This thesis examines 5-year clinical and health-economic outcomes of ischaemic stroke, and their relationship to short-term post-stroke disability, as captured by the 3-month modified Rankin Scale (mRS) - the favoured primary outcome measure in acute stroke trials. I use data from the Oxford Vascular Study (recruited 2002-2014), a population-based prospective cohort for which I followed patients in-person and via medical records until 15-May-2017. I demonstrate that 3-month mRS strongly predicts 5-year post-stroke disability and mortality, including in clinically-relevant groups (treatable major strokes, atrial fibrillation-related strokes, and lacunar strokes), reaffirming its use as a trial outcome measure. About one in four patients experience functional recovery between 3-12 months post-stroke, and mortality follow-up beyond 1-year by stroke trials can show translation of early disability gains into lower mortality. Contrary to previously reported apparent sex-differences, I find no evidence of worse outcomes in women after accounting for differences in age and pre-stroke mRS. I find that late recovery between 3-12 months occurs more often in lacunar strokes, supporting the focus of restorative therapies in this group, but highlighting that uncontrolled studies cannot assume that improvements after 3-months are treatment-related. In addition, I demonstrate that like death/disability, outcomes of institutionalization, post-stroke dementia, health/social-care costs, and quality-adjusted life expectancy (QALE) also show meaningful differences with each step up the mRS ladder. Consequently, ordinal analysis of the 3-month mRS (capturing transitions across the scale's range) better predicts long-term outcomes than dichotomous approaches, which also foster high exclusion rates of relevant patient segments from trials owing to their pre-morbid disability. However, the mRS should be weighted in ordinal analyses, as different state transitions carry different implications for long-term outcomes. Using 3-month mRS-stratified data for clinical endpoints, care costs, and QALE, I derive mRS weights that could be used for meaningful ordinal analyses, clinical prognostication, and cost-effectiveness analyses of stroke therapies.

Master thesis discusses the growing need of electric energy storage and its effectivity and capacity. It describes an overview of possible technologies with their advantages and disadvantages. Greater attention is paid to the storage of energy in gas, so-called Power to Gas, which combines the electrolytic production of hydrogen from water and the Sabatier reaction to produce synthetic methane. This technology is introduced in the so-called SIT Brno cycle of Siemens Industrial Turbomachinery company. The main part of the thesis is focused on the description of this cycle and on the calculation of the steam-gas turbine (high-pressure and low pressure module). This thesis describes the methodology of turbine calculation and the composition of the steam gas mixture after combustion of methane. The carbon dioxide formed by combustion in the steam-gas mixture generator was replaced by steam. Part of the diploma thesis are drawings of cross-section of individual turbine modules.

This diploma thesis deals with the problematics of fan cooling towers. The very first part of the text is research, focusing mainly on the theory of cooling and the function of fan cooling towers in general. The following chapter deals with the water resource management of the Dukovany nuclear power plant and the specification of its objects of forced draft cooling towers. The second part describes a computational model created to determine the cooling performance of these towers under the given input conditions. In the following chapters, the results from the computational model are compared with the available data from warranty measurements and with the provided characteristics. The final pages deal with the study of the influence of changes in input parameters on the cooling performance and the research of the behavior of the cooling towers under extreme weather conditions.

In mid-April 1945, US and UK forces swept through Germany. The Western Allies had spent years preparing for the moment, cultivating a civil affairs capacity since the Interwar Period and devoting thousands of hours to planning for the occupation. However, the rapid pace of the advance stretched the new capability beyond its limits as frontline forces seized large swaths of Germany and encountered exponentially increasing numbers of displaced persons. The accidental discoveries of Buchenwald and Bergen-Belsen and the tens of thousands of survivors suffering appalling levels of starvation and disease overwhelmed the forces dispatched to address the sites, resulting in a sluggish response. Significant flaws in Allied planning assumptions caused the breakdown that potentially cost hundreds of unnecessary deaths. Yet, operational staff officers from the Supreme Headquarters down to the division level recognized the poor response and, in two short weeks, adapted the plan to address the conditions on the front. Policy adjustments and messages from General Eisenhower removed ambiguity in existing guidance and provided clear direction to frontline forces. More importantly, the Western Allies formally merged the campaign plan guiding combat operations, OVERLORD, with the plan for occupation, ECLIPSE. The changes produced a marked improvement in the US liberation of Dachau on 29 April 1945, thereby demonstrating adaptation and innovation at the operational level of war.

La présente étude analyse les représentations de la ville dans la série policière d’Ian Rankin dont l’inspecteur John Rebus est le protagoniste. La polarité étant l’un des principes organisateurs de l’écriture rankinienne, notre analyse s’articule autour de plusieurs couples de notions antinomiques. Nous remettons d’abord en cause la légitimité de l’antinomie qui oppose la littérature à la « littérature de masse », dans laquelle est souvent classé le roman policier. Cela nous conduit à redéfinir le roman policier, et mettre en perspective la série dans le contexte du monde littéraire et artistique écossais contemporain. Puis nous étudions l’articulation entre topographie réelle et lieu imaginaire dans l’Edimbourg de Rankin. Toute une géographie urbaine se dessine dans les romans ; l’arpentage incessant de l’espace par le protagoniste fournit l’occasion de références très spécifiques à la topographie et à la toponymie, et la sérialité tisse peu à peu un dense réseau de points nodaux ainsi qu’une multiplicité de trajets potentiels que nous avons représentés par des cartes fournies en annexe. Mais dans d’autres cas, l’espace se fait générique, se réfère plus à des conventions cinématographiques qu’à la carte de la ville. Nous envisageons enfin la ville d’Edimbourg comme un personnage ambivalent dans la lignée des personnages du roman gothique. La filiation gothique est perceptible dans l’esthétique de la ville, et la surface de la carte est compartimentée suivant un ensemble d’axes polarisants. Toutefois, cette carte se déploie elle-même par-dessus un double souterrain et non cartographiable d’Edimbourg, à la fois mémoire et inconscient de la ville. / The aim of the present study is to analyse the representations of the city to be found in Ian Rankin’s crime fiction series of which Inspector Rebus is the protagonist. Polarization being one of the structuring principles of the author’s writing, our work focuses on several pairs of antagonist notions in turn.The first one is the opposition between “high” and “low” (or “popular”) literature, the latter category being often associated with crime fiction. New categorizations of contemporary Scottish crime fiction are thus put to the test so as to assess its role and place within the landscape of Scottish literary and artistic life.Next the way Rankin’s novels map Edinburgh as a topography both real and imaginary is explored. As John Rebus endlessly paces the streets of the city, a literary geography gradually emerges and takes shape from one novel to the next, thus determining a network of focal points and potential trajectories which are depicted in the maps to be found in the annexes. This does not preclude the use of a more urban-generic type of space, which seems to have been modelled on representations of the city deriving from movies.In time, Rebus’ Edinburgh can be seen as a character in its own right, one fraught with ambiguities stemming from the Gothic novel tradition. This Gothic filiation is visible in the aesthetic of the city, while the polarity between surface representations and subterranean depths, full of twists and turns, calls into question the very possibility of mapping the city as it gradually discloses its past and unconscious memories.

La présente étude analyse les représentations de la ville dans la série policière d'Ian Rankin dont l'inspecteur John Rebus est le protagoniste. La polarité étant l'un des principes organisateurs de l'écriture rankinienne, notre analyse s'articule autour de plusieurs couples de notions antinomiques. Nous remettons d'abord en cause la légitimité de l'antinomie qui oppose la littérature à la " littérature de masse ", dans laquelle est souvent classé le roman policier. Cela nous conduit à redéfinir le roman policier, et mettre en perspective la série dans le contexte du monde littéraire et artistique écossais contemporain. Puis nous étudions l'articulation entre topographie réelle et lieu imaginaire dans l'Edimbourg de Rankin. Toute une géographie urbaine se dessine dans les romans ; l'arpentage incessant de l'espace par le protagoniste fournit l'occasion de références très spécifiques à la topographie et à la toponymie, et la sérialité tisse peu à peu un dense réseau de points nodaux ainsi qu'une multiplicité de trajets potentiels que nous avons représentés par des cartes fournies en annexe. Mais dans d'autres cas, l'espace se fait générique, se réfère plus à des conventions cinématographiques qu'à la carte de la ville. Nous envisageons enfin la ville d'Edimbourg comme un personnage ambivalent dans la lignée des personnages du roman gothique. La filiation gothique est perceptible dans l'esthétique de la ville, et la surface de la carte est compartimentée suivant un ensemble d'axes polarisants. Toutefois, cette carte se déploie elle-même par-dessus un double souterrain et non cartographiable d'Edimbourg, à la fois mémoire et inconscient de la ville.

Le Cycle Organique de Rankine (abrégé ORC de l’anglais Organic Rankine Cycle) est une technologie permettant la conversion de chaleur basse température en électricité. L’ORC transcritique a été identifié comme une solution prometteuse pour la valorisation de la chaleur fatale. Cependant, peu d’installations expérimentales ont permis de confirmer ces performances. Ce travail de thèse présente le fonctionnement et l’optimisation d’ORC sous-critique et transcritique pour la conversion de chaleur basse température en électricité à partir de différentes sources. Premièrement, les contextes thermodynamique et technologique de l’ORC sont présentés. Des critères de performance énergétiques et exergétiques sont définis et appliqués à une base de données d’installations expérimentales afin d’exposer l’état de l’art actuel des ORC. Deuxièmement, les outils numériques et expérimentaux, spécifiquement développés ou utilisé pour ces travaux, sont présentés. Trois installations expérimentales d’ORC transcritique complet ou incomplet fournissent les données expérimentales. Différents modèles numériques sont utilisés : sous l’environnement Matlab pour la modélisation en permanent, l’analyse des données expérimentales et l’analyse énergétique/exergétique ; L’environnement Modelica/Dymola pour l’analyse des transitoires et de la dynamique du système. Dans un troisième temps, ces différents outils sont utilisés pour étudier quatre différentes problématiques : - Le fonctionnement de la pompe de circulation est étudié, d’un point de vue énergétique et volumétrique. Des modèles semi-empiriques et des corrélations de performance sont présentés. - Les transferts thermiques en supercritique sont examinés, en local et en global. Les coefficients de transfert thermique sont comparés avec différentes corrélations de la littérature. - L’influence de la charge de réfrigérant sur les performances et le comportement de l’ORC est analysée. La charge optimale est estimée pour différentes conditions de fonctionnement et des mécanismes de régulation de la charge sont présentés. - Les performances énergétiques et exergétiques de l’ORC sont comparées avec la base de données. Une analyse exergétique du procédé a permis d’identifier des voies d’amélioration. / The Organic Rankine Cycle (ORC) is a technology used for low-grade thermal energy conversion into electricity. Transcritical ORC has been identified as a solution for efficient waste heat recovery. However, few experimental tests have been conducted to confirm the interest of transcritical ORC and investigate its operational behaviors. The work presented focuses on the operation and the optimization of subcritical and transcritical Organic Rankine Cycles for low-grade heat conversion into electricity from various heat sources (solar, industrial waste heat). First, the thermodynamic framework of ORC technology is presented. Energetic and exergetic performance criteria, appropriate to each type of input source, are introduced and selected. The criteria are later applied to a database of ORC prototypes, in order to objectively analyze the state-of-the-art. In a second step, the experimental and numerical tools, specifically developed or used in the present thesis, are presented. Three subcritical and transcritical ORC test benches (hosted by CEA and AUA) provided experimental data. Numerical models were developed under different environments: Matlab for steady-state modeling, data processing and energy/exergy analysis. The Modelica/Dymola environment for system dynamics and transient operations. Lastly, the different tools are exploited to investigate four different topics: - The ORC pump operation is investigated, both under an energetic and volumetric standpoint, while semi-empirical models and correlations are exposed. - Supercritical heat transfers are explored. Global and local heat transfer coefficients are estimated and analyzed under supercritical conditions, while literature correlations are introduced for comparison. - Working fluid charge influence over the ORC performance and behavior is investigated. Optimal fluid charge is estimated under various operating conditions and mechanisms for charge active regulation are exposed. - ORC system performances and behavior are discussed. Through both an energetic and exergetic standpoint, performances are compared with the state-of-the-art, while optimization opportunities are identified through an exergetic analysis.

This thesis discusses contemporary Scottish crime fiction in light of its transatlantic contexts. It argues that, despite participating in a globalized popular genre, examples of Scottish crime fiction nevertheless meaningfully intervene in notions of Scottishness. The first chapter examines Scottish appropriations of the hard-boiled mode in the work of William McIlvanney, Ian Rankin, and Irvine Welsh, using their representation of traditional masculinity as an index for wider concerns about community, class, and violence. The second chapter examines examples of Scottish crime fiction that exploit the baroque aesthetics of gothic and noir fiction as a means of dealing with the same socio-political contexts. It argues that the work of Iain Banks and Louise Welsh draws upon a tradition of distinctively Scottish gothic in order to articulate concerns about the re-incursion of barbarism within contemporary civilized societies. The third chapter examines the parodic, carnivalesque aspects of contemporary Scottish crime fiction in the work of Christopher Brookmyre and Allan Guthrie. It argues that the structure of parody replicates the structure of genre, meaning that the parodic examples dramatize the textual processes at work in more central examples of Scottish crime fiction. The fourth chapter focuses on examples of Scottish crime fiction that participate in the culturally English golden-age and soft-boiled traditions. Unpacking the darker, more ambivalent aspects of these apparently cosy and genteel traditions, this final chapter argues that the novels of M. C. Beaton and Kate Atkinson obliquely refract the particularly Scottish concerns about modernity that the more central examples more openly express.

The diploma thesis deals with the design of the industrial boiler for biomass, Which deals with the issue of the energy future of combustion of fuels using current power generation - microcogeneration, designed for larger houses or smaller com- panies. The shape of the device is the interconnection of individual functional and technological parts of the boiler, a view of a new product that re ects its function. It uses modern and timeless materials, color and control technology to achieve overall comfort and time savings and service.

LNG, natural gas, Brayton cycle, Rankine cycle