Osteogenesis imperfecta is an inherited disorder caused mainly by collagen type I genes mutations, COL1A1 and COL1A2. These mutations affect especially connective tissue. Disease is characterized by fragile bones, deformations and increased frequency of fractures. It's worldwide extensive disorder regardless of age, sex, nationality or races. The incidence is 1: 16 - 20 000 births. Currently, we described nine clinically distinct forms of Osteogenesis imperfecta. Only the first four types OI, type I-IV, are caused by collagen type I genes mutations . In these nine types there are distinguished mild and severe forms. Type II and III are lethal forms, death occur offen during prenatal period or in the first days of the life affected individuals. Characteristic clinical features of collagen forms OI are an increased incidence of fractures, deformations of bones, blue sclera, hearing loss, Dentinogenesis imperfecta small or subnormal growth (Marini, 2010). This study alignment is mainly the description of the clinical forms, exploring the molecular basis of disease and determine the relationship between the type and position of the mutation and the resulting phenotype of affected individuals. We have analysed exons 31-40, including associated non-coding regions, of the COL1A1 gene (so-called MLBR =...

Population structure, biogeography and phylogenetic relationships of the fruit bat genus Rousettus have been studied in Africa and adjacent regions. The current population patterns of rousettine fruit bats in the Old World are influenced by several environmental attributes, namely the topography, climate and land cover. These variables are mirrored in fruit bat plesiomorphies related to the ecological niche of tropical flying frugivore, as well as apomorphies of rousettines including echolocation ability, roosting in caves and dispersal capacity in open landscapes with discontinuous tree cover. Phylogenetic relationships among species and subspecies of the genus have been indicated and confronted with the existing colonization scenarios. Insular populations (including habitat islands within desert oases) show frequent genetic differentiation from their mainland relatives suggesting successful founder events after traversing stretches of unsuitable habitats. Genetic differentiation evolving in less distant islands suggests involving behavioural mechanisms maintaining cohesion of isolated demes as site fidelity and natal habitat-biased dispersal. In sub-Saharan mainland Africa within the large range reaching from the southern border of Sahara to Cape Peninsula, Rousettus populations share a...

This diploma thesis called "Koncept biopolitiky v díle Michela Foucaulta s konkrétním zaměřením na bezpečnost v rámci oblasti ČR od roku 1990" is devoted to the theme of biopolitics in the writings of Michel Foucault. At first the thesis focuses on previous writings of Michel Foucault, which inspired his concept of biopolitics. It's all about the archeology of knowledge, discipline and sexuality dispozitiv. Biopolitics is a government practice that focuses on the population as a mass. The population by biopolitics is influenced by factors such as the environment, health issues, mortality etc. According to Foucault, biopolitics is originated in the political direction called liberalism. Foucault's ideas and theses are mainly related to the 19th century, but the theme of biopolitics is also relevant for our time. Therefore the diploma thesis focuses on the drugs problem in the Czech Republic on the basis of Foucault's biopolitics. The thesis acquaints us with the evolution of the drug scene in the Czech Republic after 1990, when there was a new political constitution. It acquaints us with the drug policy that works in the Czech Republic and with legislation that resolves the criminal page of drug problems. The thesis also deals with ways of helping drug addicts. Keywords biopolitics, discourse,...

The present thesis focuses on the comparison of the Czech pension system before 2010 with the one after the changes made in 2010-2013. The parameters of the first pillar which changed in the mentioned period are analysed. The partial adjustments of the first pillar are viewed by prism of the following criteria: budget accountability, quality of life, solidarity, contributory principles, participation and the persistence of the chosen solution in the time. Furthermore the thesis focuses on the effects induced by the implementation of the second pillar. And last but not least is attention paid to the chosen components of the third pillar, which under went changes in 2010-2013 years. Important part of the thesis is a research conducted by online questionnaire, which aimed to find out what knowledge about the pension system and its changes in 2010-2013, do the citizens have. Theoretical bases includes the theory of path dependency, the theory of institutionalism, the welfare state theory and the criterion anchoring. The present thesis applies the method of analysis of secondary data and the method of comparative analysis. To obtain secondary data, methods of document and data record searching are used. Powered by TCPDF (www.tcpdf.org)

Diploma thesis deals with the identification of the influence of population aging on public finances in the Czech Republic. The thesis describes the effect of population aging on selected items of the state budget with a focus on state expenditures. The greatest attention is paid to old-age pensions. There is also an estimate of the impact of population aging on old-age pensions by the sensitivity coefficient and the prediction of old-age pensions expenditures for 2018-2050. Subsequently attention is given to evaluation the impact on public finances and their sustainability and propose economic and policy recommendations.

Needs analysis of the outreach program's clients in the Beroun region The needs of outreach programme clients depends if the the drug scene is open or closed. The thesis is focused on outreach programme in a town, where the drug scene is ussually closed. The theoretical part is focused on the location advantages and disadvantages, service provided and outreach work based on the harm reduction principles. In the Czech Republic, there are 53 outreach programmes, not only in large cities, but also in smaller ones, where outreach work attitude is adapted to clients needs. Needs analysis in one of the evalution tools that helps to view the current needs of clients and also suggest their further improvement and development. The aim of the thesis is to describe the scope, characteristics and needs of problem users and to evaluate the other services accessibility in the Beroun region. The partial goals of the work are the closed drug scene monitoring and the need for establishing a contact center in the region. The method of data collection was a semi-structured interview recorded on a record sheet and IN- COME questionnaires realized with clients of the outreach programme in the Beroun region. There was also a structuring of interventions provided by other organizations in the locality. The selection of...

Population structure, biogeography and phylogenetic relationships of the fruit bat genus Rousettus have been studied in Africa and adjacent regions. The current population patterns of rousettine fruit bats in the Old World are influenced by several environmental attributes, namely the topography, climate and land cover. These variables are mirrored in fruit bat plesiomorphies related to the ecological niche of tropical flying frugivore, as well as apomorphies of rousettines including echolocation ability, roosting in caves and dispersal capacity in open landscapes with discontinuous tree cover. Phylogenetic relationships among species and subspecies of the genus have been indicated and confronted with the existing colonization scenarios. Insular populations (including habitat islands within desert oases) show frequent genetic differentiation from their mainland relatives suggesting successful founder events after traversing stretches of unsuitable habitats. Genetic differentiation evolving in less distant islands suggests involving behavioural mechanisms maintaining cohesion of isolated demes as site fidelity and natal habitat-biased dispersal. In sub-Saharan mainland Africa within the large range reaching from the southern border of Sahara to Cape Peninsula, Rousettus populations share a...

The purpose of this diploma work is to describe the possibilities of senior education and specific needs of senior education. The population of Czech republic is ageing. In order to this it is necessary to define very important terms like age, ageing, age management. Demographic situation will need new solutions in learning, because people will have to work longer than it was in history. To be successful at labour market, older people will have to pass various courses and trainings. It is also necessary to prepare for age, because people are living longer, this period can last 30 or 40 years. Learning is a very good way to keep healthy and vital. Senior education has many variations - for ambitious people it can be University of third age, for less demanding students it can be for example Leisure time university. It was proofed, that senior education has positive influence on their health, they are not so often sick, have better mood. Seniors can thank to learning understand the current world and that is useful for them and for the society too. Key words: age, ageing, age management, senior, lifelong learning, specifics of senior education, ageing society, preparing for ageing

6 Abstract Title: Public opinion research of visitors of the Olympic Park Sochi - Letna 2014 Goal: To evaluate the importance of the Olympic Park Sochi - Letna 2014 based on public opinion of visitors. To propose conceptual improvements for the following Olympic parks during the Summer and the Winter Olympic Games. Methods: Quantitative questionnaire was used as the main method to determine public opinion. Qualitative in-depth interview with representatives of sports institutions and analysis of documents from internal resources served as a secondary analysis. Results: The Olympic Park Sochi - Letna 2014 was visited mainly by sport active people from Prague and Central Bohemia. Most of them were satisfied with the concept of the park and they would visit this kind of park in the next years, for which they would recommend bigger capacity and fitting refreshments. People came to the park to play sports and to try lesser known sports. They think that the concept of Olympic park would help to motivate public to practise sports. Key words: Public opinion, sport and population, Olympic Park Sochi - Letna 2014, Winter Olympic Games

The theoretical part of this thesis describes addictive behavior on the Internet and on- line games, the profile of the target group of students in primary schools in connection with a range of personality traits in terms of posing a risk of substance use. The purpose of the research thesis is the implementation of a questionnaire study on the prevalence of addictive behavior in using the Internet to play on-line games and identify links between this behavior and the various activities carried out on the Internet, sociodemographic characteristics, experience with substance use and risk factors for anxiety, hopelessness, search experiences and impulsivity. The basic set consists of all students 6 to 9 years of school districts in Kolin and Kutna Hora. The aim is to get around the 50 respondents showing signs of addictive behavior or threat of execution dependency behavior of the correlation study, the research file contains more than 600 pupils.