L'autorenouvellement est une propriété fondatrice du concept de cellule souche. Cependant, malgré l'avancée des connaissances actuelles, les mécanismes moléculaires sous-jacents restent mal compris. Nous nous sommes donc intéressés à cette question, en étudiant l'équilibre entre autorenouvellement et différenciation dans des progéniteurs érythrocytaires primaires. D'une part, grâce à une étude combinant des approches pharmacologiques et de génétique fonctionnelle, nos résultats montrent que le contrôle de la synthèse cellulaire du cholestérol joue un rôle essentiel dans la régulation du basculement de l'autorenouvellement vers la différenciation. D'autre part, nous avons étudié la nature stochastique de l'expression génique au cours du passage de l'autorenouvellement vers la différenciation. En effet, contrairement au caractère déterministe initialement attribué à l'expression des gènes, les données accumulées au cours des dernières années démontrent que cette expression repose sur des processus stochastiques. Nous avons en particulier oeuvré à la conception et à la mise en place d'un dispositif permettant de suivre en temps réel l'expression génique dans des cellules individualisées, afin de pouvoir mesurer et évaluer cette stochasticité. Au final, l'ensemble de ces travaux participent à la compréhension des bases moléculaires de l'autorenouvellement et du contrôle des choix du devenir cellulaire.

Electroacoustic music is often regarded as not being sufficiently accessible to the general public because of its sound-based abstract quality and the complexity of its language. Live electronic music introduces the figure of the performer as a gestural bodily agent that re-enables our multimodal perception of sound and seems to alleviate the accessibility dilemma. However, live electronic music generally lacks the level of detail found in studio-based fixed media works, and it can hardly be transferred outside the concert hall situation (e.g. as a video recording) without losing most of its fresh, dynamic and unpredictable nature. Recent developments in 3D simulation environments and game audio technologies suggest that alternative approaches to music composition and distribution are possible, presenting an opportunity to address some of these issues. In particular, this Portfolio of Compositions proposes the use of real and virtual space as a new medium for the creation and organisation of sound events via computer-simulated audio-sources. In such a context, the role of the performer is sometimes assumed by the listener itself, through the operation of an interactive-adaptive system, or it is otherwise replaced by a set of automated but flexible procedures. Although all of these works are sonic centric in nature, they often present a visual component that reinforces the multimodal perception of meaningful musical structures, either as real space locations for sonic navigation (locative audio), or live visualisations of physically-informed gestural agents in 3D virtual environments. Consequently, this thesis draws on general game-audio concepts and terminology, such as procedural sound, non-linearity, and generative music; but it also embraces game development tools (game engines) as a new methodological and technological approach to electroacoustic music composition. In such context, space and the real-time generation, control, and manipulation of assets combine to play an important role in broadening the routes of musical expression and the accessibility of the musical language. The portfolio consists of six original compositions. Three of these works–Swirls, Alice - Elegy to the Memory of an Unfortunate Lady, and Alcazabilla–are interactive in nature and they required the creation of custom software solutions (e.g. SonicMaps) in order to deal with open-form musical structures. The last three pieces–Singularity, Apollonian Gasket, and Boids–are based on fractal or emergent behaviour models and algorithms, and they propose a non-interactive linear organisation of sound materials via real-time manipulation of non-conventional 3D virtual instruments. These original instrumental models exhibit strong spatial and kinematic qualities with an abstract and minimal visual representation, resulting in an extremely efficient way to build spatialisation patterns, texture, and musical gesture, while preserving the sonic-centric essence of the pieces.

This thesis deals with the design and implementation of system for recording and repeating of events for audio systems. The introductory part is devoted to the study of sound systems, their user interfaces and communication protocols that are used by audio systems. Hereafter the description of essential features of Mac OS X, as well as the characteristic of its user interface and principles of development on this platform, are given. The core of the thesis consists of the design of system for recording and repeating of events and the concept of events which specifies the reprezentation of events in the system and their subsequent processing. In~the end of the thesis is presented the implementation of the designed system for Mac OS X with respect to possible extensions of the system and its features.

The main goal of this thesis is the analysis, design and implementation of a new system, which would be able to generate music in real-time, based on terrain data or any raster image. The thesis deals with history of development of various attempts to formalize musical composition and presents contemporary approaches to its algorithmic creation. Technique of constraint programming is explored as well, because it is suitable also for automatic composition, and it is a part of implemented solution. Application components (interface, generator, music core and sound unit) and their interactions are examined in more detail. All approaches used for generating music are described in depth and, moreover, they are supported by many pictures and practical examples. Musical outputs are tested and results of these tests outline strengths, weaknesses and also inner possibilities of the designed system. Conclusion summarises author's contribution to the field of computer generated music and reveals possible prospects for application usage and its extensions.

<p>Maria Jönsson: Track_4</p><p>Performers: Maria Jönsson - flute, Reuben Fenemore - clarinet, Gustav Broman - electric bass, Albin Vesterberg - electric guitar; Wendy Liao, Artur Musalimov, Naama Freedman, Hue Trinh Luong - pedestrians.</p><p>Video and audio recording of Track_4 with: Maria Jönsson - flute, Reuben Fenemore - clarinet, Gustav Broman - electric bass, Albin Vesterberg - electric guitar; Wendy Liao, Artur Musalimov, Naama Freedman, Hue Trinh Luong - pedestrians.</p>

Three-way catalysis (TWC) involves simultaneous removal of the three pollutants (i.e., CO, NOx, and HCs) which led to the branch of auto-exhaust catalysis. CeO2 has become the main component of TWC catalyst because of its oxygen storage storage (OSC) property to supply oxygen under excess fuel condition and store oxygen under lean condition. Substitution of smaller isovalent cations like Ti4+, Zr4+ and Hf4+ ions in CeO2 forming Ce1-xMxO2 (M = Ti, Zr &Hf) solid solution enhance the OSC property. XRD along with EXAFS study showed that cations arrange in FCC lattice but oxygen coordination around metal ions is split into 4 + 4 coordination in Ce1-xMxO2 instead of ideal 8 coordination in CeO2. The longer Ce/Ti/Zr – O bonds are weakly bound and can be easily removed by H2 giving high OSC value than pure CeO2. Among the three OSC systems studied here, Ce0.5Zr0.5O2 showed exceptionally high OSC which lead to formation of a new a pyrochlore, Ce2Zr2O6.3. This compound is nearly metallic. Ce0.85-xTi0.15PtxO2- (x = 0.01 & 0.02) crystallizes in fluorite structure and Pt is ionically substituted with 2+ and 4+ oxidation states. H/Pt atomic ratio at 30 oC over Ce0.84Ti0.15Pt0.01O2- is 5 and over Ce0.99Pt0.01O2-δ is 4 against just 0.078 for 8 nm Pt metal particles. Carbon monoxide and hydrocarbon oxidation activity are much higher over Ce1-x-yTixPtyO2 (x= 0.15, y= 0.01, 0.02) compared to Ce1-xPtxO2 (x= 0.01, 0.02). Synergistic involvement of Pt2+/Pt0 and Ti4+/Ti3+ redox couples in addition to Ce4+/Ce3+ due to the overlap of Pt(5d), Ti(3d), and Ce(4f) bands near EF is shown to be responsible for enhanced redox property and higher catalytic activity. On substitution of Pd ion in Ce1-xTixO2, more lattice oxygen is found to be more labile than Pd in CeO2. The easy removal of oxygen from the more reducible Ti4+ containing support plays a major role in showing higher catalytic activity of this material for CO oxidation, N2O and NO reduction by CO. The catalyst shows 100% N2 selectivity  240 oC in NO+CO reaction. It has been shown that oxide ion vacancy creation created by removal of lattice oxygen by CO is responsible for dissociation of NO or N2O at a lower temperature. Ionicity of Pd2+ ion in different support could be varied by varying the ionicity of the oxide support itself. Rates of CO oxidation increases or activation energy decreases over Ce1-xPdxO2-δ, Ti1-xPdxO2-δ and Ce1-x-yMxPdyO2-δ (M = Ti, Zr, Hf ; x = 0.25, 0.4 ; y = 0.02) is increased with ionicity of Pd2+ ion. The substitution of Sn in CeO2 forming Ce1-xSnxO2 (x = 0.1-0.5) solid solution was prepared using tin oxalate precursor by solution combustion method. These oxides can be promising support for noble metals because of the Sn4+  Sn2+ redox couple in addition to Ce3+/Ce4+. The two electron process involved in the redox reaction of Sn as well as easy reducibility of Sn4+ to Sn2+ offers a far better redox catalytic system hitherto not reported. Ce1-xSnxO2 solid solutions as well as Pd ion substituted Ce1-xSnxO2 was prepared for the first time.

This thesis describes the design and implementation of a software for digital mixing console built on the Windows platform. This software is designed to offer real-time multi-channel audio processing using multiple input and output units, signal routing between these units and insertion and management of VST plug-in modules. The software uses an audio interface connected with ASIO technology. The thesis is divided into several applications. Main application which computes audio samples and allows insertion and management of plug-ins is programmed in C++ using JUCE technology. This application can be controlled with its own local graphical interface or with web control interface, which is programmed in TypeScript with the use of React technology. Web interface allows user to control VST plug-in modules with its own custom implementation of plug-in control.

In the production of paper, the quality of the pulp is an important factor both for the productivity and for the final quality. Reliable real-time measurements of pulp quality are therefore needed. One way is to use acoustic or vibration sensors that give information-rich signals and place the sensors at suitable locations in a pulp production line. However, these sensors are not selective for the pulp properties of interest. Therefore, advanced signal processing and multivariate calibration are essential tools. The current work has been focused on the development of calibration routes for extraction of information from acoustic sensors and on signal processing algorithms for enhancing the information-selectivity for a specific pulp property or class of properties. Multivariate analysis methods like Principal Components Analysis (PCA), Partial Least Squares (PLS) and Orthogonal Signal Correction (OSC) have been used for visualization and calibration. Signal processing methods like Fast Fourier Transform (FFT), Fast Wavelet Transform (FWT) and Continuous Wavelet Transform (CWT) have been used in the development of novel signal processing algorithms for extraction of information from vibrationacoustic sensors. It is shown that use of OSC combined with PLS for prediction of Canadian Standard Freeness (CSF) using FFT-spectra produced from vibration data on a Thermo Mechanical Pulping (TMP) process gives lower prediction errors and a more parsimonious model than PLS alone. The combination of FFT and PLS was also used for monitoring of beating of kraft pulp and for screen monitoring. When using regular FFT-spectra on process acoustic data the obtained information tend to overlap. To circumvent this two new signal processing methods were developed: Wavelet Transform Multi Resolution Spectra (WT-MRS) and Continuous Wavelet Transform Fibre Length Extraction (CWT-FLE). Applying WT-MRS gave PLS-models that were more parsimonious with lower prediction error for CSF than using regular FFT-Spectra. For a Medium Consistency (MC) pulp stream WT-MRS gave predictions errors comparable to the reference methods for CSF and Brightness. The CWT-FLE method was validated against a commercial fibre length analyzer and good agreement was obtained. The CWT-FLE-curves could therefore be used instead of other fibre distribution curves for process control. Further, the CWT-FLE curves were used for PLS modelling of tensile strength and optical parameters with good results. In addition to the mentioned results a comprehensive overview of technologies used with acoustic sensors and related applications has been performed. / Vid framställning av pappersprodukter är kvaliteten på massan en viktig faktor för produktiviteten och kvalitén på slutresultatet. Det är därför viktigt att ha tillgång till tillförlitliga mätningar av massakvalitet i realtid. En möjlighet är att använda akustik- eller vibrationssensorer i lämpliga positioner vid enhetsoperationer i massaprocessen. Selektiviteten hos dessa mätningar är emellertid relativt låg i synnerhet om mätningarna är passiva. Därför krävs avancerad signalbehandling och multivariat kalibrering. Det nu presenterade arbetet har varit fokuserat på kalibreringsmetoder för extraktion av information ur akustiska mätningar samt på algoritmer för signalbehandling som kan ge förbättrad informationsselektivitet. Multivariata metoder som Principal Component Analysis (PCA), Partial Least Squares (PLS) and Orthogonal Signal Correction (OSC) har använts för visualisering och kalibrering. Signalbehandlingsmetoderna Fast Fourier Transform (FFT), Fast Wavelet Transform (FWT) och Continuous Wavelet Transform (CWT) har använts i utvecklingen av nydanande metoder för signalbehandling anpassade till att extrahera information ur signaler från vibrations/akustiska sensorer. En kombination av OSC och PLS applicerade på FFT-spektra från raffineringen i en Termo Mechnaical Pulping (TMP) process ger lägre prediktionsfel för Canadian Standard Freeness (CSF) än enbart PLS. Kombinationen av FFT och PLS har vidare använts för monitorering av malning av sulfatmassa och monitorering av silning. Ordinära FFT-spektra av t.ex. vibrationssignaler är delvis överlappande. För att komma runt detta har två signalbehandlingsmetoder utvecklats, Wavelet Transform Multi Resolution Spectra (WT-MRS) baserat på kombinationen av FWT och FFT samt Continuous Wavelet Transform Fibre Length Extraction (CWT-FLE) baserat på CWT. Tillämpning av WT-MRS gav enklare PLS-modeller med lägre prediktionsfel för CSF jämfört med att använda normala FFT-spektra. I en annan tillämpning på en massaström med relativt hög koncentration (Medium Consistency, MC) kunde prediktioner för CSF samt ljushet erhållas med prediktionsfel jämförbart med referensmetodernas fel. Metoden CWT-FLE validerades mot en kommersiell fiberlängdsmätare med god överensstämmelse. CWT-FLE-kurvorna skulle därför kunna användas i stället för andra fiberdistributionskurvor för processtyrning. Vidare användes CWT-FLE kurvor för PLS modellering av dragstyrka samt optiska egenskaper med goda resultat. Utöver de nämnda resultaten har en omfattande litteratursammanställning gjorts över området och relaterade applikationer. / QC 20100629

Organic solar cells (OSCs) based on non-fullerene acceptors (NFAs) have attracted a great deal of attention in recent years due to their rapidly increasing efficiency and enormous potential. In this work, the optical and electronic properties of systems containing the very promising non-fullerene acceptor PYT have been thoroughly studied with the use of the density functional theory (DFT) and the time-dependent density functional theory (TDDFT). By changing the electron linker from thiophene to furan and selenophene, respectively, the PYT was divided into three variants, each of which was studied independently. In addition, these three systems were combined with the donor PBDB-T to generate two distinct interface conformations. The properties studied in this work include the optimized geometries, HOMO-LUMO levels, UV-Vis spectra, frontier molecular orbitals (FMOs), natural transition orbitals (NTOs), density of states (DOS), dipole moments, open-circuit voltages, exciton binding energies, and local exciton (LE) and charge transfer (CT) energies. The calculations were performed in chlorobenzene solution utilizing the polarizable continuum model (PCM). It was discovered that PBDB-T/PY-Se exhibited remarkable flatness employing the π-π stacking conformation which corresponds well with the excellent D/A compatibility observed experimentally. All interfaces displayed appropriate positioning of the HOMO-LUMO levels, with the acceptor dominating the LUMO and the donor dominating the HOMO, with HOMO-LUMO gaps ranging between 1.34 and 1.38 eV. The differences in the interchanging of the electron linker were not that significant, and neither was the change in interface conformation in terms of the HOMO-LUMO levels. This may indicate that the system can be effective even without the presence of a π-π stacking conformation. The first excited states for all interface systems were shown to be pure CT transitions, and on average, 80% of the states exhibit CT character. The remaining contributions consisted of transitions within the pure materials, with a larger contribution within the acceptor. The theoretical results of this study indicate that systems containing the novel polymer acceptor PYT and its variants PY-O and PY-Se exhibit very intriguing properties, and further development of OSCs containing these polymers might further aid in the development of high-performance OSCs. / Organiska solceller (OSC) baserade på icke-fullerenacceptorer (NFA) har väckt stor uppmärksamhet de senaste åren på grund av dess snabbt ökande effektivitet och enorma potential. I detta arbete har de optiska och elektroniska egenskaperna hos system innehållande den mycket lovande icke-fullerenacceptorn PYT studerats grundligt med användning av täthetsfunktionalteorin (DFT) och den tidsberoende täthetsfunktionalteorin (TDDFT). Genom att ändra elektronförbindelsen från tiofen till furan respektive selenofen så delades PYT upp i tre varianter som var och en studerades oberoende av varandra. Dessutom kombinerades dessa tre system med donatorn PBDB-T för att generera två distinkta gränssnittskonformationer. Egenskaperna som studeras i detta arbete inkluderar optimerade geometrier, HOMO-LUMO-nivåer, UV-vis spektra, gränsmolekylära orbitaler (FMO), naturliga övergångsorbitaler (NTO), tillståndstäthet (DOS), dipolmoment, tomgångsspänning, excitonbindningsenergi samt lokal exciton (LE) och laddningsöverförings (CT) energier. Beräkningarna utfördes i klorbensenlösning med användning av den polariserbara kontinuummodellen (PCM). I resultatet uppvisade PBDB-T/PY-Se en anmärkningsvärd planhet med användning av π-π staplingskonformationen som överensstämmer väl med den utmärkta D/A-kompatibiliteten som observerats experimentellt. Alla gränssnitt visade lämplig positionering av HOMO-LUMO-nivåerna, med acceptorn som dominerade LUMO och donatorn som dominerade HOMO, med HOMO-LUMO-gap mellan 1.34 och 1.38 eV. Skillnaderna i utbytet av elektronförbindelsen visade sig inte vara signifikanta och inte heller skillnaden i gränssnittskonformation när det gäller HOMO-LUMO-nivåerna. Detta kan indikera att systemet kan vara effektivt även utan förekomst av π-π staplingskonformation. De första exciterade tillstånden för alla gränssnittssystem visade sig vara rena CT-övergångar och i genomsnitt uppvisade 80% av tillstånden CT-karaktär. Resterande andel bestod av övergångar inom de rena materialen med en större andel inom acceptorn. De teoretiska resultaten av denna studie indikerar att system innehållande den nya polymeracceptorn PYT och dess varianter PY-O och PY-Se uppvisar mycket spännande egenskaper samt att vidareutveckling av OSC:er som innehåller dessa polymerer ytterligare kan hjälpa till i utvecklingen av högpresterande OSC:er.

La FAO, institution spécialisée des Nations Unies dans les domaines de l'alimentation et l'agriculture, créée en 1945, a pour mission de «libérer l'humanité de la faim» (préambule de son acte constitutif). Pour atteindre l'objectif de sécurité alimentaire, la FAO n'hésite pas à s'entourer de partenaires. Parmi ceux-ci, on trouve diverses entités appartenant à la société civile internationale : ONG internationales, organisations d'agriculteurs locaux, entreprises du secteur privé, associations de consommateurs… Ainsi, l'intérêt de la présente thèse est double. Tout d'abord, au regard de la FAO elle-même : organisation internationale suscitant peu d'engouement auprès de la doctrine internationaliste, elle fait preuve d'un indéniable esprit d'ouverture à l'égard des entités non gouvernementales. L'étude des modalités (y compris juridiques), des nombreux avantages mais également des limites non négligeables de la coopération permet de mettre en évidence l'utilité d'intégrer ces entités aux activités normatives et opérationnelles de l'Organisation. Ensuite, cette étude est éclairante au regard du droit des organisations internationales : grâce à l'apport précieux de ces entités, on observe une réinterprétation voire un élargissement du mandat initial de la FAO. On peut tirer une telle conclusion en ce qui concerne le domaine normatif mais surtout pour ce qui est des activités réalisées sur le terrain par l'Organisation. / The FAO is a specialized institution of the United Nations in the fields of food and agriculture, founded in 1945. Its purpose is to «ensure humanity's freedom from hunger» (preamble of its constitution). In order to reach the food security goal, FAO does not hesitate to cooperate with various partners. Among them, can be found entities belonging to the international civil society : international NGOs, local farmer's organizations, companies from the private sector, consumer associations... Thus, the concern of thus thesis is twofold. First, regarding FAO itself : as an international organization while inspiring little interest in international legal doctrine, it demonstrates an undeniable attitude of openness towards non-governmental entities. The study of the modalities (including the legal aspects), the numerous benefits but also the non-insignificant limits of the cooperation permits to highlight the usefulness to integrate these entities with FAO's nonnative and operational activities. Thus, this research is enlightening regarding the law of international organizations : thanks to these entities precious contribution, can be observed a reinterpretation and even an extension of FAO's initial mandate. Such a conclusion can be drawn in the normative area but mainly in the Organization's activities realized in the field.