O objetivo dessa pesquisa foi avaliar aspectos genéticos que relacionados à produção in vitro de embriões na raça Guzerá. O primeiro estudo focou na estimação de (co) variâncias genéticas e fenotípicas em características relacionadas a produção de embriões e na detecção de possível associação com a idade ao primeiro parto (AFC). Foi detectada baixa e média herdabilidade para características relacionadas à produção de oócitos e embriões. Houve fraca associação genética entre características ligadas a reprodução artificial e a idade ao primeiro parto. O segundo estudo avaliou tendências genéticas e de endogamia em uma população Guzerá no Brasil. Doadoras e embriões produzidos in vitro foram considerados como duas subpopulações de forma a realizar comparações acerca das diferenças de variação anual genética e do coeficiente de endogamia. A tendência anual do coeficiente de endogamia (F) foi superior para a população geral, sendo detectado efeito quadrático. No entanto, a média de F para a sub- população de embriões foi maior do que na população geral e das doadoras. Foi observado ganho genético anual superior para a idade ao primeiro parto e para a produção de leite (305 dias) entre embriões produzidos in vitro do que entre doadoras ou entre a população geral. O terceiro estudo examinou os efeitos do coeficiente de endogamia da doadora, do reprodutor (usado na fertilização in vitro) e dos embriões sobre resultados de produção in vitro de embriões na raça Guzerá. Foi detectado efeito da endogamia da doadora e dos embriões sobre as características estudadas. O quarto (e último) estudo foi elaborado para comparar a adequação de modelos mistos lineares e generalizados sob método de Máxima Verossimilhança Restrita (REML) e sua adequação a variáveis discretas. Quatro modelos hierárquicos assumindo diferentes distribuições para dados de contagem encontrados no banco. Inferência foi realizada com base em diagnósticos de resíduo e comparação de razões entre componentes de variância para os modelos em cada variável. Modelos Poisson superaram tanto o modelo linear (com e sem transformação da variável) quanto binomial negativo à qualidade do ajuste e capacidade preditiva, apesar de claras diferenças observadas na distribuição das variáveis. Entre os modelos testados, a pior qualidade de ajuste foi obtida para o modelo linear mediante transformação logarítmica (Log10 X +1) da variável resposta. / The objective of this research was to evaluate genetic aspects permeating in vitro embryo production in Guzerá cattle. The first study aimed for estimating genetic and phenotypic (co)variances among embryo production traits and detecting possible genetic association with the age at first calving (AFC). Low and medium heritabilities were detected for oocyte and embryo production traits. A weak genetic association between artificial reproduction traits and AFC was identified. The second study evaluated genetic and inbreeding trends in the Brazilian Guzerá population. Female donors and in vitro produced embryos were considered as two subpopulations in order to perform comparisons and infer over differences in inbreeding and genetic annual variations. Embryos\' subpopulation showed higher genetic gains for age at first calving and milk production than donors\' subpopulation and the general population. Higher annual mean inbreeding values were also detected for the embryos\' subpopulation. The third study examined the effects of donor, sire (used for in vitro fertilization) and embryos\' inbreeding coefficient over in vitro embryo production traits in Guzerá cattle. Donors\' and embryos\' inbreeding effects over the analyzed traits were detected. Fourth and final study was designed to compare the performance of Linear and Generalized Linear Mixed Models under Restricted Maximum Likelihood method when fitting discrete variables. Four hierarchical models assuming different distributions for the response variable were fit to the (count) data. Inference was performed upon residual diagnostics and comparison of variance component ratios between models within each trait. Poisson models outperformed both linear (with and without variable transformation) and negative binomial models for goodness of fit and predictive ability despite clear differences in each trait\'s distribution. Logarithmic transformation (Log10 X +1) showed lowest goodness of fit among all models tested.

Les défis environnementaux et l’augmentation de la population viennent en preuve de l’importance de réfléchir à d’autres moyens de production tout en maintenant la sécurité et la fiabilité du système électrique. La sûreté du système électrique exige à tout moment que la production soit égale à la demande des consommateurs, pour ça, différentes solutions sont déjà mises en place, ces solutions consistent à mettre en marche des moyens de pointes couteux et polluants pendant les périodes de pointes, mais comme les moyens de production son insuffisants et vue la difficulté d’exploitation de nouveaux moyens de production, une nouvelle réflexion sur la gestion de la demande est apparue; celle-ci se base sur la possibilité à gérer la demande du consommateur final au lieu de la satisfaire.L’objectif de la thèse est d’étudier la possibilité à rendre des services au système électrique en appliquant des actions de contrôle dites de DR (Demand Response), sur différents types de charges électriques. Ces actions de DR représentent des interruptions partielles appliquées sur les charges électriques de type thermique. Notre choix s’est basé sur ces types de charges parce que celles-ci emmagasinent de la chaleur respectivement dans l’air et dans l’eau; qui peut être restituée pendant la période de contrôle ou d’interruption. Néanmoins, il existe un effet négatif qui suit le contrôle de ces charges car l’énergie effacée de ces charges est reportée à l’instant de reconnexion de celles-ci; ce report prend la forme d’un pic de consommation nommé CLPU (Cold Load Pick-Up) et qui apparait au moment de la reconnexion. Le CLPU représente un problème qui doit être géré, et sa magnitude dépend des types d’actions de contrôle qu’on veut implanter et aussi des conditions du système électrique (contingence, défaillance d’une unité de production ou besoin de réserve de puissance). Pendant la thèse, le CLPU est contrôlé et optimisé ainsi que la puissance effacée. Un cas d’étude est présenté sur la contribution des actions de gestion de la demande à l‘ajustement entre la demande et la production et l’effet généré sur le réglage secondaire de fréquence. / Environmental challenges and the increasing in electric demand show the importance of considering other form of production while maintaining the safety and reliability of the electrical system. The electrical power systems stability lays on a fundamental constraint: supply and demand must be equal at each instant, so, different solutions are already in place, these solutions include controlling generators’ production during peak periods. But, power units (mainly nuclear, thermal, hydro) capacities are not always sufficient and flexible to follow the demand variations during these periods; an alternative solution to this insufficiency is to make the demand following the electrical power generation by providing bulks of electrical power to the power system by curtailing consumer’s electric load consumption. Such a solution that represents a new organization in the power system industry can be done by Demand Side Management (DSM) actions. The aim of the thesis is to study the possibility to offer services to the electrical system by applying control actions called DR (Demand Response) on different types of electric loads. These DR actions represent partial interruptions of electrical loads’ consumption and especially thermal loads’ consumption.Our choice was based on the thermal electric loads because they store heat respectively in air and water, which can be restored during the control period or interruption. However, there is a negative effect that follows the control of these type of loads because the reduced energy during curtailment period is deferred at the time of reconnection, this deferred power takes the form of a power peak named CLPU (Cold Load Pick-Up), which appears at the time of reconnection. The CLPU is a problem that must be managed, and its magnitude depends on the type of control actions and on the electric system conditions (ie: contingency or failure of a generating unit). In the thesis, the CLPU is controlled and optimized as well as the load reduction during curtailment period. The contribution of control actions in balancing mechanisms and the effect produced on the secondary control of frequency are analyzed.

The embryonic development and pregnancy rates are influenced by variations in embryo in vitro production (IVP) systems and protocols for bovine embryos, such as gaseous atmosphere, culture media and the protein supply adopted in the different steps of IVP. Two studies were performed to evaluate the effect of O2 tension on in vitro maturation (IVM) and fertilization (IVF) of bovine oocytes, and the protein supply in the embryonic in vitro culture. Immature Cumulusoocytes complexes (COC) were recovered by transvaginal ultrasound guided follicular aspiration (OPU) from Bos taurus indicus donors from commercial programs and randomly assigned according to the number and quality of the COC. Standard bovine IVM procedure was carried out in modified TCM-199, added of FSH, LH, Oestradiol, EGF, insulin and 10% bovine fetal serum (FCS), for 24h. Frozen semen was selected by Percoll gradient (90, 60 and 30%). The insemination was performed with 2x106 spermatozoa/mL in Fert-Talp with heparin and PHE, for 18 to 22h. Presumptive zygotes were in vitro cultured (IVC) in SOFaaci during 6 to 9 days with 5%CO2, 5%O2 and 90% N2 in air. All steps of IVC were performed in an incubator at 39ºC with satured humidity. The cleavage and blastocyst rates were analysed by GLM procedure. Hatching, quality I blastocyst and pregnancy rates were compared by Chi-square Test with 5% of significance. In experiment I (11 replicates) IVM and IVF of COC (n=1092) were conducted under 5% CO2 (20% O2) in air or in 5%CO2, 5%O2 and 90% N2 (5%O2). Experiment II was divided in two steps (IIa and IIb). In experiment IIa (n=1745 COC), the IVM and IVF was followed by in vitro culture (IVC) in SOFaaci added of 4mg/mL bovine serum albumin (BSA) or 4mg/mL BSA+2% bovine fetal serum (BSA+FCS). In experiment IIb (n=704 COC), after standard IVM and IVF, IVC was performed in the two media of Experiment IIa (BSA and BSA+FCS) and in a third group the SOFaaci was added of 4mg/mL BSA+2% FCS (BSA+FCSD4) on day 4 of IVC. The viability was accessed by morphological evaluation in D2 (cleavage), D7 (blastocysts and quality categories), D9 (hatched blastocysts), D45 (experiment I) and D60 (experiment II; pregnancy rates), considering day zero (D0) as the fertilization day. In experiment I, no differences were found (P>0.05) in cleavage rates (69 and 70%), blastocyst in D7 (37 and 38%) and blastocyst quality I (79 and 74%) in an atmosphere of 5% or 20%O2, respectively. The hatching rate in D9 considering all COC submitted to IVM was higher (P<0.05) for the 5%O2 group (21%) compared to the IVM and IVF group under 20%O2 (11%). A pregnancy rate of transferred embryos at 45 days (n=278) was similar (P=0.15) between treatments (25.8 e 33.6% for 5%O2 e 20%O2 ,respectively ). In experiment IIa blastocyst rates (51%) and quality I blastocysts (41%) in D7, was higher (P<0.05) in BSA+FCS group compared to the BSA group (42 and 30%), respectively. In experiment IIb, blastocyst rates were higher (P<0.05) in group BSA+FCS (47%) and similar between BSA (34%) and BSA+FCSD4 (43%) groups. Blastocyst rates quality I were higher (P<0.05) for groups BSA+FCS (34%) and BSA+FCSD4 (32%), compared to the BSA group (19.9%). A pregnancy rate of the transferred embryos (n=820) was similar between treatments in experiments IIa and IIb. Considering pregnancy rates corresponding only to IVM COC (Experiment IIa), the rates were higher (P<0.05) for the BSA+FCS group (16%) than the BSA group (12%). There was no detrimental effect in IVP of bovine embryos and their pregnancy rates when IVM, IVF and IVC were performed in 5%O2, 5%CO2 and 90%N2. IVP of bovine embryos is increased by the addition of 2% FCS to the IVC medium without any detrimental effect on their morphological quality and pregnancy rates. On the other hand, pregnancy rates related to IVM of COC incremented by the addition of 2% de Fc to the IVC medium SOFaaci+BSA. / Diferenças nos protocolos e sistemas de produção in vitro (PIV) de embriões bovinos incluindo atmosfera gasosa, meios de cultivo e suplementação de proteína utilizados nas diferentes etapas da PIV, influenciam diretamente os resultados finais de desenvolvimento embrionário e prenhez. Dois experimentos foram conduzidos com o objetivo de avaliar a influência da concentração de oxigênio na maturação in vitro (MIV) e fecundação in vitro (FIV) de oócitos bovinos e da suplementação protéica no cultivo in vitro (CIV) de embriões bovinos. Complexos cumulus-oócitos imaturos (COC) obtidos de fêmeas Bos taurus indicus por aspiração folicular transvaginal guiada por ultra-sonografia (OPU) foram divididos homogeneamente quanto ao número e a qualidade entre os tratamentos, sendo maturados por 24h, em TCM-199 modificado, acrescido FSH, LH, Estradiol, EGF, Insulina e 10% de SFB. Sêmen congelado selecionado por gradientes de Percoll (2 x 106 células/mL) foi utilizado para a fecundação em Fert-TALP com heparina e PHE, por 18 a 22h. Os prováveis zigotos foram cultivados in vitro em SOFaaci por 6 a 9 dias em atmosfera de 5%CO2, 5%O2 e 90% N2. Todas as etapas foram conduzidas em estufa a 39ºC com umidade saturada. Os percentuais de clivagem e de blastocistos foram analisados pelo procedimento GLM. As taxas de eclosão dos blastocistos e de prenhez foram comparadas por Qui-quadrado com significância de 5%. No experimento I (11 repetições), a MIV e FIV dos COC (n=1092) foram realizadas sob atmosfera de 5% de CO2 em ar (20%O2) ou em 5%CO2, 5%O2 e 90% N2 (5%O2). O experimento II foi dividido em 2 etapas (IIa e IIb). No experimento IIa (n=1745 COC) após a MIV e FIV foi realizado o CIV em meio SOFaaci acrescido de 4mg/mL albumina sérica bovina (BSA) ou 4mg/mL de BSA + 2% de soro fetal bovino (BSA+SFB). No experimento IIb (n=704 COC), após a MIV e FIV, o CIV foi conduzido nos dois meios do experimento IIa (BSA e BSA+SFB) e um terceiro grupo onde o SOFaaci+BSA foi suplementado com 2% de SFB no quarto dia de cultivo (BSA+SFBD4). As avaliações morfológicas foram efetuadas no D2 (clivagem), D7 (blastocistos e grau de qualidade), D9 (blastocistos eclodidos) e taxa de prenhez aos 45 (experimento I) e 60 dias (experimento II), considerando-se o dia da fecundação como D0. No experimento I, não houve diferença (P>0,05) nas taxas de clivagem (69 e 70%), blastocistos em D7 (37 e 38%) e blastocistos qualidade I (79 e 74%) entre atmosfera de 5%O2 ou 20% de O2, respectivamente. A taxa de eclosão em D9 sob o total de oócitos MIV foi superior (P<0,05) no grupo 5%O2 (21%) comparado ao grupo MIV e FIV sob 20%O2 (11%). A taxa de prenhez aos 45 dias dos embriões transferidos (n=278) foi semelhante (P=0,15) entre os tratamentos (25,8 e 33,6% para 5%O2 e 20%O2 respectivamente). No experimento IIa, a taxa de blastocistos (51,5%) e de blastocistos qualidade I (41%) em D7, foi superior (P<0,05) para o grupo BSA+SFB em relação ao BSA (42 e 30%), respectivamente. No experimento IIb, a taxa de blastocistos foi superior (P<0,05) no grupo BSA+SFB e semelhante (P>0,05) entre o grupo BSA e BSA+SFBD4. A taxa de blastocistos qualidade I foi superior para os grupos BSA+SFB (34%) e BSA+SFBD4 (32,2%) em comparação ao grupo BSA (19,9%). A taxa de prenhez em relação aos embriões transferidos (n=820) foi semelhante entre os tratamentos nos experimentos IIa e IIb. A taxa de prenhez correspondente aos oócitos colocados para MIV foi superior (P<0,05) para o grupo BSA+SFB (16%) comparado ao grupo BSA (12%) no experimento IIa. Não há comprometimento da PIV de embriões bovinos bem como da taxa de prenhez quando a MIV, FIV e CIV são conduzidas com 5%O2, 5%CO2 e 90%N2. A produção in vitro de embriões é incrementada pela adição de 2% de SFB ao meio de CIV, sem prejudicar a qualidade morfológica dos mesmos e a taxa de prenhez. A porcentagem de prenhez produzida em relação aos COC colocados para MIV é aumentada pela adição de 2% de SFB ao meio de cultivo in vitro SOFaaci+BSA.

No description available.

O objetivo dessa pesquisa foi avaliar aspectos genéticos que relacionados à produção in vitro de embriões na raça Guzerá. O primeiro estudo focou na estimação de (co) variâncias genéticas e fenotípicas em características relacionadas a produção de embriões e na detecção de possível associação com a idade ao primeiro parto (AFC). Foi detectada baixa e média herdabilidade para características relacionadas à produção de oócitos e embriões. Houve fraca associação genética entre características ligadas a reprodução artificial e a idade ao primeiro parto. O segundo estudo avaliou tendências genéticas e de endogamia em uma população Guzerá no Brasil. Doadoras e embriões produzidos in vitro foram considerados como duas subpopulações de forma a realizar comparações acerca das diferenças de variação anual genética e do coeficiente de endogamia. A tendência anual do coeficiente de endogamia (F) foi superior para a população geral, sendo detectado efeito quadrático. No entanto, a média de F para a sub- população de embriões foi maior do que na população geral e das doadoras. Foi observado ganho genético anual superior para a idade ao primeiro parto e para a produção de leite (305 dias) entre embriões produzidos in vitro do que entre doadoras ou entre a população geral. O terceiro estudo examinou os efeitos do coeficiente de endogamia da doadora, do reprodutor (usado na fertilização in vitro) e dos embriões sobre resultados de produção in vitro de embriões na raça Guzerá. Foi detectado efeito da endogamia da doadora e dos embriões sobre as características estudadas. O quarto (e último) estudo foi elaborado para comparar a adequação de modelos mistos lineares e generalizados sob método de Máxima Verossimilhança Restrita (REML) e sua adequação a variáveis discretas. Quatro modelos hierárquicos assumindo diferentes distribuições para dados de contagem encontrados no banco. Inferência foi realizada com base em diagnósticos de resíduo e comparação de razões entre componentes de variância para os modelos em cada variável. Modelos Poisson superaram tanto o modelo linear (com e sem transformação da variável) quanto binomial negativo à qualidade do ajuste e capacidade preditiva, apesar de claras diferenças observadas na distribuição das variáveis. Entre os modelos testados, a pior qualidade de ajuste foi obtida para o modelo linear mediante transformação logarítmica (Log10 X +1) da variável resposta. / The objective of this research was to evaluate genetic aspects permeating in vitro embryo production in Guzerá cattle. The first study aimed for estimating genetic and phenotypic (co)variances among embryo production traits and detecting possible genetic association with the age at first calving (AFC). Low and medium heritabilities were detected for oocyte and embryo production traits. A weak genetic association between artificial reproduction traits and AFC was identified. The second study evaluated genetic and inbreeding trends in the Brazilian Guzerá population. Female donors and in vitro produced embryos were considered as two subpopulations in order to perform comparisons and infer over differences in inbreeding and genetic annual variations. Embryos\' subpopulation showed higher genetic gains for age at first calving and milk production than donors\' subpopulation and the general population. Higher annual mean inbreeding values were also detected for the embryos\' subpopulation. The third study examined the effects of donor, sire (used for in vitro fertilization) and embryos\' inbreeding coefficient over in vitro embryo production traits in Guzerá cattle. Donors\' and embryos\' inbreeding effects over the analyzed traits were detected. Fourth and final study was designed to compare the performance of Linear and Generalized Linear Mixed Models under Restricted Maximum Likelihood method when fitting discrete variables. Four hierarchical models assuming different distributions for the response variable were fit to the (count) data. Inference was performed upon residual diagnostics and comparison of variance component ratios between models within each trait. Poisson models outperformed both linear (with and without variable transformation) and negative binomial models for goodness of fit and predictive ability despite clear differences in each trait\'s distribution. Logarithmic transformation (Log10 X +1) showed lowest goodness of fit among all models tested.

With the increasingly prevalent use of robots, this paper presents the design and evaluation of a multifunctional Unmanned Ground Vehicle (UGV) with an adjustable suspension system, overmolding omni-wheels, and a unique tool head pick-up mechanism. The UGV addresses current adaptability, performance, and versatility limitations across various industries, including agriculture, construction, and surveillance. The adjustable suspension system enhances the UGV's stability and adaptability on diverse terrains, and the overmolding omni-wheels improve maneuverability and durability in off-road conditions. The tool head pick-up mechanism allows for the seamless integration of various tools, enabling the UGV to perform multiple tasks without manual intervention. A comprehensive performance evaluation assessed the UGVs' versatility, load capacity, passability, and adaptability. The results indicate that the proposed UGV design successfully addresses current limitations and has the potential to revolutionize various applications in different industries. Further research and development are necessary to optimize the UGV's performance, safety, and cost-effectiveness. / Thesis / Master of Applied Science (MASc)

The work for this thesis is in line with the field of Instrumentation for Particle Accelerators, so called Beam Diagnostics. It is presented the development of a series of electro-mechanical devices called Inductive Pick-Ups (IPU) for Beam Position Monitoring (BPM). A full set of 17 BPM units (16 + 1 spare), named BPS units, were built and installed into the Test Beam Line (TBL), an electron beam decelerator, of the 3rd CLIC Test Facility (CTF3) at CERN ¿European Organization for the Nuclear Research¿. The CTF3, built at CERN by an international collaboration, was meant to demonstrate the technical feasibility of the key concepts for CLIC ¿Compact Linear Collider¿ as a future linear collider based on the novel two-beam acceleration scheme, and in order to achieve the next energy frontier for a lepton collider in theMulti-TeV scale. Modern particle accelerators and in particular future colliders like CLIC requires an extreme alignment and stabilization of the beam in order to enhance its quality, which rely heavily on a beam based alignment techniques. Here the BPMs, like the BPS-IPU, play an important role providing the beam position with precision and high resolution, besides a beam current measurement in the case of the BPS, along the beam lines. The BPS project carried out at IFIC was mainly developed in two phases: prototyping and series production and test for the TBL. In the first project phase two fully functional BPS prototypes were constructed, focusing in this thesis work on the electronic design of the BPS on-board PCBs (Printed Circuit Boards) which are based on transformers for the current sensing and beam position measurement. Furthermore, it is described the monitor mechanical design with emphasis on all the parts directly involved in its electromagnetic functioning, as a result of the coupling of the EM fields generated by the beam with those parts. For that, it was studied its operational parameters, according the TBL specifications, and it was also simulated a new circuital model reproducing the BPS monitor frequency response for its operational bandwidth (1kHz-100MHz). These prototypes were initially tested in the laboratories of the BI-PI section¿Beam Instrumentation - Position and Intensity¿ at CERN. In the second project phase the BPS monitor series, which were built based on the experience acquired during the prototyping phase, the work was focused on the realization of the characterization tests to measure the main operational parameters of each series monitor, for which it was designed and constructed two test benches with different purposes and frequency regions. The first one is designed to work in the low frequency region, between 1kHz-100MHz, in the time scale of the electron beam pulse with a repetition period of 1s and an approximate duration of 140ns. This kind of test setups called Wire Test-bench are commonly used in the accelerators instrumentation field in order to determine the characteristic parameters of a BPM (or pick-up) like its linearity and precision in the position measurement, and also its frequency response (bandwidth). This is done by emulating a low current intensity beam with a stretched wire carrying a current signals which can be precisely positioned with respect the device under test. This test bench was specifically made for the BPS monitor and conceived to perform the measurement data acquisition in an automated way, managing the measurement equipment and the wire positioning motors controller from a PC workstation. Each one of the BPS monitors series were characterized by using this system at the IFIC labs, and the test results and analysis are presented in this work. On the other hand, the high frequency tests, above the X band in the microwave spectrum and at the time scale of the micro-bunch pulses with a bunching period of 83ps (12GHz) inside a long 140ns pulse, were performed in order to measure the longitudinal impedance of the BPS monitor. This must be low enough in order to minimize the perturbations on the beam produced at crossing the monitor, which affects to its stability during the propagation along the line. For that, it was built the high frequency test bench as a coaxial waveguide structure of 24mm diameter matched at 50¿ and with a bandwidth from 18MHz to 30GHz, which was previously simulated, and having room in the middle to place the BPS as the device under test. This high frequency test bench is able to reproduce the TEM (Transversal Electro-Magnetic) propagative modes corresponding to an ultra-relativistic electron beam of 12GHz bunching frequency, so that the Scattering parameters can be measured to obtain the longitudinal impedance of the BPS in the frequency range of interest. Finally, it is also presented the results of the beam test made in the TBL line, with beam currents from 3.5A to 13A (max. available at the moment of the test). In order to determine the minimum resolution attainable by a BPS monitor in the measurement of the beam position, being the device figure of merit, with a resolution goal of 5¿m at maximum beam current of 28A according to the TBL specifications. / García Garrigós, JJ. (2013). Development of the Beam Position Monitors for the Diagnostics of the Test Beam Line in the CTF3 at CERN [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/34327

[EN] The Compact Linear Collider (CLIC) is an electron-positron collider conceived for the study of High-Energy Physics in the TeV center of mass energy region, is based on a two-beam operation principle: instead of using active elements (klystrons), the necessary RF power to accelerate the Main Beam (MB) is obtained from the deceleration of a high-current, moderate energy Drive Beam (DB) in the so-called Power Extraction and Transfer Structures (PETS). These structures emit an RF signal of about 130 MW power at 12 GHz. As this frequency is above the cut-o ff frequency of the fundamental mode for the specified beam pipe dimensions (7.6 GHz), the inference propagates from the PETS to the neighboring devices, including the Beam Position Monitors (BPM). According to the CLIC Conceptual Design Report (CDR), an ef ficient beam position monitoring system for the CLIC DB decelerator needs to meet the following requirements: - It should be as simple and economic as possible, as 41580 units are required, amounting to 75% of all CLIC BPMs. - The signal processing scheme should not be a ffected by the PETS interference. This rules out processing the signals at the beam bunching frequency (12 GHz). - The resulting position signal should detect changes in the beam position whose duration is 10 ns or longer. - The required spatial resolution is 2 um for a 23 mm diameter vacuum pipe. - Wide dynamic range: the electronic acquisition system must be able to process signals with extreme levels, induced by either very high (100 A) or very low (3 A) current beams. This PhD thesis describes the electromagnetic and mechanical design of the first prototype BPM developed for the CLIC Drive Beam and its characterization tests in laboratory and with beam. The first two chapters introduce the CLIC project and review the state-of-the-art beam position monitoring techniques. Chapter 3 presents the design of the BPM. The stripline technology has been selected, as it is the only one among the most commonly used BPM techniques to present a suitable frequency response to filter out the RF interference caused by the PETS. Choosing an appropriate length for the electrodes, it is possible to tune one the periodic notches in the stripline frequency response to 12 GHz. The influence of di erent electromagnetic and geometrical aspects is also studied, such as beam coupling impedance or the ratio between longitudinal and transverse dimensions. The design of the electronic acquisition system is presented in Chapter 4, considering the project requirements in terms of resolution (2 u m), accuracy (20 um) and time resolution (10 ns). Due to the high amount of units required, the number of electronics components has been minimized. As the designed signal processing scheme is based on charge integration, it can be adapted to di erent stripline pick-ups by simply modifying the attenuator settings according to the required output signal levels. The laboratory characterization tests of the prototype stripline BPM, in the low and the high frequency ranges, performed with a thin wire and a coaxial waveguide, respectively, are described in Chapter 5. The measurement results are compared with the theoretical estimation and the electromagnetic field simulations. In addition, the high-frequency test reveals that the first prototype stripline BPM does not provide su cient suppression of the 12 GHz PETS RF interference. An additional study proposed several modifications and guidelines for a second prototype stripline BPM. Finally, Chapter 6 presents the beam tests of the prototype stripline BPM at the CLIC Test Facility 3 (CTF3) in the Test Beam Line (TBL), a scaled version of the CLIC Drive Beam decelerator. Two types of tests were performed: linearity/sensivity and resolution. These results are compared to the ones in the laboratory characterization tests. An upper bound of the resolution is estimated performing a Singular Value Decomposition (SVD) analysis. / [ES] El Colisionador Lineal Compacto (Compact Linear Collider, CLIC), un colisionador de electrones y positrones concebido en el CERN para el estudio de la Física de Altas Energías en la región de los TeV, se basa en un principio de funcionamiento de doble haz: en lugar de emplear elementos activos (klystrons) para proporcionar la potencia RF requerida para acelerar el haz principal (Main Beam, MB), ésta se obtiene de la deceleración de un haz secundario (Drive Beam, DB), de alta corriente y energía moderada, en las llamadas estructuras de extracción y transferencia de potencia (Power Extraction and Transfer Structures, PETS). Estas estructuras emiten una señal interferente RF de más de 130 MW de potencia a 12 GHz, que, por estar localizada en una frecuencia superior a la de corte del modo fundamental en el tubo de vacío del haz (7.6 GHz), se propaga por éste hacia los dispositivos adyacentes, entre los cuales se encuentran los sistemas de monitorización de la posición (Beam Position Monitor, BPM). De acuerdo con el informe conceptual de diseño de CLIC (Conceptual Design Report, CDR) , un sistema eficiente de monitorización de la posición del haz en el decelerador del haz secundario deberá cumplir los siguientes requisitos: - Debe ser lo más sencillo y económico posible, ya que se precisan 41580 unidades: el 75% de todos los BPMs de CLIC. - El procesado de señal en el sistema de adquisición deberá ser inmune a la interferencia generada en las PETS. Esto excluye la solución habitual de procesar las señales del BPM a la frecuencia de pulsado del haz (12 GHz). - La señal de posición resultante del procesado debe ser capaz de detectar cambios en la posición del haz de duración igual o mayor a 10 ns (resolución temporal). - La resolución espacial requerida es de 2 um para un tubo de vacío de 23 mm de diámetro, con una calibración precisa. - Amplio rango dinámico: el sistema electrónico de adquisición del BPM debe poder resistir los altos valores de señal provocados por los casos de desviación extrema del haz nominal (se contempla una desviación máxima de la mitad del radio del tubo), así como detectar las señales inducidas por las configuraciones de haz con menor carga de todas las previstas, cuyos niveles serán muy débiles. / [CA] El Col·lisionador Lineal Compacte (Compact Linear Collider, CLIC), un col·lisionador d'electrons i positrons concebut per l'estudi de la Física d'Altes Energies a la regió dels TeV (energía del centre de massa), es basa en un principi de funcionament de doble feix:en lloc de fer servir elements actius (klystrons) per proporcionar la potència RF requerida per accelerar el feix principal (Main Beam, MB), aquesta s'obtè de la desacceleració d'un feix secundari (Drive Beam, DB), d'alt corrent i energia moderada, a les anomenades estructures d'extracció i transferència de potència (Power Extraction and Transfer Structures, PETS). Aquestes estructures emeten una senyal interferent RF de més de 130 MW de potència a 12 GHz, que, pel fet d'estar localitzada a una freqüència superior a la de tall del mode fonamental al tub de buit del feix (7.6 GHz), es propaga a través d'aquest fins els dispositius adjacents, entre els quals trobem els sistemes de monitorització de la posició (Beam Position Monitor, BPM). D'acord amb l'informe conceptual de disseny de CLIC (Conceptual Design Report, CDR), un sistema eficient de monitorització de la posició del feix al desaccelerador del feix secundari haurà de complir els següents requisits: ¿ - Ha de ser el més senzill i econòmic possible, ja que es necessiten 41580 unitats: el 75% de tots els BPMs de CLIC. ¿ - El processat de la senyal al sistema d'adquisició haurà de ser inmune a la interferència generada als PETS. Això exclou la solució habitual de processar les senyals del BPM a la freqüència de pulsacions del feix (12 GHz). ¿- La senyal de posició resultant del processat ha de ser capaç de detectar canvis a la posició del feix de durada igual o més gran que 10 ns (resolució temporal). ¿- La resolució espaial necessària és de 2 um per a un tub de buit de 23 mm de diàmetre. ¿- Ampli rang dinàmic: el sistema electrònic d'adquisició del BPM ha de poder processar senyals amb nivells extrems, induïdes per feixos de molt alt (100 A) i molt baix (3 A) corrent. / Benot Morell, A. (2016). Beam position monitoring in the clic drive beam decelerator using stripline technology [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/64067

L’imagerie par résonance magnétique (IRM) est un outil d’investigation majeur donnant accès de manière non invasive à des nombreuses informations quantitatives et fonctionnelles. La qualité des images obtenues (rapport-signal-sur-bruit, RSB) est cependant limitée dans certaines applications nécessitant des résolutions spatiales et/ou temporelles poussées. Afin d’améliorer la sensibilité de détection des équipements d’IRM, diverses orientations peuvent être suivies telles qu’augmenter l’intensité du champ magnétique des imageurs, améliorer les performances des systèmes de détection radiofréquence (RF), ou encore développer des séquences d’acquisition et des techniques de reconstruction d’images plus efficaces. La thématique globale dans laquelle s’inscrit cette thèse concerne le développement des systèmes de détection RF à haute sensibilité pour l’IRM à haut champ chez l’homme. En particulier, des antennes auto-résonantes basées sur le principe des lignes de transmission sont utilisées parce qu’elles peuvent être réalisée sur substrat souple. Cette adaptabilité géométrique du résonateur permet d’ajuster précisément sa forme aux spécificités morphologiques de la zone anatomique observée, et ainsi d’augmenter le RSB. La première visée technologique de ce projet concerne le développement, de la conception jusqu’à la mise en œuvre dans un appareil 7 T corps entier, d’un système de détection RF flexible à haute sensibilité, utilisant des antennes miniatures associées en réseau. L’utilisation d’un réseau d’antennes miniatures permet d’obtenir des images sur un champ de vue élargi tout en conservant la haute sensibilité inhérente à chaque antenne miniature. De plus, la technologie de l’imagerie parallèle devient accessible, ce qui permet d’accélérer l’acquisition des images. De surcroît, un nouveau schéma de résonateur de ligne transmission avec un degré de liberté supplémentaire est introduit, ce qui permet de réaliser de grands résonateurs multi-tours pour l’IRM à haut champ. Cette thèse décrit le développement, la mise en œuvre et l’évaluation des nouveaux systèmes de détection RF au moyen de simulations analytiques et numériques, et des études expérimentales. / Magnetic resonance imaging (MRI), among other imaging techniques, has become a major backbone of modern medical diagnostics. MRI enables the non-invasive combined, identification of anatomical structures, functional and chemical properties, especially in soft tissues. Nonetheless, applications requiring very high spatial and/or temporal resolution are often limited by the available signal-to-noise ratio (SNR) in MR experiments. Since first clinical applications, image quality in MRI has been constantly improved by applying one or several of the following strategies: increasing the static magnetic field strength, improvement of the radiofrequency (RF) detection system, development of specialized acquisition sequences and optimization of image reconstruction techniques. This work is concerned with the development of highly sensitive RF detection systems for biomedical ultra-high field MRI. In particular, auto-resonant RF coils based on transmission line technology are investigated. These resonators may be fabricated on flexible substrate which enables form-fitting of the RF detector to the target anatomy, leading to a significant SNR gain. The main objective of this work is the development of a flexible RF coil array for high-resolution MRI on a human whole-body 7 T MR scanner. With coil arrays, the intrinsically high SNR of small surface coils may be exploited for an extended field of view. Further, parallel imaging techniques are accessible with RF array technology, allowing acceleration of the image acquisition. Secondly, in this PhD project a novel design for transmission line resonators is developed, that brings an additional degree of freedom in geometric design and enables the fabrication of large multi-turn resonators for high field MR applications. This thesis describes the development, successful implementation and evaluation of novel, mechanically flexible RF devices by analytical and 3D electromagnetic simulations, in bench measurements and in MRI experiments.

Componentes de buraco de nêutrons nos isótopos ANTPOT 99, 101, 103 Ru foram investigadas atrav6s de reações (d,t), induzidas por dêuterons de 15,5 MeV em ANTPOT 100Ru e 16 MeV em ANTPOT 102 Ru e ANTPOT 101 Ru. Os grupos de trítons emergentes, analisados em momento por um espectrógrafo magnético, foram detectados em placas de emulsão nuclear. Resolução em energia melhor que 8 keV permitiu a identificação de 14, 36 e 46 níveis, até as energias de excitação de 1,4; 2,1 e 2,5 MeV, respectivamente, nos ANTPOT 99, 101, 103 Ru. Os momentos angulares orbitais transferidos, l, e as intensidades espectroscópicas foram obtidos a partir da comparação entre distribuições angulares experimentais, medidas cm ângulos judiriosamente escolhidos entre 8º e 46º, e as previstas pela Aproximação de Born com Ondas Distorcidas. A análise das distribuições das intensidades espectroscópicas, associadas a cada l, nos três isótopos revela um padrão de semelhança, embora haja um deslocamento das maiores intensidades espectroscópicas para menores energias, quando se eleva o número de nêutrons, que indica, juntamente com um aumento da densidade de níveis, crescente deformação nuclear. Especial atenção é dirigida a transições para estados de baixa energia de excitação com l = 3 e l = 1, associadas a orbitais não pertencentes à camada de valência, cuja descrição é discutida em termos de um modelo quase-partícula-rotor prolato, não-rígido, com o tratamento completo da interação de Coriolis, e do Modelo de Bósons e Férmions Interatuantes. / Neutron-hole components in 99, 101, 103 Ru Isotopes were Investigated by (d,t) reactions at incident deuteron energies of 15.5 MeV and 16 MeV on, respectively, 100 Ru and 102,104 Ru. Outgoing triton groups were momentum analyzed by a magnetic spectrograph and dctectcd in nuclear emulsion plates with an energy resolution better than 8 keV. A total of 14, 36 and 46 leveis up to 1.4, 2.1 and 2.5 MeV excitation energy were identified, respectively, 99, 101, 103 Ru. The transferred orbital angular momenta, l, and the spectroscopic strengths were obtained by con1paring experimental angular distributions, measured at carefully chosen scattering angles between 8º and 46º, with Distorted Wave Born Approximation predictions. The analysis of the spectroscopic strength distributions corresponding to each l-value reveals a similar pattern among the three isotopes, although there is a shift of the highest strengths towards low energy, for increasing neutron number, indicating increasing deform at ion. Special attention is drawn to transitions to low-lying states with l=3 and l=1 character, associated with the next major shell, whose description is discussed in terms of a quasiparticle-prolate non-rigid rotor model with the Coriolis effect fully treated, and the Interacting Boson-Fermion Model.