The enterprise systems are built with a monolithic way of software architecture which may not be the very suitable and realistic solutions, due to the quantity and diversity of Internet of Things (IOT) devices connected to the internet. The large code is based as a single deployable unit; making it cumbersome and difficult to change, test, and deploy – typically in the monthly deployment cycles. Which could potentially be a large impact and high-risk for updates and deployment build up between releases.  The thesis aims to exploit Microservices Architecture in context of the Internet of Things. Because of scalability and rapid deployment, Microservices Architecture (MSA) naturally fits for M2M and IOT developments. Therefore, it has become increasingly popular and highly suited as a design choice in the context of developing IOT applications. We have proposed various ontologies for conceptual architecture designs. Our conceptual model encompasses all the essential elements and entities that constitute IOT; describing various characteristics of microservices and consideration to be used as a basis for developing a Reference Architecture model. The reference architecture is effectively exploiting Microservices Architectural Style for a diverse set of things composition like sensor devices, connectivity and transportation protocols for IP enabled IOT smart objects.  The thesis will contribute to the conceptual space of more successful reference architectures. The goal is to provide features and deployment information with instantiation guidelines to derive the software architecture instances in a given IOT application domain. Thus, it promises to become a valuable framework in the derivation of the Microservices IOT architectures.

Lösenord är viktiga för att skydda användare från otillåten åtkomst till deras tjänster. Sådana tjänster kan både innehålla olika former av personlig information som bankkonto eller streaming tjänster. I denna studie kombineras funktionalitet av två tidigare segmenteringsalgoritmer för att skapa en ny segmenteringsalgoritm kallad Moses Segmenteringsalgoritm (MSA). Efteråt evalueras styrkan av lösenord skapade av användarna med hjälp av två databaser med läckta lösenord, samt användarnas upplevelse av en valideringstjänst som innehåller MSA. Algoritmen jämförs även med Googles lösenordskrav. Resultatet av studien visar på att lösenord som skapats med hjälp av MSA blir aldrig svaga, samt att användarna tycker att lösenord är lätta att skapa. Däremot upplevdelite mer än hälften av användarna att de inte skulle komma ihåg lösenordet med MSA. Användarna ansåg inte alltid att deras lösenord var säkert, även om lösenordet klassificerades som säkert enligt Nordpass lösenordsmätare. / <p>Stavningsjusterad titel: Utvärdering av valideringstjänst för lösenord byggd på segmenteringsalgoritm</p>

Syftet med detta arbete är att utifrån skrivtest och enkäter undersöka elevernas skrivförmåga, nämligen hur arabisktalande elever klarar att använda standardarabiska vid skrivning med hänsyn till fonologisk medvetenhet och vokalisering.De viktigaste resultaten av vårt arbete är att vi fann stora brister hos eleverna gällande skrivning på standardarabiska (MSA). Fonologiska stavningsfel var mer vanliga än andra stavningsfel bland eleverna. Resultaten har också visat att majoriteten av de testade eleverna inte kan differentiera när de skriver enkla satsdelar, såsom subjekt och direkt objekt. De i undersökningen deltagande modersmålslärarna håller med om betydelsen av användandet av MSA som bas i modersmålsundervisningen för utveckling av skriftspråket hos eleverna. Genom testen och enkäterna fick vi fram intressanta resultat om skrivundervisningen i modersmålundervisningen i arabiska och vi fick fler tankar om hur man kan utveckla undervisningen.

No description available.

Platinum-based drugs are an important group of alkylating-like agents which are used in cancer chemotherapy treatment. Cisplatin and oxaliplatin in particular are still commonly used today and are the focus of this thesis. As with most chemotherapy drugs, the efficacy of these drugs are limited by toxicity as well as tumour resistance, and therefore by increasing our understanding of these areas it is hoped to one day achieve personalised chemotherapy. The use of ICP-MS in the study of bio-sciences is still relatively new, however it has the ability to provide robust, fast and accurate methods for the quantification of platinum in biological samples. The research presented here utilised mass spectrometry in the study of the formation of Pt-DNA adducts in the clinical samples, the binding of oxaliplatin to short peptides and the effect of selenium supplementation on oxaliplatin in colorectal cancer cell lines. A comparison in the number of Pt-DNA adducts in saliva and leukocyte samples obtained from patients undergoing Pt-based chemotherapy demonstrated a lack of correlation between the two sample types. Samples were taken pre- and post-treatment and analysed via SF-ICP-MS and significant inter-patient variability was observed as expected. In both leukocyte and saliva samples, not only was Pt from previous chemotherapy cycles observed, but Pt was detected in the DNA in both sample types 1 hour after treatment. However a lack of correlation between platinum levels seen in the blood and saliva, combined with unexpected difficulties obtaining patient adherence to the saliva sampling protocol, indicated that saliva does not at present offer a reliable alternative to leukocytes for this assay. The binding of oxaliplatin to short nitrogen and sulfur rich peptides was investigated. Platinum binding to the peptides was observed and no significant differences in the level of binding were observed between the range of N and S rich peptides studied in this investigation. Partly due to the inability to reproduce biological conditions in this study, oxaliplatin was observed as a whole molecule, and furthermore dimers and multimers were also observed. The effect of selenium supplementation on the total cellular uptake of platinum was investigated in cultured cells via ICP-MS and LA-ICP-MS. It was observed that selenium decreased the amount of Pt taken up by the cancer cells. This was seen in analysis of populations of cells as well as by single cell analysis. Furthermore, while problems were encountered measuring selenium in subcellular experiments, the effect of selenium on the subcellular distribution of platinum as well as the number of Pt-DNA adducts could be determined.

A group of small GTPases consist of over twenty protein families in the super class P-loop. It has a very diverse cell functions. Small GTPases regulate the formation of vesicular follicles, cytoskeleton and nuclear transport. They participate also on cell proliferation and signaling. The aim of my work is to find important amino acids that define family and distinguish each other. I focus on families Arf, Rab, Ran, Ras and Rho. At the Rho family I am also devoted to classes Rho, Rac and Cdc42. Amino acids are identified using bioinformatic programs selected Consurf and Sca5. The objective is also to test P2RANK specialized tool developed at the Charles University in Prague that predict ligand binding sites from protein structure in different families. Founding amino acids can have a big role in the functional divergence of individual families and classes of small GTPases and can be the basis for future study example for the proliferation of cancerous cells. 1.1 Keywords Powered by TCPDF (www.tcpdf.org)

Le présent travail se propose de décrire les propriétés thermodynamiques des solutions d'intérêt industriel. Notre modèle s'appuie sur un travail antérieur (N. Papaiconomou et al.), combinant la théorie Mean Spherical Approximation (MSA) pour décrire les interactions électrostatiques à longue portée et le modèle NRTL (très populaire en génie chimique), pour celles qui sont à courte portée. Par rapport à ce précédent travail, nous avons de plus pris en compte l'effet de solvatation ionique, à l'aide de deux modèles différents : (a) celui de Stokes et Robinson impliquant un nombre de solvatation constant (en fonction de la concentration du sel) ; (b) une solution procédant d'équilibre réactionnels avec les molécules d'eau, résultant en un degré de solvatation variant avec la concentration de sel. De plus, nous avons cherché à décrire les équilibres L-V pour des solutions aqueuses et de mélanges de solvants, pour des températures allant de 25°C à 100°C.

This research project analyzes the beef grading system in Australia. Firstly, the Meat Standards Australia (MSA) grading system as a potential value-creating and value chain-coordinating mechanism is investigated. In-depth interviews with value chain stakeholders and industry experts suggest that the implementation of the MSA grading system has had a catalytic effect of moving value chains toward a greater level of coordination. The concept of best value supply chains is also used as a benchmark in determining MSAs effect on value chain performance. Secondly, using a survey of Australian consumers, findings suggest that the MSA certification is perceived as a trustworthy signal for tenderness and quality, reducing information asymmetry at the consumer level. This thesis then addresses the questions of whether or not it is necessary to use a grading system in consumer marketing (e.g. quality label) in order to be successful in terms of adding value to the industry. / Agricultural and Resource Economics

No description available.

For the purpose of an future machine vision system development in Tyco Electronics Czech s.r.o. I have developed Cognex Designer template. Template will serve as a flexible basis for further development of camera applications on the Cognex VC5 industrial computer. The functionality of the program template has been successfully verified by modifying it to a particular application of the laboratory manual station used to measure the parameters of the manufactured connectors. A camera with lens and lightning was chosen and installed on the station. DIO communication was put into operation between VC5 and PLC system. The application has been calibrated and verified as a measurement system using MSA Type I and Capability study standard methods.