline levels. Pain pressure threshold differences were also found between time points (p = 0.001): manipulation significantly increased pain threshold bilaterally (p < 0.001) similar to baseline levels. Conclusions: Cervical, cervicothoracic, and thoracic joint manipulations acutely increased pain pressure threshold and decreased self-reported shoulder pain in participants with experimentally induced shoulder pain. Physiotherapists may consider the combination of such techniques to achieve short-term hypoalgesic effects and facilitate the application of more active interventions.

Objectives: To determine the subacute effects of cervicothoracic spinal thrust/non-thrust in addition to shoulder non-thrust plus exercise in patients with subacromial pathology. Methods: This was a randomized, single blinded controlled trial pilot study. This trial was registered at ClinicalTrials.gov (NCT01753271) and reported according to Consolidated Standards of Reporting Trials requirements. Patients were randomly assigned to either shoulder treatment plus cervicothoracic spinal thrust/non-thrust or shoulder treatment-only group. Primary outcomes were average pain intensity (Numeric Pain Rating Scale) and physical function (Shoulder Pain and Disability Index) at 2 weeks, 4 weeks, and patient discharge. Results: 18 patients, mean age 43.1(15.8) years satisfied the eligibility criteria and were analyzed for follow-up data. Both groups showed statistically significant improvements in both pain and function at 2 weeks, 4 weeks, and discharge. The between-group differences for changes in pain or physical function were not significant at any time point. Discussion: The addition of cervicothoracic spinal thrust/non-thrust to the shoulder treatment-only group did not significantly alter improvement in pain or function in patients with subacromial pathology. Both approaches appeared to provide an equally notable benefit. Both groups improved on all outcomes and met the criteria for clinical relevance for both pain and function. Level of Evidence: 2b.

Background: Osteoarthritis (OA) in the knee is one of the most common joint diseases in the world. The symptoms include local joint pain, joint stiffness, crepitation etc. Treatment follows national clinical guidelines which includes patient education, exercise and weight loss. Manual therapy can be used as an additional treatment and has shown a positive effect on pain, range of motion (ROM) and function but the method is not studied enough. Purpose: To investigate the effect of manual mobilization with the OMT Nordic System method as a complement to exercise and patient education for patients with knee OA on pain, Quality of Life (QoL) and ROM. Method: A Single subject experimental design study with 4 participants was conducted. Participants underwent a standardized patient education followed by a 6-week baseline of physical exercise, then a 3-week intervention phase which added manual therapy of the knee joint two times a week for the entire phase. The data was analysed regarding changes in both trend and level. Result: All participants had a significant positive change in level of pain and one participant had a positive change in trend. QoL varied among the participants, two had no change in level, one had a significantly positive change and one had a significantly negative change. Only one participant had a positive change of trend in QoL. ROM increased significantly in level in three out of four participants and the trend changed positively among two of the participants Conclusion: This study indicates that OMT Nordic system as a complement to physical exercise and patient education have a positive effect on pain and ROM in patients with knee OA in the short term. However, since not both level and trend were all over significant the result lacks in significance. Due to the study’s design the results should not be generalized on a group level. To be able to draw general conclusions further studies needs to investigate the effect of the OMT Nordic System with more participants and in different settings.

No description available.

Low Back Pain (LBP) is a condition that most people experience at least once in their lifetime and for which many will seek physiotherapeutic intervention. Recently published and internationally recognised clinical guidelines for the management of LBP recommend the use of spinal manual and manipulative therapy techniques alongside exercise, advice, education and pharmaceutical therapies, particularly in the early stages. Other areas of development in the last decade include classification systems, clinical prediction rules (CPR’s), patient-reported outcome measures (PROMS’s) and minimum clinically important difference (MCID) thresholds. Additionally, sympathetic nervous system (SNS) measures of treatment responses are now recognised as providing quantifiable indicators of peripheral, spinal and central effects of manual therapy interventions although research in the lumbar spine is very limited with none providing data on a patient population. The aims of the study were; to determine the reliability and stability of the Biopac System in recording skin conductance (SC) activity levels and calculate the smallest real difference (SRD) statistic; to generate data on the magnitude of SC response to two commonly utilised treatments for LBP; and to observe the changes in a clinical population receiving guideline-endorsed physiotherapy treatment for the management of acute and sub-acute LBP. Furthermore, clinical data analysis sought to identify correlations of SC measures to PROM’s and evaluate the feasibility of using SC responses as a predictive tool for therapeutic outcome. The ability of the Biopac System to reliably record SNS activity was established by using SC measurements with 12 participants on two occasions, one-week apart. Data was recorded within a natural, non-laboratory setting. Results established that SC measurements could be reliably recorded between data sessions with a measurement variability of; ICC=0.99 (p<0.005) with an SRD value of 0.315 μmho’s (4.633%). In conclusion, any SC change above the SRD could be regarded as an SNS change that is independent of any measurement error or variability thus representing a real change ascribable to the intervention under investigation. The pre-clinical investigation compared the magnitude of SC response (SCR) of two, independently administered, specific MT techniques, applied, after randomisation, to the Lumbar 4/5 segment of 50 asymptomatic healthy volunteers. Treatments included; a rotatory lumbar manipulation technique or a repeated McKenzie extension in lying exercise. Findings revealed that both techniques produced statistically significant changes in SNS activity in the lower limbs (> SRD) with manipulative technique SCR’s (76%) that were twice the size of the McKenzie repeated extension in lying exercise (EIL) technique (35.7%)( p=0.0005). Only the manipulation technique had a lasting effect that was carried into the final rest period (p=0.012) but the SNS response was not a side-specific phenomenon (p= 0.76). The final clinical study recruited 60 acute and sub-acute LBP patients (symptoms of up to 12 weeks duration) who received guideline-recommended physiotherapy treatment within a hospital-based musculoskeletal out-patient physiotherapy department. SCRs were recorded throughout all treatment episodes with standardised, validated PROM’s used for comparison of status at inception, mid-point and at discharge. Functional impairment was determined using the Oswestry Disability Index (ODI) and the Roland Morris Disability Questionnaire (RMDQ) with pain intensity evaluated with the Narrative Pain Rating Score (NPRS). A preliminary comparison, between the asymptomatic population and a random selection from the patient population, revealed that patients had treatment SCR’s that were significantly greater (three-fold) than those of the asymptomatic groups (manipulation, p=0.003; EIL exercises p=0.001). Analysis of the patient data indicated that pre-treatment/baseline SC activity levels in the inception data capture point were lower than at discharge (18 µMho’s; p<0.0005) but, conversely, that treatment SC levels were initially high, but diminished in magnitude by discharge (230 to 172 µMho’s; p<0.0005) representing a SCR reduction of 125%. Correlational analyses of change scores of maximum SCR’s to PROM’s, from inception to discharge suggested weak positive correlations of SCR treatment responses to functional disability score improvements (rho 0.278) and pain intensity reductions (rho=0.229) that were significant for function (p=0.033) but not significant for pain (p=0.080). The final analyses indicated that there were trends in the magnitude of response to specific elements of treatment with manipulation having the largest SCR (266%). Further evaluative analysis of SC readings as a predictor, at inception, of functional outcome, at discharge indicated that a critical/cut-off value of 195% may indicate those patients least and most likely to respond positively to MT treatment. Preliminary logistic regression analysis indicated that the 195% SCR value was excellent at identifying poor responders but less successful at identifying good responders, functionally, to treatment. Nonetheless, SCR was a better predictor of outcome than duration of symptoms and patient age. Characteristically, patients achieving the 195% value were most likely to have higher functional disability and pain intensity scores at inception but by discharge had required fewer treatments, had greater overall functional improvement and lower pain intensities than those not achieving this threshold. In conclusion, SC activity levels and SCR’s may be a reliable, stable, alternative and objective measure of LBP patients’ SNS status and changes that occur as a result of symptom abatement throughout a course of physiotherapy treatment. SC readings may (indirectly) reflect the state of dorsal horn (DH) sensitisation and of the central nervous system (CNS) processing system and its facilitatory capacity to activate the descending pain inhibitory system (DPIS). Further research, in patient populations (including chronic LBP patients), is recommended to verify these findings and validate the 195% SCR cut-off point. Definitive RCT’s are indicated to further the understanding of guideline-endorsed physiotherapy treatment (a complex intervention –MRC, 2000) and to determine whether the SNS activity measurements can be used to help classify, predict, and ultimately, direct the care of patients with LBP.

Ankle sprains are among the most common injuries sustained by physically active individuals. Although ankle sprains are often considered innocuous in nature, a large percentage of individuals experience repetitive sprains, residual symptoms, and recurrent ankle instability following a single acute sprain; otherwise known as chronic ankle instability (CAI). In addition to repetitive ankle trauma, those with CAI experience reductions in functional capacity over the life span. This indicates that current intervention strategies for CAI are inadequate and require further investigation. The objective of this dissertation was to explore differences in walking and running gait parameters between individuals with and without CAI; as well as, examine the effects of a 2-week Maitland Grade III anterior-to-posterior talocrural joint mobilization intervention on self-reported function, ankle mechanics, postural control, and walking and running gait parameters in a cohort of individuals with CAI. It was hypothesized that individuals with CAI would exhibit different gait kinematics and joint coupling variability patterns compared to healthy individuals and the joint mobilization intervention would improve patient-oriented, clinician-oriented, and laboratory-oriented measures of function in those with CAI. Several observations were made from the results. In the first study, alterations in single joint kinematics and joint coupling variability were found between those with CAI and healthy individuals. In the second study, it was determined that the joint mobilization intervention improved patient-oriented and clinician-oriented measures of function as indicated by improved Foot and Ankle Ability Measure scores, increased weight-bearing dorsiflexion range of motion, and increased reach distances on the Star Excursion Balance Test. However, there were no changes in measures of instrumented ankle arthrometry or laboratory measures of postural control. In the third study, there were no changes in single joint kinematics or joint coupling variability during walking and running associated with the joint mobilization intervention. It can be concluded that joint mobilizations had a significant positive impact on patient-, and clinician-oriented measures of function. Though the laboratory measures did not detect any improvements, joint mobilizations did not produce deleterious effects on function. Therefore, future investigation on the effects of joint mobilization in conjunction with other, more active, rehabilitation strategies is warranted.

O Diabetes Mellitus (DM) é uma doença de grande prevalência, e um dos principais problemas de saúde pública em todo o mundo, tendo como complicações o déficit no desempenho funcional dos membros inferiores, que podem interferir na manutenção do equilíbrio, além de ser um forte preditor de limitações funcionais. Os indivíduos acometidos pelo diabetes apresentam predisposição à redução da mobilidade da articulação tíbio-társica. A terapia manual é frequentemente utilizada com a finalidade de melhorar a amplitude de movimento. O objetivo do estudo foi avaliar o efeito agudo da terapia manual na mobilidade articular do tornozelo de pacientes diabéticos. Foram avaliados 40 voluntários, de ambos os sexos com média de idade de 59,35±7,85 anos, portadores de DM tipo 2 com limitação da amplitude da articulação tíbio-társica, divididos em dois grupos: grupo Sham (GS), submetido a tratamento simulado e follow up de sete dias, e grupo intervenção (GI), submetido a intervenção manual manipulativa e follow up de sete dias. A análise da amplitude de movimento articular foi efetuada por meio de goniometria digital, e a descarga estática de peso avaliada por baropodometria computadorizada com olhos abertos e fechados. A distribuição dos dados foi avaliada pelo teste de normalidade de Shapiro-Wilk. Diante de uma distribuição normal e relacionada, foram utilizados os testes ANOVA seguido de pós-hoc de TuKey. Para as variáveis que apresentaram distribuição não normal, foi utilizado o teste Kruskal-Wallis, seguido do pós-hoc de Dunn. Foi utilizado software estatístico SAS e considerado nível de significância de 5%. Os resultados demonstraram aumento da amplitude de movimento articular, nas flexões plantares e dorsiflexões, direita e esquerda, do GI entre o momento inicial e os momentos pós-manipulação, bem como após sete dias da intervenção terapêutica (follow-up). Também houve diferença significativa entre o GI quando comparado ao GS nos momentos pós e follow-up. Com relação ao efeito clínico da intervenção ao longo do tempo, a análise intragrupo mostrou que no GS não ocorreu diferença entre os registros de amplitude de movimento comparando-se o momento pré-intervenção com os registros subsequentes (pós e follow-up), tanto para os movimentos de flexão plantar como de dorsiflexão, em ambos os lados. Em relação a descarga de peso plantar estática verificou-se alteração de valores registrados para o pico de pressão total no pé, dos lados direito e esquerdo no GI, entre os momentos pós-intervenção imediata e na aferição 7 dias após a intervenção manipulativa (follow-up), para registro com olhos abertos. Com relação às comparações intragrupos ao longo do tempo (pré, pós-intervenção e follow-up), foi observada diferença significativa para a condição amplitude de deslocamento anteroposterior (DAP) com olhos abertos do GI, observando-se incremento após a intervenção e redução no followup. Diante dos resultados obtidos, pode-se inferir que a intervenção aguda com terapia manual produz incremento da amplitude articular do tornozelo de indivíduos diabéticos. / Diabetes Melittus (DM) is a disease of great incidence, and one of the main public health problems worldwide, having as complications the deficit in the functional performance of the lower limbs, which can interfere in the maintenance of the balance, besides being a Strong predictor of functional limitations. Individuals affected by diabetes are predisposed to reduce the mobility of the tibial-tarsal joint. Manual therapy is often used for the purpose of improving range of motion. The objective of this study is to evaluate the acute effect of manual therapy on ankle joint mobility in diabetic patients. 40 volunteers, aged 59,35±7,85 years, DM type 2 and tibial-tarsal joint amplitude limitation, of both genders were recruited, divided into two groups: group 1 (Sham: submitted to evaluations and follow up of seven days), and group 2 (intervention: submitted to the evaluations, manipulative manual intervention, with follow up of seven days). The analysis of joint range of motion was acessed by digital goniometry and the static discharge of weight was evaluated by baropodometry computed with open and closed eyes. After tabulation of variables, the Shapiro-Wilk normality test was applied to analyze the distribution. Before a normal and related distribution, ANOVA followed by Tukey post-hoc tests were used. For the variables that presented a non-normal distribution, the Kruskal-Wallis test was used, followed by the Dunn post-hoc test. For the variables that presented a non-normal distribution, the Kruskal-Wallis test was used, followed by the Dunn post-hoc test. The SAS software was used and a significance level of 5% was considered. The results showed an increase in joint range of motion, in the right and left dorsiflexions of the GI between the initial moment and the postmanipulation moments, as well as after seven days of the follow-up. There was also a significant difference between GI when compared to GS in the post and follow-up moments. Regarding the clinical effect of the intervention over time, the intragroup analysis showed that in GS there was no difference between the amplitude of movement registers comparing the pre-intervention moment with the subsequent records (post and follow-up), even for plantar and dorsiflexion flexion movements on both sides. In relation to static plantar weight discharge, there was a change in recorded values for the peak of total foot pressure, on the right and left sides of the GI, between the moments after the immediate intervention and in the measurement 7 days after the manipulative intervention (follow -up), for registration with open eyes. Regarding intra-group comparisons over time (pre, post-intervention and followup), a significant difference was observed for the condition amplitude of anteroposterior displacement (DAP) with open eyes of the GI, observing an increase after intervention and reduction in the follow-up. In view of the obtained results, it can be inferred that the acute intervention with manual therapy produces an increase in the joint amplitude of the ankle of diabetic individuals

A migrânea está relacionada às disfunções das estruturas da coluna cervical, impulsos aferentes desse local podem ser facilitadores ou mesmo gatilhos da dor. Tratamentos com manipulação cervical isolada e combinada a medicação já foram testados, porém os resultados são conflitantes. O objetivo desse trabalho foi avaliar o efeito adicional da fisioterapia ao tratamento medicamentoso da migrânea na frequência, intensidade e duração da dor de cabeça. Foram inclusas mulheres com migrânea, na faixa etária de 18 e 55 anos, com mínimo de 06 dias de dor por mês, e que apresentasse dor na região craniocervical através do relato. Cinquenta mulheres foram igualmente randomizadas para um dos dois grupos de tratamento, Grupo Fisioterapia (terapia manual + medicação) e Grupo Controle (medicação). O diagnóstico de migrânea foi realizado por uma única neurologista, segundo a Classificação Internacional de Cefaleias. Foram realizadas 12 sessões de terapia manual, duas vezes por semana, durante 50 minutos, por uma única fisioterapeuta. A avaliação, a reavaliação e follow-up foram cegos. Os desfechos primários de frequência, intensidade e duração da dor de cabeça, foram avaliados por meio do diário de dor; e secundários, Limiar de dor por pressão (Algômetro), incapacidade relacionada à cefaleia (Migraine disability assessment program) e a coluna cervical (Neck disability índex), Patient Health Questionnaire eight-item depression scale (PHQ-8), alodinia com Allodynia Sympton Checklist (ASC- /12) e satisfação com Patients Global Impression of Change Scale (PGIC). A análise foi realizada por intenção de tratamento e foi utilizado o Modelo Linear de efeitos mistos e para atribuir relevância clínica o Effect size (ES) e Mínima mudança importante (MID). Não foram observadas diferenças entre os grupos na avaliação inicial. O GF apresentou redução de 37% na frequência de dias de dor de cabeça comparado ao GC que apresentou 22% (p<0.05 e ES 0,4) e (p<0.05 e ES 0,3) respectivamente. Não foram observadas diferenças clínicas significativas entre os grupos na duração e na intensidade da dor de cabeça. Também foi observado aumento significativo (p<0,05) do limiar de dor por pressão, bem como maior satisfação e percepção de mudança da doença ao paciente (p<0,05) no GF em comparação ao GC. Não foram observadas diferenças significativas nos demais parâmetros avaliados. A redução do limiar de dor dos músculos cervicais com o tratamento fisioterapêutico promoveu um efeito benéfico adicional ao medicamentoso, com maior redução da frequência de dias de dor de cabeça e maior satisfação e percepção de melhora dos pacientes. REBEC nº RBR-6kvx74 / Migraine is related to disorders of the cervical spine structures, afferent impulses that location can be facilitators or even triggers pain. Treatments with cervical manipulation alone and combined medication have been tested, but results are conflicting. The aim of this study was to evaluate the additional effect of physical therapy to drug treatment of migraine in frequency, intensity and duration of headache. Women with migraine were included, aged 18 to 55 years, with a minimum of 06 days of pain per month and report of pain in the craniocervical region. Fifty women were equally randomized to one of the two treatment groups, Physiotherapy Group (manual therapy and medication) and control group (medication). The diagnosis of migraine was performed according to the International Classification of headache by a single neurologist. All subjects received similar medications. 12 sessions of manual therapy, twice per week, during for 50 minutes, were done by same physical therapist. The assessment, revaluation and follow-up were blind. The primary endpoints of frequency, intensity and duration of headache were evaluated through diary pain, and secondary endpoints like pain threshold pressure (algometer), headache related disability (Migraine disability assessment program) and cervical spine (Neck disability index), patient Health Questionnaire eight- item depression scale (PHQ-8), with the severity of Allodynia Sympton Checklist (ASC-12) and patients Global Impression of Change Scale to assess satisfaction and perception of patient changes as its disease condition. The analysis was by intention to treat and we used the linear mixed effects model. To assign the clinical relevance Effect size (ES) and Minimum important change (MID) were used. No differences between groups were observed at baseline. The PG showed a 37% reduction in the frequency of headache days compared to GC showed that 22 % (p<0.05 to ES0.4) and (p<0.05 to ES0.3) respectively. No clinically significant differences were observed between groups regarding the duration and intensity of the headache. Significant increase (p<0.05) pain threshold pressure was also observed, as well as greater satisfaction and changing perception of the disease to the patient (p<0.05) in the PG compared with the CG. No significant differences were observed in the other parameters. The reduction of the pain threshold of cervical muscles with physical therapy promoted a beneficial additional effect to medication, with greater reduction in frequency of headache days and greater satisfaction and perceived improvement of patients. REBEC no RBR - 6kvx74