Le but de ce travail a été de proposer des méthodes d'inférence pour décrire l'histoire naturelle de la phase pré-diagnostic de la démence. Durant celle-ci, qui dure une quinzaine d'années, les trajectoires de déclin cognitif sont non linéaires et hétérogènes entre les sujets. Pour ces raisons, nous avons choisi un modèle à changement de pente aléatoire pour les décrire. Une première partie de ce travail a consisté à proposer une procédure de test pour l'existence d'un changement de pente aléatoire. En effet, dans certaines sous-populations, le déclin cognitif semble lisse et la question de l'existence même d'un changement de pente se pose. Cette question présente un défi méthodologique en raison de la non-identifiabilité de certains paramètres sous l'hypothèse nulle rendant les tests standards inutiles. Nous avons proposé un supremum score test pour répondre à cette question. Une seconde partie du travail concernait l'ordre temporel du temps de changement entre plusieurs marqueurs. La démence est une maladie multidimensionnelle et plusieurs dimensions de la cognition sont affectées. Des schémas hypothétiques existent pour décrire l'histoire naturelle de la démence mais n'ont pas été éprouvés sur données réelles. Comparer le temps de changement de différents marqueurs mesurant différentes fonctions cognitives permet d'éclairer ces hypothèses. Dans cet esprit, nous proposons un modèle bivarié à changement de pente aléatoire permettant de comparer les temps de changement de deux marqueurs, potentiellement non gaussiens. Les méthodes proposées ont été évaluées sur simulations et appliquées sur des données issues de deux cohortes françaises. Enfin, nous discutons les limites de ces deux modèles qui se concentrent sur une accélération tardive du déclin cognitif précédant le diagnostic de démence et nous proposons un modèle alternatif qui estime plutôt une date de décrochage entre cas et non-cas. / The aim of this work was to propose inferential methods to describe natural history of the pre-diagnosis phase of dementia. During this phase, which can last around fifteen years, the cognitive decline trajectories are nonlinear and heterogeneous between subjects. Because heterogeneity and nonlinearity, we chose a random changepoint mixed model to describe these trajectories. A first part of this work was to propose a testing procedure to assess the existence of a random changepoint. Indeed, in some subpopulations, the cognitive decline seems smooth and the question of the existence of a changepoint itself araises. This question is methodologically challenging because of identifiability issues on some parameters under the null hypothesis that makes standard tests useless. We proposed a supremum score test to answer this question. A second part of this work was the comparison of the temporal order of different markers changepoint. Dementia is a multidimensional disease where different dimensions of the cognition are affected. Hypothetic cascade models exist for describing this natural history but have not been evaluated on real data. Comparing change over time of different markers measuring different cognitive functions gives precious insight on this hypothesis. In this spirit, we propose a bivariate random changepoint model allowing proper comparison of the time of change of two cognitive markers, potentially non Gaussian. The proposed methodologies were evaluated on simulation studies and applied on real data from two French cohorts. Finally, we discussed the limitations of the two models we used that focused on the late acceleration of the cognitive decline before dementia diagnosis and we proposed an alternative model that estimates the time of differentiation between cases and non-cases.

This study was undertaken to establish whether rights of personality are known in indigenous law. Since indigenous law differs not only between tribes but is also affected by the degree of exposure to Western values, a micro-study has been done in a semi-rural environment in the Kingdom of Swaziland to establish to what extent own value systems have been influenced or altered when Western legal concepts are utilised. The information, obtained by interviewing a panel of experts, was compared with the available literature. During the process of gathering information, the aims of the research were not only to describe how the legal principles function, but also to take note of those socio-cultural processes which function outside of the law. Rights of personality were studied against a background of the culture and way of life of the peoples concerned. The importance of culture has been acknowledged in the Constitution of the Republic of South Africa, wherein the recognition and application of indigenous law generally rests on a constitutionally protected right to culture. Whilst the identifiable rights of personality may generally be classified according to specialised legal systems, the separation of rights to good name and to dignity may be inappropriate in the indigenous sphere. Dignity in indigenous legal systems is to be viewed as a comprehensive right of personality, into which should be subsumed the right to good name and reputation in the community. It is such dignity, embracing the ubuntu quality of humanness that is protected as a comprehensive indigenous right of personality. Although the indigenous law of personality is showing some signs of adapting to new developments, there is also proof that the established legal principles and human values are being retained. However, these changes are unique and are neither typically traditional nor Western. The indigenous law of personality, operating in a changing social environment, has to retain its flexibility and adaptability in order to remain ”living” law for the peoples concerned. / Jurisprudence / LL.D.

競爭風險之下對邊際分配的估計，是許多領域中常遇到的問題。由於主要事件及次要事件互相競爭，只要一種事件先發生即終止對另一事件的觀察，在兩事件同時發生的機率為0之下，連一筆完整的資料我們都無法蒐集到。除非兩事件互為獨立或加上其它條件，否則會有邊際分配無法識別的問題。但是獨立的條件在有些情況下並不合理，為解決相依競爭風險之邊際分配無法識別的問題，可先假定兩事件發生時間之間的關係。 由於關聯結構定義出兩變數間的結合關係，我們可利用關聯結構解釋兩事件發生時間之間的關係。假定兩變數之相關性參數為已知，且採用機率積分轉換的觀念，本論文討論了Zheng 與 Klein提出的關聯結構-圖形估計量，是否會依設限程度、相關性強度和關聯結構形式的不同，以致估計能力有別。 / The problem of estimating marginal distributions in a competing risks study is often met in scientific fields. Because main event and secondary event compete with each other, and a first occurring event prevents us from observing another event promptly, the intact lifetimes or survival times are unable to be collected in the circumstances that the probability of both lifetimes coinciding is 0. Unless lifetimes being independent or adding other conditions, there is a problem that the marginal distributions are non-identifiable. But the condition of independence is not always reasonable, we may assume the relation between lifetimes has some special form Because the copula defines the association between two variables, it can be employed to explain relation between lifetimes. Assuming that the dependence parameter in the copula framework is known, and adopting the concept of the probability integral transformations, this thesis has demonstrated whether the estimating abilities of the copula-graphic estimator, that Zheng and Klein put forward, are different in rates of censoring, intensities of dependence, and forms of the copula.

This study was undertaken to establish whether rights of personality are known in indigenous law. Since indigenous law differs not only between tribes but is also affected by the degree of exposure to Western values, a micro-study has been done in a semi-rural environment in the Kingdom of Swaziland to establish to what extent own value systems have been influenced or altered when Western legal concepts are utilised. The information, obtained by interviewing a panel of experts, was compared with the available literature. During the process of gathering information, the aims of the research were not only to describe how the legal principles function, but also to take note of those socio-cultural processes which function outside of the law. Rights of personality were studied against a background of the culture and way of life of the peoples concerned. The importance of culture has been acknowledged in the Constitution of the Republic of South Africa, wherein the recognition and application of indigenous law generally rests on a constitutionally protected right to culture. Whilst the identifiable rights of personality may generally be classified according to specialised legal systems, the separation of rights to good name and to dignity may be inappropriate in the indigenous sphere. Dignity in indigenous legal systems is to be viewed as a comprehensive right of personality, into which should be subsumed the right to good name and reputation in the community. It is such dignity, embracing the ubuntu quality of humanness that is protected as a comprehensive indigenous right of personality. Although the indigenous law of personality is showing some signs of adapting to new developments, there is also proof that the established legal principles and human values are being retained. However, these changes are unique and are neither typically traditional nor Western. The indigenous law of personality, operating in a changing social environment, has to retain its flexibility and adaptability in order to remain ”living” law for the peoples concerned. / Jurisprudence / LL.D.

企業因為經濟自由化、貿易國際化潮流之影響，逐漸成為資本集中與技術密集之經營型態。為求擴充生產規模、增加產品種類、分散投資風險、拓展國際市場等目的，因而成立新公司或兼併其他公司，或購買其他公司之股份，或母公司與子公司交叉持股，而形成關係企業之組織型態，已成為普遍趨勢。職是，關係企業之經濟發展與經營模式，已然占有重要之地位。 關係企業具有特殊屬性，舉凡管理組織、生產規劃、人事制度、市場行銷、財務風險、獲利能力、公共事務與社會歸屬，均有相當程度之影響力。我國公司法對於關係企業專章之規範，仍有不足之處，導致受一九九八年亞洲金融風暴影響所及，爆發若干關係企業之經營弊端，其中以股票流通市場之證券交易違法行為，最為嚴重。綜觀其原因，除肇始於東南亞金融危機及國際不景氣環境外，亦顯示關係企業在股票市場存有許多問題，諸如負責人欠缺誠信、掏空公司資產，造成企業發生危機，發生多起上市或上櫃公司之經營弊端，嚴重損害公司、股東權益與債權人利益，並衝擊社會投資人與整體經濟，值得探討研究。 本論文研究方向，以法制理論、比較法學及實證案例為基礎，論述關係企業證券交易之違法行為，以股票流通市場為中心，並闡述近年來若干重要之關係企業案例，分析法院裁判之論處法律邏輯。包括關係企業之市場操縱行為（違約交割、沖洗買賣、相對委託、連續交易炒作行為）、關係企業「護盤」之違法性、關係企業之內線交易行為，等重要項目。亦討論關係企業藉由無形資產之高估或低估而買賣有價證券之非常規交易行為，兼述國際會計準則公報之規範，佐以實際案例研究。此外，亦闡論關係企業財務預測制度與證券交易違法行為之牽連、證券投資人之保護。 本論文內容之參考文獻資料，包括學位論文（例如前輩先進之博碩士論文）、教授學者之著作書籍、著名期刊與國內外網站資訊。所參考資料則以我國與美國法制文獻為主，至於其他國家之部分，則略以要旨參酌。最後，再針對作者執業律師參與關係企業案例之辯護瞭解，提出若干防弊機制之建議，俾供各界參考。 / UNLAWFUL ACTS BY AFFILIATED ENTERPRISES RESPECTING SECURITIES TRANSACTIONS WITH A FOCUS ON THE STOCK EXCHANGE MARKET Abstract Due to the impact of economic liberalization and trade internationalization, operations of enterprises have gradually become capital-intensive and technology-intensive. In order to increase production, expand product line, spread out investment risks, and develop international markets, enterprises have established new companies, merged with others, and purchased shares of other companies, or have engaged in cross-holding of shares between parent companies and subsidiaries. As a result, the formation of affiliated enterprises has become a popular trend. The economic development and business model of affiliated enterprises have likewise become important issues. Affiliated enterprises have their unique attributes; their management organization, production planning, personnel policy, marketing, financial risks, profitability, public affairs, and social affiliation have significant impact on enterprises. Due to inadequacies in the regulations on affiliated enterprises in Taiwan’s Company Law, several affiliated enterprises were exposed to have engaged in fraudulent business operations as a result of the 1998 Asian financial crisis. Among these, most serious were cases involving unlawful securities transactions in the stock market. An analysis of the factors leading to such anomaly shows that in addition to the Southeast Asian financial crisis and international economic slowdown, problems caused by of affiliated enterprises in the stock market, such as integrity and credibility issues on the part of the persons-in-charge and their swindling of company assets, resulted in corporate crises. Many incidents of business malpractices in public or OTC companies occurred, severely undermining the interests of companies, shareholders, and creditors, as well as those of the public investors and the overall economy. All these are worthy of further exploration and study. This paper uses legal theories, comparative jurisprudence, and empirical studies to discuss the unlawful activities in securities transactions by affiliated enterprises. This paper focuses on the stock market to explain the major cases involving affiliated enterprises in recent years and to analyze the legal grounds in the court’s decision on punishment. The cases covered include market manipulation by enterprises, default of securities delivery, wash sales, matched order, manipulation of series of transactions, the unlawfulness of stock market intervention by affiliated enterprises, and insider trading by affiliated enterprises. In addition, this paper discusses the transaction anomalies resulting from overvalue or undervalue of intangible assets by affiliated enterprises. Regulations on the International Accounting Standards gazette are explained and supplemented by actual case studies. In addition, this paper explores the inter-relation between financial forecast systems in affiliated enterprises, unlawful activities in securities transaction, and investor protection. Reference literature used in this paper includes academic dissertations, publications by professors and scholars, periodicals, and information from local and foreign Web sites. Reference materials are based primarily on literature on Taiwan and U.S. laws, supplemented by summary of information from other countries. Finally, recommendations of mechanisms to prevent malpractices are put forward, drawing on the author’s experience as defense lawyer for affiliated enterprises.