An influence of variations in human genome is perceptible at a first glance on human itself to see differences between the individuals and entire populations. Also, behavior or probability of certain diseases are influenced in large way by differences at genome's level. This work presents methods for detecting variations in the human genome that were developed after an arose of the second-generation sequencing technologies. A new tool that combines read pair and split read methods, with information about a depth of coverage was also designed and implemented. The tool was tested on simulated and real data and compared with a reference outputs.

Este proyecto busca demostrar los efectos positivos del Supply Chain Management en una empresa de concreto en Perú. La gestión de la cadena de suministro a través del Supply Chain Managent permite desarrollar un mejor enfoque para las redes de proveedores. SCM necesita que las empresas mantengan relaciones a largo plazo con proveedores y que integren su sistema de gestión de la cadena de suministro. Este proyecto muestra los beneficios logrados en términos de costos y tiempo en una empresa del sector del concreto en Perú, lo que demuestra que las herramientas lean aplicadas a una cadena de suministro integrada logran excelentes resultados para la empresa. / This project seeks to demonstrate the positive effects of Supply Chain Management in a concrete company in Peru. The management of the Lean supply chain illustrates a new approach for supplier networks. Lean principles require long-term relationships with suppliers and a highly integrated supply chain management system. This project shows the benefits achieved in terms of costs and time in a company in the concrete sector in Peru, demonstrating that the lean tools applied to an integrated supply chain achieve great results for the company. / Trabajo de Suficiencia Profesional

En Lima metropolitana falta agua potable en determinados lugares y el suministro no es uniforme. Asimismo, las proyecciones que se presentan para el futuro marcan un déficit por mucha demanda poblacional y cambio climático. Ante esta situación, es fundamental buscar medidas que aporten al ahorro del agua potable, y la industria del concreto premezclado en la ciudad ha presentado un crecimiento vertiginoso en los últimos años a excepción del 2020 por el Covid-19 con gran demanda de agua potable. Ante la problemática planteada, es factible usar aguas residuales provenientes de plantas de tratamientos para elaborar concreto premezclado. Se usó 4 tipos de aguas. Tres proveniente de las Plantas de Tratamiento de Agua Residuales (PTARs) de Santa Clara, Carapongo y San Antonio de Carapongo con sistema de tratamiento lodos activados, aireación y filtros de arena para la primera. Anaerobio-Aerobio para la segunda y lodos activados y aireación extendida para la tercera y agua potable del Laboratorio de Ensayo de Materiales (LEM-UNI) para elaborar concreto f'c=210 Kg/cm2 La investigación consta de 7 capítulos: En capítulo 1, se presenta el marco teórico que nos presenta las bases fundamentales empleadas. En el capítulo 2, se tiene los materiales y método utilizados donde de elaboraron 116 muestras en total para ensayos de compresión axial, tracción por compresión diametral, flexión en vigas y permeabilidad al agua. En el capítulo 3, los resultados de los objetivos específicos planteados y su interpretación. En el capítulo 4, las conclusiones finales. En el capítulo 5, las recomendaciones y en capítulo 6 se presenta las referencias consultadas. Finalmente, el capítulo 7 todos los anexos de la investigación. Se llegó a la conclusión que es muy factible elaborar concreto con aguas residuales tratadas procedentes de las 3 PTARs, ya que presentaron un comportamiento óptimo al ser evaluados en sus propiedades físicas, mecánicas y de durabilidad. / In Metropolitan Lima, there is no water in certain places and the supply is not uniform. Also the projections that are presented to the future show a deficit due as a resulto of high population demand and climate change, is essential to look up some ways that contribute to the saving of drinking wáter and the premix concrete industry, in the city has presented dizzy groth in the last years except for 2020 due to the COVID 19 with high demand for drinking wáter. Face with the problem raised, it is very feasible to use wasteater from treatment plants to make premix concrete. It was used four types of water. Three from Santa Clara, Carapongo and San Antonio de Carapongo wastewater treatment plants (PTARs) with a treatment system activated sludge, aeration and sand filters for the first. Anaerobic – Aerobic for the second and activated sludge and extended aeration for the third and drinking wáter from the material testing (LEM-UNI) to make concrete f'c=210 Kg/cm2 This research has 7 chapters: In the 1rst chapter presents us, the theorical framework is about the fundamental bases used. In the 2nd consists about materials and methods used where 116 samples in total were prepared for trials of axial compression, diametral compression traction, vending in beams and wáter permeability. In the 3rd chapter, the results of the specific objectives set and their interpretation. In the 4th last conclusions, in the 5th the recommendations and in the 6th the consulte references are presented. Finally, In the last chapter all the research annexes. It was concluded that is very feasible to makeconcrete with treated wastewater from 3 PTARs, since they presente an optimal behavior when evaluated in their physical, mechanical and durability properties. / Tesis

<p>  </p> <p>Mentorship has served as an effective strategy in helping African American college students persist at predominantly White institutions of higher education (Sinanan, 2016). African American students have reported finding these campus environments to be unwelcoming, even racist. These environmental challenges along with the challenges of unfamiliar academic terrain merge to form frequently formidable barriers to their satisfaction and success. The presence of African American mentors has helped African American students overcome the wide range of challenges they face on such campuses. This qualitative study analyzed the perceptions of African American mentors and mentees about the impact of mentorship on the college persistence of the mentees. The target mentorship community was situated at a private school in the Midwest. Semi-structured interviews were used to solicit the experiential knowledge of participants about their lived experiences. The data was codified and thematically analyzed. Six themes emerged from participant responses including (1) targeted mentorship and modeling, (2) belonging, (3) connections (4) advocacy, (5) racism and anti-Blackness, and (6) persistence. These themes fortify the existing research affirming mentorship as an invaluable tool in helping African American undergraduates persist through degree completion. The assertions and recommendations at the conclusion of the study are purposed to assist scholar-activists, university staff, and students with improving the conditions in which African American students’ study and push toward persistence.</p>

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Диссертационное исследование посвящено выявлению наиболее эффективных организационно-методических условий подготовки детей 6-7 лет к сдаче норм ГТО 1 ступени. В ходе исследования было выявлено, что для успешной подготовки детей старшего дошкольного возраста к сдаче норм ГТО 7 1 ступени можно использовать различные технологии (игровую, онлайн, технологию развития предпосылок универсальных учебных действий). При этом наиболее эффективной для развития большинства физических качеств является технология развития предпосылок универсальных учебных действий. / The dissertation research is devoted to identifying the most effective organizational and methodological conditions for preparing children 6-7 years old to pass the TRP standards of the 1st stage. In the course of the study, it was revealed that various technologies (gaming, online, technology for the development of prerequisites for universal educational actions) can be used for the successful preparation of older preschool children for passing the standards of the TRP 7 of the 1st stage. At the same time, the most effective technology for the development of most physical qualities is the technology for the development of prerequisites for universal educational activities.

Die in den letzten Jahrzehnten aufgenommenen Satellitenbilder zur Erdbeobachtung bieten eine ideale Grundlage für eine genaue Langzeitüberwachung und Kartierung der Erdoberfläche und Atmosphäre. Unterschiedliche Sensoreigenschaften verhindern jedoch oft eine synergetische Nutzung. Daher besteht ein dringender Bedarf heterogene Multisensordaten zu kombinieren und als geometrisch und spektral harmonisierte Zeitreihen nutzbar zu machen. Diese Dissertation liefert einen vorwiegend methodischen Beitrag und stellt zwei neu entwickelte Open-Source-Algorithmen zur Sensorfusion vor, die gründlich evaluiert, getestet und validiert werden. AROSICS, ein neuer Algorithmus zur Co-Registrierung und geometrischen Harmonisierung von Multisensor-Daten, ermöglicht eine robuste und automatische Erkennung und Korrektur von Lageverschiebungen und richtet die Daten an einem gemeinsamen Koordinatengitter aus. Der zweite Algorithmus, SpecHomo, wurde entwickelt, um unterschiedliche spektrale Sensorcharakteristika zu vereinheitlichen. Auf Basis von materialspezifischen Regressoren für verschiedene Landbedeckungsklassen ermöglicht er nicht nur höhere Transformationsgenauigkeiten, sondern auch die Abschätzung einseitig fehlender Spektralbänder. Darauf aufbauend wurde in einer dritten Studie untersucht, inwieweit sich die Abschätzung von Brandschäden aus Landsat mittels synthetischer Red-Edge-Bänder und der Verwendung dichter Zeitreihen, ermöglicht durch Sensorfusion, verbessern lässt. Die Ergebnisse zeigen die Effektivität der entwickelten Algorithmen zur Verringerung von Inkonsistenzen bei Multisensor- und Multitemporaldaten sowie den Mehrwert einer geometrischen und spektralen Harmonisierung für nachfolgende Produkte. Synthetische Red-Edge-Bänder erwiesen sich als wertvoll bei der Abschätzung vegetationsbezogener Parameter wie z. B. Brandschweregraden. Zudem zeigt die Arbeit das große Potenzial zur genaueren Überwachung und Kartierung von sich schnell entwickelnden Umweltprozessen, das sich aus einer Sensorfusion ergibt. / Earth observation satellite data acquired in recent years and decades provide an ideal data basis for accurate long-term monitoring and mapping of the Earth's surface and atmosphere. However, the vast diversity of different sensor characteristics often prevents synergetic use. Hence, there is an urgent need to combine heterogeneous multi-sensor data to generate geometrically and spectrally harmonized time series of analysis-ready satellite data. This dissertation provides a mainly methodical contribution by presenting two newly developed, open-source algorithms for sensor fusion, which are both thoroughly evaluated as well as tested and validated in practical applications. AROSICS, a novel algorithm for multi-sensor image co-registration and geometric harmonization, provides a robust and automated detection and correction of positional shifts and aligns the data to a common coordinate grid. The second algorithm, SpecHomo, was developed to unify differing spectral sensor characteristics. It relies on separate material-specific regressors for different land cover classes enabling higher transformation accuracies and the estimation of unilaterally missing spectral bands. Based on these algorithms, a third study investigated the added value of synthesized red edge bands and the use of dense time series, enabled by sensor fusion, for the estimation of burn severity and mapping of fire damage from Landsat. The results illustrate the effectiveness of the developed algorithms to reduce multi-sensor, multi-temporal data inconsistencies and demonstrate the added value of geometric and spectral harmonization for subsequent products. Synthesized red edge information has proven valuable when retrieving vegetation-related parameters such as burn severity. Moreover, using sensor fusion for combining multi-sensor time series was shown to offer great potential for more accurate monitoring and mapping of quickly evolving environmental processes.

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No description available.

В диссертационном исследовании проанализирован рынок услуг обучающих мероприятий в сфере реализации Комплекса ГТО в г. Екатеринбурге и исследованы потребительские предпочтения целевой аудитории. Разработанный обучающий тренинг может быть использован в ходе работы других муниципальных образований с целью освоения обучающимися на данном тренинге новых инструментов по привлечению широких слоев населения к выполнению нормативов Комплекса ГТО. / The dissertation research analyses the market of training services in the sphere of Ready for Labor and Defense complex implementation in Ekaterinburg and studies consumer preferences of the target audience. The developed training session can be used in the course of work of other municipal structures with the purpose of mastering by the trainees of this training course of new tools on attraction of general population to meet the requirements of the Ready for Labor and Defense complex.